Endocrinology and Metabolic Syndrome最新文献_第3页

Effects of Somatostatin Analogs on Catecholamine Biosynthesis Regulated by Corticosteroids and Bone Morphogenetic Proteins in Rat Pheochromocytoma Cells 生长抑素类似物对大鼠嗜铬细胞瘤细胞中皮质类固醇和骨形态发生蛋白调控的儿茶酚胺生物合成的影响

Endocrinology and Metabolic Syndrome Pub Date : 2020-01-01 DOI: 10.35248/2161-1017.20.9.307

Takahiro Nada, M. Komatsubara, Nahoko Iwata, Y. Nakano, F. Otsuka

{"title":"Effects of Somatostatin Analogs on Catecholamine Biosynthesis Regulated by Corticosteroids and Bone Morphogenetic Proteins in Rat Pheochromocytoma Cells","authors":"Takahiro Nada, M. Komatsubara, Nahoko Iwata, Y. Nakano, F. Otsuka","doi":"10.35248/2161-1017.20.9.307","DOIUrl":"https://doi.org/10.35248/2161-1017.20.9.307","url":null,"abstract":"Regulatory roles of SSAs in catecholamine synthesis have not been elucidated. To clarify the actions of SSAs on catecholamine biosynthesis, we investigated the mutual interactions among SSAs including octreotide and pasireotide, steroids and BMPs using rat pheochromocytoma PC12 cells. Treatment with octreotide and pasireotide (10 nM to 10 μM) had no significant effect on mRNA levels of Th, DOPA decarboxylase and dopamine-β-hydroxylase in PC12 cells. Regarding the interaction with steroids, treatments with SSAs also had no effect on dexamethasone- or aldosterone-induced Th mRNA expression, while pasireotide reduced mRNA expression of the GR. As for the interaction with BMP-4, which can suppress Th mRNA expression by PC12 cells, SSAs did not affect Th expression reduced by BMP-4 and Id1 or Smad1/5/9 activation induced by BMP-4. However, BMP-4 treatment up-regulated MR expression, while treatment with noggin, which neutralizes endogenous BMPs, downregulated MR expression, and the presence of noggin also attenuated aldosterone-induced Th expression, suggesting that endogenous BMPs act to enhance MR activity. Moreover, BMP-4 treatment suppressed the expression of somatostatin receptors including Sstr2 and Sstr5 in PC12 cells, while treatment with noggin up-regulated the expression of Sstr2 and Sstr5, suggesting that BMPs play a desensitizing role in SSA actions. Collectively, the results revealed that SSAs have no direct effect on catecholamine synthesis; however, adrenomedullar BMPs could be modulators for the responsiveness to MR and SSTRs.","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"13 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85442262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment and Association between Lipid and Hormonal Profile in Nonpregnant Females Having Polycystic Ovarian Syndrome 未怀孕女性多囊卵巢综合征的脂质和激素水平评估及其相关性

Endocrinology and Metabolic Syndrome Pub Date : 2019-02-20 DOI: 10.4172/2161-1017.1000297

Farhatul-Ain Arshad, Rubaida Mehmood, S. Perveen, S. Hussain, M. A. Khan

{"title":"Assessment and Association between Lipid and Hormonal Profile in Nonpregnant Females Having Polycystic Ovarian Syndrome","authors":"Farhatul-Ain Arshad, Rubaida Mehmood, S. Perveen, S. Hussain, M. A. Khan","doi":"10.4172/2161-1017.1000297","DOIUrl":"https://doi.org/10.4172/2161-1017.1000297","url":null,"abstract":"Introduction: PCOS is a gynecological endocrine disorder with ovarian dysfunction, hyperandrogenism, infertility, hirsutism, acne, dyslipidemia, and menstrual irregularities. \u0000 \u0000Objectives: The aim of our study is to evaluate the fluctuations of hormonal profile regarding PCOS in fasting and random state as well as the possible risk factor of cardiovascular disorders towards PCOS. \u0000 \u0000Method: Blood was taken by CSLI (Clinical and Laboratory Standards Institution) procedure. Merk and Roach diagnostic systems were used to analyze lipid and hormonal profiles. \u0000 \u0000Results: Significant differences were observed in cholesterol (p=0.004), HDL, LDL (p<0.001) in fasting PCOS vs. control, LDL, HDL (p<0.001), cholesterol (p=0.08), lipid profile ratios in fasting vs. random PCOS, FSH (p=0.01), Progesterone (p=0.000), Estradiol (p=0.000), LH/FSH (p=0.04) in fasting PCOS vs. control, LH (p=0.04) in fasting vs. random PCOS. Significant positive correlation was found among estradiol with cholesterol (r=0.376, p=0.08), LDL (r=0.39, p=0.006) in fasting PCOS, estradiol with cholesterol (r=-0.334, p=0.02), FSH with LDL (r=0.36, p=0.01), progesterone with HDL (r=0.338, p=0.02) in random PCOS. \u0000 \u0000Conclusion: This study assesses the worth of lipid profile in PCOS towards cardiovascular risk factors because lipid and hormonal profile have a direct correlation with PCOS. Besides CVDs hormonal profile fluctuates frequently in random and fasting state. To diagnose treat PCOS properly, patients should be monitored in the fasting state.","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"59 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89353182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

A Retrospective Cohort Study Evaluating the Prevalence of Vitamin D Deficiency and its Impact on the Biochemical and Clinical Presentations of Patients with Primary Hyperparathyroidism (PHPT) 一项评估维生素D缺乏症患病率及其对原发性甲状旁腺功能亢进(PHPT)患者生化和临床表现影响的回顾性队列研究

Endocrinology and Metabolic Syndrome Pub Date : 2019-01-01 DOI: 10.4172/2161-1017.1000298

S. Criseno, J. Virk, H. Kim, P. Nightingale, T. Geberhiwot, N. Gittoes

{"title":"A Retrospective Cohort Study Evaluating the Prevalence of Vitamin D Deficiency and its Impact on the Biochemical and Clinical Presentations of Patients with Primary Hyperparathyroidism (PHPT)","authors":"S. Criseno, J. Virk, H. Kim, P. Nightingale, T. Geberhiwot, N. Gittoes","doi":"10.4172/2161-1017.1000298","DOIUrl":"https://doi.org/10.4172/2161-1017.1000298","url":null,"abstract":"Background: Primary Hyperparathyroidism (PHPT) is the third most common endocrine disorder, with an estimated prevalence of 1 to 4 per 1,000 in the general population. It is well established that vitamin D deficiency co-exists with PHPT. However, there are very few studies that have compared the prevalence of vitamin D deficiency between symptomatic and asymptomatic PHPT patients. Aim: This research evaluated the prevalence of vitamin D deficiency in patients with PHPT, and compared the prevalence of vitamin D deficiency in patients with symptomatic and asymptomatic disease. Methods: This observational cohort study employed a retrospective design where clinical records of 400 new patients referred to the metabolic bone clinics for investigation of hypercalcaemia, between 2010 and 2017, were reviewed. The study population was grouped as ‘asymptomatic’ or ‘symptomatic’ based on the absence or presence of at least one classical hypercalcaemia-related symptom. Results: PHPT is more prevalent in women with female to male ratio of 4.4:1. Symptomatic patients were significantly younger compared to the asymptomatic group (60.97 year+15.356 vs 65.88 years+13.924, p=0.001). There was a high prevalence of vitamin D deficiency (64.25%) with no difference between the symptomatic and asymptomatic groups. The prevalence of osteoporosis was 53.35% whilst the prevalence of renal stone was 13.54% with no between group differences. Conclusion: PHPT is more common in women than in men. Symptomatic patients were younger compared with those without symptoms. Vitamin D deficiency is highly prevalent in patients with PHPT regardless of whether the patients were symptomatic or not.","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"60 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85679524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Incidence of Diabetic Foot Ulcer among Diabetes Mellitus Patients Admitted to Nekemte Referral Hospital, Western Ethiopia: Prospective Observational Study 埃塞俄比亚西部Nekemte转诊医院糖尿病患者糖尿病足溃疡的发病率:前瞻性观察研究

Endocrinology and Metabolic Syndrome Pub Date : 2019-01-01 DOI: 10.24105/2161-1017.8.300

F. Bekele, Ginenus Fekadu, Kumera Bekele, Dinka Dugassa

{"title":"Incidence of Diabetic Foot Ulcer among Diabetes Mellitus Patients Admitted to Nekemte Referral Hospital, Western Ethiopia: Prospective Observational Study","authors":"F. Bekele, Ginenus Fekadu, Kumera Bekele, Dinka Dugassa","doi":"10.24105/2161-1017.8.300","DOIUrl":"https://doi.org/10.24105/2161-1017.8.300","url":null,"abstract":"Background: Diabetic foot is defined as the foot of the diabetic patients with ulceration, infection, and/or distraction of the deep tissues associated with neurological abnormalities and varying degrees of peripheral vascular disease of the lower limb. Diabetic foot ulcers are a common and much feared complication of diabetes. The study is aimed to identify incidence of diabetic foot ulcer in diabetes patients of Nekemte Referral Hospital (NRH). Methods: A prospective observational study of diabetes mellitus patients who had diabetic foot ulcer was conducted from March15 to June 15, 2018.The data was entered into EPI-manager 4.0.2 software and analyzed using SPSS V.24. The Wagner classification of diabetic foot ulcer was used to assess the severity of foot ulcers. Size of ulcer was determined by multiplying the largest by the second largest diameter perpendicular to the first and the etiology of diabetic foot ulcer was identified by using gram stains. Results: Over the study period, 644 diabetes patients were admitted to the NRH medical service; of these, 115 (17.86%) had foot ulcers. About 61 (55.7%) were males and mean age of participants was 44.4 ± 14.7. After the gram stain was performed, about 77 (66.96%) of the patients with foot ulcer developed infection. From the diabetes mellitus who had developed diabetic foot ulcer, about 31 (26.96%) of ulcer were located on dorsal/interdigital toes. About 49 (42.61%) of the diabetic foot ulcer patients had previous history of ulcer of any location. Of infected diabetic foot ulcers, Forty two (54.55%) of microorganism isolated was gram positive. Conclusion: The incidence of diabetic foot ulcer among diabetic patients in Nekemte referral hospital was high. Therefore, East wollega zone health sector and Nekemtereferal hospital diabetic clinic diabetic care providers should strive to reduce its incidence through enhancing the regular diabetic foot evaluation.","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"2 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89619910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Diabetes and Its Complication: Aqueous Leaf Extract of Alafia barteri Maintained the Pancreatic and Gastric Integrity in Allosan Induced Diabetic Rats (Rattus novergicus) 糖尿病及其并发症:巴氏Alafia barbari叶水提物维持异丙沙诱导的糖尿病大鼠胰腺和胃的完整性

Endocrinology and Metabolic Syndrome Pub Date : 2019-01-01 DOI: 10.4172/2161-1017.1000299

A. O. Atilade, Fakile Adedoyin Ruth, Ekunseitan Olawunmi Magret, Dare Babatunde Joseph, O. W. Adetunji, Ebiwonjumi Adetunji Segun, Okeniran Olatayo Segun

{"title":"Diabetes and Its Complication: Aqueous Leaf Extract of Alafia barteri Maintained the Pancreatic and Gastric Integrity in Allosan Induced Diabetic Rats (Rattus novergicus)","authors":"A. O. Atilade, Fakile Adedoyin Ruth, Ekunseitan Olawunmi Magret, Dare Babatunde Joseph, O. W. Adetunji, Ebiwonjumi Adetunji Segun, Okeniran Olatayo Segun","doi":"10.4172/2161-1017.1000299","DOIUrl":"https://doi.org/10.4172/2161-1017.1000299","url":null,"abstract":"Alafia barteri, Apocynaceae has been valued for its efficiency in traditional medicine system in Nigeria and other African countries, as an anti-inflammatory and fever remedy. This study was carried out to know the effect of Alafia barteri leaf extract on the histo-architecture of the pancreas and stomach in Alloxan induced diabetic wistar rats. A total of Twenty (20) Wistar rats were used for this study, animals were randomly selected into Four (4) groups of Five (5) animals and were acclimatized for period of Two (2) weeks Group 1 the Control Group (CG) received 2mls of distilled water, Group 2 Normoglycemic Treated (NT) with 400 mg/kg of Alafia barteri aqueous leaf extract, Group 3 Induced Hyperglycaemic Untreated (IU), and Group 4 Induced Hyperglycaemic Treated (IT) with 400 mg/kg of Alafia barteri aqueous leaf extract. Hyperglycaemic was induced in Groups 3 and 4 by a single dose of intraperitoneal injection of Alloxan at 120 mg/kg. Administration was done for period of nine (9) weeks of experiment; animals were euthanized by cervical dislocation. Pancreas and stomach were excised following abdominal incision and fixed in 10% formol saline for histological studies using H/E and Masson Trichrome stains. Aqueous leaf extract of Alafia barteri caused significant reduction (p-value","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"72 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84538700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-menapousal hirsutism due to ovarian theca-cell hyperplasia and Leydig cell tumour: A case report 卵巢卵泡细胞增生及间质细胞瘤所致绝经后多毛1例

Endocrinology and Metabolic Syndrome Pub Date : 2018-10-05 DOI: 10.4172/2161-1017-c2-027

pDemet Corapcioglup

引用次数: 0

Heme oxygenase is an important switch-box that ameliorates cardio-renal complications in diabetes 血红素加氧酶是改善糖尿病心肾并发症的重要开关

Endocrinology and Metabolic Syndrome Pub Date : 2018-10-05 DOI: 10.4172/2161-1017-C2-025

pSermin Kesebirp

引用次数: 0

Radiofrequency ablation for non-functioning benign thyroid nodules in children and adolescent 射频消融治疗儿童和青少年无功能良性甲状腺结节

Endocrinology and Metabolic Syndrome Pub Date : 2018-08-31 DOI: 10.4172/2161-1017-C1-024

P. Hassan, Kiran Rafiqp

引用次数: 0

A Mixture of Glycine and Cinnamon Extract Improves Glucose Uptake and Imparts Favourable Metabolic Changes in Men and Women in Response to an Oral Glucose Load 甘氨酸和肉桂提取物的混合物在口服葡萄糖负荷下改善葡萄糖摄取并赋予男性和女性有利的代谢变化

Endocrinology and Metabolic Syndrome Pub Date : 2018-08-23 DOI: 10.4172/2161-1017.1000289

R. Bloomer, M. Butawan, Judi Quilici Timmcke, B. Qin

{"title":"A Mixture of Glycine and Cinnamon Extract Improves Glucose Uptake and Imparts Favourable Metabolic Changes in Men and Women in Response to an Oral Glucose Load","authors":"R. Bloomer, M. Butawan, Judi Quilici Timmcke, B. Qin","doi":"10.4172/2161-1017.1000289","DOIUrl":"https://doi.org/10.4172/2161-1017.1000289","url":null,"abstract":"Objective: slightly elevated have been independently reported to favorably impact blood glucose. To our knowledge, no study has combined these two ingredients through oral supplementation in an attempt to modify the glycemic response to a glucose load. We determined the impact of acute ingestion of a novel glycine-cinnamon extract mixture on blood glucose, insulin, and related variables following an oral glucose challenge.Methods: Ten men and women (25.4 ± 8.3 yrs) with elevated fasting blood glucose (101.2 ± 6.6 mg•dL-1) ingested a 25 gram glucose beverage with and without SugarClear™, a proprietary blend of glycine+cinnamon extract (as Cinnulin PF®), separated by approximately one week. Blood was collected before and at 20, 60, and 120 minutes post ingestion and analyzed for glucose, insulin, glucagon-like peptide-1 (GLP-1), glucagon, ATP, and brainderived neurotrophic factor (BDNF).Results: Significant reductions in the area under the curve (AUC) were noted for both glucose (15% for total AUC and 52% for net incremental AUC) and insulin (7% for total AUC and 57% for net incremental AUC). The total AUC for GLP-1 was increased by 36%, while the AUC for ATP was increased by 20%. Glucagon was lower by 10% and BDNF higher by 5% with treatment but not in a statistically significant manner (p>0.05).Conclusion: Acute ingestion of SugarClear™, a proprietary blend of glycine and cinnamon extract, promotes a positive impact on blood glucose and insulin following an oral glucose load. The mixture also leads to an increase in both the plasma GLP-1 and ATP. These alterations may have favourable metabolic implications in those with elevated blood glucose. Future work is needed to determine the effect of chronic ingestion of SugarClear™ on glucose regulation and related variables.","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"57 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2018-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84062808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sirtuins Regulation In Diabetic Condition 糖尿病条件下Sirtuins的调节

Endocrinology and Metabolic Syndrome Pub Date : 2018-05-26 DOI: 10.4172/2161-1017.1000e126

Abhinav Kanwal, A. Thaliath

引用次数: 0