Endocrine Research最新文献

{"title":"T Cell Subsets are Associated with Clinical Activity and Efficacy of 4.5g Intravenous Glucocorticoid for Moderate-To-Severe Thyroid-Associated Ophthalmopathy.","authors":"Huixia Li,&nbsp;Bin Wang,&nbsp;Qin Li,&nbsp;Qing Li,&nbsp;Jie Qiao,&nbsp;Dongping Lin,&nbsp;Chunhua Sui,&nbsp;Lin Ye,&nbsp;Hualing Zhai,&nbsp;Boren Jiang,&nbsp;Ningjian Wang,&nbsp;Bing Han,&nbsp;Mengda Jiang,&nbsp;Xiaofeng Tao,&nbsp;Ziyang Shao,&nbsp;Chenfang Zhu,&nbsp;Yubo Ma,&nbsp;Ping Xiong,&nbsp;Jing Sun,&nbsp;Huifang Zhou,&nbsp;Yingli Lu","doi":"10.1080/07435800.2023.2219734","DOIUrl":"https://doi.org/10.1080/07435800.2023.2219734","url":null,"abstract":"<p><strong>Background: </strong>Intravenous glucocorticoid (IVGC) remains the main treatment for moderate-to-severe and active thyroid-associated ophthalmopathy (TAO). However, a substantial number (20-30%) of active moderate-to-severe TAO patients may not respond to IVGC. Some patients may have disease progression despite IVGC treatment or relapse after steroid withdrawal.</p><p><strong>Objectives: </strong>To analyze risk factors for clinical activity and predictive factors for clinical outcomes of 4.5 g IVGC therapy in patients with moderate-to-severe TAO.</p><p><strong>Design and methods: </strong>Our study was performed in two steps: step 1 involved 110 moderate-to-severe TAO patients and analyzed risk factors for TAO activity; step 2 involved 53 active moderate-to-severe TAO patients from step 1 who were treated with 4.5 g IVGC therapy and analyzed predictive factors for clinical outcomes of IVGC therapy. Multivariate logistic regression analysis was used to identify the independent predictors and establish the predictive model.</p><p><strong>Results: </strong>Abnormal TRAb (OR = 4.717; <i>P</i> = 0.019) and the percentage of CD3+CD4+ T cell (OR = 1.092; <i>P</i> = 0.028) were independently associated with the activity of moderate-to-severe TAO patients. The pretreatment CAS-max in both eyes (OR = 7.221; <i>P</i> = 0.013) and the percentage of pretreatment CD3+T cell (OR = 0.718; <i>P</i> = 0.037) were independently associated with therapeutic efficacy. The pretreatment CAS-max in both eyes (OR = 156.53; <i>P</i> = 0.028) and the percentage of post-treatment CD3+T cell (OR = 0.554; <i>P</i> = 0.043) were independently associated with therapeutic efficacy. Besides, multivariable prediction models were established, which were better in the forecasting aspect than single-variable prediction models.</p><p><strong>Conclusions: </strong>Based on the findings of this study, we should monitor the peripheral blood T cell subsets for TAO, which could be helpful to timely judge the condition of clinical manifestation and effect of treatment for TAO patients. Multivariable prediction models have been established, which have great significance for clinical work.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"48 2-3","pages":"55-67"},"PeriodicalIF":2.1,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9749934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Hypothyroidism Treatment and Mortality in Patients Hospitalized in Surgical Wards.","authors":"Hiba Masri-Iraqi,&nbsp;Yaron Rudman,&nbsp;Carmel Friedrich Dubinchik,&nbsp;Idit Dotan,&nbsp;Talia Diker-Cohen,&nbsp;Liat Sasson,&nbsp;Tzipora Shochat,&nbsp;Ilan Shimon,&nbsp;Eyal Robenshtok,&nbsp;Amit Akirov","doi":"10.1080/07435800.2023.2220022","DOIUrl":"https://doi.org/10.1080/07435800.2023.2220022","url":null,"abstract":"<p><p>Limited data are available regarding the association between pre-admission thyroid-stimulating hormone (TSH) levels and prognosis in hospitalized surgical patients treated for hypothyroidism. We retrospectively evaluated a cohort of 1,451 levothyroxine-treated patients, hospitalized to general surgery wards. The 30-day mortality risk was 2-fold higher for patients with TSH of 5.0-10.0 mIU/L (adjusted OR, 2.3; 95% CI 1.1-5.1), and 3-fold higher for those with TSH > 10.0 mIU/L (3.4; 95% CI 1.3-8.7). Long-term mortality risk was higher in patients with TSH of 5.0-10.0 and above 10.0 mIU/L (adjusted HR, 1.2; 95% CI, 1.0-1.6, and 1.7; 95% CI 1.2-2.4, respectively). We found that in levothyroxine-treated adults hospitalized to surgical wards, increased pre-admission TSH levels are associated with increased short- and long-term mortality.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"48 2-3","pages":"68-76"},"PeriodicalIF":2.1,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10108694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Spectrum of Thyroid Function Tests and Autoantibodies During Hospitalization and After Six Months of Discharge in COVID-19 Patients: Does COVID-19 Trigger Autoimmunity?","authors":"Ziynet Alphan Uc,&nbsp;Pinar Yagcı,&nbsp;Zelal Adibelli,&nbsp;Cevdet Duran","doi":"10.1080/07435800.2023.2188086","DOIUrl":"https://doi.org/10.1080/07435800.2023.2188086","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study was to investigate thyroid function test (TFT) results and anti-thyroid antibody titers in acutely infected COVID-19 patients, as well as the changes in TFT and autoantibody results during the 6-months recovery period among survivors.</p><p><strong>Patients and design: </strong>A total of 163 adult COVID-19 patients and 124 COVID-19 survivors were evaluated in terms of TFT (thyroid stimulating hormone [TSH], free triiodothyronine [fT3], and free thyroxine [fT4]) and anti-thyroid antibodies (anti-thyroglobulin [anti-Tg] and anti-thyroid peroxidase [anti-TPO]).</p><p><strong>Results: </strong>Thyroid dysfunction was noted in 56.4% of patients on admission, including the non-thyroidal illness syndrome (NTIS) in most cases. Presence vs. absence of thyroid dysfunction on admission was associated with significantly higher rate of severe disease (<i>p</i> < 0.001), while severe vs. mild-to-moderate disease was associated with significantly lower serum fT3 levels (<i>p</i> = 0.001). Overall, 94.4% of survivors were euthyroid at the time of 6 months post-discharge, while in some patients, the post-COVID-19 recovery period was also associated with significantly increased anti-TPO titers and the presence of new-onset or persistent subclinical hypothyroidism.</p><p><strong>Conclusion: </strong>This is one of the few studies to evaluate TFT and autoantibodies over a 6-month period after recovery from COVID-19. The presence of emergent or persistent subclinical hypothyroidism and the significantly increased anti-TPO titers in some patients during the convalescence period suggest the need for follow-up for development of thyroid dysfunction and autoimmunity among COVID-19 survivors.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"48 2-3","pages":"44-54"},"PeriodicalIF":2.1,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10125843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Adrenal Reserve in Patients with Differentiated Thyroid Cancer Receiving Thyroid Hormone Suppression Therapy- case-control Comparative Study.","authors":"Muhammet Cuneyt Bilginer,&nbsp;Abbas Ali Tam,&nbsp;Sevgul Faki,&nbsp;Nagihan Bestepe,&nbsp;Fatma Dilek Dellal,&nbsp;Didem Ozdemir,&nbsp;Oya Topaloglu,&nbsp;Reyhan Ersoy,&nbsp;Bekir Cakir","doi":"10.1080/07435800.2022.2158338","DOIUrl":"https://doi.org/10.1080/07435800.2022.2158338","url":null,"abstract":"<p><strong>Background: </strong>Patients with differentiated thyroid cancer (DTC) are exposed to subclinical exogenous hyperthyroidism for the suppression of thyroid-stimulating hormone (TSH). In this study, we aimed to evaluate the adrenal reserve in DTC patients receiving suppression therapy.</p><p><strong>Materials and methods: </strong>The study included 55 DTC patients on suppression therapy and 32 healthy volunteers. Basal serum cortisol of all participants and adrenocorticotropic hormone (ACTH) of the patient group were measured. A standard-dose ACTH test (0.25 mg) was performed in patients with a basal cortisol <14.5 mcg/dL.</p><p><strong>Results: </strong>In the patient group, TSH was lower, free thyroxine (fT4) was higher, and free triiodothyronine (fT3) was similar to those of the control group (p < .01, p < .01, p = .140, respectively). The serum cortisol of the patient group was significantly lower than the control group (12.14 ± 5.12 mcg/dL vs 18.00 ± 5.56 mcg/dL, p < .001). A total of 34 (61.8%) patients with DTC had a basal cortisol <14.5 mcg/dL. Prolonged TSH suppression (≥5 years vs <5 years) was associated with lower basal cortisol (7.46 ± 2.63 mcg/dL vs 9.48 ± 2.65 mcg/dL, p = .022). The ACTH stimulation test showed that 2 (5.8%) patients had a cortisol response <18 mcg/dL. The rate of adrenal insufficiency was 3.6% in DTC patients. A moderate negative correlation was found between ACTH and fT3 of patients with low basal cortisol (r = -0.358, p = .038).</p><p><strong>Conclusion: </strong>Patients with DTC receiving TSH suppression therapy are at risk for adrenal insufficiency. The duration and severity of suppression might increase this possibility. Dynamic testing with synthetic ACTH can be used to reveal insufficient cortisol response in case of clinical suspicion.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"48 1","pages":"9-15"},"PeriodicalIF":2.1,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10756664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Difference in the Association of Hyperuricemia with Insulin Resistance and beta-cell Function in Nondiabetic Korean Adults: The 2019 Korea National Health and Nutrition Examination Survey.","authors":"Jeong Min Seong,&nbsp;Mi Young Gi,&nbsp;Ju Ae Cha,&nbsp;Hyun Ho Sung,&nbsp;So Young Park,&nbsp;Cho Hee Park,&nbsp;Hyun Yoon","doi":"10.1080/07435800.2022.2142239","DOIUrl":"https://doi.org/10.1080/07435800.2022.2142239","url":null,"abstract":"<p><strong>Aims: </strong>This study was conducted to assess the association of uric acid (UA) with the homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-<i>B</i>) by gender in nondiabetic Korean adults.</p><p><strong>Materials and methods: </strong>The study was carried out using data from the 2019 Korean National Health and Nutrition Examination Survey and included nondiabetic Korean men, premenopausal women, and postmenopausal women aged 20 years or older.</p><p><strong>Results: </strong>First, after adjusted for the related variables (excluding obesity), the prevalence of hyperuricemia (UA ≥ 7.0 mg/dL in men or UA ≥ 6.0 mg/dL in women) was positively associated with the quartiles of HOMA-IR and HOMA-<i>B</i> in men, premenopausal women, and postmenopausal women. Second, when further adjusted for obesity, hyperuricemia was positively associated with the quartiles of HOMA-IR and HOMA-<i>B</i> in men and postmenopausal women but not in premenopausal women. Third, after adjusted for the related variables (including obesity), UA level was positively associated with the quartiles of HOMA-IR and HOMA-<i>B</i> in men and postmenopausal women but not in premenopausal women.</p><p><strong>Conclusions: </strong>hyperuricemia is positively associated with insulin resistance and beta-cell function in nondiabetic Korean men and postmenopausal women but not in premenopausal women.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"48 1","pages":"1-8"},"PeriodicalIF":2.1,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10743424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity of Different ACTH and Cortisol Concentration Values in Corticotropin-Releasing Hormone Based Tests in Cushing's Disease.","authors":"Shehrban Sobeh Khalil,&nbsp;Mohammad Sheikh Ahmad,&nbsp;Talia Sarah-Hefer,&nbsp;Ekaterina Yovanovich,&nbsp;Maria Reut,&nbsp;Limor Chen-Konak,&nbsp;Nariman Saba-Khazen,&nbsp;Leonard Saiegh","doi":"10.1080/07435800.2023.2176869","DOIUrl":"https://doi.org/10.1080/07435800.2023.2176869","url":null,"abstract":"<p><strong>Purpose: </strong>In Cushing's disease (CD) patients, the aim of the present study is to confirm sensitivity of several ACTH and cortisol concentration values in different time points, during corticotropin-releasing hormone (CRH) stimulation test and during CRH stimulation following dexamethasone suppression (DEX-CRH) test.</p><p><strong>Methods: </strong>We retrospectively analyzed cortisol and ACTH concentration increment during CRH and DEX-CRH tests in 23 patients with confirmed CD. Cortisol and ACTH concentrations were determined immediately before, 15 min and 30 min after CRH stimulation. We evaluated the sensitivity of different cutoff values including those reported in previous studies, in the diagnosis of CD.</p><p><strong>Results: </strong>During DEX-CRH test, 15 min serum cortisol concentration of 1.4 μg/dl (38 nmol/L) had a sensitivity of 90.9%, and serum cortisol concentration ≥1.27 μg/dl (35 nmol/L) had a sensitivity of 100%. For plasma ACTH, sensitivity of 100% was obtained using ACTH ≥3.5pmol/L (16 pg/ml) at 30 min. During CRH test, 35% increase from baseline in ACTH concentration had a sensitivity of 72.7%. Twenty percent increase in cortisol 30 minutes after stimulation yielded a sensitivity of 85.7%. The best sensitivity of ACTH and cortisol increment was obtained 15 min after stimulation, using 19% and 9% increase, respectively (sensitivity of 100% and 92.8%, respectively).</p><p><strong>Conclusion: </strong>During CRH and DEX-CRH tests, the study findings agree with the good sensitivity of ACTH and cortisol cutoff values suggested in previous studies; yet, other cutoff values may give a higher diagnostic sensitivity.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"48 1","pages":"27-34"},"PeriodicalIF":2.1,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9306759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre- and Post-treatment Serum BAFF Levels and BAFF Gene Polymorphisms in Patients with Graves' Disease.","authors":"Tarak Dhaouadi,&nbsp;Imen Rojbi,&nbsp;Sameh Ghammouki,&nbsp;Ibtissem Ben Nacef,&nbsp;Meriem Adel,&nbsp;Sabrine Mekni,&nbsp;Karima Khiari,&nbsp;Taïeb Ben Abdallah,&nbsp;Imen Sfar,&nbsp;Yousr Gorgi","doi":"10.1080/07435800.2023.2167087","DOIUrl":"https://doi.org/10.1080/07435800.2023.2167087","url":null,"abstract":"<p><strong>Background: </strong>B cell activating factor (BAFF), a crucial factor for B cell survival and differentiation, has been linked to several autoimmune conditions. The aim of this study was to evaluate the association of BAFF gene's polymorphisms with its serum levels and to assess their effect on Graves' disease (GD) susceptibility and presentation.</p><p><strong>Methods: </strong>Sixty-two GD patients and 152 healthy controls have been enrolled to investigate BAFF rs9514827 (-2841 T/C), rs1041569 (-2701 T/A) and rs9514828 (-871 C/T) gene's polymorphism by PCR-RFLP and serum BAFF level's kinetics under medical treatment by ELISA.</p><p><strong>Results: </strong>Median serum BAFF level at baseline was significantly higher in GD patients (841.7 pg/ml [685.23-1058.32]) comparatively to controls (495.75 pg/ml [383.17-595.7]), <i>p</i> = 7.29 E-25. A ROC curve was used to assess BAFF performances in GD diagnosis and revealed an AUC of 94.9% [0.919-0.979], <i>p</i> = 7.29 E-25. At a cutoff value of 654.9 pg/ml of BAFF at baseline, the sensitivity and the specificity were, respectively, 83.9% and 90.8%. BAFF level was significantly increased in smoking patients (1079.55 pg/ml [875.35-1203]) comparatively to nonsmokers (746.95 pg/ml [643.2-915.7]), <i>p</i> = 3.1 E-5. While -2841 T/C and -2701 T/A genotypes and alleles frequencies were similar between patients and controls, the -871*T allele was significantly more prevalent in patients (0.613) than in controls (0.477); <i>p</i> = .01, OR [95% CI] = 1.73 [1.13-2.65]. The three studied polymorphisms were not associated with serum BAFF level at baseline.</p><p><strong>Conclusion: </strong>Serum BAFF level is significantly increased in GD especially in smoking patients. rs9514828 - 871*T allele might be a susceptibility variant for GD.</p>","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"48 1","pages":"16-26"},"PeriodicalIF":2.1,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9073395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are We Only Detecting the Tip of the Iceberg? A Nationwide Study on Primary Aldosteronism with up to 8-Year Follow-up","authors":"Hrafnhildur Gunnarsdóttir, G. Jónsdóttir, G. Birgisson, Jon Gudmundsson, H. Sigurjonsdottir","doi":"10.1080/07435800.2022.2068572","DOIUrl":"https://doi.org/10.1080/07435800.2022.2068572","url":null,"abstract":"ABSTRACT Background Long-term follow-up studies on primary aldosteronism (PA) are lacking. Objective We aim to review results of diagnostic procedures and histopathology for patients diagnosed during 2012–2016 in Iceland, compare unilateral (UD) and bilateral disease (BD) and assess treatment response. Methods Thirty-two patients aged 28–88 were diagnosed and treated according to guidelines. Results The majority had BD. Everyone needed potassium supplementation at case detection. We saw a reduction in systolic blood pressure (p < .001, both groups), antihypertensive agents (p = .002 UD and p = .04 BD) and potassium supplementation (p < .001, both groups). Conclusion Similar treatment response was seen in both subgroups. Ratio of hypokalemia and number of cases indicates severe PA underdiagnosis in Iceland.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"47 1","pages":"104 - 112"},"PeriodicalIF":2.1,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44786403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Triglycerides and Glucose Index Is Associated with Mild Cognitive Impairment in Older Adults","authors":"Y. Weyman-Vela, L. Simental‐Mendía, Abelardo Camacho-Luis, C. Gamboa-Gómez, F. Guerrero‐Romero","doi":"10.1080/07435800.2022.2061508","DOIUrl":"https://doi.org/10.1080/07435800.2022.2061508","url":null,"abstract":"ABSTRACT Background It has been reported that insulin resistance is related to cognitive decline. The triglycerides and glucose (TyG) index, is a reliable and inexpensive surrogate test for detecting insulin resistance. Aims The goal of this study was to evaluate the association between the TyG index and the mild cognitive impairment (MCI) in older adults. Methods A total of 135 individuals, men and women aged 60 to 90 years, were enrolled in a case and control study. Individuals with a diagnosis of MCI (n = 65) were allocated into the case group and compared with individuals without MCI (n = 70) in the control group. Alcohol intake, diabetes duration ≥5 years, diagnoses of cerebrovascular disease, brain injury, folic acid deficiency, dementia, moderate or severe CI, major depressive disorders, and thyroid disease were exclusion criteria. Results Individuals in the case group exhibited higher waist circumference (97.9 ± 13.9 versus 93.5 ± 13.0, p = .001) and TyG index (5.0 ± 0.3 versus 4.1 ± 0.2, p = .001) than individuals in the control group. The TyG index ≥4.68 (OR 6.91; 95% CI 2.05–11.68) and waist circumference (OR 1.03; 95% CI 1.01–1.06) were positively associated with MCI, while education level (OR 0.44; 95% CI 0.30–0.61), occupation (OR 0.75; 95% CI 0.59–0.61), and exercise (OR 0.34; 95% CI 0.22–0.52) were inversely associated with MCI. After controlling for sex, age, waist circumference, education level, occupation, and exercise, a TyG index ≥4.68 remained significantly associated with MCI (OR 2.97; 95% CI 1.12–14.71). Conclusion The TyG index is independently associated with the presence of MCI in older people.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"47 1","pages":"89 - 93"},"PeriodicalIF":2.1,"publicationDate":"2022-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44206684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship between the Lipid Accumulation Product and Beta-cell Function in Korean Adults with or without Type 2 Diabetes Mellitus: The 2015 Korea National Health and Nutrition Examination Survey","authors":"Hye-eun Cho, Seung-Bum Yang, M. Gi, J. A. Cha, S. Park, Hyun Yoon","doi":"10.1080/07435800.2022.2053540","DOIUrl":"https://doi.org/10.1080/07435800.2022.2053540","url":null,"abstract":"ABSTRACT Aims This study was conducted to assess the relationship between the lipid accumulation product index (LAP) and the homeostasis model assessment for insulin resistance (HOMA-IR) and beta-cell function (HOMA-B) in Korean adults with or without type 2 diabetes mellitus (T2DM). Materials and Methods The study was carried out using data from the 2015 Korean National Health and Nutrition Examination Survey (KNHANES) and included 4,922 adults aged 20 or older. Results There were several key findings. First, in overall population, after adjusting for related variables, HOMA-IR (p < .001) and HOMA-B (p < .001) level were positively associated with quartiles of LAP. Second, in non-T2DM group, HOMA-IR (p < .001) and HOMA-B level (p < .001) were positively associated with quartiles of LAP. Third, in T2DM group, HOMA-IR (p < .001) level was positively associated with the quartiles of LAP, but HOMA-B (p = .153) level was not significant. In addition, HOMA-B level was increased with an increasing metabolic syndrome component in non-T2DM (p < .001) but not in T2DM (p = .267). Conclusions LAP was positively associated with both HOMA-IR and HOMA-B in non-diabetic Korean adults. However, LAP was positively associated with HOMA-IR in Korean adults with T2DM, while the association with HOMA-B was not significant.","PeriodicalId":11601,"journal":{"name":"Endocrine Research","volume":"47 1","pages":"80 - 88"},"PeriodicalIF":2.1,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42040886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}