eNeuro最新文献

{"title":"Treatment of Mitochondrial Disturbances due to Early Life Adversity in Mice Results in Restoration of Complex I Activity and Normal Reward Behavior.","authors":"Kathie L Eagleson, Pat Levitt","doi":"10.1523/ENEURO.0172-25.2025","DOIUrl":"10.1523/ENEURO.0172-25.2025","url":null,"abstract":"<p><p>The environment experienced by children, such as exposure to chronic early life adversity (ELA), increases lifespan brain disorder risk. The mechanisms that link ELA exposure to functional brain disruptions are not well understood. A limited-bedding and nesting paradigm, in which ELA is induced in mouse pups over the first postnatal week through disruption of maternal care, is characterized by limited resources, environment unpredictability, and disruption of reward and cognitive behaviors. Studies using this model demonstrated sex-selective alterations in hippocampal mitochondrial-associated proteins in response to ELA compared with care as usual (CAU). Further, oxidative phosphorylation (OXPHOS) capacity and complex I activity are increased in ELA juveniles, yet decreased in adults, with the impact of ELA moderated by sex in adults. Given that altered mitochondrial function is a key mediator in metabolic adaptations, the goal of the present study was to evaluate the possibility of reversing mitochondrial dysfunction and the anhedonia that accompanies ELA by addressing oxidative stress. Treatment with the antioxidant MitoQ began at weaning and extended to 3 months. Measures of complex I activity demonstrated full recovery in adults. Female-specific deficits in the sucrose preference task, which is a measure of rewarding behavior in rodents, also exhibited recovery, with preference for sucrose comparable with that of CAU mice. These data indicate that mitochondrial health is one component of responses to early life adversity that has lifespan implications, but with the capacity to recover normal functioning in adults.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12469007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial Attention Weakly Modulates Visual Responses in the Lateral Geniculate Nucleus.","authors":"Henry J Alitto, Jeffrey S Johnson, W Martin Usrey","doi":"10.1523/ENEURO.0153-25.2025","DOIUrl":"10.1523/ENEURO.0153-25.2025","url":null,"abstract":"<p><p>Visual responses in the cortex are strongly influenced by shifts in spatial attention. This modulation of visual processing includes changes in firing rate, decreased response variability, and decreased interneuronal correlations; all of which are thought to underlie enhanced perception near the center of attention at the cost of perception at other locations. Information from the retina is relayed to primary visual cortex via neurons in the lateral geniculate nucleus (LGN) of the thalamus. Although early studies describe an enhancement of LGN activity with spatial attention, more recent work has cast doubt on this view. Given its strategic position as the gateway to the cortex, an understanding of the effects of attention on visual processing in the LGN is important. We therefore performed experiments to reexamine the influence of spatial attention on spiking activity in macaque LGN (one male, one female) and applied a broad set of analyses and functional metrics to assess possible effects. Our results reveal a statistically significant effect of spatial attention in the LGN: firing rates were slightly higher and more reliable when monkeys directed attention toward the receptive fields of recorded neurons compared with when attention was directed to different retinotopic locations. However, effects were much smaller than previously reported (∼1 vs ∼4%) and further analyses suggest that effects are weak, inconsistent, and restricted to a small subset of parvocellular and magnocellular neurons. Thus, while spatial attention does exert an influence in the LGN, its effects are weak and may have limited impact on downstream processing.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":"12 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12469006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of 206 brain structural connectivity with different types of strokes: a Mendelian randomization study.","authors":"Xinwei Wang, Yongchun Peng, Yimeng Gao, Wenjin Zhou, Tao Huang, Zizhuang Peng","doi":"10.1523/ENEURO.0209-25.2025","DOIUrl":"https://doi.org/10.1523/ENEURO.0209-25.2025","url":null,"abstract":"<p><p>The association between brain structural connectivity (BSC) and different subtypes of stroke has not been reported. The current study determined whether some BSC patterns may contribute to the risk of stroke. A two-sample, bidirectional, multivariate Mendelian randomization (MR) analysis was performed. Genome-wide aggregated data for BSC were obtained by accessing the GWAS directory of the European Bioinformatics Institute (https://www.ebi.ac.uk/gwas). Whole-brain diffusion MRI tractograms for 26,300 UK Biobank participants were reconstructed with the MRtrix3 standard pipeline followed by SIFT2 re-weighting. A co-localization analysis was performed to determine whether the association between BSC and stroke was driven by loci within genomic regions. Reverse MR was performed to evaluate potential stroke-induced changes in BSC. Left hemisphere (LH) somatomotor network-to-LH salience /ventral attention network white matter (WM) structural connectivity (SC) [OR = 1.30, <i>P</i> = 5.96×10^-4, <i>P</i> value after Bonferroni correction [<i>P.bfr</i>] = 0.0125] and right hemisphere (RH) dorsal attention network-to-thalamus WM-SC (OR = 1.23, <i>P</i> = 1.60×10^-3, <i>P.bfr</i> = 0.0125) were shown to have a positive association with the risk of ischemic stroke. RH dorsal attention network-to-amygdala WM-SC (OR = 0.78, <i>P</i> = 1.26×10^-3, <i>P.bfr</i> = 0.0125) showed a negative relationship with the risk of ischemic stroke. A high LH somatomotor network-to-RH visual network WM-SC (OR = 1.62, <i>P</i> = 9.10×10^-3, <i>P.bfr</i> = 0.025) was associated with an increased risk of large atherosclerotic stroke. In conclusion, the results of the current study provided some evidence from the perspective of genetics, that different BSCs may have close associations with hemorrhagic stroke, ischemic stroke, and stroke subtypes. These findings may facilitate the screening and the risk stratification for stroke patients.<b>Significance Statement</b> This study provided some evidence from the perspective of genetics, that the variation in structural connectivity between some brain regions may closely relate to differential risk of stroke subtypes. The findings suggest BSC can be used as an early risk marker for the screening of stoke patients. Further investigations of the underlying cerebrovascular and neurophysiologic mechanisms are still needed for the close association between structural connectivity and stoke.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stimulus Distribution Shapes Color and Vibrotactile Perception.","authors":"Avi Aizenman, Kani Gaff, Dimitris Voudouris","doi":"10.1523/ENEURO.0121-25.2025","DOIUrl":"https://doi.org/10.1523/ENEURO.0121-25.2025","url":null,"abstract":"<p><p>Perception is shaped by both the physical properties of stimuli and their contextual presentation, often leading to systematic biases such as the central tendency effect, where perceptual judgments shift toward the average of the stimulus set. This study explored the central tendency bias in vibrotactile perception, an area that has received limited attention, while also replicating its well-documented occurrence in color perception to validate previous findings. Using a within-subjects design, participants (5 males, 15 females) completed color and vibrotactile discrimination tasks, each consisting of three blocks, which comprised systematically shifted stimulus sets. In an established virtual reality color task, stimuli ranged from yellow-green to blue-green, while in the vibrotactile task, stimuli varied in vibration intensity around a baseline distribution. As predicted, the point of subjective equality (PSE) shifted toward the mean of the stimulus sets in both tasks, confirming the presence of a central tendency bias. These findings demonstrate that perception of both color and vibrotactile intensity is not determined solely based on the physical properties of the stimulus per se, but it is rather influenced by the distribution of the presented stimuli, underscoring the pervasive role of contextual factors in shaping sensory judgments.<b>Significance Statement</b> Our senses do not work like measuring devices-they integrate incoming information with past experience and surrounding context. What we perceive can be biased toward the average of recently encountered stimuli, a phenomenon called the central tendency bias. Although this bias is well established in vision and hearing, it has never been directly tested for how we perceive touch intensity, despite the critical role of tactile information in daily activities and motor control. By determining whether touch perception is shaped by stimulus context, this research clarifies whether widely used tactile sensitivity measures reflect stable sensory thresholds or are influenced by prior experience. These findings have implications for experimental design, sensory assessment, and technologies that rely on accurate touch feedback.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loudness and Sound Category: Their Distinct Roles in Shaping Perceptual and Physiological Responses to Soundscapes.","authors":"Mercede Erfanian, Tin Oberman, Maria Chait, Jian Kang","doi":"10.1523/ENEURO.0146-25.2025","DOIUrl":"10.1523/ENEURO.0146-25.2025","url":null,"abstract":"<p><p>When compared with nature sounds, exposure to mechanical sounds evokes higher levels of perceptual and physiological arousal, prompting the recruitment of attentional and physiological resources to elicit adaptive responses. However, it is unclear whether these attributes are solely related to the sound intensity of mechanical sounds, since in most real-world scenarios, mechanical sounds are present at high intensities or if other acoustic or semantic factors are also at play. We measured the skin conductance response (SCR), reflecting sympathetic nervous system activity as well as the pleasantness and eventfulness of the soundscape across two passive and active listening tasks in healthy subjects (<i>N</i> = 25; 14 females, 11 males). The auditory stimuli were divided into two categories, nature and mechanical sounds, and were manipulated to vary in three perceived loudness levels. As expected, we found that the sound category influenced perceived soundscape pleasantness and eventfulness. SCR was analyzed by taking the mean level across the stimulus epoch and also by quantifying its dynamics. We found that mean SCR was modulated by loudness only. SCR rise-time (a measure of the time it takes the skin response to increase from the baseline to its maximum value) correlated significantly with soundscape pleasantness and eventfulness for nature and mechanical sounds. This study highlights the importance of considering both the loudness level and sound category in evaluating the perceptual soundscape, and it identifies SCR as a valuable tool for such assessments.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective Listening to Unpredictable Sound Sequences Increases Tonic Muscle Activity in the Human Vestigial Auriculomotor System.","authors":"Adrian Mai, Steven A Hillyard, Daniel J Strauss, Farah I Corona-Strauss","doi":"10.1523/ENEURO.0301-25.2025","DOIUrl":"https://doi.org/10.1523/ENEURO.0301-25.2025","url":null,"abstract":"<p><p>Recent investigations have revealed that selective attention to lateralized speech increases ipsilateral tonic electromyographic activity in the vestigial human auriculomotor system. However, it has yet to be determined whether this modulation depends upon predictive cues that are inherent in continuous speech or whether it is a general concomitant of selective attention to sounds in the auditory periphery. The present study addressed this question by replacing speech with randomized, unpredictable sequences of brief tonal stimuli in a dichotic listening task that necessitated a sustained anticipatory focus of attention. Participants (8 female, 23 male) were presented with sequences of brief tone bursts in one ear and frequency-modulated \"chirps\" in the other ear and were instructed to focus on sounds in one ear and report attenuated deviant stimuli in that ear. Posterior auricular muscle (PAM) activity was recorded behind both ears, and non-rectified stimulus-locked responses were assessed to ensure the reliability of PAM activity. Recordings of non-stimulus-locked rectified activity indicated that ipsilateral tonic PAM amplitudes were elevated when same-side sounds were attended, and follow-up analyses demonstrated that these modulations were independent of sound-evoked PAM reflexes. These findings provide evidence that this ipsilateral tonic increase in PAM activity is generally present in scenarios of lateralized selective listening and not reliant on predictive linguistic cues that may facilitate tracking of the attended stream. Due to its accessibility and capability of decoding the spatial focus of attention, this PAM modulation could support the development of intelligent hearing devices that maximize sensitivity towards a user's listening goals.<b>Significance Statement</b> This study demonstrates that ipsilateral tonic activity of the posterior auricular muscle (PAM) is elevated when lateralized sounds are selectively attended, even when stimulation sequences have an intermittent and unpredictable structure that requires a sustained, non predictive mode of attending. This represents an important extension of previous studies that revealed similar modulations during listening to continuous speech and suggests that the tonic modulation of PAM activity is generalizable across different scenarios of selective listening. Additionally, the present findings support the emerging view that the human auriculomotor system, despite its vestigial expression, operates in a remarkably nuanced manner. Integrating the observed modulations into intelligent hearing devices could provide an easily accessible means for decoding the lateralized focus of endogenously directed auditory attention.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal-Prefrontal Communication Subspaces Align with Behavioral and Network Patterns in a Spatial Memory Task.","authors":"Ryan A Young, Justin D Shin, Ziyi Guo, Shantanu P Jadhav","doi":"10.1523/ENEURO.0336-24.2025","DOIUrl":"10.1523/ENEURO.0336-24.2025","url":null,"abstract":"<p><p>Rhythmic network states have been theorized to facilitate communication between brain regions, but how these oscillations influence communication subspaces, i.e., the low-dimensional neural activity patterns that mediate interregional communication, and in turn how subspaces impact behavior remain unclear. Using a spatial memory task in rats (male Long-Evans rats), we simultaneously recorded ensembles from hippocampal CA1 and the prefrontal cortex (PFC) to address this question. We found that task behaviors best aligned with low-dimensional, shared subspaces between these regions rather than local activity in either region. Critically, both network oscillations and speed modulated the structure and performance of this communication subspace. To understand the communication space, we visualized shared CA1-PFC communication geometry using manifold techniques and found ring-like structures. We hypothesize that these shared activity manifolds are utilized to mediate the task behavior. These findings suggest that memory-guided behaviors are driven by shared CA1-PFC interactions that are dynamically modulated by oscillatory states, offering a novel perspective on the interplay between rhythms and behaviorally relevant neural communication.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dentate Granule Cell Capacitance Is Stable across the Light/Dark Cycle.","authors":"Jose Carlos Gonzalez, Reagan L Pennock, Asan F Abdulkareem, Bryan W Luikart, Jacques I Wadiche, Linda Overstreet-Wadiche","doi":"10.1523/ENEURO.0213-25.2025","DOIUrl":"10.1523/ENEURO.0213-25.2025","url":null,"abstract":"<p><p>The plasma membrane acts as a capacitor that plays a critical role in neuronal excitability and signal propagation. Neuronal capacitance is proportional to the area of the cell membrane; thus it is often used as a measure of the cell size that is assumed to be relatively stable. Recent work proposes that the capacitance of dentate granule cells (dGCs) and cortical pyramidal cells changes across the light/dark (LD) cycle in a manner that alters synaptic integration. We addressed this potential change in capacitance using a large dataset of dGC recordings from adult male and female mice across the light cycle. Our data show that daily changes in the membrane time constant result from fluctuation in membrane resistance rather than capacitance. We also confirm the ability to resolve changes in neuronal capacitance induced by altering dGC membrane area via acute axotomy or genetically induced overgrowth using either voltage-clamp or current-clamp approaches. Our results demonstrate that the capacitance of dGCs remains stable over the LD cycle and that daily changes in the membrane time constant and excitability are mediated by fluctuations in membrane resistance.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SpinalTRAQ: A Novel Pipeline for Volumetric Cervical Spinal Cord Analysis Identifies the Corticospinal Tract Synaptic Projectome in Healthy and Post-stroke Mice.","authors":"Katherine Poinsatte, Matthew Kenwood, Dene Betz, Ariana Nawaby, Apoorva D Ajay, Wei Xu, Erik J Plautz, Xiangmei Kong, Julian P Meeks, Denise M O Ramirez, Mark P Goldberg","doi":"10.1523/ENEURO.0276-25.2025","DOIUrl":"10.1523/ENEURO.0276-25.2025","url":null,"abstract":"<p><p>The corticospinal tract (CST) is essential for forelimb-specific fine motor skills. In rodents, it undergoes extensive structural remodeling across development, injury, and disease states, with major implications for motor function. A vast body of literature, spanning numerous injury models, frequently assesses these projections. Despite this, a cohesive imaging modality for rapid, quantitative assessment of the bilateral cervical spinal cord projectome is lacking. To address this, we developed SpinalTRAQ (Spinal cord Tomographic Registration and Automated Quantification), a novel mouse cervical spinal cord volumetric reference atlas and machine learning-based analytical pipeline. Using serial two-photon tomography, SpinalTRAQ enables unbiased, region-specific quantification of fluorescently labeled CST presynaptic terminals. In healthy male mice, the CST exhibits a distinct bilateral synaptic projectome, with the densest innervation in laminae 5 and 7 on the contralateral side and lamina 7 on the ipsilateral side. We additionally observed sparse synaptic input in lamina 9, specifically axial motor neuron pools, which we found was targeted to spinal motoneurons. Following focal motor cortical stroke, the injured CST axons are depleted, and contralesional CST projections are significantly increased after 4 and 6 weeks. By 6 weeks post-stroke, ipsilateral CST synapses were increased by fivefold, with the greatest increases seen in homotopic laminae and all motor neuron pools. SpinalTRAQ offers detailed, level- and lamina-specific quantification of the bilateral cervical spinal cord synaptic projectome, revealing previously unrecognized CST connectivity and plasticity after injury.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of a Monogamous California Mouse Model of Chemotherapy.","authors":"Melina M Seng, Zoe M Tapp, Erica R Glasper, Leah M Pyter","doi":"10.1523/ENEURO.0159-25.2025","DOIUrl":"10.1523/ENEURO.0159-25.2025","url":null,"abstract":"<p><p>Chemotherapy can cause debilitating behavioral side effects (e.g., fatigue, depression, cognitive decline); however, having an intimate partner can buffer these effects. The California mouse (<i>Peromyscus californicus</i>) is a rare monogamous mouse species that offers a novel opportunity to model human intimate partnership to identify the neurobiological mechanisms by which mate bonding reduces chemotherapy-associated behavioral side effects. As a first step toward this goal, this pilot study aimed to develop the first chemotherapy model, to our knowledge, in adult male and female California mice. Following a repeated paclitaxel chemotherapy regimen, well characterized in laboratory mice (<i>Mus musculus</i>), gross sickness physiology was first assessed after various doses. The 20 mg/kg paclitaxel dose, injected six times every other day, was the highest tolerable, clinically relevant dose and was characterized by moderate body mass loss and increased spleen mass. Thus, further investigation of the effects of this chemotherapy paradigm on peripheral and neural inflammatory gene expression, based on previous reports in laboratory mice, was undertaken; results were mixed. Consistent across the spleen, hippocampus, and hypothalamus, some proinflammatory genes were unexpectedly decreased with chemotherapy (<i>Il1β</i>, <i>Tnf</i>), whereas one gene was increased (<i>Icam1</i>). Chemotherapy also increased fatigue and sociability, but not anxiety-like behavior or cognition. Taken together, this pilot study characterized a translational model of chemotherapy in California mice with clinically relevant gross physiological changes and modest changes in neuroinflammation and behavioral side effects. This work also highlights the need for comparative studies and the growth of research tools for this socially relevant mouse species.</p>","PeriodicalId":11617,"journal":{"name":"eNeuro","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12453628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}