Enfermedades infecciosas y microbiologia clinica最新文献

{"title":"Fibrosis mediastínica como complicación de la infección por Histoplasma capsulatum en paciente inmunocomprometida","authors":"Susana Laura García Aguilera , Beatriz Villar Navas , Alba Mohedano Sánchez , Nerea Mohino Farré","doi":"10.1016/j.eimc.2025.05.007","DOIUrl":"10.1016/j.eimc.2025.05.007","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 10","pages":"Pages 711-713"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fiebre Q aguda en Mallorca, 2017-2022. Un problema infraestimado","authors":"Mercedes García-Gasalla ,&nbsp;Sophia Pinecki Socias ,&nbsp;Pablo A. Fraile ,&nbsp;Victoria Fernández-Baca ,&nbsp;Aroa Villoslada ,&nbsp;Antonio Adrover ,&nbsp;Sandra Gregorio ,&nbsp;Marta González-Moreno ,&nbsp;Alfredo Pinheiro Martins ,&nbsp;Alexander Zidouh ,&nbsp;Gemma Mut ,&nbsp;Meritxell Gavaldà ,&nbsp;Melchor Riera ,&nbsp;Luisa Martín Pena ,&nbsp;Javier Murillas Angoiti","doi":"10.1016/j.eimc.2025.01.004","DOIUrl":"10.1016/j.eimc.2025.01.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Q fever (QF) is a zoonotic infection caused by <em>Coxiella burnetii</em>. Previous studies suggest that the incidence in the island of Majorca may be high. The objective was to know the epidemiological, clinical, diagnostic, and therapeutic characteristics of acute QF (AQF) on the island of Majorca during the years 2017 to 2022.</div></div><div><h3>Methods</h3><div>Retrospective analysis of a series of cases of AQF diagnosed in 3 out 4 hospitals of the Health Service of the island of Majorca. AQF was considered if a clinically compatible syndrome was present with one of the following serological criteria: confirmed AQF if IgG seroconversion phase II, very possible if only IgG<!--> <!-->≥<!--> <!-->1/128 is available in addition to a positive IgM, and AQF possible if IgG<!--> <!-->≥<!--> <!-->1/512 with negative IgM or if IgM positive with negative IgG in a single serological determination.</div></div><div><h3>Results</h3><div>223 cases of AQF were diagnosed, of which 102 (45.7%) were confirmed, 84 (37.7%) very possible and 37 (16.6%) possible AQF. Prolonged febrile syndrome was the most frequent clinical diagnosis (107, 48.0%), followed by pneumonia with/without pleural effusion (49, 21.9%), acute hepatitis (38, 17.0%), pericarditis and/or myocarditis (6, 2.6%). Three patients developed endocarditis (one in the acute phase, two others during follow-up). The median number of cases per year was 34 (p25-p75: 31.7 - 40.25). AQF-related mortality was 1.8% (4 patients).</div></div><div><h3>Conclusion</h3><div>AQF is a preventable and little recognized zoonosis, causing significant morbidity and mortality in Majorca.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 10","pages":"Pages 639-644"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unsuccessful tuberculosis-treatment in HIV-positive patients and associated factors","authors":"Guillermo Bosch ,&nbsp;Joan-Pau Millet ,&nbsp;Àngels Orcau ,&nbsp;Isabel Moreira ,&nbsp;Carles Pericas ,&nbsp;Lluïsa Forns ,&nbsp;Isabel Marcos ,&nbsp;Raquel Prieto ,&nbsp;Anna Hernandez ,&nbsp;Lídia Arranz ,&nbsp;Cristina Rius","doi":"10.1016/j.eimc.2025.06.008","DOIUrl":"10.1016/j.eimc.2025.06.008","url":null,"abstract":"<div><h3>Background</h3><div>TB is one of the most deathly infections worldwide, affecting disproportionally people living with HIV (PLHIV). Furthermore, HIV co-infection is related to worse outcomes for TB patients, including lower treatment success.</div></div><div><h3>Methods</h3><div>Using surveillance records of all TB cases notified in Barcelona city from 2001 to 2021, we analyzed TB treatment success according to HIV status. Additionally, we explored potential social and health related and factors associated to unsuccessful treatment in PLHIV, using multiple regression analyses.</div></div><div><h3>Results</h3><div>Out of the 8406 new TB cases diagnosed during the study period, 9% were co-infected with HIV. According to our regression models, PLHIV were more frequently men, users of injected drugs (aOR<!--> <!-->=<!--> <!-->45.81; 95% CI (33.10–64.26)), had previously been treated for TB (aOR<!--> <!-->=<!--> <!-->1.77; 95% CI (1.30–2.40)) and had a lower rate of contact tracing (aOR<!--> <!-->=<!--> <!-->0.51; 95% CI (0.40–0.64)). Among PLHIV, unsuccessful treatment was related to the use of injected drugs and homelessness, but it was lower for those who had undergone contact tracing.</div></div><div><h3>Conclusion</h3><div>PLHIV have higher odds of unsuccessful TB treatment, especially those who are homeless and use injected drugs. Contact tracing improved treatment success, calling for further efforts and resources to correctly follow-up on these patients, with the goal of increasing treatment success.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 10","pages":"Pages 666-673"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sobre «Análisis comparativo de las infecciones respiratorias agudas de etiología viral en menores de 6 meses con y sin nirsevimab en Baleares (2022-2023 y 2023-2024)»","authors":"Paula Corihuela Menéndez,&nbsp;Sacramento M. Segovia López,&nbsp;Alejandra Méndez Sánchez,&nbsp;Lara González García","doi":"10.1016/j.eimc.2025.06.020","DOIUrl":"10.1016/j.eimc.2025.06.020","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 10","pages":"Pages 723-724"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on the relationship between HPV infection and alterations in vaginal microbial ecology","authors":"Min Guo ,&nbsp;Chaoyang Chen ,&nbsp;Wenling Wang ,&nbsp;Cairong Zhang ,&nbsp;Jie Ma ,&nbsp;Maidinamu Sadike ,&nbsp;Mayinuer Niyazi ,&nbsp;Xiaoli Feng ,&nbsp;Kaichun Zhu","doi":"10.1016/j.eimc.2025.07.008","DOIUrl":"10.1016/j.eimc.2025.07.008","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the changes in vaginal microbiota under different HPV infection statuses and explore the correlation between vaginal microbiota alterations and HPV infection.</div></div><div><h3>Methods</h3><div>151 cervical samples from gynecological outpatients were grouped into HPV-negative (HN, <em>N</em> <!-->=<!--> <!-->51), transient infection (HTI, <em>N</em> <!-->=<!--> <!-->42), and persistent infection (HPI, <em>N</em> <!-->=<!--> <!-->58). Vaginal secretions were collected to assess microecology (pH, vaginal cleanliness, hydrogen peroxide, leukocyte esterase) via genital secretion analyzer. 16S ribosomal RNA (rRNA) sequencing analyzed vaginal microbiota characteristics, community state types (CST), richness, diversity, and biomarkers.</div></div><div><h3>Results</h3><div>16S rRNA sequencing identified 5 CST II, 52 CST III, and 94 mixed CST IV samples, showing diverse microbiota. Compared with HN, HTI and HPI had lower vaginal cleanliness, higher sialidase activity, elevated pH, and fewer <em>Lactobacilli</em> (<em>P</em> <!-->&lt;<!--> <!-->0.05). <em>Lactobacillus iners</em> dominated all groups, while <em>Sneathia amnii</em> was significantly higher in HPI (<em>P</em> <!-->&lt;<!--> <!-->0.05). HPV infection increased vaginal microbiota richness (HPI<!--> <!-->&gt;<!--> <!-->HTI/HN, <em>P</em> <!-->&lt;<!--> <!-->0.05), with distinct group compositions (<em>P</em> <!-->&lt;<!--> <!-->0.05). Linear Discriminant Analysis Effect Size identified <em>Lactobacillus gasseri</em>, <em>Atopobium vaginae</em>, and <em>Lactobacillus jensenii</em> as biomarkers.</div></div><div><h3>Conclusion</h3><div>This study found significant differences in microbial community characteristics under different HPV infection statuses. The identification of biomarkers in vaginal microbiota under different infection statuses could provide new targets for clinical screening and prevention of cervical cancer.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 10","pages":"Pages 688-697"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifocal hydatidosis with osteoarticular, gynecological and hepatic involvement","authors":"Loreto Sangorrin-Lapieza ,&nbsp;Pilar Hernández-Jiménez ,&nbsp;Cristina Ojeda-Thies ,&nbsp;Ana Pérez-Ayala","doi":"10.1016/j.eimc.2025.05.002","DOIUrl":"10.1016/j.eimc.2025.05.002","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 10","pages":"Pages 709-710"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infección de prótesis mamaria por Burkholderia cenocepacia","authors":"María Alonso Girón ,&nbsp;Laura Sante Fernández ,&nbsp;Eulalia Vives Rodríguez ,&nbsp;José Andrés Agulla Budiño","doi":"10.1016/j.eimc.2025.07.004","DOIUrl":"10.1016/j.eimc.2025.07.004","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 10","pages":"Pages 719-721"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-effort HIV training in Spanish primary care: Long-term impact on testing and diagnosis","authors":"Alejandro G. García-Ruiz de Morales ,&nbsp;María Jesús Vivancos ,&nbsp;Beatriz Romero-Hernández ,&nbsp;David Rial-Crestelo ,&nbsp;Francisco Arnaiz de las Revillas ,&nbsp;Jorge Sanchez-Villegas ,&nbsp;Marta Montero Alonso ,&nbsp;María de la Villa López Sánchez ,&nbsp;María Remedios Alemán Valls ,&nbsp;Santiago Moreno ,&nbsp;Javier Martínez-Sanz ,&nbsp;María Jesús Pérez-Elías ,&nbsp;on behalf of CoRIS","doi":"10.1016/j.eimc.2025.06.016","DOIUrl":"10.1016/j.eimc.2025.06.016","url":null,"abstract":"<div><h3>Background</h3><div>Recent improvements in the HIV care cascade have reduced HIV incidence in high- and middle-income countries, yet late HIV diagnosis remains a critical issue. This study examines the impact of a two-hour training session on HIV testing and diagnosis rates in primary care centers in Madrid, Spain.</div></div><div><h3>Methods</h3><div>In 2017, we conducted a non-mandatory, two-hour training session on updated HIV and HCV guidelines for primary care providers in 20 centers within the Ramón y Cajal Hospital area. We compared yearly HIV testing rates and late diagnosis rates in the five years before and after the intervention. We used data from Ramón y Cajal Hospital Microbiology Department's electronic records and the CoRIS cohort, including demographic and clinical information.</div></div><div><h3>Results</h3><div>Of the 630 target primary care providers, 454 (72%) attended the sessions. HIV testing rates increased from 1780 to 2155 tests per 100,000 inhabitants (<em>p</em> <!-->&lt;<!--> <!-->0.0001) post-intervention, with a stable rate of positive tests. Late diagnosis rates in our area decreased from 58.9% to 48.7%, while rates in the rest of Madrid and Spain increased (AOR 1.22, <em>p</em> <!-->&lt;<!--> <!-->0.001). The intervention area showed a significant reduction in advanced HIV disease (AOR 0.66, <em>p</em> <!-->=<!--> <!-->0.095), contrasting with the upward trend in other regions.</div></div><div><h3>Conclusion</h3><div>A simple two-hour training session for primary care providers effectively increased HIV testing rates and reduced late diagnoses in our health area compared to national trends. Implementing similar strategies on a broader scale could help mitigate the rising rates of late HIV diagnosis and improve overall community health outcomes.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 10","pages":"Pages 645-651"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mycolicibacterium iranicum en un paciente con bronquiectasias: importancia clínica y dificultades diagnósticas","authors":"Diego González Polo,&nbsp;David Vázquez Gómez,&nbsp;Nieves Gutiérrez Zufiaurre","doi":"10.1016/j.eimc.2025.06.014","DOIUrl":"10.1016/j.eimc.2025.06.014","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 10","pages":"Pages 717-718"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacto de la implementación de MALDI-TOF y programas PROA en la optimización de la antibioterapia en bacteriemias por Staphylococcus aureus","authors":"Sara Vela-Bernal ,&nbsp;Carlos Bea-Serrano ,&nbsp;Ana Isabel de Gracia-Leon ,&nbsp;Andreu Belmonte-Domingo ,&nbsp;Carolina Pinto-Pla ,&nbsp;Ana Ferrer-Ribera ,&nbsp;Andrea de Castro-Oliver ,&nbsp;Ignacio Torres ,&nbsp;Javier Colomina ,&nbsp;María Rosa Oltra-Sempere","doi":"10.1016/j.eimc.2025.06.005","DOIUrl":"10.1016/j.eimc.2025.06.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Rapid pathogen identification is key in the management of bloodstream infections. Antimicrobial stewardship programs (ASPs) have been shown to reduce resistance, adverse effects, and healthcare costs. MALDI-TOF MS enables fast and accurate microbial identification. This study evaluates the impact of its implementation on antibiotic therapy adequacy and mortality in <em>Staphylococcus aureus</em> bacteremia.</div></div><div><h3>Methods</h3><div>A quasi-experimental pre-post study was conducted at a university hospital, covering two periods: June 2015/April 2017 (pre) and June 2021/April 2023 (post). The impact of MALDI-TOF on antibiotic adequacy and mortality was analyzed<strong>.</strong></div></div><div><h3>Results</h3><div>A total of 176 episodes were included (85 pre, 91 post). No significant epidemiological differences were observed between groups, although higher rates of sepsis and septic shock were noted in the post phase. MALDI-TOF was associated with improved antibiotic adjustment (3.51 vs. 1.75 days; <em>P</em>&lt;.001). A non-significant trend toward lower early mortality was observed in the post-intervention group (<em>P</em>=.06). Mortality was associated with higher comorbidity (Charlson index), sepsis/septic shock, and MRSA bacteremia.</div></div><div><h3>Conclusion</h3><div>The implementation of MALDI-TOF, in conjunction with a multidisciplinary ASP, enhances early adjustment of empirical antibiotic therapy and may be associated with reduced early mortality in <em>Staphylococcus aureus</em> bacteremia. Incorporating rapid diagnostics, especially for MRSA detection, is a key strategy to improve clinical outcomes.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 10","pages":"Pages 674-681"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}