Emerging Microbes & Infections最新文献_第3页

Correction. 修正。

IF 7.5 2区医学

Emerging Microbes & Infections Pub Date : 2025-12-01 Epub Date: 2025-09-24 DOI: 10.1080/22221751.2025.2565118

引用次数: 0

The modified mRNA vaccine protects immunocompromised AG129 mice from lethal challenge and multi-tissue infection by Zika virus. 改良的mRNA疫苗可保护免疫功能低下的AG129小鼠免受寨卡病毒的致命攻击和多组织感染。

IF 7.5 2区医学

Emerging Microbes & Infections Pub Date : 2025-12-01 Epub Date: 2025-09-18 DOI: 10.1080/22221751.2025.2556729

Yuhuan Yan, Junbin Wang, Hao Yang, Yun Yang, Longhai Yuan, Cong Tang, Yanan Zhou, Qing Huang, Wenhai Yu, Xiaoming Liang, Dongdong Lin, Yanwen Li, Xuena Du, Yuxia Yuan, Rui Peng, Jiali Xu, Zhaolan Guo, Wenhao Xie, Wenqi Quan, Hongyu Chen, Jian Zhou, Shuaiyao Lu, Xiaozhong Peng

{"title":"The modified mRNA vaccine protects immunocompromised AG129 mice from lethal challenge and multi-tissue infection by Zika virus.","authors":"Yuhuan Yan, Junbin Wang, Hao Yang, Yun Yang, Longhai Yuan, Cong Tang, Yanan Zhou, Qing Huang, Wenhai Yu, Xiaoming Liang, Dongdong Lin, Yanwen Li, Xuena Du, Yuxia Yuan, Rui Peng, Jiali Xu, Zhaolan Guo, Wenhao Xie, Wenqi Quan, Hongyu Chen, Jian Zhou, Shuaiyao Lu, Xiaozhong Peng","doi":"10.1080/22221751.2025.2556729","DOIUrl":"10.1080/22221751.2025.2556729","url":null,"abstract":"The multiple epidemics of Zika virus (ZIKV) posed a substantial threat to public health. Clinical evidence suggests that ZIKV could break through the blood-brain, blood-placenta, and blood-testis barriers, leading to severe outcomes such as congenital malformations in newborns and Guillain-Barré syndrome in adults. Currently, there are no specific treatments for ZIKV infection. To address the antibody-dependent enhancement (ADE) of dengue virus (DENV) infection induced by ZIKV vaccination, we designed two modified prM-E RNAs (ZA and ZB) with specific mutations either shielding or disrupting the conserved fusion-loop epitope in the E protein. Then, we chose the mRNA-LNP vaccine platform to evaluate the safety and efficacy. After prime-boost immunization, ZA vaccine could induce high levels of T cells secreting IFN-γ and exhibit limited neutralizing ability against Asian-lineage and African-lineage ZIKV. After ZIKV challenge, ZA vaccine could provide complete protection in immunocompromised AG129 mice at low levels of neutralizing antibodies, preventing viral dissemination to the brain, uterus, and testes. Importantly, the ZA vaccine also reduced the ADE effect of DENV infection. Although ZB vaccine exhibited good immunogenicity, it could not achieve complete viral clearance in AG29 mice. Our findings suggested that the ZA vaccine could prevent both lethal ZIKV infection and DENV ADE induced by infection or vaccination.","PeriodicalId":11602,"journal":{"name":"Emerging Microbes & Infections","volume":" ","pages":"2556729"},"PeriodicalIF":7.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marked neurotropism and potential adaptation of H5N1 clade 2.3.4.4.b virus in naturally infected domestic cats. H5N1进化分支2.3.4.4的显着嗜神经性和潜在适应性。b病毒在自然感染的家猫。

IF 8.4 2区医学

Emerging Microbes & Infections Pub Date : 2025-12-01 Epub Date: 2024-12-17 DOI: 10.1080/22221751.2024.2440498

Shubhada K Chothe, Surabhi Srinivas, Sougat Misra, Noel Chandan Nallipogu, Elizabeth Gilbride, Lindsey LaBella, Swastidipa Mukherjee, Christian H Gauthier, Heidi L Pecoraro, Brett T Webb, James M Pipas, Santhamani Ramasamy, Suresh V Kuchipudi

{"title":"Marked neurotropism and potential adaptation of H5N1 clade 2.3.4.4.b virus in naturally infected domestic cats.","authors":"Shubhada K Chothe, Surabhi Srinivas, Sougat Misra, Noel Chandan Nallipogu, Elizabeth Gilbride, Lindsey LaBella, Swastidipa Mukherjee, Christian H Gauthier, Heidi L Pecoraro, Brett T Webb, James M Pipas, Santhamani Ramasamy, Suresh V Kuchipudi","doi":"10.1080/22221751.2024.2440498","DOIUrl":"10.1080/22221751.2024.2440498","url":null,"abstract":"In April 2024, ten cats died in a rural South Dakota (SD) residence, showing respiratory and neurological symptoms. Necropsy and laboratory testing of two cats confirmed H5N1 clade 2.3.4.4b infection. The viral genome sequences are closely related to recent SD cattle H5N1 sequences. Cat H5N1 genomes had unique mutations, including T143A in haemagglutinin, known to affect infectivity and immune evasion, and two novel mutations in PA protein (F314L, L342Q) that may affect polymerase activity and virulence, suggesting potential virus adaptation. Dead cats showed systemic infection with lesions and viral antigens in multiple organs. Higher viral RNA and antigen in the brain indicated pronounced neurotropism. Lectin-histochemistry revealed widespread co-expression of sialic acid α-2,6 and α-2,3 receptors, suggesting cats could serve as mixing vessels for reassortment of avian and mammalian influenza viruses. No differences in clade 2.2 or 2.3.4.4b H5 pseudoviruses binding to cat lung/brain tissues indicated the neurotropism is unlikely mediated by receptor binding affinity.","PeriodicalId":11602,"journal":{"name":"Emerging Microbes & Infections","volume":" ","pages":"2440498"},"PeriodicalIF":8.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced antibody response to the conformational non-RBD region via DNA prime-protein boost elicits broad cross-neutralization against SARS-CoV-2 variants. 通过DNA引物-蛋白增强对构象非rbd区的抗体反应引发针对SARS-CoV-2变体的广泛交叉中和

IF 8.4 2区医学

Emerging Microbes & Infections Pub Date : 2025-12-01 Epub Date: 2025-03-03 DOI: 10.1080/22221751.2024.2447615

Yun-Fei Ma, Kun Chen, Bowen Xie, Jiayi Zhu, Xuan He, Chunying Chen, Yuhe Renee Yang, Ye Liu

{"title":"Enhanced antibody response to the conformational non-RBD region via DNA prime-protein boost elicits broad cross-neutralization against SARS-CoV-2 variants.","authors":"Yun-Fei Ma, Kun Chen, Bowen Xie, Jiayi Zhu, Xuan He, Chunying Chen, Yuhe Renee Yang, Ye Liu","doi":"10.1080/22221751.2024.2447615","DOIUrl":"10.1080/22221751.2024.2447615","url":null,"abstract":"Preventing immune escape of SARS-CoV-2 variants is crucial in vaccine development to ensure broad protection against the virus. Conformational epitopes beyond the RBD region are vital components of the spike protein but have received limited attention in the development of broadly protective SARS-CoV-2 vaccines. In this study, we used a DNA prime-protein boost regimen to evaluate the broad cross-neutralization potential of immune response targeting conformational non-RBD region against SARS-CoV-2 viruses in mice. Mice with enhanced antibody responses targeting conformational non-RBD region show better performance in cross-neutralization against the Wuhan-01, Delta, and Omicron subvariants. Via analyzing the distribution of conformational epitopes, and quantifying epitope-specific binding antibodies, we verified a positive correlation between the proportion of binding antibodies against the N-terminal domain (NTD) supersite (a conformational non-RBD epitope) and SARS-CoV-2 neutralization potency. The current work highlights the importance of high ratio of conformational non-RBD-specific binding antibodies in mediating viral cross-neutralization and provides new insight into overcoming the immune escape of SARS-CoV-2 variants.","PeriodicalId":11602,"journal":{"name":"Emerging Microbes & Infections","volume":" ","pages":"2447615"},"PeriodicalIF":8.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genotypic variations and clinical implications of JEV-associated peripheral nerve injury: a commentary on multicenter findings from high-endemic regions. jev相关周围神经损伤的基因型变异和临床意义：对高流行地区多中心研究结果的评论。

IF 7.5 2区医学

Emerging Microbes & Infections Pub Date : 2025-12-01 Epub Date: 2025-08-28 DOI: 10.1080/22221751.2024.2449073

Liangping Zhang, Lei Pan, Rongqi Cao

{"title":"Genotypic variations and clinical implications of JEV-associated peripheral nerve injury: a commentary on multicenter findings from high-endemic regions.","authors":"Liangping Zhang, Lei Pan, Rongqi Cao","doi":"10.1080/22221751.2024.2449073","DOIUrl":"10.1080/22221751.2024.2449073","url":null,"abstract":"We read with great interest the recent article by Wang et al. on peripheral nerve injury (PNI) associated with Japanese encephalitis virus (JEV) infection in high-endemic regions of China. The study provides important insights into the significant relationship between JEV infection and PNI, particularly highlighting clinical manifestations such as acute flaccid paralysis and respiratory muscle paralysis. While we commend the authors' work, we suggest caution in interpreting the findings due to several limitations. First, genotype-specific differences, notably between GIb and GIII strains, may influence disease severity, clinical progression, and prognosis, warranting further investigation for personalized management. Second, although adjustments were made for certain demographic and epidemiological variables, additional confounders such as vaccination status, environmental conditions, and socioeconomic factors should be incorporated to strengthen the robustness of future analyses. Third, reliance on surveillance data introduces potential biases due to incomplete or inaccurate reporting, especially in rural or underserved populations. Enhanced data collection methods, including digital health tools and standardized questionnaires, could improve accuracy and comprehensiveness. Beyond methodological considerations, the study underscores the importance of early diagnosis, biomarker development, and multidisciplinary collaboration in mitigating neurological complications of JEV. Strengthening vaccination coverage, particularly in remote regions, and expanding health education are also critical to reducing disease burden. Overall, this research advances understanding of JEV-associated PNI and highlights avenues for future studies to refine diagnostic, preventive, and therapeutic strategies that will improve long-term patient outcomes.","PeriodicalId":11602,"journal":{"name":"Emerging Microbes & Infections","volume":" ","pages":"2449073"},"PeriodicalIF":7.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mosquito populations originating from nonendemic areas have the potential to transmit recently emerging Japanese encephalitis virus genotype IV. 来自非流行地区的蚊子种群具有传播新近出现的日本脑炎病毒基因型IV的潜力。

IF 8.4 2区医学

Emerging Microbes & Infections Pub Date : 2025-12-01 Epub Date: 2025-01-02 DOI: 10.1080/22221751.2024.2438661

Astri Nur Faizah, Daisuke Kobayashi, Faustus Akankperiwen Azerigyik, Ryo Matsumura, Izumi Kai, Yoshihide Maekawa, Yukiko Higa, Kentaro Itokawa, Toshinori Sasaki, Kris Cahyo Mulyatno, Sri Subekti, Maria Inge Lusida, Etik Ainun Rohmah, Yasuko Mori, Yusuf Ozbel, Chizu Sanjoba, Tran Vu Phong, Tran Cong Tu, Shinji Kasai, Kyoko Sawabe, Haruhiko Isawa

{"title":"Mosquito populations originating from nonendemic areas have the potential to transmit recently emerging Japanese encephalitis virus genotype IV.","authors":"Astri Nur Faizah, Daisuke Kobayashi, Faustus Akankperiwen Azerigyik, Ryo Matsumura, Izumi Kai, Yoshihide Maekawa, Yukiko Higa, Kentaro Itokawa, Toshinori Sasaki, Kris Cahyo Mulyatno, Sri Subekti, Maria Inge Lusida, Etik Ainun Rohmah, Yasuko Mori, Yusuf Ozbel, Chizu Sanjoba, Tran Vu Phong, Tran Cong Tu, Shinji Kasai, Kyoko Sawabe, Haruhiko Isawa","doi":"10.1080/22221751.2024.2438661","DOIUrl":"10.1080/22221751.2024.2438661","url":null,"abstract":"Japanese encephalitis virus (JEV) genotype IV (GIV) is one of the least common and most neglected genotypes worldwide, having been identified only on a few Indonesian islands until it was recently found to be the cause of outbreaks that occurred in several Australian states in early 2022. Given the limited availability of information, the vector range for JEV GIV remains unknown; thus, understanding this range could prove invaluable for future prevention efforts in new areas. Herein, we experimentally exposed four mosquito colonies originated from various countries with no previous reports of GIV to JEV GIV strain 19CxBa-83-Cv, which was isolated from Culex vishnui Theobald collected in Bali in 2019. At 7 and 14 days post-JEV GIV exposure through a membrane feeding method, mosquito bodies, head-wings-legs, and saliva were harvested for infection, dissemination, and transmission efficiency analyses. The results showed robust transmission efficiencies of the virus by Culex tritaeniorhynchus Giles (∼74%) and Aedes albopictus Skuse (∼52%) from Japan, followed by Culex quinquefasciatus Say from Vietnam (∼35%) and Culex pipiens form molestus from Turkey (∼18%). Although significant differences were observed, we found that the four mosquito species could transmit JEV GIV. The efficiency of biological transmission of this restricted genotype by mosquitoes from various origins suggests that these mosquito species could support localized transmission if the genotype were introduced to their respective areas. This study emphasizes the importance of remaining vigilant and continuing arbovirus surveillance in all locations.","PeriodicalId":11602,"journal":{"name":"Emerging Microbes & Infections","volume":" ","pages":"2438661"},"PeriodicalIF":8.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SARS-CoV-2 and HCoV-OC43 regulate host m6A modification via activation of the mTORC1 signalling pathway to facilitate viral replication. SARS-CoV-2和HCoV-OC43通过激活mTORC1信号通路调节宿主m6A修饰，促进病毒复制。

IF 8.4 2区医学

Emerging Microbes & Infections Pub Date : 2025-12-01 Epub Date: 2025-02-24 DOI: 10.1080/22221751.2024.2447620

Shixiong Zhou, Xianfeng Hui, Weiwei Wang, Chunbei Zhao, Meilin Jin, Yali Qin, Mingzhou Chen

{"title":"SARS-CoV-2 and HCoV-OC43 regulate host m6A modification via activation of the mTORC1 signalling pathway to facilitate viral replication.","authors":"Shixiong Zhou, Xianfeng Hui, Weiwei Wang, Chunbei Zhao, Meilin Jin, Yali Qin, Mingzhou Chen","doi":"10.1080/22221751.2024.2447620","DOIUrl":"10.1080/22221751.2024.2447620","url":null,"abstract":"N6-methyladenosine (m6A) is the most prevalent post-transcriptional modification in eukaryotic RNA and is also present in various viral RNAs, where it plays a crucial role in regulating the viral life cycle. However, the molecular mechanisms through which viruses regulate host RNA m6A methylation are not fully understood. In this study, we reveal that SARS-CoV-2 and HCoV-OC43 infection enhance host m6A modification by activating the mTORC1 signalling pathway. Specifically, the viral non-structural protein nsp14 upregulates the expression of S-adenosylmethionine synthase MAT2A in an mTORC1-dependent manner. This mTORC1-MAT2A axis subsequently stimulates the synthesis of S-adenosylmethionine (SAM). The increase of SAM then enhances the m6A methylation of host RNA and facilitates viral replication. Our findings uncover a molecular mechanism by which viruses regulate host m6A methylation and provide insights into how SARS-CoV-2 hijacks host cellular epitranscriptomic modifications to promote its replication.","PeriodicalId":11602,"journal":{"name":"Emerging Microbes & Infections","volume":" ","pages":"2447620"},"PeriodicalIF":8.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly pathogenic avian influenza virus (H5N5) detected in an Atlantic walrus (Odobenus rosmarus rosmarus) in the Svalbard Archipelago, Norway, 2023. 2023年在挪威斯瓦尔巴群岛的大西洋海象（Odobenus rosmarus rosmarus）中检测到高致病性禽流感病毒（H5N5）。

IF 8.4 2区医学

Emerging Microbes & Infections Pub Date : 2025-12-01 Epub Date: 2025-02-03 DOI: 10.1080/22221751.2025.2456146

Alexander Postel, Nele Gremmel, Christian Lydersen, Kit M Kovacs, Luca A Schick, Ursula Siebert, Ingebjørg H Nymo, Paul Becher

引用次数: 0

Serotype epidemiology and case-fatality risk of invasive pneumococcal disease: a nationwide population study from Switzerland, 2012-2022. 侵袭性肺炎球菌病的血清型流行病学及病死率2012-2022年瑞士全国人口研究。

IF 8.4 2区医学

Emerging Microbes & Infections Pub Date : 2025-12-01 Epub Date: 2025-04-24 DOI: 10.1080/22221751.2025.2488189

Werner C Albrich, Nicolaj Just, Christian Kahlert, Carlo Casanova, Florent Baty, Markus Hilty

{"title":"Serotype epidemiology and case-fatality risk of invasive pneumococcal disease: a nationwide population study from Switzerland, 2012-2022.","authors":"Werner C Albrich, Nicolaj Just, Christian Kahlert, Carlo Casanova, Florent Baty, Markus Hilty","doi":"10.1080/22221751.2025.2488189","DOIUrl":"10.1080/22221751.2025.2488189","url":null,"abstract":"In Switzerland, thirteen-valent pneumococcal conjugate vaccine (PCV13) has been introduced in 2011. During the COVID-19 pandemic, cases of invasive pneumococcal disease (IPD) have decreased but consequences on the serotype epidemiology are less clear. The objective of the study has been to analyse the impact of PCV13 introduction and the COVID-19 pandemic on the IPD epidemiology and investigate the changes in the case fatality risk (CFR). We analysed data from the Swiss nationwide surveillance for the period 2012-2022. Poisson and logistic regression analyses were performed allowing us to inspect trends over time and to define serotypes that are associated with case fatality. In total, 8747 IPD cases were included from 2012 to 2022. IPD incidence dropped in the years 2020 (6.0/100,000) and 2021 (5.5/100,000) but recovered in 2022 (9.1/100,000). While the incidence numbers of patients >65 years did not reach the pre-pandemic level, numbers significantly increased in infants <1 year in 2022 (IRR 1.08, 95%CI: 1.01-1.16). The incidence of PCV13 serotypes among all IPD cases decreased until 2019 before increasing again during the pandemic (in 2022). Logistic regression analyses revealed that the PCV20 serotype 11A (OR: 1.76, 95%CI: 1.14-2.64), and the PCV13 serotypes 3 (OR: 1.26, 95% CI: 1.04-1.53) and 19F (OR: 1.76, 95%CI: 1.14-2.65) were significantly associated with increased CFR. In conclusion, the COVID-19 pandemic has had only minor temporary effects on the serotype distribution. Continued use of vaccines with extended serotype coverage may further reduce IPD disease burden and mortality.","PeriodicalId":11602,"journal":{"name":"Emerging Microbes & Infections","volume":" ","pages":"2488189"},"PeriodicalIF":8.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12024505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utilizing wastewater surveillance to model behavioural responses and prevent healthcare overload during "Disease X" outbreaks. 利用废水监测模拟行为反应，防止“疾病X”爆发期间医疗保健超载。

IF 8.4 2区医学

Emerging Microbes & Infections Pub Date : 2025-12-01 Epub Date: 2025-01-18 DOI: 10.1080/22221751.2024.2437240

Wenxiu Chen, Wei An, Chen Wang, Qun Gao, Chunzhen Wang, Lan Zhang, Xiao Zhang, Song Tang, Jianxin Zhang, Lixin Yu, Peng Wang, Dan Gao, Zhe Wang, Wenhui Gao, Zhe Tian, Yu Zhang, Wai-Yin Ng, Tong Zhang, Ho-Kwong Chui, Jianying Hu, Min Yang

{"title":"Utilizing wastewater surveillance to model behavioural responses and prevent healthcare overload during \"Disease X\" outbreaks.","authors":"Wenxiu Chen, Wei An, Chen Wang, Qun Gao, Chunzhen Wang, Lan Zhang, Xiao Zhang, Song Tang, Jianxin Zhang, Lixin Yu, Peng Wang, Dan Gao, Zhe Wang, Wenhui Gao, Zhe Tian, Yu Zhang, Wai-Yin Ng, Tong Zhang, Ho-Kwong Chui, Jianying Hu, Min Yang","doi":"10.1080/22221751.2024.2437240","DOIUrl":"10.1080/22221751.2024.2437240","url":null,"abstract":"During the COVID-19 pandemic, healthcare systems worldwide faced severe strain. This study, utilizing wastewater virus surveillance, identified that periodic spontaneous avoidance behaviours significantly impacted infectious disease transmission during rapid and intense outbreaks. To incorporate these behaviours into disease transmission analysis, we introduced the Su-SEIQR model and validated it using COVID-19 wastewater data from Beijing and Hong Kong. The results demonstrated that the Su-SEIQR model accurately reflected trends in susceptible populations and confirmed cases during the COVID-19 pandemic, highlighting the role of spontaneous collective avoidance behaviours in generating periodic fluctuations. These fluctuations helped reduce infection peaks, thereby alleviating pressure on healthcare systems. However, the effect of these spontaneous behaviours on mitigating healthcare overload was limited. Consequently, we incorporated healthcare capacity constraints into the model, adjusting parameters to further guide population behaviours during the pandemic, aiming to keep the outbreak within manageable limits and reduce strain on healthcare resources. This study provides robust support for the development of environmental and public health policies during pandemics by constructing an innovative transmission model, which effectively prevents healthcare overload. Additionally, this approach can be applied to managing future outbreaks of unknown viruses or \"Disease X\".","PeriodicalId":11602,"journal":{"name":"Emerging Microbes & Infections","volume":" ","pages":"2437240"},"PeriodicalIF":8.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0