A Rare Case of Ovarian Sertoli-Leydig Cell Tumor in Postmenopausal Woman Presenting with Alopecia

Abstract

Mild hirsutism and alopecia in postmenopausal women can be a normal physiological response. Sex cord stromal tumors of ovary account for approximately 5-8% of all ovarian tumors. When hirsutism is accompanied by signs of virilization such as severe balding, deepening of voice or clitoromegaly, an underlying androgen-secreting tumor, that may be malignant must be ruled out. We report a rare case of 46 year old female with premature menopause and symptom of hair loss. She had high testosterone levels and left ovary mass. As Cushing syndromes and late onset congenital adrenal hyperplasia were ruled out, an ovarian source of androgen was suspected. She underwent hysterectomy with bilateral salpingo-oophorectomy. A diagnosis of left ovarian sex-cord stromal tumor favoring Sertoli-Leydig cell tumor was confirmed. We report this case for its rare nature and atypical presentation.