eNeuro最新文献

{"title":"Adapt-A-Maze: An Open-Source Adaptable and Automated Rodent Behavior Maze System.","authors":"Blake S Porter, Jacob M Olson, Christopher A Leppla, Éléonore Duvelle, John H Bladon, Matthijs A A van der Meer, Shantanu P Jadhav","doi":"10.1523/ENEURO.0138-25.2025","DOIUrl":"10.1523/ENEURO.0138-25.2025","url":null,"abstract":"<p><p>Mazes are a fundamental and widespread tool in behavior and systems neuroscience research in rodents, especially in spatial navigation and spatial memory investigations in <i>ad libitum</i> behaving animals. However, their form and inflexibility often restrict potential experimental paradigms that involve multiple or adaptive maze designs. Unique layouts often lead to elevated costs, whether financially or in terms of time investment from scientists. To alleviate these issues, we have developed an automated, modular maze system that is flexible and scalable. This open-source Adapt-A-Maze (AAM) system will allow for experiments with multiple track configurations in rapid succession. Additionally, the flexibility can expedite prototyping of behavioral paradigms. Automation ensures less variability in experimental parameters and higher throughput. Finally, the standardized componentry enhances experimental repeatability within labs and replicability across labs. Our maze was successfully used across labs, in multiple experimental designs, with and without extracellular or optical recordings, in rats. The AAM system presents multiple advantages over current maze options and can facilitate novel behavior and systems neuroscience research.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Development of Hypothalamic Neurons Expressing Proopiomelanocortin Peptides, Neuropeptide Y, and Kisspeptin in Fetal Rhesus Macaques.","authors":"Oline K Rønnekleiv, Martha A Bosch","doi":"10.1523/ENEURO.0087-25.2025","DOIUrl":"10.1523/ENEURO.0087-25.2025","url":null,"abstract":"<p><p>We have documented the early embryonic development of hypothalamic neurons expressing β-endorphin, α-melanocyte-stimulating hormone, neuropeptide Y, and kisspeptin in rhesus macaques, an animal model that is very similar to humans. Neurons expressing both β-End and αMSH are the first to develop and are initially located in the lateral basal hypothalamus (LBH) as early as day 32-34 of gestation. By day 45 of gestation, these neurons have migrated into the medial basal hypothalamic (MBH) area as their final destination. NPY neurons within the ARH develop later and first appear at day 44 of fetal life, at which time a cluster of neurons is present within the ARH-MBH area. NPY neurons continue to be expressed within the ARH area at all of the later fetal ages analyzed. Similarly, kisspeptin neurons develop later compared with β-End, although only a few cells are present in the ARH by day 44 of gestation, at which time kisspeptin is also expressed in the developing anterior lobe of the pituitary. By day 70 of gestation, the rostral to caudal distribution and cell size of Kiss1 neurons within the MBH are similar in females and males. In addition, Kiss1 fibers are also expressed in the POA by day 70. By day 130 of gestation, Kiss1 neurons exhibit a wider dorsal and lateral distribution within the MBH, with highly increased fiber distribution. Therefore, the development of these neurons is much earlier than what had been described previously for αMSH and NPY in primates.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Brain Mechanisms of Music Stimulation, Motor Observation, and Motor Imagination in Virtual Reality Techniques: A Functional Near-Infrared Spectroscopy Study.","authors":"Junjie Liang, Boyuan Liang, Zengquan Tang, Xingchen Huang, Sitong Ou, Chunli Chang, Yujue Wang, Zishu Yuan","doi":"10.1523/ENEURO.0557-24.2025","DOIUrl":"10.1523/ENEURO.0557-24.2025","url":null,"abstract":"<p><p>Virtual reality (VR) has gained popularity in recent years, integrating with conventional music stimulation (MS), action observation (AO), and motor imagination (MI). It offers promising opportunities for developing innovative rehabilitation treatments, though the mechanisms underlying these effects remain unclear. This study aims to compare brain activation and network mechanisms following the fusion of MS, AO, and MI with VR. Fifty healthy participants were recruited and underwent functional near-infrared spectroscopy synchronization with three VR tasks: MS (VRMS), AO (VRAO), and MI (VRMI). The results indicate that VRMS significantly enhances functional connectivity of the bilateral primary sensory cortex (S1), premotor cortex, and supplementary motor area (PM&SMA) compared with VRAO and VRMI. Furthermore, the interaction among the bilateral PM&SMA, right dorsolateral prefrontal cortex, and right primary motor cortex (M1) regions is notably stronger with VRMS than with the other VR tasks. These findings elucidate the brain activation and network characteristics of the three VR tasks, highlighting VRMS's potential in boosting the functional interaction among brain regions. Future research should explore additional brain regions, broader diseased brain samples, and alternative brain-stimulation effects of VRMS.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12216803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interference Underlies Attenuation upon Relearning in Sensorimotor Adaptation.","authors":"Guy Avraham, Richard B Ivry","doi":"10.1523/ENEURO.0132-25.2025","DOIUrl":"10.1523/ENEURO.0132-25.2025","url":null,"abstract":"<p><p>Savings refers to the gain in performance upon relearning. In sensorimotor adaptation, savings is tested by having participants adapt to perturbed feedback and, following a washout block during which the system resets to baseline, presenting the same perturbation again. While savings has been observed with these tasks, we have shown that the contribution from implicit adaptation, a process that uses errors to recalibrate the sensorimotor map, is attenuated upon relearning ( Avraham et al., 2021). Here, we test the hypothesis that this attenuation is due to interference arising from the different relationship between the movement and the feedback during washout. Removing the perturbation at the start of the washout block typically results in a salient error signal in the opposite direction to that observed during learning. We first replicated the finding that implicit adaptation is attenuated following a washout period that introduces salient opposite errors. When we eliminated feedback during washout, relearning was no longer attenuated, consistent with the interference hypothesis. Next, we created a scenario in which the perceived errors during washout were not salient, falling within the range of motor noise. Nonetheless, attenuation was still prominent. Inspired by this observation, we tested participants with an extended initial experience with veridical feedback and found that this was sufficient to attenuate adaptation during the first learning block. This effect was context specific and did not generalize to other movements. Taken together, the implicit sensorimotor adaptation system is highly sensitive to memory interference from a recent experience with a discrepant action-outcome contingency.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Release of Extracellular Matrix Components after Human Traumatic Brain Injury.","authors":"Michael Bambrick, Deena Godfrey, Mark D Johnson, Jeffrey D Esko, Biswa Choudhury, Alejandro Gomez Toledo, Mousumi Paulchakrabarti, Carla Fortes, Kevin J Staley, Ann-Christine Duhaime","doi":"10.1523/ENEURO.0488-24.2025","DOIUrl":"10.1523/ENEURO.0488-24.2025","url":null,"abstract":"<p><p>Animal studies and human tissue experiments have demonstrated that traumatic brain injury (TBI) causes damage to the extracellular matrix (ECM). To test the hypothesis that TBI causes disruption of sulfated glycosaminoglycan (sGAG) in the ECM, we measured levels of sGAG in the cerebrospinal fluid (CSF), blood, and urine, in patients with severe TBI in the acute postinjury period. Samples of CSF, blood, and urine were obtained within 72 h of injury in patients who received external ventricular drains as part of their treatment of severe TBI. Levels of chondroitin and heparan sGAGs were measured, along with their disaccharide constituents. Demographic information, presence of polytrauma, brain injury load, and distance of radiologically visible parenchymal injury from the ventricle were analyzed for correlation with total subtype sGAG levels. Levels were measured in 14 patients ranging in age from 17 to 90 years. CSF sGAG levels were variable among patients, with higher sGAG levels in plasma compared with CSF. Patients with polytrauma had nonsignificantly higher blood sGAG compared with patients with isolated head injury. Subcategories of CSF sGAG levels correlated with distance from the ventricle of parenchymal injury but not with brain injury load. This study is the first to measure sGAG levels in ventricular CSF and the first to analyze levels in TBI. These data demonstrate the elevation locally of intracranial sGAGs after severe TBI and suggest rapid local metabolism of these breakdown products. The consequences of ECM breakdown may provide unique therapeutic and preventive avenues to mitigate postinjury sequelae.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic OptoDrive for Extracellular Recordings and Optogenetic Stimulation in Freely Moving Mice.","authors":"Alberto Caballero-Ruiz, Erick Lopez-Roldan, Monica Luna, Luis Rodriguez-Blanco, Leopoldo Emmanuel Polo-Castillo, Mario G Moreno, Leopoldo Ruiz-Huerta, Ranier Gutierrez","doi":"10.1523/ENEURO.0015-25.2025","DOIUrl":"10.1523/ENEURO.0015-25.2025","url":null,"abstract":"<p><p>Extracellular recordings in freely moving mice, especially those with movable electrodes (microdrives), are crucial for understanding brain function. However, existing microdrives are often heavy, expensive, fragile, and unsuited for long-term studies with multichannel recordings. The OptoDrive is a new, lightweight (3.2 g), low-cost system for chronic neural recordings and optogenetic manipulation in mice. It features a detachable, 16-channel tungsten-wire electrode assembly with a 3 mm stroke (15 μm step displacement) and an integrated optical fiber. This system enables repeated implantation and explantation without surgery, requiring only gas anesthesia. The OptoDrive has demonstrated stable recordings from the lateral hypothalamus of freely behaving mice for nearly 1 month and successful optogenetic silencing of neuronal activity. In conclusion, OptoDrive offers a cost-effective, compact solution for long-term electrophysiology and optogenetics in freely moving mice.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":"12 6","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accurate Tracking of Locomotory Kinematics in Mice Moving Freely in Three-Dimensional Environments.","authors":"Bogna M Ignatowska-Jankowska, Lakshmipriya I Swaminathan, Tara H Turkki, Dmitriy Sakharuk, Aysen Gurkan Ozer, Alexander Kuck, Marylka Yoe Uusisaari","doi":"10.1523/ENEURO.0045-25.2025","DOIUrl":"10.1523/ENEURO.0045-25.2025","url":null,"abstract":"<p><p>Marker-based motion capture (MBMC) is a powerful tool for precise, high-speed, three-dimensional tracking of animal movements, enabling detailed study of behaviors ranging from subtle limb trajectories to broad spatial exploration. Despite its proven utility in larger animals, MBMC has remained underutilized in mice due to the difficulty of robust marker attachment during unrestricted behavior. In response to this challenge, markerless tracking methods, facilitated by machine learning, have become the standard in small animal studies due to their simpler experimental setup. However, trajectories obtained with markerless approaches at best approximate ground-truth kinematics, with accuracy strongly dependent on video resolution, training dataset quality, and computational resources for data processing. Here, we overcome the primary limitation of MBMC in mice by implanting minimally invasive markers that remain securely attached over weeks of recordings. This technique produces high-resolution, artifact-free trajectories, eliminating the need for extensive post-processing. We demonstrate the advantages of MBMC by resolving subtle drug-induced kinematic changes that become apparent only within specific behavioral contexts, necessitating precise three-dimensional tracking beyond simple flat-surface locomotion. Furthermore, MBMC uniquely captures the detailed spatiotemporal dynamics of harmaline-induced tremors, revealing previously inaccessible correlations between body parts and thus significantly improving the translational value of preclinical tremor models. While markerless tracking remains optimal for many behavioral neuroscience studies in which general posture estimation suffices, MBMC removes barriers to investigations demanding greater precision, reliability, and low-noise trajectories. This capability significantly broadens the scope for inquiry into the neuroscience of movement and related fields.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Open-Source and Highly Adaptable Rodent Limited Bedding and Nesting Apparatus for Chronic Early Life Stress.","authors":"Olivia S O'Neill, Dylan J Terstege, Amisha K Gill, Moriah Edge-Partington, Raksha Ramkumar, Jonathan R Epp, Derya Sargin","doi":"10.1523/ENEURO.0081-25.2025","DOIUrl":"10.1523/ENEURO.0081-25.2025","url":null,"abstract":"<p><p>Early life stress (ELS) increases susceptibility to cognitive and socioemotional dysfunction by disrupting the neurobiological systems that regulate these behaviors. Animal models provide a valuable tool for investigating the underlying mechanisms, enabling precise manipulation of stress exposure during development. The limited bedding and nesting (LBN) model, which induces maternal stress by restricting access to bedding and nesting materials in rodents, has been instrumental in advancing our understanding of chronic ELS. While this paradigm has been widely adopted, variations in apparatus designs and subtle differences in methodologies could impact consistency across studies. Here, we provide standardized guidelines for a cost-effective open-source mouse LBN apparatus design, which could further enhance the model's utility while supporting pup survival. We additionally present our findings observed during the duration of the LBN paradigm, which spans from postnatal day (PND) 2 to 10, for both dams and pups. We observe comparable corticosterone in control and LBN dams from PND 3 to 5. However, from PND 6 to 10, corticosterone remains elevated in LBN dams, while control dams show a decline. Notably, the LBN paradigm disrupts maternal care, as LBN dams exhibit more frequent nest exits and stereotypic behaviors during the dark phase. At PND 10, pups exhibit significantly reduced blood serum corticosterone levels and lower body weight compared with those reared under control conditions. By providing open-source equipment and detailed experimental protocols, our work aims to build on existing LBN paradigms to further enhance the accessibility and reproducibility of chronic ELS models.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":"12 6","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural Speech Tracking during Selective Attention: A Spatially Realistic Audiovisual Study.","authors":"Paz Har-Shai Yahav, Eshed Rabinovitch, Adi Korisky, Renana Vaknin Harel, Martin Bliechner, Elana Zion Golumbic","doi":"10.1523/ENEURO.0132-24.2025","DOIUrl":"10.1523/ENEURO.0132-24.2025","url":null,"abstract":"<p><p>Paying attention to a target talker in multitalker scenarios is associated with its more accurate neural tracking relative to competing non-target speech. This \"neural bias\" to target speech has largely been demonstrated in experimental setups where target and non-target speech are acoustically controlled and interchangeable. However, in real-life situations this is rarely the case. For example, listeners often look at the talker they are paying attention to while non-target speech is heard (but not seen) from peripheral locations. To enhance the ecological-relevance of attention research, here we studied whether neural bias toward target speech is observed in a spatially realistic audiovisual context and how this is affected by switching the identity of the target talker. Group-level results show robust neural bias toward target speech, an effect that persisted and generalized after switching the identity of the target talker. In line with previous studies, this supports the utility of the speech-tracking approach for studying speech processing and attention in spatially realistic settings. However, a more nuanced picture emerges when inspecting data of individual participants. Although reliable neural speech tracking could be established in most participants, this was not correlated with neural bias or with behavioral performance, and >50% of participants showed similarly robust neural tracking of both target and non-target speech. These results indicate that neural bias toward the target is not a ubiquitous, or necessary, marker of selective attention (at least as measured from scalp-EEG), and suggest that individuals diverge in their internal prioritization among concurrent speech, perhaps reflecting different listening strategies or capabilities under realistic conditions.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene Variants Related to Primary Familial Brain Calcification: Perspectives from Bibliometrics and Meta-Analysis.","authors":"Dehao Yang, Yangguang Lu, Honghao Huang, Yiqun Chen, Zihan Jiang, Ruotong Yao, Yiran Bu, Yu Li, Zhidong Cen, Wei Luo","doi":"10.1523/ENEURO.0058-25.2025","DOIUrl":"10.1523/ENEURO.0058-25.2025","url":null,"abstract":"<p><p>The genetic role and specific effects of primary familial cerebral calcification (PFBC) are still unclear. We aim to analyze bibliometric features in studies related to PFBC, investigate variant detection rates in patients with brain calcifications, and examine the phenotypic characteristics of PFBC patients. A comprehensive search of studies on the genetic effects of PFBC up until December 31, 2024, was conducted across Web of Science, PubMed, Embase, and Scopus. A random-effects meta-analysis combined variant detection rates for genes <i>SLC20A2</i>, <i>PDGFRB</i>, <i>PDGFB</i>, <i>XPR1</i>, <i>MYORG</i>, <i>JAM2</i>, <i>CMPK2</i>, and <i>NAA60</i> Data on total calcification scores (TCS), age of onset, and the prevalence of various phenotypes in PFBC patients were also aggregated. Publication bias was assessed using Egger's linear regression, and a leave-one-out sensitivity analysis was performed. Of 1,267 records, 224 were included in the bibliometric analysis. Keywords \"primary familial brain calcification\" and \"<i>SLC20A2</i>\" were most prominent. Eighteen articles were included in the meta-analysis, revealing higher variant rates for <i>SLC20A2</i> (16.7%, 95% CI: 10.0-24.6) and <i>MYORG</i> (16.8%, 95% CI: 0.0-54.0), which were associated with higher TCS. The average age of onset was 43.69 years (95% CI: 36.17-51.21). Cognitive impairment (45.3%, 95% CI: 35.7-55.1) and psychiatric symptoms (30.8%, 95% CI: 17.2-46.2) had relatively higher prevalence rates. No significant publication bias was found (<i>p</i> > 0.05), and the sensitivity analysis confirmed the results' robustness. <i>SLC20A2</i> and <i>MYORG</i> variants had higher detection rates, with cognitive impairment and psychiatric symptoms being common in PFBC patients. Continued research is essential to further explore these genetic variants.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12186716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}