Enfermedades infecciosas y microbiologia clinica最新文献

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Trends in antimicrobial consumption at 72 adult and pediatric hospitals in Catalonia. Results of the VINCat Program 2008–2022 加泰罗尼亚72家成人和儿科医院的抗菌药物消费趋势。2008-2022年VINCat项目结果
IF 2.6 4区 医学
Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-01-13 DOI: 10.1016/j.eimc.2024.07.011
Ariadna Padullés , Sergi Hernàndez , Aurora Fernández-Polo , Santi Grau , Alexander Almendral , Susana Melendo , Enric Limón , Miquel Pujol , Juan Pablo Horcajada , on behalf of VINCat-PROA Hospital, Pediatric Group, Pharmacy Department members of the participating hospitals in VINCat-PROA
{"title":"Trends in antimicrobial consumption at 72 adult and pediatric hospitals in Catalonia. Results of the VINCat Program 2008–2022","authors":"Ariadna Padullés ,&nbsp;Sergi Hernàndez ,&nbsp;Aurora Fernández-Polo ,&nbsp;Santi Grau ,&nbsp;Alexander Almendral ,&nbsp;Susana Melendo ,&nbsp;Enric Limón ,&nbsp;Miquel Pujol ,&nbsp;Juan Pablo Horcajada ,&nbsp;on behalf of VINCat-PROA Hospital, Pediatric Group, Pharmacy Department members of the participating hospitals in VINCat-PROA","doi":"10.1016/j.eimc.2024.07.011","DOIUrl":"10.1016/j.eimc.2024.07.011","url":null,"abstract":"<div><h3>Introduction</h3><div>Antimicrobial stewardship programs (ASPs) monitor antimicrobial consumption and implement interventions in order to improve their use. Here, we analyze the trends in antimicrobial consumption at hospitals participating in the VINCat Program over a 15-year period in Catalonia, Spain.</div></div><div><h3>Methods</h3><div>We conducted a time-series analysis of systemic antimicrobial consumption in both adult and pediatric populations across 72 acute care centers. The annual measurement of systemic antibiotic and antifungal use was conducted using defined daily dose (DDD) in adults and days of therapy (DOT) in children. To analyze trends in antimicrobial use, we considered the annual consumption defined in DDD or DOT per 100 patient-days.</div></div><div><h3>Results</h3><div>Overall adult consumption (2008–2022) of antimicrobials, antibiotics, and antifungals averaged 73.54, 70.08, and 3.46 DDD/100 patient-days respectively. There was a significant increase in overall antimicrobial (rho<!--> <!-->=<!--> <!-->0.554; <em>p</em> <!-->=<!--> <!-->0.035) and also in antifungal (rho<!--> <!-->=<!--> <!-->0.657; <em>p</em> <!-->=<!--> <!-->0.01) consumption during the study period. Antibiotic consumption showed an upward trend in the first period followed by an unchanged consumption in the following years (rho<!--> <!-->=<!--> <!-->0.482; <em>p</em> <!-->=<!--> <!-->0.071). Penicillins were the most frequently used (33.5%), followed by cephalosporins (18.2%), quinolones (13.9%), and other systemic antibacterials (10.8%) and antifungals (4.7%). Pediatric consumption was analyzed between 2020 and 2022. Overall, antimicrobial, antibiotic, and antifungal use in this population averaged 60.04, 53.47, and 6.57<!--> <!-->DOT/100 patient-days respectively. As in adults, in children penicillins were the most used family (34.3%); within this group, penicillin combinations with beta-lactamase inhibitors (21.1%) were the most used, followed by cephalosporins (19.3%).</div></div><div><h3>Conclusions</h3><div>Participation on the VINCat Program was high at both adult and pediatric hospitals. Fifteen-year trends showed a significant increase in overall antimicrobial consumption in adults.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 ","pages":"Pages S69-S79"},"PeriodicalIF":2.6,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surveillance of device-associated infection rates at adult intensive care units in the VINCat program (2010–2022) VINCat项目成人重症监护病房器械相关感染率监测(2010-2022)
IF 2.6 4区 医学
Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-01-13 DOI: 10.1016/j.eimc.2024.09.004
Xavier Nuvials , Inmaculada Fernández , Alexander Almendral , Enric Limón , Miquel Pujol , Emili Diaz , on behalf of VINCat Programme ICU group
{"title":"Surveillance of device-associated infection rates at adult intensive care units in the VINCat program (2010–2022)","authors":"Xavier Nuvials ,&nbsp;Inmaculada Fernández ,&nbsp;Alexander Almendral ,&nbsp;Enric Limón ,&nbsp;Miquel Pujol ,&nbsp;Emili Diaz ,&nbsp;on behalf of VINCat Programme ICU group","doi":"10.1016/j.eimc.2024.09.004","DOIUrl":"10.1016/j.eimc.2024.09.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Surveillance is an essential part of the control of device-related nosocomial infections (NI) in intensive care units (UCIs). The aim of this study was to analyze the evolution of device-related infection rates in ICUs over the last 13 years, including ventilator-associated pneumonia (VAP), catheter-related bloodstream infection (CRBSI) and catheter-associated urinary tract infection (CAUTI).</div></div><div><h3>Material and methods</h3><div>Patients admitted to the 44 ICUs at 43 participating hospitals of the VINCat Program from 2010 to 2022 were included, taking into account three periods: first period (2010–2013), second period (2014–2017) and third period (2018–2022). Hospitals were classified into three groups according to their size: small (&lt;200 beds), medium (200–500 beds) and large (&gt;500 beds). Complexity was assessed based on the use of invasive mechanical ventilation. The incidence rate of VAP, CRBSI and CAUTI was recorded at least during three consecutive months/year in each unit by an intensivist with extensive experience.</div></div><div><h3>Results</h3><div>The device utilization ratio (DUR) of mechanical ventilation was 0.39, varying between 0.38 in large hospitals and 0.42 in small hospitals. The DUR of central venous catheter was 0.6, ranging from 0.59 (large hospitals) to 0.64 (small). The DUR of urinary catheter was 0.66, with a range of 0.65 (large hospitals) to 0.68 (small). The complexity of the different ICUs influenced the DUR of the different devices and the infections associated with them. The average rates of VAP, CRBSI, and CAUTI were 6.4, 1.9, and 3.4 episodes per 1000 device days respectively.</div></div><div><h3>Conclusions</h3><div>Surveillance systems provide information on intra-ICU infections. ICU complexity, measured in terms of the use of mechanical ventilation, influences device-associated infections.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 ","pages":"Pages S52-S59"},"PeriodicalIF":2.6,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Central line-associated bloodstream infections (CLABSI) in pediatric and neonatal intensive care units—The VINCat program 2013–2022 中心静脉相关血流感染(CLABSI)在儿科和新生儿重症监护病房- VINCat计划2013-2022
IF 2.6 4区 医学
Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-01-13 DOI: 10.1016/j.eimc.2024.09.005
Mireia Urrea Ayala , Alexander Almendral , Iolanda Jordan García , Mar Reyne Vergeli , Rosario Porrón , Yolanda Lladó Maura , Enric Limón , Miquel Pujol , on behalf of VINCat Pediatric and Neonatal ICU Bacteremia Programme
{"title":"Central line-associated bloodstream infections (CLABSI) in pediatric and neonatal intensive care units—The VINCat program 2013–2022","authors":"Mireia Urrea Ayala ,&nbsp;Alexander Almendral ,&nbsp;Iolanda Jordan García ,&nbsp;Mar Reyne Vergeli ,&nbsp;Rosario Porrón ,&nbsp;Yolanda Lladó Maura ,&nbsp;Enric Limón ,&nbsp;Miquel Pujol ,&nbsp;on behalf of VINCat Pediatric and Neonatal ICU Bacteremia Programme","doi":"10.1016/j.eimc.2024.09.005","DOIUrl":"10.1016/j.eimc.2024.09.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Central line-associated bloodstream infections (CLABSI) are among the most common and preventable hospital-acquired infections in pediatric and neonatal intensive care units (PICU–NICU). CLABSI is a common etiology of late-onset sepsis and is associated with high morbidity and mortality. The aim of this study was to describe the incidence of CLABSI in PICUs and NICUs in our geographical setting.</div></div><div><h3>Methods</h3><div>Descriptive study conducted as part of the VINCat program, investigating the incidence of CLABSI in NICUs and PICUs at acute care hospitals in Catalonia from 2013 to 2022. The annual CLABSI incidence rate was calculated by multiplying the total detected cases in a year by 1000 and dividing by the total patient-days with central venous catheter (CVC).</div></div><div><h3>Results</h3><div>NICU: The overall incidence rate was 5.59 per 1000 patient-days. Peripherally inserted CVC was involved in 59.8% of catheter-related infection, and an overall median duration of 7 days from catheter insertion to the onset of infection. PICU: The overall incidence rate was 3.62 per 1000 patient-days. Jugular venous access (44.1%) was the most common location of infections, with a median of 12 days to CLABSI. Gram-positive bacteria, especially coagulase-negative Staphylococci, were the most prevalent in both units.</div></div><div><h3>Conclusions</h3><div>A standardized surveillance system based on the calculation of the incidence rate of CLABSI in PICUs and NICUs can broaden our understanding of this HAI and will guide the implementation of measures of infection control and prevention.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 ","pages":"Pages S90-S97"},"PeriodicalIF":2.6,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surveillance of surgical site infections among caesarean section in VINCat hospitals: Results from 2008 to 2022 2008 - 2022年长春地区医院剖宫产手术部位感染监测
IF 2.6 4区 医学
Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-01-13 DOI: 10.1016/j.eimc.2024.07.014
Ma Pilar Barrufet , Alexander Almendral , Àngels Garcia , Oscar del Rio , Carme Agusti , Leonor Invernon , David Coroleu , Enric Limón , Miquel Pujol , members of VINCat caesarean section SSI surveillance
{"title":"Surveillance of surgical site infections among caesarean section in VINCat hospitals: Results from 2008 to 2022","authors":"Ma Pilar Barrufet ,&nbsp;Alexander Almendral ,&nbsp;Àngels Garcia ,&nbsp;Oscar del Rio ,&nbsp;Carme Agusti ,&nbsp;Leonor Invernon ,&nbsp;David Coroleu ,&nbsp;Enric Limón ,&nbsp;Miquel Pujol ,&nbsp;members of VINCat caesarean section SSI surveillance","doi":"10.1016/j.eimc.2024.07.014","DOIUrl":"10.1016/j.eimc.2024.07.014","url":null,"abstract":"<div><h3>Background</h3><div>The VINCat programme focuses on monitoring surgical site infections (SSI) in caesarean sections (CS) performed across affiliated hospitals.</div></div><div><h3>Methods</h3><div>The study included CS performed from 2008 to 2022, with a follow-up of 30 days after the intervention. The analysis of cumulative incidence rate of SSI was stratified into three 5-year periods (Periods 1–3). SSI was defined according to the National Healthcare Safety Network (NHSN) classification. SSI surveillance was carried out in accordance with the methodology established by the VINCat programme.</div></div><div><h3>Results</h3><div>From 2008 to 2022, 36,387 CS were surveyed at 34 hospitals: 13,502 in Period 1, 12,985 in Period 2 and 9900 in Period 3. The mean age was 33 years. Overall, SSI incidence fell from 3.81% in Period 1 to 2.66% in Period 3 (rho<!--> <!-->=<!--> <!-->−0.838; <em>p<!--> </em>&lt;<!--> <!-->0.001). Superficial SSI decreased from 3.1% in Period 1 to 2.15% in Period 3 (rho<!--> <!-->=<!--> <!-->−0.795; <em>p</em> <!-->&lt;<!--> <!-->0.001). The rate of organ-space SSI remained consistent across all three periods, maintaining a rate of 0.27 (rho<!--> <!-->=<!--> <!-->−0.092; <em>p<!--> </em>=<!--> <!-->0.745). Culture was performed in 58.9% of infections. The microorganisms most frequently identified were <em>Staphylococcus aureus</em> (20.64%), Coagulase-negative staphylococci (CoNS) (13.52%), and <em>Escherichia coli</em> (11.27%). Antibiotic prophylaxis was appropriate in 73.76% of the procedures.</div></div><div><h3>Conclusions</h3><div>Appropriate monitoring of post-CS SSI rates allows the implementation of preventive measures to reduce their incidence.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 ","pages":"Pages S37-S43"},"PeriodicalIF":2.6,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduction of surgical site infection rates in elective colorectal surgery by means of a nationwide interventional surveillance programme. A cohort study 通过全国性介入监测计划降低择期结直肠手术的手术部位感染率。队列研究
IF 2.6 4区 医学
Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-01-13 DOI: 10.1016/j.eimc.2024.04.012
Josep M. Badia , Alexander Almendral , Miriam Flores-Yelamos , Aina Gomila-Grange , David Parés , Marta Pascual , Domenico Fraccalvieri , Ana Abad-Torrent , Alejandro Solís-Peña , Lucrecia López , Marta Piriz , Mercè Hernández , Enric Limón , Miquel Pujol , on behalf of VINCat Colorectal Program
{"title":"Reduction of surgical site infection rates in elective colorectal surgery by means of a nationwide interventional surveillance programme. A cohort study","authors":"Josep M. Badia ,&nbsp;Alexander Almendral ,&nbsp;Miriam Flores-Yelamos ,&nbsp;Aina Gomila-Grange ,&nbsp;David Parés ,&nbsp;Marta Pascual ,&nbsp;Domenico Fraccalvieri ,&nbsp;Ana Abad-Torrent ,&nbsp;Alejandro Solís-Peña ,&nbsp;Lucrecia López ,&nbsp;Marta Piriz ,&nbsp;Mercè Hernández ,&nbsp;Enric Limón ,&nbsp;Miquel Pujol ,&nbsp;on behalf of VINCat Colorectal Program","doi":"10.1016/j.eimc.2024.04.012","DOIUrl":"10.1016/j.eimc.2024.04.012","url":null,"abstract":"<div><h3>Introduction</h3><div>Colorectal surgery has the highest surgical site infection (SSI) rates of all abdominal surgeries. Epidemiological surveillance is an excellent instrument to reduce SSI rates, but its effects may be time-limited and need to be monitored periodically. This study analyses the effectiveness of an interventional surveillance programme with regard to reducing SSI rates after elective colorectal surgery.</div></div><div><h3>Methods</h3><div>Cohort study analysing a SSI surveillance programme in elective colorectal surgery over a 15-year period. Prospectively collected data were stratified by 5-year periods (Periods 1, 2 and 3), and SSI rates, length of stay, readmission, mortality and microbiological aetiology were investigated.</div></div><div><h3>Results</h3><div>A total of 64,074 operations were included (42,665 colon surgery and 21,409 rectal surgery). Overall SSI incidence in colon surgery fell from 19.6% in Period 1 to 7.6% in Period 3 (rho<!--> <!-->=<!--> <!-->−0.961). Organ-space SSI (O/S-SSI) was 8.3% in Period 1 and 4.7% in Period 3 (rho<!--> <!-->=<!--> <!-->−0.815). In rectal surgery, overall SSI fell from 20.6% to 12.8% (rho<!--> <!-->=<!--> <!-->−0.839), and O/S-SSI from 8.5% to 8.3%, the latter difference being non-significant. The intervention that achieved the greatest SSI reduction was a preventive bundle comprising six measures. Hospital stay and mortality rates decreased, while SSIs after discharge and readmissions increased. An increase in Gram-positive cocci and fungi, and reductions in Gram-negative bacteria and anaerobes were detected for both incisional and O/S-SSI.</div></div><div><h3>Conclusions</h3><div>Detailed analysis of SSI rates allows the design of strategies for reducing their incidence. An interventional surveillance programme was effective in decreasing SSI rates in colorectal surgery.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 ","pages":"Pages S28-S36"},"PeriodicalIF":2.6,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of healthcare-associated urinary tract infections in Catalonia 加泰罗尼亚地区卫生保健相关尿路感染的患病率
IF 2.6 4区 医学
Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-01-13 DOI: 10.1016/j.eimc.2024.06.011
Alex Smithson , Nerea Roch Villaverde , Raúl López Salas , Evelyn Shaw , Alexander Almendral , Rosario Porrón , Enric Limon , Miquel Pujol , on behalf of VINCat Program
{"title":"Prevalence of healthcare-associated urinary tract infections in Catalonia","authors":"Alex Smithson ,&nbsp;Nerea Roch Villaverde ,&nbsp;Raúl López Salas ,&nbsp;Evelyn Shaw ,&nbsp;Alexander Almendral ,&nbsp;Rosario Porrón ,&nbsp;Enric Limon ,&nbsp;Miquel Pujol ,&nbsp;on behalf of VINCat Program","doi":"10.1016/j.eimc.2024.06.011","DOIUrl":"10.1016/j.eimc.2024.06.011","url":null,"abstract":"<div><h3>Introduction</h3><div>Healthcare-associated urinary tract infections (HCA-UTIs) account for an important number of infections in acute care hospitals (ACH) and long-term care facilities (LTCF). Our objective was to evaluate the prevalence of HCA-UTIs in Catalonia.</div></div><div><h3>Methods</h3><div>Descriptive observational study in which we analyzed the prevalence of HCA-UTIs, including catheter-associated UTIs (CAUTIs) and non-CAUTIs, from point prevalence surveys conducted in 55 ACH (44,734 patients) and 97 LTCF (116,882 residents) between 2013 and 2022 as part of the VINCat program. Prevalence time trends were also assessed by using a Spearman correlation.</div></div><div><h3>Results</h3><div>In ACH, the overall prevalence of HCA-UTI was 1.6%. The prevalence of CAUTI was 3.9%, while the prevalence of non-CAUTI was 1%, with no significant changes over time. CAUTIs were more prevalent in large size and specialty hospitals. Among the 695 HCA-UTIs, 325 (46.8%) were CAUTIs and 370 (53.2%) non-CAUTIs. The overall prevalence of HCA-UTI in LTCF was 3.6%. The prevalence of CAUTI and non-CAUTI was 11% and 2.8%, respectively, with no significant changes over time. Among the 4190 HCA-UTIs, 1200 (28.6%) were CAUTIs and 2990 (71.4%) non-CAUTIs.</div></div><div><h3>Conclusion</h3><div>Most HCA-UTIs, in ACH and LTCF, were non-CAUTIs although patients with a urinary catheter had a higher risk of HCA-UTIs. HCA-UTIs surveillance programs are essential for identifying at risk patients and developing preventive strategies.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 ","pages":"Pages S106-S114"},"PeriodicalIF":2.6,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolving SARS-CoV-2 severity among hospital and university affiliates in Spain and Greater Boston 西班牙和大波士顿地区医院和大学附属机构中 SARS-CoV-2 严重程度的变化
IF 2.6 4区 医学
Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-01-01 DOI: 10.1016/j.eimc.2023.12.011
Fares Amer , Fan-Yun Lan , Mario Gil-Conesa , Amalia Sidossis , Daniel Bruque , Eirini Iliaki , Jane Buley , Neetha Nathan , Lou Ann Bruno-Murtha , Silvia Carlos , Stefanos N. Kales , Alejandro Fernandez-Montero
{"title":"Evolving SARS-CoV-2 severity among hospital and university affiliates in Spain and Greater Boston","authors":"Fares Amer ,&nbsp;Fan-Yun Lan ,&nbsp;Mario Gil-Conesa ,&nbsp;Amalia Sidossis ,&nbsp;Daniel Bruque ,&nbsp;Eirini Iliaki ,&nbsp;Jane Buley ,&nbsp;Neetha Nathan ,&nbsp;Lou Ann Bruno-Murtha ,&nbsp;Silvia Carlos ,&nbsp;Stefanos N. Kales ,&nbsp;Alejandro Fernandez-Montero","doi":"10.1016/j.eimc.2023.12.011","DOIUrl":"10.1016/j.eimc.2023.12.011","url":null,"abstract":"<div><h3>Introduction</h3><div>The COVID-19 pandemic caused by the SARS-CoV-2 virus greatly affected healthcare workers and healthcare systems. It also challenged schools and universities worldwide negatively affecting in-person education. We conducted this study is to assess the evolution of SARs-CoV-2 virulence over the course of the pandemic.</div></div><div><h3>Methods</h3><div>A combined cohort of University students in Spain and HCWs from the two hospitals in Spain, and one healthcare system in the Greater Boston area was followed prospectively from March 8th, 2020, to January 31st, 2022 for diagnosis with COVID-19 by PCR testing and related sequelae. Follow-up time was divided into four periods according to distinct waves of infection during the pandemic. Severity of COVID-19 was measured by case-hospitalization rate. Descriptive statistics and multivariable-adjusted statistics using the Poisson mixed-effects regression model were applied. As a sensitivity analysis, information on SARS-CoV-2 RNA in wastewater and COVID-19 deaths through May 30, 2023 from the Boston area was collected.</div></div><div><h3>Results</h3><div>For the last two periods of the study (January 1st to December 15th, 2021 and December 16th, 2021 to January 31st, 2022) and relative to the first period (March 8th to May 31st, 2020), the incidence rate ratios (IRRs) of hospitalization were 0.08 (95% CI, 0.03–0.17) and 0.03 (95% CI, 0.01–0.15), respectively. In addition, a relative risk 0.012 CI95% (0.012–0.012) was observed when comparing COVID-19 mortality versus SARS-CoV-2 RNA copies/mL in Boston-area wastewater over the period (16th December 2021 to 30th May 2023) and relative to the first period.</div></div><div><h3>Conclusions</h3><div>The severity of COVID-19 and immunity of our populations evolved over time, resulting in a decrease in case severity. We found the case-hospitalization rate decreased more than 90% in our cohort despite an increase in incidence.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 1","pages":"Pages 17-22"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139666939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of carbapenemases in Enterobacterales susceptible in vitro to meropenem 美罗培南体外敏感肠杆菌中碳青霉烯酶的检测
IF 2.6 4区 医学
Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-01-01 DOI: 10.1016/j.eimc.2024.07.015
Luana Silva Dornelles , Mariana Preussler Mott , Gabriela da Silva Collar , Luciana Giordani , Rodrigo Minuto Paiva , Larissa Lutz
{"title":"Detection of carbapenemases in Enterobacterales susceptible in vitro to meropenem","authors":"Luana Silva Dornelles ,&nbsp;Mariana Preussler Mott ,&nbsp;Gabriela da Silva Collar ,&nbsp;Luciana Giordani ,&nbsp;Rodrigo Minuto Paiva ,&nbsp;Larissa Lutz","doi":"10.1016/j.eimc.2024.07.015","DOIUrl":"10.1016/j.eimc.2024.07.015","url":null,"abstract":"<div><h3>Introduction</h3><div>Carbapenemase-producing Enterobacterales (CPE) is a global threat. We evaluate the prevalence of CPE among isolates categorized as meropenem-susceptible, but that meet the European Committee on Antimicrobial Susceptibility Testing (EUCAST) screening cut-off values for carbapenemase detection, and analyze the susceptibility of these isolates to new available drugs.</div></div><div><h3>Methods</h3><div>We analyzed 257 isolates from patients hospitalized in a tertiary hospital in Brazil, from July 2022 to April 2023. Only isolates that met the screening cut-off values established by EUCAST for detection of carbapenemases were analyzed (i.e. meropenem inhibition zones of 25–27<!--> <!-->mm by disk diffusion). The detection of carbapenemases was performed by immnunochromatographic testing and confirmed by high-resolution melting-PCR (HRM-qPCR).</div></div><div><h3>Results</h3><div>We identified 12 (4.7%) CPE including 7 KPC, 4 NDM, and 1 OXA-48-like. The isolates were susceptible to ceftazidime–avibactam (72.7%), meropenem–vaborbactam (100%), imipenem–relebactam (63.6%) and ceftolozane–tazobactam (36.4%).</div></div><div><h3>Conclusion</h3><div>We highlight the importance of tracking carbapenemases for epidemiological control and therapeutic guidance.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 1","pages":"Pages 32-35"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143181435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A man with recurrent axillary abscess 一名患有复发性腋窝脓肿的男子
IF 2.6 4区 医学
Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-01-01 DOI: 10.1016/j.eimc.2024.03.012
Gamze Durmaz , Esin Beycan , Abdurrahman Kaya , Ali Mert
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引用次数: 0
¿Debemos implantar un marcapasos a todo paciente joven con bloqueo auriculoventricular de alto grado? La importancia de la sospecha clínica en la carditis de Lyme 我们是否应该为每一位患有严重心室梗塞的年轻患者植入心脏起搏器?临床怀疑莱姆病的重要性
IF 2.6 4区 医学
Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-01-01 DOI: 10.1016/j.eimc.2024.07.004
Ester Minguez de la Guía, Macarena López Vázquez, Pablo Miguel Valentín García, Miguel José Corbi Pascual
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引用次数: 0
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