Emerging Microbes & Infections最新文献

{"title":"Characterising the epidemiology of <i><b>Mycoplasma pneumoniae</b></i> infections in China in 2022-2024: a nationwide cross-sectional study of over 1.6 million cases.","authors":"Yamin Sun, Pei Li, Ronghua Jin, Yaoming Liang, Jiale Yuan, Zhongxin Lu, Junrong Liang, Yingmiao Zhang, Hongyu Ren, Yuanyuan Zhang, Jianchun Chen, Yun Huang, Chuixu Lin, Yinghua Li, Jianfeng Zhou, Xi Wang, You Li, Senzhong Huang, Jianguo Xu, Tian Qin","doi":"10.1080/22221751.2025.2482703","DOIUrl":"https://doi.org/10.1080/22221751.2025.2482703","url":null,"abstract":"<p><p><i>Mycoplasma pneumoniae</i> (MP) is a leading cause of community-acquired pneumonia (CAP), accounting for 10-40% of cases in children. In China, the high prevalence of macrolide-resistant MP (MRMP) and recurrent MP epidemics place a significant burden on the healthcare system. Leveraging data from over 1.6 million cases, this study provides a comprehensive analysis of the epidemiological characteristics of MP across China. Seasonal patterns analysis revealed three distinct transmission zones in China. Transmission Zone 1 exhibited two annual epidemic peaks, while Zones 2 and 3 showed a single annual peak of distinct timings. Notably, winter travel to popular tourist destinations appears to influence MP infection patterns in China. Age- and sex- specific analysis indicated male newborns aged [0-1) years face a 1.67 times higher risk of MP infection compared to females. Conversely, females aged [23-38) years have a higher infection risk, likely due to their caregiving roles. The proportion of MRMP surged from 80.00% to 93.02% between July 2023 and May 2024, with a median growth rate of 10.21%. This rapid increase contrasts sharply with the modest 5.3% rise observed from 2011 to 2019, and we attribute this escalation in part to the growing prevalence of the T1-3R clade strain in China. These findings have important implications for the identification of high-risk population, place, and time for more targeted efforts of prevention and treatment. Furthermore, the rapidly increased proportion of MRMP in the 2023-24 season raises a concerning signal regarding antibiotic use.</p>","PeriodicalId":11602,"journal":{"name":"Emerging Microbes & Infections","volume":" ","pages":"2482703"},"PeriodicalIF":8.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential replication, pathology, and immune response of clade IIb mpox virus in C57BL/6 and BALB/c mice.","authors":"Meimei Duan, Xiangmei Zhang, Xian Tang, Zhuohuan Li, Wenqi Huang, Qi Chen, Mingxia Zhang, Lin Cheng, Zheng Zhang","doi":"10.1080/22221751.2025.2479043","DOIUrl":"https://doi.org/10.1080/22221751.2025.2479043","url":null,"abstract":"<p><p>We have previously established a clade Ⅱb mpox virus (MPXV) pathogenic BALB/c mouse model for developing mpox countermeasures. Here, we comprehensively investigated the susceptibility of BALB/c and C57BL/6 mice to MPXV and found that Clade IIb MPXV was capable of rapid replication in the lungs of both mouse strains, thus triggering similar dynamic pathological changes and antibody responses. However, C57BL/6 mice, compared to BALB/c mice, seem less susceptible to MPXV, evidenced by no significant weight loss, lower viral load, faster viral clearance, and earlier pathological improvement, as well as weaker antibody response. Interestingly, C57BL/6 <i>stat1</i>^-/- mice intranasally infected with MPXV displayed a significant body weight loss, indicating the crucial role of innate immunity in the susceptibility to MPXV. The C57BL/6 model mimics clinical characteristics of asymptomatic or mildly symptomatic patients with mild mpox, which will be beneficial for exploring MPXV infection, transmission, pathogenesis, and immune responses.</p>","PeriodicalId":11602,"journal":{"name":"Emerging Microbes & Infections","volume":" ","pages":"2479043"},"PeriodicalIF":8.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic islands and molecular mechanisms relating to drug-resistance in <i>Clostridioides</i> (<i>Clostridium</i>) <i>difficile</i> PCR ribotype 176.","authors":"Krutova Marcela, Kovarovic Vojtech, Brajerova Marie, Demay Fanny, Zikova Jaroslava, Prasad Suhanya, Soltesova Anna, Novakova Elena, Pituch Hanna, Kuijper Ed, Smits Wiep Klaas, Balikova Novotna Gabriela","doi":"10.1080/22221751.2025.2482698","DOIUrl":"https://doi.org/10.1080/22221751.2025.2482698","url":null,"abstract":"<p><strong>Objectives: </strong>To analyse characteristics of <i>Clostridioides difficile</i> PCR ribotype 176 clinical isolates from Poland, the Czech Republic and Slovakia with regard to the differences in its epidemiology.</p><p><strong>Methods: </strong>Antimicrobial susceptibility testing and whole genome sequencing were performed on a selected group of 22 clonally related isolates as determined by multilocus variable-number tandem repeat analysis (n = 509). Heterologous expression and functional analysis of the newly identified methyltransferase were performed.</p><p><strong>Results: </strong>Core genome multilocus sequence typing found 10-37 allele differences. All isolates were resistant to fluoroquinolones (<i>gyr</i>A_p. T82I), aminoglycosides with <i>aac</i>(6')-<i>Ie-aph</i>(2'')-<i>Ia</i> in six isolates. Erythromycin resistance was detected in 21/22 isolates and 15 were also resistant to clindamycin with <i>erm</i>B. Fourteen isolates were resistant to rifampicin with <i>rpo</i>B_p. R505 K or p. R505 K/H502N, and five to imipenem with <i>pbp</i>1_p. P491L and <i>pbp</i>3_p. N537 K. P<i>nim</i>B^G together with <i>nim</i>B_p. L155I were detected in all isolates but only five were resistant to metronidazole on chocolate agar. The <i>cfr</i>E, <i>van</i>Z1 and <i>cat</i>-like genes were not associated with linezolid, teicoplanin and chloramphenicol resistance, respectively. The genome comparison identified six transposons carrying antimicrobial resistance genes. The <i>erm</i>B was carried by new Tn<i>7808</i>, Tn<i>6189</i> and Tn<i>6218</i>-like. The <i>aac</i>(6')-<i>Ie-aph</i>(2'')-<i>Ia</i> were carried by Tn<i>6218</i>-like and new Tn<i>7806</i> together with <i>cfr</i>E. New Tn<i>7807</i> carried a <i>cat</i>-like gene. Tn<i>6110</i> and new Tn<i>7806</i> contained an RlmN-type 23S rRNA methyltransferase, designated MrmA, associated with high-level macrolide resistance in isolates without <i>erm</i>B.</p><p><strong>Conclusions: </strong>Multidrug-resistant <i>C. difficile</i> PCR ribotype 176 isolates carry already described and unique transposons. A novel mechanism for erythromycin resistance in <i>C. difficile</i> was identified.</p>","PeriodicalId":11602,"journal":{"name":"Emerging Microbes & Infections","volume":" ","pages":"2482698"},"PeriodicalIF":8.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unique Immune and Other Responses of Human Nasal Epithelial Cells Infected with H5N1 Avian Influenza Virus Compared to Seasonal Human Influenza A and B Viruses.","authors":"Tan Kai Sen, Liu Jing, Andiappan Anand, Lew Zhe Zhang Ryan, He Ting Ting, Ong Hsiao Hui, Tay Douglas, Aw Zhen Qin, Yi Bowen, Fauzi Arfah Mohd, Yogarajah Thinesshwary, Lee Ching Pei Carmen, Chu Justin Jang Hann, Chow Vincent T, Prabakaran Mookhan, Wang De-Yun","doi":"10.1080/22221751.2025.2484330","DOIUrl":"https://doi.org/10.1080/22221751.2025.2484330","url":null,"abstract":"<p><p>Highly pathogenic avian influenza (HPAI) virus (e.g. H5N1) infects the lower airway to cause severe infections, and constitute a prime candidate for the emergence of disease X. The nasal epithelium is the primary portal of entry for respiratory pathogens, serving as the airway's physical and immune barrier. While HPAI virus predominantly infects the lower airway, not much is known about its interactions with the nasal epithelium. Hence, we sought to elucidate and compare the differential responses of the nasal epithelium against HPAI infection that may contribute to its pathology, and to identify critical response markers. We infected human nasal epithelial cells (hNECs) cultured at the air-liquid interface from multiple healthy donors with clinical isolates of major human seasonal influenza viruses (H1N1, H3N2, influenza B) and HPAI H5N1. The infected cells were subjected to virologic, transcriptomic and secretory protein analyses. While less adapted to infecting the nasal epithelium, HPAI H5N1 elicited unique host responses unlike seasonal influenza. Interestingly, H5N1 infection of hNECs induced responses indicative of subdued antiviral activity (e.g. reduced expression of IFNβ, and inflammasome mediators, IL-1α and IL-1β); decreased wound healing; suppressed re-epithelialization; compromised epithelial barrier integrity; diminished responses to oxidative stress; and increased transmembrane solute and ion carrier gene expression. These unique molecular changes in response to H5N1 infection may represent potential targets for enhancing diagnostic and therapeutic strategies for better surveillance and management of HPAI infection in humans.</p>","PeriodicalId":11602,"journal":{"name":"Emerging Microbes & Infections","volume":" ","pages":"2484330"},"PeriodicalIF":8.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccine Effectiveness Dynamics against Influenza and SARS-CoV-2 in Community-tested Patients in France 2023-2024.","authors":"Claire Nour Abou Chakra, François Blanquart, Vincent Vieillefond, Vincent Enouf, Benoit Visseaux, Stéphanie Haim-Boukobza, Laurence Josset, Marie-Anne Rameix-Welti, Bruno Lina, Marta C Nunes, Antonin Bal","doi":"10.1080/22221751.2025.2466699","DOIUrl":"https://doi.org/10.1080/22221751.2025.2466699","url":null,"abstract":"<p><strong>Background: </strong>The epidemiology of respiratory viruses and vaccine effectiveness (VE) in the community is not well described. This study assessed VE against a positive test of influenza (VEf) and SARS-CoV-2 (VECov).</p><p><strong>Methods: </strong>Data from two large networks of community-based laboratories in France were collected during standard of care in the 2023-2024 epidemic season (n = 511,083 RT-PCR tests). Multiplex PCR diagnostic tests were used. Patients' demographics and symptoms were reported in addition to viral sequencing results. Test-negative design was used to separately estimate VEf and VECov, overall and stratified, by time since vaccination and calendar week.</p><p><strong>Results: </strong>Adjusted VEf by age-group, sex, presence of symptoms, PCR technique, and week of testing, was 47.6% (95% CI: 44.3%-50.7%). VEf was lower in patients ≥65 years (42.0%; 95% CI: 36.6%-46.9%) than 18-64 years (52.9%; 95% CI: 48.6%-56.8%). The adjusted VEf against type A influenza, that represented 98% of typed viruses, was 51% (95% CI: 45%-56.6%) for patients vaccinated 15 days to 3 months before testing, and 35.5% (95% CI: 24.2%-45.3%) for those vaccinated 3 to 6 months before testing. For VECov, the adjusted estimate in patients vaccinated 15 days to 3 months prior to testing were 40.6% (95% CI: 7.2%-58.6%) at week 39, 24.8% (95% CI: 4.0%-38.8%) at week 45, and dropped systematically through the epidemic season as the JN.1 variant became dominant.</p><p><strong>Conclusion: </strong>This study showed moderate VEf and VECov against infection in the community and highlighted the impact of time since vaccination and age for both estimates, and the new variant emergence on VECov. These findings should be considered in future vaccination campaigns.</p>","PeriodicalId":11602,"journal":{"name":"Emerging Microbes & Infections","volume":" ","pages":"2466699"},"PeriodicalIF":8.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CpG oligodeoxynucleotides and pan-serotype inhibitors control neurotropic Dengue infection in novel immune competent neonatal mouse model.","authors":"Mirian Mendoza, Derek D C Ireland, Ha-Na Lee, Logan Kelly-Baker, Monica Chowdhury, Daniela Verthelyi, Mohanraj Manangeeswaran","doi":"10.1080/22221751.2025.2477668","DOIUrl":"https://doi.org/10.1080/22221751.2025.2477668","url":null,"abstract":"<p><p>Dengue virus (DENV) is a growing global public health threat. The lack of symptomatic immune competent animal models for Dengue has hindered the screening and development of effective therapeutics that can be used to control dengue virus replication and thereby control the progression to severe dengue disease. To address this, we established an infection model in neonatal C57BL/6 mice and showed that a systemic Dengue challenge leads to ataxia, seizures, paralysis, and death within 15 days. The virus was found predominantly in the eye and brain where DENV infects neurons but not astrocytes and causes extensive infiltration of macrophages and microglia activation. The response to infection included upregulation of multiple genes linked to interferons (<i>Ifna, Ifnb, Ifng, Irf7, Irf8, Mx1, Stat1</i> and <i>Bst2</i>), inflammation (<i>Il6,Tnfa</i>), complement (<i>Cfb,C1ra,C2, C3</i>), cytolysis (<i>Gzma, Gzmb, Prf1</i>) consistent with antiviral responses and inflammation together with neuroprotective regulatory signals (<i>Il27, Il10, and stat2)</i>. The increased proinflammatory signature was associated downregulation neurodevelopmental genes <i>(Calb2, Pvalb, Olig1</i> and <i>Olig2)</i>. We tested the utility of this mouse model by assessing the protection conferred by direct antivirals JNJ-A07 and ST-148 and host-directed antiviral immunomodulatory CpG oligodeoxynucleotide (ODN), alone or in combination against lethal dengue viral infection. The data showed that immunomodulatory CpG ODN and antiviral JNJ-A07 improved survival of neonatal mice, and protection from lethal neurotropic infection was optimal when treatments were combined. This study suggests that combination of an effective dengue antiviral along with a host directed therapeutic may be a useful strategy to protect against Dengue virus infections.</p>","PeriodicalId":11602,"journal":{"name":"Emerging Microbes & Infections","volume":" ","pages":"2477668"},"PeriodicalIF":8.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143583723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dengue Virus and Lipid Metabolism: Unraveling the Interplay for Future Therapeutic Approaches.","authors":"Ying Xie, Li Jiao, Qiangming Sun","doi":"10.1080/22221751.2025.2477647","DOIUrl":"https://doi.org/10.1080/22221751.2025.2477647","url":null,"abstract":"<p><p>In recent years, Dengue virus (DENV) has continued to pose significant health risks in tropical and subtropical areas worldwide, raising health alerts worldwide. It can cause hyperviremia in humans and can even lead to fatal clinical diseases. The life cycle of DENV is intricately linked to cellular lipids, and the virus selectively utilizes relevant enzymes involved in lipid metabolism to modulate the existing metabolic system in host cells during entry, replication, assembly, and other stages, thereby creating an environment conducive to its complete replication cycle. At present, there is a lack of effective and specific anti-DENV treatment measures. This review summarizes the recently identified lipid metabolism molecules and metabolic related diseases that affect DENV infection, explores the dependence of DENV on lipid metabolism and provides potential targets for the treatment of dengue fever (DF).</p>","PeriodicalId":11602,"journal":{"name":"Emerging Microbes & Infections","volume":" ","pages":"2477647"},"PeriodicalIF":8.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms Underlying Delayed loss of HBeAg and HBV DNA Following HBsAg Seroclearance in PEG-IFNα Treated Patients of chronic hepatitis B.","authors":"Bei Jiang, Guiwen Guan, Kaitao Zhao, Zhiqiang Gu, Lin Wang, Weilin Gu, Minghui Li, Yuchen Xia, Xiangmei Chen, Yifei Guo, Jiming Zhang, Zhenhuan Cao, Man-Fung Yuen, Fengmin Lu","doi":"10.1080/22221751.2025.2475847","DOIUrl":"10.1080/22221751.2025.2475847","url":null,"abstract":"<p><strong>Background & aims: </strong>A notable proportion of CHB patients undergoing PEG-IFNα based therapy experience lagged serum HBeAg and/or HBV DNA disappearance in patients achieving HBsAg loss. In this study, we explored the molecular mechanisms behind this clinical phenomenon, offering novel insights into the sustainability of chronic HBV infection.</p><p><strong>Methods: </strong>Two independent clinical cohorts were enrolled to validate this phenomenon. Then comprehensive analysis was performed using public datasets, coupled with a series of molecular biology experiments.</p><p><strong>Results: </strong>Approximately 17-20% CHB patients underwent PEG-IFNα based therapy experienced seroclearance of HBsAg, while serum HBeAg and/or HBV DNA remained positive. These patients are more prone to serum HBsAg reappearance compared to those achieving complete virological response. Analysis of public datasets revealed that compared to the PC/BCP, the SP1/SP2 promoter displayed more pronounced inhibitory epigenetic modifications in HBeAg-negative patients and SP1/SP2 in-frame mutation peaked in immune active patients. In vitro experiments demonstrated that introduced SP1/SP2 inactive mutations would enhance PC/BCP transcriptional activity by a mechanism known as adjacent transcriptional interference. Furthermore, the deletion of L-HBsAg facilitated intracellular cccDNA replenishment.</p><p><strong>Conclusion: </strong>This study elucidates that under IFNα treatment and low viral load, transcriptional suppression of SP1/SP2 promoters through mutations and/or epigenetic changes would favor the maintenance of sustain chronic HBV infection, via enhancing the transcription activity of BCP to promote cccDNA replenishment.</p>","PeriodicalId":11602,"journal":{"name":"Emerging Microbes & Infections","volume":" ","pages":"2475847"},"PeriodicalIF":8.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"North American-Origin Influenza A (H10) viruses in Eurasian Wild Birds (2022-2024): Implications for the Emergence of Human H10N5 Virus.","authors":"Jiaying Wu, Xiaoqing Zhang, Yubo Zhao, Shunyuan Zhang, Yanhai Wang, Wenxue Yang, Haizhou Liu, Jiang Feng, Wenzhuo Tan, Ke Wang, Qianqian Shi, Qichao Wei, Jianqing Sun, Yuan Zhang, Jianjun Chen","doi":"10.1080/22221751.2025.2465308","DOIUrl":"https://doi.org/10.1080/22221751.2025.2465308","url":null,"abstract":"<p><p>During our surveillance of avian influenza viruses (AIVs) in wild birds across China, H10Nx viruses were isolated from diverse migratory flyways between 2022 and 2024. We identified one wild-bird H10N5 strain that shared a common ancestor with the human H10N5 virus in multiple gene segments. Phylogenetic and molecular dating revealed the origin and evolution of H10N5, highlighting the need for continued monitoring.</p>","PeriodicalId":11602,"journal":{"name":"Emerging Microbes & Infections","volume":" ","pages":"2465308"},"PeriodicalIF":8.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The first appearance of the zoonotic parasite Cryptosporidium mortiferum in human and tree and ground squirrels in Central Europe.","authors":"Martin Kváč,Alena Konvalinová,Nikola Holubová,Zuzana Hůzová,Marta Kicia,John McEvoy,Kristina Beranová,Bohumil Sak","doi":"10.1080/22221751.2025.2456148","DOIUrl":"https://doi.org/10.1080/22221751.2025.2456148","url":null,"abstract":"","PeriodicalId":11602,"journal":{"name":"Emerging Microbes & Infections","volume":"51 1","pages":"2456148"},"PeriodicalIF":13.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142989709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}