IF 2.7 3区医学

eNeuro Pub Date : 2025-01-23 Print Date: 2025-01-01 DOI: 10.1523/ENEURO.0571-24.2024

引用次数: 0

Alterations of White Matter Microstructure in Migraine Patients Vary in the Peri-ictal Phases. 偏头痛患者白质微结构的改变在周周期有所不同。

IF 2.7 3区医学

eNeuro Pub Date : 2025-01-17 Print Date: 2025-01-01 DOI: 10.1523/ENEURO.0300-24.2024

Ana R Fouto, Rita G Nunes, Irene Guadilla, Amparo Ruiz-Tagle, Inês Esteves, Gina Caetano, Nuno A Silva, Pedro Vilela, Raquel Gil-Gouveia, Patrícia Figueiredo

{"title":"Alterations of White Matter Microstructure in Migraine Patients Vary in the Peri-ictal Phases.","authors":"Ana R Fouto, Rita G Nunes, Irene Guadilla, Amparo Ruiz-Tagle, Inês Esteves, Gina Caetano, Nuno A Silva, Pedro Vilela, Raquel Gil-Gouveia, Patrícia Figueiredo","doi":"10.1523/ENEURO.0300-24.2024","DOIUrl":"10.1523/ENEURO.0300-24.2024","url":null,"abstract":"Alterations in white matter (WM) microstructure are commonly found in migraine patients. Here, we employ a longitudinal study of episodic migraine without aura using diffusion magnetic resonance imaging (dMRI) to investigate whether such WM microstructure alterations vary through the different phases of the pain cycle. Fourteen patients with episodic migraine without aura related with menstruation were scanned through four phases of their (spontaneous) migraine cycle (interictal, preictal, ictal, and postictal). Fifteen healthy controls were studied in the corresponding phases of the menstrual cycle. Multishell dMRI data were acquired and preprocessed to obtain maps of diffusion parameters reflecting WM microstructure. After a whole-brain analysis comparing patients with controls, a region-of-interest analysis was performed to determine whether the patients' microstructural changes varied across the migraine cycle in specific WM tracts. Compared with controls, patients showed reduced axial diffusivity (AD) in several WM tracts across the whole brain in the interictal phase and increased fractional anisotropy (FA) in commissural fibers in the ictal phase. Interestingly, AD returned to baseline levels during peri-ictal phases in specific projection and association fibers. In contrast, FA values decreased in the ictal phase away from normal values in a few commissural and projection tracts. Widespread WM fiber tracts suffer structural variations across the migraine cycle, suggesting microstructural changes potentially associated with limbic and salience functional networks and highlighting the importance of the cycle phase in imaging studies of migraine.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Relevant Features for EEG-Based Investigation of Sound Perception in Naturalistic Soundscapes. 探索基于脑电图的自然声景中声音感知研究的相关特征。

IF 2.7 3区医学

eNeuro Pub Date : 2025-01-17 Print Date: 2025-01-01 DOI: 10.1523/ENEURO.0287-24.2024

Thorge Haupt, Marc Rosenkranz, Martin G Bleichner

{"title":"Exploring Relevant Features for EEG-Based Investigation of Sound Perception in Naturalistic Soundscapes.","authors":"Thorge Haupt, Marc Rosenkranz, Martin G Bleichner","doi":"10.1523/ENEURO.0287-24.2024","DOIUrl":"10.1523/ENEURO.0287-24.2024","url":null,"abstract":"A comprehensive analysis of everyday sound perception can be achieved using electroencephalography (EEG) with the concurrent acquisition of information about the environment. While extensive research has been dedicated to speech perception, the complexities of auditory perception within everyday environments, specifically the types of information and the key features to extract, remain less explored. Our study aims to systematically investigate the relevance of different feature categories: discrete sound-identity markers, general cognitive state information, and acoustic representations, including discrete sound onset, the envelope, and mel-spectrogram. Using continuous data analysis, we contrast different features in terms of their predictive power for unseen data and thus their distinct contributions to explaining neural data. For this, we analyze data from a complex audio-visual motor task using a naturalistic soundscape. The results demonstrated that the feature sets that explain the most neural variability were a combination of highly detailed acoustic features with a comprehensive description of specific sound onsets. Furthermore, it showed that established features can be applied to complex soundscapes. Crucially, the outcome hinged on excluding periods devoid of sound onsets in the analysis in the case of the discrete features. Our study highlights the importance to comprehensively describe the soundscape, using acoustic and non-acoustic aspects, to fully understand the dynamics of sound perception in complex situations. This approach can serve as a foundation for future studies aiming to investigate sound perception in natural settings.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eye Movements during Measurements of Visual Vertical in the Poststroke Subacute Phase. 脑卒中后亚急性期视觉垂直测量时的眼球运动。

IF 2.7 3区医学

eNeuro Pub Date : 2025-01-17 Print Date: 2025-01-01 DOI: 10.1523/ENEURO.0279-24.2024

Yasuaki Arima, Kae Nakamura, Kimihiko Mori, Shingo Hashimoto, Masanori Wakida, Hironori Ishii, Kimitaka Hase

{"title":"Eye Movements during Measurements of Visual Vertical in the Poststroke Subacute Phase.","authors":"Yasuaki Arima, Kae Nakamura, Kimihiko Mori, Shingo Hashimoto, Masanori Wakida, Hironori Ishii, Kimitaka Hase","doi":"10.1523/ENEURO.0279-24.2024","DOIUrl":"10.1523/ENEURO.0279-24.2024","url":null,"abstract":"The subjective visual vertical (VV), the visually estimated direction of gravity, is essential for assessing vestibular function and visuospatial cognition. In this study, we aimed to investigate the mechanisms underlying altered VV perception in stroke participants with unilateral spatial neglect (USN), specifically by examining their eye movement patterns during VV judgment tasks. Participants with USN demonstrated limited eye movement scanning along a rotating bar, often fixating on prominent ends, such as the top or bottom. This suggests a reflexive response to visually salient areas, potentially interfering with accurate VV perception. In contrast, participants without USN showed broader scanning around the center of the bar. Notably, participants with USN without frontal lobe lesions occasionally exhibited extended scanning that included the bar's center, which was associated with accurate VV judgments. These findings suggest that (1) a tendency to fixate on peripheral, prominent areas and (2) frontal lobe involvement in disengaging and redirecting spatial attention may influence VV perception in USN. Based on these results, targeted rehabilitation strategies that encourage individuals with USN to extend their visual scanning beyond prominent endpoints and include central areas could improve VV accuracy. This study highlights the specific eye movement behaviors contributing to VV misperception, emphasizing the importance of training that broadens scanning to improve VV perception effectively.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loss of PV Interneurons in the BLA May Contribute to Altered Network and Behavioral States in Chronically Epileptic Mice. 慢性癫痫小鼠脑区PV中间神经元的缺失可能导致神经网络和行为状态的改变。

IF 2.7 3区医学

eNeuro Pub Date : 2025-01-17 Print Date: 2025-01-01 DOI: 10.1523/ENEURO.0482-23.2024

Phillip L W Colmers, Pantelis Antonoudiou, Trina Basu, Emanuel M Coleman, Yingchu He, Garrett Scapa, Patrick Fuller, Jamie Maguire

{"title":"Loss of PV Interneurons in the BLA May Contribute to Altered Network and Behavioral States in Chronically Epileptic Mice.","authors":"Phillip L W Colmers, Pantelis Antonoudiou, Trina Basu, Emanuel M Coleman, Yingchu He, Garrett Scapa, Patrick Fuller, Jamie Maguire","doi":"10.1523/ENEURO.0482-23.2024","DOIUrl":"10.1523/ENEURO.0482-23.2024","url":null,"abstract":"Psychiatric disorders, including anxiety and depression, are highly comorbid in people with epilepsy. However, the mechanisms mediating the shared pathophysiology are currently unknown. There is considerable evidence implicating the basolateral amygdala (BLA) in the network communication of anxiety and fear, a process demonstrated to involve parvalbumin-positive (PV) interneurons. The loss of PV interneurons has been well described in the hippocampus of chronically epileptic mice and in postmortem human tissue of patients with temporal lobe epilepsy (TLE). We hypothesize that a loss of PV interneurons in the BLA may contribute to comorbid mood disorders in epilepsy. To test this hypothesis, we employed a ventral intrahippocampal kainic acid model of TLE in mice, which exhibits profound behavioral deficits associated with chronic epilepsy. We demonstrate a loss of PV interneurons and dysfunction of the remaining PV interneurons in the BLA of chronically epileptic mice. Furthermore, we demonstrate altered principal neuron function and impaired coordination of BLA network and behavioral states in chronically epileptic mice. To determine whether the loss of PV interneurons contributes to these altered network and behavioral states, we partially ablated PV interneurons in the BLA by stereotaxically injecting AAV-Flex-DTA into the BLA of PV-Cre mice. Loss of PV interneurons in the BLA is sufficient to alter behavioral states, such as increasing avoidance behaviors and impairing fear learning. These data suggest that compromised inhibition in the BLA in chronically epileptic mice may contribute to behavioral deficits, suggesting a novel mechanism contributing to comorbid anxiety and epilepsy.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applied Motor Noise Affects Specific Learning Mechanisms during Short-Term Adaptation to Novel Movement Dynamics. 在对新动作动态的短期适应过程中，应用运动噪音会影响特定的学习机制。

IF 2.7 3区医学

eNeuro Pub Date : 2025-01-16 Print Date: 2025-01-01 DOI: 10.1523/ENEURO.0100-24.2024

Katherine Foray, Weiwei Zhou, Justin Fitzgerald, Pierre G Gianferrara, Wilsaan M Joiner

{"title":"Applied Motor Noise Affects Specific Learning Mechanisms during Short-Term Adaptation to Novel Movement Dynamics.","authors":"Katherine Foray, Weiwei Zhou, Justin Fitzgerald, Pierre G Gianferrara, Wilsaan M Joiner","doi":"10.1523/ENEURO.0100-24.2024","DOIUrl":"10.1523/ENEURO.0100-24.2024","url":null,"abstract":"Short-term motor adaptation to novel movement dynamics has been shown to involve at least two concurrent learning processes: a slow process that responds weakly to error but retains information well and a fast process that responds strongly to error but has poor retention. This modeling framework can explain several properties of motion-dependent motor adaptation (e.g., 24 h retention). An important assumption of this computational framework is that learning is only based on the experienced movement error, and the effect of noise (either internally generated or externally applied) is not considered. We examined the respective error sensitivity by quantifying adaptation in three subject groups distinguished by the noise added to the motion-dependent perturbation. We assessed the feedforward adaptive changes in motor output and examined the adaptation rate, retention, and decay of learning. Applying a two-state modeling framework showed that the applied noise during training mainly affected the fast learning process, with the slow process largely unaffected; participants in the higher noise groups demonstrated a reduced force profile following training, but the decay rate across groups was similar, suggesting that the slow process was unimpaired across conditions. Collectively, our results provide evidence that noise significantly decreases motor adaptation, but this reduction may be due to its influence over specific learning mechanisms. Importantly, this may have implications for how the motor system compensates for random fluctuations, especially when affected by brain disorders that result in movement tremor (e.g., essential tremor).","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142727110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Perspective in Epileptic Seizure Classification: Applying the Taxonomy of Seizure Dynamotypes to Noninvasive EEG and Examining Dynamical Changes across Sleep Stages. 癫痫分类的新视角：将癫痫发作动力型分类法应用于无创脑电图并检测睡眠阶段的动态变化。

IF 2.7 3区医学

eNeuro Pub Date : 2025-01-16 Print Date: 2025-01-01 DOI: 10.1523/ENEURO.0157-24.2024

Miriam Guendelman, Rotem Vekslar, Oren Shriki

{"title":"A New Perspective in Epileptic Seizure Classification: Applying the Taxonomy of Seizure Dynamotypes to Noninvasive EEG and Examining Dynamical Changes across Sleep Stages.","authors":"Miriam Guendelman, Rotem Vekslar, Oren Shriki","doi":"10.1523/ENEURO.0157-24.2024","DOIUrl":"10.1523/ENEURO.0157-24.2024","url":null,"abstract":"Epilepsy, a neurological disorder characterized by recurrent unprovoked seizures, significantly impacts patient quality of life. Current classification methods focus primarily on clinical observations and electroencephalography (EEG) analysis, often overlooking the underlying dynamics driving seizures. This study uses surface EEG data to identify seizure transitions using a dynamical systems-based framework-the taxonomy of seizure dynamotypes-previously examined only in invasive data. We applied principal component and independent component (IC) analysis to surface EEG recordings from 1,177 seizures in 158 patients with focal epilepsy, decomposing the signals into ICs. The ICs were visually labeled for clear seizure transitions and bifurcation morphologies (BifMs), which were then examined using Bayesian multilevel modeling in the context of clinical factors. Our analysis reveals that certain onset bifurcations (saddle node on invariant circle and supercritical Hopf) are more prevalent during wakefulness compared with their reduced rate during nonrapid eye movement (NREM) sleep, particularly NREM3. We discuss the possible implications of our results in the context of modeling approaches and suggest additional avenues to continue this exploration. Furthermore, we demonstrate the feasibility of automating this classification process using machine learning, achieving high performance in identifying seizure-related ICs and classifying interspike interval changes. Our findings suggest that the noise in surface EEG may obscure certain BifMs, and we suggest technical improvements that could enhance detection accuracy. Expanding the dataset and incorporating long-term biological rhythms, such as circadian and multiday cycles, may provide a more comprehensive understanding of seizure dynamics and improve clinical decision-making.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distributed Cortical Regions for the Recall of People, Places, and Objects. 负责回忆人、地点和物体的皮质分布区域。

IF 2.7 3区医学

eNeuro Pub Date : 2025-01-15 Print Date: 2025-01-01 DOI: 10.1523/ENEURO.0496-24.2024

Alexis Kidder, Edward H Silson, Matthias Nau, Chris I Baker

{"title":"Distributed Cortical Regions for the Recall of People, Places, and Objects.","authors":"Alexis Kidder, Edward H Silson, Matthias Nau, Chris I Baker","doi":"10.1523/ENEURO.0496-24.2024","DOIUrl":"10.1523/ENEURO.0496-24.2024","url":null,"abstract":"The human medial parietal cortex (MPC) is recruited during multiple cognitive processes. Previously, we demonstrated regions specific to recall of people or places and proposed that the functional organization of MPC mirrors the category selectivity defining the medial-lateral axis of the ventral-temporal cortex (VTC). However, prior work considered recall of people and places only, and VTC also shows object selectivity sandwiched between face- and scene-selective regions. Here, we tested a strong prediction of our proposal: like VTC, MPC should show a region specifically recruited during object recall, and its relative cortical position should mirror the one of VTC. While responses during people and place recall showed a striking replication of prior findings, we did not observe any evidence for object-recall effects within MPC, which differentiates it from the spatial organization in VTC. Importantly, beyond MPC, robust recall effects were observed for people, places, and objects on the lateral surface of the brain. Place-recall effects were present in the angular gyrus, frontal eye fields, and peripheral portions of the early visual cortex, whereas people recall selectively drove response in the right posterior superior temporal sulcus. Object-recall effects were largely restricted to a region posterior to the left somatosensory cortex, in the vicinity of the supramarginal gyrus. Taken together, these data demonstrate that while there are distributed regions active during recall of people, places, and objects, the functional organization of MPC does not mirror the medial-lateral axis of VTC but reflects only the most salient features of that axis-namely, representations of people and places.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microglia Morphology in the Developing Primate Amygdala and Effects of Early Life Stress. 灵长类动物杏仁核发育中的小胶质细胞形态及早期生活应激的影响。

IF 2.7 3区医学

eNeuro Pub Date : 2025-01-15 Print Date: 2025-01-01 DOI: 10.1523/ENEURO.0466-24.2024

Dennisha P King, Miral Abdalaziz, Ania K Majewska, Judy L Cameron, Julie L Fudge

{"title":"Microglia Morphology in the Developing Primate Amygdala and Effects of Early Life Stress.","authors":"Dennisha P King, Miral Abdalaziz, Ania K Majewska, Judy L Cameron, Julie L Fudge","doi":"10.1523/ENEURO.0466-24.2024","DOIUrl":"10.1523/ENEURO.0466-24.2024","url":null,"abstract":"A unique pool of immature glutamatergic neurons in the primate amygdala, known as the paralaminar nucleus (PL), are maturing between infancy and adolescence. The PL is a potential substrate for the steep growth curve of amygdala volume during this developmental period. A microglial component is also embedded among the PL neurons and likely supports local neuronal maturation and emerging synaptogenesis. Microglia may alter neuronal growth following environmental perturbations such as stress. Using multiple measures in rhesus macaques, we found that microglia in the infant primate PL had relatively large somas and a small arbor size. In contrast, microglia in the adolescent PL had a smaller soma and a larger dendritic arbor. We then examined microglial morphology in the PL after a novel maternal separation protocol, to examine the effects of early life stress. After maternal separation, the microglia had increased soma size, arbor size, and complexity. Surprisingly, strong effects were seen not only in the infant PL, but also in the adolescent PL from subjects who had experienced the separation many years earlier. We conclude that under normal maternal-rearing conditions, PL microglia morphology tracks PL neuronal growth, progressing to a more \"mature\" phenotype by adolescence. Maternal separation has long-lasting effects on microglia, altering their normal developmental trajectory, and resulting in a \"hyper-ramified\" phenotype that persists for years. We speculate that these changes have consequences for neuronal development in young primates.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fxr1 Deletion from Cortical Parvalbumin Interneurons Modifies Their Excitatory Synaptic Responses. 皮层小白蛋白中间神经元FXR1缺失改变其兴奋性突触反应。

IF 2.7 3区医学

eNeuro Pub Date : 2025-01-15 Print Date: 2025-01-01 DOI: 10.1523/ENEURO.0363-24.2024

Katherine S Scheuer, Anna M Jansson, Minjie Shen, Xinyu Zhao, Meyer B Jackson

{"title":"Fxr1 Deletion from Cortical Parvalbumin Interneurons Modifies Their Excitatory Synaptic Responses.","authors":"Katherine S Scheuer, Anna M Jansson, Minjie Shen, Xinyu Zhao, Meyer B Jackson","doi":"10.1523/ENEURO.0363-24.2024","DOIUrl":"10.1523/ENEURO.0363-24.2024","url":null,"abstract":"Fragile X autosomal homolog 1 (FXR1), a member of the fragile X messenger riboprotein 1 family, has been linked to psychiatric disorders including autism and schizophrenia. Parvalbumin (PV) interneurons play critical roles in cortical processing and have been implicated in FXR1-linked mental illnesses. Targeted deletion of FXR1 from PV interneurons in mice has been shown to alter cortical excitability and elicit schizophrenia-like behavior. This indicates that FXR1 regulates behaviorally relevant electrophysiological functions in PV interneurons. We therefore expressed a genetically encoded hybrid voltage sensor in PV interneurons and used voltage imaging in slices of mouse somatosensory cortex to assess the impact of targeted FXR1 deletion. These experiments showed that PV interneurons lacking FXR1 had excitatory synaptic potentials with larger amplitudes and shorter latencies compared with wild type. Synaptic potential rise-times, decay-times, and half-widths were also impacted to degrees that varied between cortical layer and synaptic input. Thus, FXR1 modulates the responsiveness of PV interneurons to excitatory synaptic inputs. This will enable FXR1 to control cortical processing in subtle ways, with the potential to influence behavior and contribute to psychiatric dysfunction.","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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