Endocrinology and Metabolic Syndrome最新文献_第10页

Effect of the Endoplasmic Reticulum Stress on Diabetes Mellitus Type 2 in Hypothalamic Cells 内质网应激对下丘脑2型糖尿病细胞的影响

Endocrinology and Metabolic Syndrome Pub Date : 2016-06-29 DOI: 10.4172/2161-1017.1000243

C. Mesquita, D. Ferreira, Assaly

引用次数: 11

Influence of Oxidative Stress on Blood Pressure among Japanese Community- Dwelling Persons 氧化应激对日本社区居民血压的影响

Endocrinology and Metabolic Syndrome Pub Date : 2016-06-27 DOI: 10.4172/2161-1017.1000242

R. Kawamoto, D. Ninomiya, Y. Kasai, T. Kusunoki, N. Ohtsuka, T. Kumagi, M. Abe

{"title":"Influence of Oxidative Stress on Blood Pressure among Japanese Community- Dwelling Persons","authors":"R. Kawamoto, D. Ninomiya, Y. Kasai, T. Kusunoki, N. Ohtsuka, T. Kumagi, M. Abe","doi":"10.4172/2161-1017.1000242","DOIUrl":"https://doi.org/10.4172/2161-1017.1000242","url":null,"abstract":"Introduction: Blood pressure (BP) is one of the most significant manifestations of aging and vascular disease. Oxidative stress is thought to be involved in the development of vascular dysfunction, however, the effect on baseline and changes in peripheral BP is unknown. We investigated whether baseline and changes in the oxidative stress marker, malondialdehyde-modified low density lipoprotein (MDA-LDL) are associated with baseline and change in BP, by a 12-week exercise among Japanese community-dwelling persons. \u0000Methods: The subjects comprised 10 men and 76 women aged 70 ± 7 (range, 61-82) and 67 ± 7 (range, 53-81) years, respectively. Before and at the end of the 12-week training program, metabolic variables including MDA-LDL, and systolic BP (SBP) anddiastolic BP (DBP) were obtained. \u0000Results: Gender, baseline TG, and MDL-LDL correlated significantly with baseline SBP; gender, age, BMI, TG, MDA-LDL, hsCRP, GGT, and HMA-IR correlated significantly with DBP. Stepwise linear regression analysis for baseline BP status showed that baseline BMI and MDA-LDL are significantly and independently associated with SBP, and age while baseline GGT significantly and independently associated with DBP. After the 12-week Nordic walking exercise, change in MDA-LDL significantly correlated with changes in SBP and DBP. Stepwise multivariate linear regression analysis for changes in BP parameters showed that reduction in MDA-LDL was significantly and independently associated with reduction in SBP. \u0000Conclusions:These results suggest that reduction in MDA-LDL may be a predictor for reduction in SBP after a 12-week exercise in community-dwelling persons.","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"69 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80359765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The Effects of Cord Blood Serum on Survival of Rat Pancreatic Islets during In vitro Culturing 脐带血血清对体外培养大鼠胰岛存活的影响

Endocrinology and Metabolic Syndrome Pub Date : 2016-06-27 DOI: 10.4172/2161-1017.1000241

B. Karbek, PÄ±narlÄ± Fa, G. Erden, E. Çakal, T. Delibaşı

{"title":"The Effects of Cord Blood Serum on Survival of Rat Pancreatic Islets during In vitro Culturing","authors":"B. Karbek, PÄ±narlÄ± Fa, G. Erden, E. Çakal, T. Delibaşı","doi":"10.4172/2161-1017.1000241","DOIUrl":"https://doi.org/10.4172/2161-1017.1000241","url":null,"abstract":"Background: Transplantation of islets of Langerhans can improve glycometabolic control in type 1 diabetic patients; however, recipients usually require islets from 1-3 donor pancreas. Current isolation techniques generally recover <50% of the islets from a given pancreas. This study aimed to determine the effect of cord blood serum (CBS) on isolated pancreatic islet cells in vitro. \u0000Methods: Rat pancreatic islets were isolated via collagenase digestion, and then cultured with and without the presence of 50 μl, 100 μl, and 150 μl of CBS. Next, islet cell viability was determined using a fluorescein diacetate and propidium iodide mixture via fluorescence microscopy. Additionally, islet function was evaluated based on insulin secretion. \u0000Results: Treatment of primary cultures of rat pancreatic islets with CBS resulted in augmented β-cell viability. It was observed that the viability rate increased as the concentration of CBS increased and that viability was higher in the 150 μl of CBS group than in the control group. CBS was observed to preserve β-cell glucose responsiveness and insulin secretion under basal (3.3 mmoll-1) and stimulated (16.7 mmoll-1) glucose conditions. Moreover, a significant increase in insulin secretion was observed following treatment with 50 μl of CBS. \u0000Conclusions: The present findings show that cord blood serum treatment of freshly isolated rat islets had a positive effect on islet survival by increasing their viability. We think these findings suggest that CBS might be a suitable factor for optimizing and stimulating recovery, and subsequent function of islets during in vitro culturing, indicating that CBS might play an important role in the biophysiological function of pancreatic islets.","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"35 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2016-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73766311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Embedded Dental Cortisol Content: A Pilot Study 牙内嵌皮质醇含量:一项初步研究

Endocrinology and Metabolic Syndrome Pub Date : 2016-06-20 DOI: 10.4172/2161-1017.1000240

G. Nejad, C. Jeong, H. Shahsavarani, S. Kil, J. Lee

{"title":"Embedded Dental Cortisol Content: A Pilot Study","authors":"G. Nejad, C. Jeong, H. Shahsavarani, S. Kil, J. Lee","doi":"10.4172/2161-1017.1000240","DOIUrl":"https://doi.org/10.4172/2161-1017.1000240","url":null,"abstract":"Objective: This study tests the feasibility and validity of analyzing cortisol levels within human teeth and the possibility of any potential gender differences. \u0000Methods: As a precursor, to confirm the general presence and existence of cortisol within teeth, six healthy supernumerary teeth were initially extracted and examined following the ELISA method. After confirming that cortisol was in fact present within human teeth, we began the main experiment. In order to examine any potential gender differences, twenty-one extracted wisdom teeth were collected from subjects (11 male and 10 female) within the age range of 27-29 yrs. \u0000Results: The results showed irrefutable proof of the existence of cortisol within the dentin of the teeth. Observations revealed that gender had no significant impact upon a subject’s dental cortisol levels (p>0.05), suggesting that cortisol in teeth can be used as an unbiased and reliable means of studying stress. Conclusions: This is the first report on extraction and analysis of cortisol levels in hard tissues, such as teeth, leading to the discovery of a novel biomarker that can be used when studying chronic stress. Practical application of this study can be used postmortem to assess cortisol levels in patients suffering from prolonged disorders, including patients having undergone chemotherapy treatments, when hair cortisol analysis proved to be problematic.","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"47 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78389091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

A Review on Cancer Progression - Related Pineal Endocrine Deficiency:Possible Mechanisms and Clinical Implications 癌症进展相关的松果体内分泌缺乏:可能的机制和临床意义

Endocrinology and Metabolic Syndrome Pub Date : 2016-06-20 DOI: 10.4172/2161-1017.1000239

L. P, Rovelli F

{"title":"A Review on Cancer Progression - Related Pineal Endocrine Deficiency:Possible Mechanisms and Clinical Implications","authors":"L. P, Rovelli F","doi":"10.4172/2161-1017.1000239","DOIUrl":"https://doi.org/10.4172/2161-1017.1000239","url":null,"abstract":"Several experimental studies have demonstrated the existence of a natural immunobiological resistance cancer growth, which is mediated by both immune and neuroendocrine mechanism. Moreover, further researches have shown that the pineal gland plays a fundamental role in the natural antitumor resistance, by representing the most important anti-cancer organ in the human body. The anticancer property of the pineal gland is due to the production of several anticancer molecules, including the indole hormone melatonin (MLT), which represent the most investigated pineal hormone, other indoles, such as the 5-methoxytryptamine, and beta-carbolines. MLT has been proven to play anticancer activity through several mechanisms, consisting of cytotoxic antiproliferative action and stimulation of the anticancer immunity, by promoting IL-2 production by T helper lymphocytes and IL-12 secretion by dendritic cells. Cancer-progression has appeared to be associated with a progressive decline in MLT nocturnal production. Then, the pineal failure would constitute the main cancer-related endocrine deficiency. Preliminary clinical studies have demonstrated that MLT therapy at mild pharmacological doses may prolong the survival time of metastatic cancer patients, for whom no other effective standard therapy was available, and improve their clinical status. Therefore, a neuroendocrine therapy with MLT and other pineal hormones could constitute a new strategy in cancer treatment, either as a substitutive therapy of cancer-related MLT diminished endogenous production, or to employ its antitumor pharmacological properties.","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"15 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82676391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Strain Elastosonography of Thyroid Nodules: A New Tool for Malignancy Prediction? Overview of Literature 应变弹性超声诊断甲状腺结节:预测恶性肿瘤的新工具?文学概论

Endocrinology and Metabolic Syndrome Pub Date : 2016-06-15 DOI: 10.4172/2161-1017.1000238

G. Cannataro, D. Mastrodicasa, Cotroneo Ar, M. Caulo

{"title":"Strain Elastosonography of Thyroid Nodules: A New Tool for Malignancy Prediction? Overview of Literature","authors":"G. Cannataro, D. Mastrodicasa, Cotroneo Ar, M. Caulo","doi":"10.4172/2161-1017.1000238","DOIUrl":"https://doi.org/10.4172/2161-1017.1000238","url":null,"abstract":"Ultrasound (US) elastography is a new non-invasive technique that uses ultrasounds to provide quantitative information about tissue stiffness. Two kinds of elastography (strain and shear wave elastography) are currently used in clinical practice. Although fine needle aspiration (FNA) is the most important procedure for the management of thyroid nodules, several studies have used US elastography as an adjunctive tool to conventional US, to differentiate malignant from benign nodules. In these studies malignant nodules are often associated with a greater elasticity scoring compared to benign. The conventional US plays an important role in defining which nodules are suitable for the US elastography because calcified and cystic nodules could be responsible for false positive and negative results respectively. On the other hand, follicular carcinoma gross anatomy and cellular pattern may resemble those of benign follicular adenoma. The histologic examination is often necessary to discover capsular or vascular invasion. Moreover, in contemporary literature there is disagreement about the role of US elastography in thyroid nodules with indeterminate or non-diagnostic cytology.","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"156 Suppl 1 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90136061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Diagnosis of Osteoporosis in Children 儿童骨质疏松症的诊断

Endocrinology and Metabolic Syndrome Pub Date : 2016-06-02 DOI: 10.4172/2161-1017.1000237

J. Chiarpenello

引用次数: 3

Development, Testing and Marketing of the Lytic Peptide Conjugates 裂解肽偶联物的开发、测试和销售

Endocrinology and Metabolic Syndrome Pub Date : 2016-05-27 DOI: 10.4172/2161-1017.1000235

W. Hansel

引用次数: 0

A Rare Case of Ovarian Sertoli-Leydig Cell Tumor in Postmenopausal Woman Presenting with Alopecia 以脱发为表现的绝经后妇女卵巢支持-间质细胞瘤1例

Endocrinology and Metabolic Syndrome Pub Date : 2016-05-26 DOI: 10.4172/2161-1017.1000234

Anagha Sahasrabuddhe

引用次数: 2

Sex Differences in the Risk of Metabolic Syndrome and its Diagnostic Components in Korean Adults 韩国成人代谢综合征风险及其诊断成分的性别差异

Endocrinology and Metabolic Syndrome Pub Date : 2016-04-29 DOI: 10.4172/2161-1017.1000233

SuJin Song, H. Paik, YoonJu Song, Won O Song

{"title":"Sex Differences in the Risk of Metabolic Syndrome and its Diagnostic Components in Korean Adults","authors":"SuJin Song, H. Paik, YoonJu Song, Won O Song","doi":"10.4172/2161-1017.1000233","DOIUrl":"https://doi.org/10.4172/2161-1017.1000233","url":null,"abstract":"Objective: We examined sex differences in the risk of metabolic syndrome (MetS) and its diagnostic components among Korean adults. \u0000Methods: A total of 17,826 adults (7,061 men, 10,765 women) aged 19+ years with no diagnosed chronic diseases, such as diabetes, hypertension, or dyslipidemia were selected from the 2008-2012 Korea National Health and Nutrition Examination Survey data. MetS was classified by the National Cholesterol Education Program Adult Treatment Panel III criteria with the Asia-Pacific specific cut-off for excessive waist circumference. All statistical analyses accounted for the complex sampling design effect and used appropriate sample weights. \u0000Results: The overall prevalence of MetS was slightly higher in men (19.0%) than in women (14.8%). The prevalent diagnostic components were elevated triglycerides (33.2%) in men whereas low HDL-cholesterol (44.9%) and excessive waist circumference (31.3%) in women. The prevalence of MetS increased with age only in women. Women < 60 years had a lower prevalence of MetS than men in the same age category but the prevalence in women surpassed that in men after 60 years. There were differences in common combinations of MetS diagnostic components between men and women. \u0000Conclusion: The MetS risk differed by sex in Korean adults and was markedly high in older women. Our findings warrant specific preventive strategies and clinical managements for MetS according to sex, especially for middleaged and elderly women.","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"61 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2016-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83885934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3