Influence of Oxidative Stress on Blood Pressure among Japanese Community- Dwelling Persons

Introduction: Blood pressure (BP) is one of the most significant manifestations of aging and vascular disease. Oxidative stress is thought to be involved in the development of vascular dysfunction, however, the effect on baseline and changes in peripheral BP is unknown. We investigated whether baseline and changes in the oxidative stress marker, malondialdehyde-modified low density lipoprotein (MDA-LDL) are associated with baseline and change in BP, by a 12-week exercise among Japanese community-dwelling persons. Methods: The subjects comprised 10 men and 76 women aged 70 ± 7 (range, 61-82) and 67 ± 7 (range, 53-81) years, respectively. Before and at the end of the 12-week training program, metabolic variables including MDA-LDL, and systolic BP (SBP) anddiastolic BP (DBP) were obtained. Results: Gender, baseline TG, and MDL-LDL correlated significantly with baseline SBP; gender, age, BMI, TG, MDA-LDL, hsCRP, GGT, and HMA-IR correlated significantly with DBP. Stepwise linear regression analysis for baseline BP status showed that baseline BMI and MDA-LDL are significantly and independently associated with SBP, and age while baseline GGT significantly and independently associated with DBP. After the 12-week Nordic walking exercise, change in MDA-LDL significantly correlated with changes in SBP and DBP. Stepwise multivariate linear regression analysis for changes in BP parameters showed that reduction in MDA-LDL was significantly and independently associated with reduction in SBP. Conclusions:These results suggest that reduction in MDA-LDL may be a predictor for reduction in SBP after a 12-week exercise in community-dwelling persons.