eNeuro最新文献

{"title":"Effects of chronic social isolation stress and alcohol on the reinforcing properties of ketamine in male and female rats.","authors":"Sarah D Jennings, Devin P Hagarty, Jordan Logue, Michelle Crawford, Samantha K Saland, Mohamed Kabbaj","doi":"10.1523/ENEURO.0452-24.2025","DOIUrl":"https://doi.org/10.1523/ENEURO.0452-24.2025","url":null,"abstract":"<p><p>While ketamine, an NMDA receptor antagonist, is effective in treating major depression, studies have not addressed the safety of repeated ketamine infusions in depressed patients with comorbid Alcohol Use Disorder (AUD). In this study, we aimed to determine whether a history of chronic social isolation and alcohol exposure alter the reinforcing properties of ketamine in male and female rats. Rats were pair-housed or socially isolated for 12 weeks and underwent intermittent access to 20% alcohol. Subsequently, rats underwent intravenous ketamine self-administration under a fixed ratio 1 schedule, followed by extinction training and one session of cue-induced reinstatement. Dendritic spine morphology was examined in the nucleus accumbens, an important area implicated in reward and motivation. Our results show that females self-administered more ketamine than males, a history of alcohol increased ketamine intake in females, and a history of isolation or alcohol independently increased ketamine intake in males. All experimental groups showed similar extinction patterns and reinstatement to ketamine cues. A pattern emerged similar to ketamine self-administration behaviors, where isolation increased the number of immature spines in males, a change that was attenuated in isolated alcohol drinkers, and a history of alcohol increased the number of immature spines in females. Our results suggest that a history of isolation and alcohol modulate the reinforcing properties of ketamine in a sex-dependent manner. This underscores the importance of considering sex differences and a history of alcohol use when employing ketamine to treat various psychopathologies, including major depression.<b>Significance Statement</b> Repeated infusions of ketamine, an NMDAR antagonist, show sustained reductions in major depressive disorder (MDD). Given the high comorbidity between MDD and Alcohol Use Disorder (AUD), we investigated the effects of a history of social isolation and alcohol on responding for ketamine. We showed sex differences in the effects of isolation stress and alcohol on ketamine intake alongside alterations in dendritic spine morphology in the nucleus accumbens. Overall, a history of alcohol consumption enhanced responding for ketamine. If extrapolated clinically, our research implies that adjustments in ketamine therapy should be made for individuals with a history of alcohol drinking undergoing treatment for MDD. Additionally, when formulating treatment protocols for this population, it is important to consider potential sex differences.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering Compromised Speech-in-Noise Intelligibility in Older Listeners: The Role of Cochlear Synaptopathy.","authors":"Markus Garrett, Viacheslav Vasilkov, Manfred Mauermann, Pauline Devolder, John L Wilson, Leslie Gonzales, Kenneth S Henry, Sarah Verhulst","doi":"10.1523/ENEURO.0182-24.2024","DOIUrl":"10.1523/ENEURO.0182-24.2024","url":null,"abstract":"<p><p>Speech intelligibility declines with age and sensorineural hearing damage (SNHL). However, it remains unclear whether cochlear synaptopathy (CS), a recently discovered form of SNHL, significantly contributes to this issue. CS refers to damaged auditory-nerve synapses that innervate the inner hair cells and there is currently no go-to diagnostic test available. Furthermore, age-related hearing damage can comprise various aspects (e.g., hair cell damage, CS) that each can play a role in impaired sound perception. To explore the link between cochlear damage and speech intelligibility deficits, this study examines the role of CS for word recognition among older listeners. We first validated an envelope-following response (EFR) marker for CS using a Budgerigar model. We then applied this marker in human experiments, while restricting the speech material's frequency content to ensure that both the EFR and the behavioral tasks engaged similar cochlear frequency regions. Following this approach, we identified the relative contribution of hearing sensitivity and CS to speech intelligibility in two age-matched (65-year-old) groups with clinically normal (<i>n</i> = 15, 8 females) or impaired audiograms (<i>n</i> = 13, 8 females). Compared to a young normal-hearing control group (<i>n</i> = 13, 7 females), the older groups demonstrated lower EFR responses and impaired speech reception thresholds. We conclude that age-related CS reduces supra-threshold temporal envelope coding with subsequent speech coding deficits in noise that cannot be explained based on hearing sensitivity alone.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA-155 Inhibition Activates Wnt/β-Catenin Signaling to Restore Th17/Treg Cell Balance and Protect against Acute Ischemic Stroke.","authors":"Wenli Huang, Quanlong Hong, Huimin Wang, Zhihua Zhu, Shujie Gong","doi":"10.1523/ENEURO.0347-24.2024","DOIUrl":"10.1523/ENEURO.0347-24.2024","url":null,"abstract":"<p><p>Acute ischemic stroke (AIS) is a severe neurological disease associated with Th17/Treg cell imbalance and dysregulation of the Wnt/β-catenin signaling pathway. This study investigates whether miR-155 inhibition can activate Wnt/β-catenin signaling, improve Th17/Treg balance, and provide neuroprotection against stroke. We conducted a multilevel experimental design, including high-throughput sequencing, bioinformatics analysis, in vivo mouse models, and in vitro cell experiments. High-throughput sequencing revealed significant differential gene expression between the miR-155 antagomir-treated and control groups (BioProject: PRJNA1152758). Bioinformatics analysis identified key genes linked to Wnt/β-catenin signaling and Th17/Treg imbalance. In vitro experiments confirmed that miR-155 inhibition activated Wnt/β-catenin signaling and improved Th17/Treg ratios. In vivo studies demonstrated that miR-155 antagomir treatment provided significant neuroprotection against AIS. These findings suggest that targeting miR-155 could be a promising therapeutic strategy for stroke by modulating immune balance and key signaling pathways.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Tracking of Selective Attention in Hearing Aid Users: The Role of Noise Reduction and Nonlinearity Compensation.","authors":"Johanna Wilroth, Emina Alickovic, Martin A Skoglund, Carine Signoret, Jerker Rönnberg, Martin Enqvist","doi":"10.1523/ENEURO.0275-24.2025","DOIUrl":"10.1523/ENEURO.0275-24.2025","url":null,"abstract":"<p><p>Hearing impairment (HI) disrupts social interaction by hindering the ability to follow conversations in noisy environments. While hearing aids (HAs) with noise reduction (NR) partially address this, the \"cocktail-party problem\" persists, where individuals struggle to attend to specific voices amidst background noise. This study investigated how NR and an advanced signal processing method for compensating for nonlinearities in Electroencephalography (EEG) signals can improve neural speech processing in HI listeners. Participants wore HAs with NR, either activated or deactivated, while focusing on target speech amidst competing masker speech and background noise. Analysis focused on temporal response functions to assess neural tracking of relevant target and masker speech. Results revealed enhanced neural responses (N1 and P2) to target speech, particularly in frontal and central scalp regions, when NR was activated. Additionally, a novel method compensated for nonlinearities in EEG data, leading to improved signal-to-noise ratio (SNR) and potentially revealing more precise neural tracking of relevant speech. This effect was most prominent in the left-frontal scalp region. Importantly, NR activation significantly improved the effectiveness of this method, leading to stronger responses and reduced variance in EEG data and potentially revealing more precise neural tracking of relevant speech. This study provides valuable insights into the neural mechanisms underlying NR benefits and introduces a promising EEG analysis approach sensitive to NR effects, paving the way for potential improvements in HAs.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are You Safe or Should I Go? How Perceived Trustworthiness and Probability of a Sexual Transmittable Infection Impact Activation of the Salience Network.","authors":"Alexander Wolber, Stephanie N L Schmidt, Brigitte Rockstroh, Daniela Mier","doi":"10.1523/ENEURO.0258-24.2024","DOIUrl":"10.1523/ENEURO.0258-24.2024","url":null,"abstract":"<p><p>Functional imaging studies indicate that both the assessment of a person as untrustworthy and the assumption that a person has a sexually transmitted infection are associated with activation in regions of the salience network. However, studies are missing that combine these aspects and investigate the perceived trustworthiness of individuals previously assessed with high or low probability of a sexually transmitted infection. During fMRI measurements, 25 participants viewed photographs of people preclassified as having high or low HIV probability and judged their trustworthiness. In a postrating, stimuli were rated for trustworthiness, attractiveness, and HIV probability. Persons preclassified as HIV- in contrast to those preclassified as HIV+ were rated more trustworthy and with lower HIV probability. Activation in medial orbitofrontal cortex was higher for those rated and preclassified as HIV- than HIV+. Based on the individual ratings, but not the preclassification, there was significantly higher activation in the insula, amygdala, anterior cingulate cortex, and nucleus accumbens in response to untrustworthy than to trustworthy faces. Activation of the salience network occurred when a person was judged as untrustworthy, but not according to a preclassification. Activation in the medial orbitofrontal cortex, a structure associated with reward, was enhanced when a person was perceived as trustworthy and also when a person was preclassified with low HIV probability. Our findings suggest that trustworthiness and HIV- perception have consistency across samples, while the perception of risk and associated activation of the salience network has restricted cross-sample consistency.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Simple, Low-Cost Implant for Reliable Diaphragm EMG Recordings in Awake, Behaving Rats.","authors":"Taylor C Holmes, Jesus D Penaloza-Aponte, Alyssa R Mickle, Rachel L Nosacka, Erica A Dale, Kristi A Streeter","doi":"10.1523/ENEURO.0444-24.2025","DOIUrl":"10.1523/ENEURO.0444-24.2025","url":null,"abstract":"<p><p>Breathing is a complex neuromuscular process vital to sustain life. In preclinical animal models, the study of respiratory motor control is primarily accomplished through neurophysiologic recordings and functional measurements of respiratory output. Neurophysiologic recordings that target neural or muscular output via direct nerve recordings or respiratory muscle electromyography (EMG) are commonly collected during anesthetized conditions. While offering tight control of experimental preparations, the use of anesthesia results in respiratory depression, may impact cardiovascular control, eliminates the potential to record volitional nonventilatory behaviors, and can limit translation. Since the diaphragm is a unique muscle which is rhythmically active and difficult to access, placing diaphragm EMGs to collect chronic recordings in awake animals is technically challenging. Here, we describe methods for fabricating and implanting indwelling diaphragm EMG electrodes to enable recordings from awake rodents for longitudinal studies. These electrodes are relatively easy and quick to produce (∼1 h), are affordable, and provide high-quality and reproducible diaphragm signals using a tethered system that allows animals to <i>ad libitum</i> behave. This system is also designed to work in conjunction with whole-body plethysmography to facilitate simultaneous recordings of diaphragm EMG and ventilation. We include detailed instructions and considerations for electrode fabrication and surgical implantation. We also provide a brief discussion on data acquisition, material considerations for implant fabrication, and the physiological implications of the diaphragm EMG signal.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholecystokinin modulates corticostriatal transmission and plasticity in rodents.","authors":"Chloé Guillaume, María Sáez, Patricia Parnet, Ramón Reig, Vincent Paillé","doi":"10.1523/ENEURO.0251-24.2025","DOIUrl":"https://doi.org/10.1523/ENEURO.0251-24.2025","url":null,"abstract":"<p><p>Recent findings have shifted the view of cholecystokinin (CCK) from being a cellular neuronal marker to being recognized as a crucial neuropeptide pivotal in synaptic plasticity and memory processes. Despite its now appreciated importance in various brain regions and abundance in the basal ganglia, its role in the striatum, which is vital for motor control, remains unclear. This study sought to fill this gap by performing a comprehensive investigation of the role of CCK in modulating striatal medium spiny neurons (MSN) membrane properties, as well as the secondary somatosensory cortex S2 to MSN synaptic transmission and plasticity in rodents. Using <i>in-vivo</i> optopatch-clamp recording in mice on identified medium spiny neurons (MSNs), we showed that the application of CCK receptor type 2 (CCK2R) antagonists decreases corticostriatal transmission in both direct and indirect pathway MSNs. Moving to an ex vivo rat preparation to maximize experimental access, we showed that CCK2R inhibition impacts MSN membrane properties by reducing spike threshold and rheobase, suggesting an excitability increase. Moreover, CCK modulates corticostriatal transmission mainly via CCK2R, and CCK2R blockage shifted spike-timing-dependent plasticity (STDP) from long-term potentiation to long-term depression. Our study advances the understanding of CCK's importance in modulating corticostriatal transmission. By showing how CCK2R blockade influences synaptic function and plasticity, we provide new insights into the mechanisms underlying striatal functions, opening new paths for exploring its potential relevance to neurological disorders involving basal ganglia related behaviors.<b>Significance Statement</b> Cholecystokinin (CCK) plays a critical role in synaptic plasticity and memory but completely unexplored in corticostriatal synapses and motor control. This study shows that blocking the CCK2 receptor (CCK2R) reduces postsynaptic potentials (EPSPs) and excitatory postsynaptic currents (EPSCs) in the motor striatum (in vivo and ex vivo) and disrupts corticostriatal spike-timing-dependent plasticity (STDP), shifting it from long-term potentiation (LTP) to long-term depression (LTD). These findings reveal CCK signaling as a key modulator of corticostriatal communication, capable of reversing the direction of synaptic plasticity. The results position CCK as a crucial regulator of synaptic and motor functions, with implications for understanding corticostriatal mechanisms.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Lobectomy Evidence for the Role of the Amygdala in Early Emotional Face and Body Processing.","authors":"Eleanor Moses, Jenna Scambler, Jessica Taubert, Ada H Y Lo, Kate Thompson, Beatrice de Gelder, Alan J Pegna","doi":"10.1523/ENEURO.0114-24.2024","DOIUrl":"10.1523/ENEURO.0114-24.2024","url":null,"abstract":"<p><p>The amygdala is believed to make invaluable contributions to visual emotion processing. Yet how this subcortical body contributes to emotion perception across time is contended. Here, we measured differences in the perceptual processing of emotional stimuli after unilateral temporal lobe and amygdala resection (TLR) in humans, using EEG. Through mass univariate analysis of brain activity, we compared responses to fearful and neutral faces (left TLR <i>N</i> = 8, right TLR <i>N</i> = 8, control <i>N</i> = 8), and fearful and neutral bodies (left TLR <i>N</i> = 9, right TLR <i>N</i> = 9, control <i>N</i> = 9). We found that TLR impaired the early-stage perceptual processing of emotional stimuli seen in the control group. Indeed, in controls a heightened responses to fearful faces was found in the 140-170 ms time window, over temporoparietal electrodes. This effect was also present in the left TLR group but disappeared in the right TLR group. For emotional bodies, brain activity was differentially sensitive to fearful stimuli at 90-120 ms in the control group, but this effect was eliminated in both TLR groups. Collectively, these results reveal the amygdala contributes to the early stages of perceptual processing that discriminate emotional stimuli from neutral stimuli. Further, they emphasize the unique role of the right medial temporal structures such as the amygdala in emotional face perception.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial Heterogeneity in Myelin Sheathing Impacts Signaling Reliability and Susceptibility to Injury.","authors":"Afroditi Talidou, Jérémie Lefebvre","doi":"10.1523/ENEURO.0402-24.2025","DOIUrl":"10.1523/ENEURO.0402-24.2025","url":null,"abstract":"<p><p>Axons in the mammalian brain show significant diversity in myelination motifs, displaying spatial heterogeneity in sheathing along individual axons and across brain regions. However, its impact on neural signaling and susceptibility to injury remains poorly understood. To address this, we leveraged cable theory and developed model axons replicating the myelin sheath distributions observed experimentally in different regions of the mouse central nervous system. We examined how the spatial arrangement of myelin affects propagation and predisposition to conduction failure in axons with cortical versus callosal myelination motifs. Our results indicate that regional differences in myelination significantly influence conduction timing and signaling reliability. Sensitivity of action potential propagation to the specific positioning, lengths, and ordering of myelinated and exposed segments reveals non-linear and path-dependent conduction. Furthermore, myelination motifs impact signaling vulnerability to demyelination, with callosal motifs being particularly sensitive to myelin changes. These findings highlight the crucial role of myelinating glia in brain function and disease.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuronal Properties in the Lateral Habenula and Adult-Newborn Interactions in Virgin Female and Male Mice.","authors":"Cheng-Hsi Wu, Manuel Mameli, Salvatore Lecca","doi":"10.1523/ENEURO.0414-24.2025","DOIUrl":"10.1523/ENEURO.0414-24.2025","url":null,"abstract":"<p><p>The behavioral interactions between adults and newborns are decisive for the fitness and the survival of offspring across the animal kingdom. In laboratory mice, while virgin females display caregiving behaviors, virgin males are rather neglectful or aggressive toward pups. Despite the importance of these behavioral variations, the underlying neural mechanisms remain poorly understood. Brain regions encoding these behaviors may exhibit sex-dependent functional differences at the baseline. Additionally, these structures might undergo sex-specific plasticity after adults interact with the offspring. Emerging evidence suggests sex-based differences in input connectivity, genetics, and receptor expression of the epithalamic lateral habenula (LHb). Moreover, LHb neuronal activity is instrumental for adult-newborn interactions. However, whether LHb neuronal function varies between sexes and/or undergoes adaptations following interactions with pups has not been fully investigated. In this study, we used in vivo and ex vivo single-cell electrophysiology to examine the basal LHb neuronal activity of virgin female and male mice. In a second set of experiments, we exposed mice to pups and recapitulated sex-based divergent behaviors. Recordings in acute slices showed no alterations in LHb firing properties, regardless of sex or pup exposure. These findings suggest that, although the LHb participates in adult behaviors toward pups, this is not mediated by sex-dependent functional differences or adaptations in the neuronal firing properties. Thus, this study provides new insights into the neural basis of sex-specific adult-newborn behaviors and the role of the LHb in these processes.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}