Assessment and Association between Lipid and Hormonal Profile in Nonpregnant Females Having Polycystic Ovarian Syndrome

Endocrinology and Metabolic Syndrome Pub Date : 2019-02-20 DOI:10.4172/2161-1017.1000297

Farhatul-Ain Arshad, Rubaida Mehmood, S. Perveen, S. Hussain, M. A. Khan

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引用次数: 5

Abstract

Introduction: PCOS is a gynecological endocrine disorder with ovarian dysfunction, hyperandrogenism, infertility, hirsutism, acne, dyslipidemia, and menstrual irregularities. Objectives: The aim of our study is to evaluate the fluctuations of hormonal profile regarding PCOS in fasting and random state as well as the possible risk factor of cardiovascular disorders towards PCOS. Method: Blood was taken by CSLI (Clinical and Laboratory Standards Institution) procedure. Merk and Roach diagnostic systems were used to analyze lipid and hormonal profiles. Results: Significant differences were observed in cholesterol (p=0.004), HDL, LDL (p<0.001) in fasting PCOS vs. control, LDL, HDL (p<0.001), cholesterol (p=0.08), lipid profile ratios in fasting vs. random PCOS, FSH (p=0.01), Progesterone (p=0.000), Estradiol (p=0.000), LH/FSH (p=0.04) in fasting PCOS vs. control, LH (p=0.04) in fasting vs. random PCOS. Significant positive correlation was found among estradiol with cholesterol (r=0.376, p=0.08), LDL (r=0.39, p=0.006) in fasting PCOS, estradiol with cholesterol (r=-0.334, p=0.02), FSH with LDL (r=0.36, p=0.01), progesterone with HDL (r=0.338, p=0.02) in random PCOS. Conclusion: This study assesses the worth of lipid profile in PCOS towards cardiovascular risk factors because lipid and hormonal profile have a direct correlation with PCOS. Besides CVDs hormonal profile fluctuates frequently in random and fasting state. To diagnose treat PCOS properly, patients should be monitored in the fasting state.

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未怀孕女性多囊卵巢综合征的脂质和激素水平评估及其相关性

简介:多囊卵巢综合征是一种妇科内分泌疾病，伴有卵巢功能障碍、雄激素过多、不孕症、多毛症、痤疮、血脂异常和月经不规律。目的:探讨PCOS患者在禁食状态和随机状态下的激素水平波动，以及PCOS患者发生心血管疾病的可能危险因素。方法:按CSLI(临床与实验室标准协会)程序采血。使用默克和罗奇诊断系统分析脂质和激素谱。结果:空腹PCOS组胆固醇(p=0.004)、HDL、LDL (p<0.001)与对照组比较，空腹PCOS组LDL、HDL (p<0.001)、胆固醇(p=0.08)、血脂比、FSH (p=0.01)、黄体酮(p=0.000)、雌二醇(p=0.000)、LH/FSH (p=0.04)与对照组比较，空腹PCOS组LH (p=0.04)与随机PCOS组比较，差异均有统计学意义。空腹PCOS患者雌二醇与胆固醇(r=0.376, p=0.08)、LDL (r=0.39, p=0.006)、随机PCOS患者雌二醇与胆固醇(r=-0.334, p=0.02)、FSH与LDL (r=0.36, p=0.01)、黄体酮与HDL (r=0.338, p=0.02)呈正相关。结论:脂质和激素水平与PCOS有直接关系，本研究评估PCOS患者脂质水平对心血管危险因素的价值。此外，心血管病患者的激素谱在随机和空腹状态下波动频繁。为了正确诊断和治疗多囊卵巢综合征，应在禁食状态下对患者进行监测。

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Endocrinology and Metabolic Syndrome

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