Endocrine reviews最新文献_第3页

Subtyping of Primary Aldosteronism by Adrenal Venous Sampling. 原发性醛固酮增多症的肾上腺静脉取样分型。

IF 22 1区医学

Endocrine reviews Pub Date : 2025-02-18 DOI: 10.1210/endrev/bnaf007

Gian Paolo Rossi, Michele Battistel, Teresa Maria Seccia, Federico Bernardo Rossi, Giacomo Rossitto

{"title":"Subtyping of Primary Aldosteronism by Adrenal Venous Sampling.","authors":"Gian Paolo Rossi, Michele Battistel, Teresa Maria Seccia, Federico Bernardo Rossi, Giacomo Rossitto","doi":"10.1210/endrev/bnaf007","DOIUrl":"https://doi.org/10.1210/endrev/bnaf007","url":null,"abstract":"Primary aldosteronism (PA), the most common cause of arterial hypertension, is surgically curable if a unilateral source of the hyperaldosteronism is discovered. To identify the patients who are curable, all current guidelines recommend adrenal venous sampling (AVS), a procedure which, albeit simple in principle, remains scarcely available and markedly under-utilized, because it is still perceived as technically challenging, invasive, and difficult to interpret. The lack of uniformly accepted standards for performance and interpretation of AVS, alongside the diffuse concerns that, albeit quite rarely, it can be complicated by adrenal vein rupture, contribute to the scant utilization of AVS. In the last decade, several major studies have contributed to a greater understanding of the use of AVS in PA patients, thus paving the way to a more rational and effective application that can allow to diagnose many more PA patients with a unilateral form of the disease to be referred for curative adrenalectomy. Moreover, microcatheters and androstenedione have been introduced to increase the success rate. This review provides updated information on the subtyping of PA by means of AVS and examines key issues on the selection and preparation of patients, the optimal performance of the procedure, and the interpretation of its results for diagnostic purposes, even in the most challenging cases. Situations when AVS can be omitted before surgery and alternative functional imaging techniques that have been proposed to identify unilateral surgical curable PA to circumvent the bottle-neck represented by the limited availability of AVS world-wide, are also discussed.","PeriodicalId":11544,"journal":{"name":"Endocrine reviews","volume":" ","pages":""},"PeriodicalIF":22.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucose-Dependent Insulinotropic Polypeptide in Incretin Physiology: Role in Health and Disease. 葡萄糖依赖型胰岛素多肽在肠促胰岛素生理学中的作用：在健康和疾病中的作用。

IF 22 1区医学

Endocrine reviews Pub Date : 2025-02-14 DOI: 10.1210/endrev/bnaf006

M Michael Wolfe, Michael O Boylan, Wiliam W Chin

{"title":"Glucose-Dependent Insulinotropic Polypeptide in Incretin Physiology: Role in Health and Disease.","authors":"M Michael Wolfe, Michael O Boylan, Wiliam W Chin","doi":"10.1210/endrev/bnaf006","DOIUrl":"https://doi.org/10.1210/endrev/bnaf006","url":null,"abstract":"Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino acid hormone that is synthesized and released from upper intestinal enteroendocrine K-cells in response to the ingestion of glucose or fat. The structure of GIP places it in the secretin/vasoactive intestinal polypeptide family of gastrointestinal regulatory peptides. Although originally named \"gastric inhibitory polypeptide\" on the basis of its ability to inhibit gastric acid secretion, GIP accounts for 60%-80% of the postprandial insulin response, consistent with the notion that this regulatory peptide constitutes the principal physiological incretin. Under normal conditions, GIP plays a major role in nutrient deposition and storage, both directly through its insulin mimetic properties and indirectly by enhancing insulin release. GIP is overexpressed in obese individuals, which may exacerbate insulin resistance manifested by many patients with type 2 diabetes mellitus. Enhanced postprandial secretion of GIP also initiates a vicious cycle characterized by increased nutrient uptake and storage in adipocytes, leading to insulin resistance and hyperinsulinemia, which then further increases adipocyte nutrient uptake and storage. Despite the deleterious consequences of GIP overexpression, when combined with glucagon-like peptide-1 analogues, GIP agonism has been demonstrated to provide benefit in treating obesity by mechanisms currently not fully elucidated. In contrast, consistent with the etiologic role of GIP overexpression in the pathogenesis of obesity, both genetic abrogation and immunoneutralization of GIP signaling have been shown to reduce the development of obesity in preclinical models. Whether these beneficial effects of GIP antagonism will be extended to humans needs to be determined.","PeriodicalId":11544,"journal":{"name":"Endocrine reviews","volume":" ","pages":""},"PeriodicalIF":22.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New horizons in Klinefelter syndrome: current evidence, gaps and research priorities. 克氏综合征的新视野：目前的证据、差距和研究重点。

IF 22 1区医学

Endocrine reviews Pub Date : 2025-02-11 DOI: 10.1210/endrev/bnaf005

Angela K Lucas-Herald, Lise Aksglaede, Ida Dyhr Caspersen, Syed Faisal Ahmed, Francesco Carlomagno, Andrea M Isidori

{"title":"New horizons in Klinefelter syndrome: current evidence, gaps and research priorities.","authors":"Angela K Lucas-Herald, Lise Aksglaede, Ida Dyhr Caspersen, Syed Faisal Ahmed, Francesco Carlomagno, Andrea M Isidori","doi":"10.1210/endrev/bnaf005","DOIUrl":"https://doi.org/10.1210/endrev/bnaf005","url":null,"abstract":"Klinefelter Syndrome (KS) is caused by the presence of a supernumerary X-chromosome (conferring the classical 47,XXY karyotype) and is the commonest sex chromosome abnormality in men. The clinical features described in the early characterisation of the syndrome include tall stature, small testes, hypogonadism, gynecomastia and neurodevelopmental deficits. However, the syndrome presents a broad phenotypic spectrum that seems to be evolving, along with environmental and general health changes. Although a proportion of men with KS are asymptomatic, others experience numerous severe comorbidities, ranging from cardiovascular to autoimmune disorders. Once considered a hallmark of the syndrome, the inability to conceive can now be overcome with assisted reproductive technology. The neuropsychological stigmata, once overstated, thereafter inadvertently dismissed, now demand a more balanced and objective approach. Significant advances have been made in our understanding of KS over recent years, including the molecular machinery involved in the chromosomal disjunction that gives rise to the syndrome. Our understanding of the risk-benefit of testosterone replacement therapy has greatly improved; however, many gaps persist. Future work should be prioritised according to the needs of people with KS. There are opportunities for new research addressing the fields of fertility, cardiovascular prevention, neurodevelopment, quality of life and bone health. Above all, solid registries and extensive prospective longitudinal studies are needed to enrol people with KS to determine their evolving needs as they progress through their lifespan. These studies would be best initiated with international collaboration to ensure the results apply to all those with this condition worldwide.","PeriodicalId":11544,"journal":{"name":"Endocrine reviews","volume":" ","pages":""},"PeriodicalIF":22.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of maternal vitamin D supplementation on childhood health. 母亲补充维生素D对儿童健康的影响。

IF 20.3 1区医学

Endocrine reviews Pub Date : 2025-01-21 DOI: 10.1210/endrev/bnaf001

Nanna S Svensson,Tabia Volqvartz,Anna Louise Vestergaard,Esben T Vestergaard,Agnete Larsen,Pinar Bor

{"title":"Effects of maternal vitamin D supplementation on childhood health.","authors":"Nanna S Svensson,Tabia Volqvartz,Anna Louise Vestergaard,Esben T Vestergaard,Agnete Larsen,Pinar Bor","doi":"10.1210/endrev/bnaf001","DOIUrl":"https://doi.org/10.1210/endrev/bnaf001","url":null,"abstract":"Vitamin D deficiency during pregnancy is associated with an increased risk of health issues in the offspring. Accordingly, recent Endocrine Society guidelines strongly support supplementation in pregnancy, also underlining that without consensus on optimal maternal vitamin D levels, routine screening is currently irrelevant. Knowledge of organ-specific effects of vitamin D and its association with maternal vitamin D status may aid to optimize vitamin D supplementation. This systematic review outlines the proposed next-generation effects of vitamin D supplementation ≥ 400 IU/d, and explores whether such effects are attributed to a specific maternal vitamin D level obtained during pregnancy. A systematic literature search was conducted in PubMed and Embase according to the PRISMA guidelines, focusing on health outcomes from ten days post-partum and beyond. Of the 2,383 screened articles, 39 were included. In 11 of 16 studies, vitamin D supplementation reduced respiratory tract infections in the first years of life. Growth or bone development benefits were observed in six of 12 studies. Positive effects on neurodevelopment and reduced autoimmune risk (diabetes-related antibodies) were noted, although further research is needed to determine the role of vitamin D. Very few studies have measured vitamin D concentrations, but even 1,600 IU/d supplementation was associated with high frequency of infant vitamin D insufficiency. Current recommendations may not ensure sufficient vitamin D levels at birth, among others, increasing the risk of early-life infections. Further studies linking maternal and infant vitamin D levels to specific outcomes would aid in personalized nutritional advice during pregnancy and improve next-generation health.","PeriodicalId":11544,"journal":{"name":"Endocrine reviews","volume":"32 1","pages":""},"PeriodicalIF":20.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiometabolic Aspects of Congenital Adrenal Hyperplasia. 先天性肾上腺皮质增生症的心脏代谢问题

IF 22 1区医学

Endocrine reviews Pub Date : 2025-01-10 DOI: 10.1210/endrev/bnae026

Robert Krysiak, Hedi L Claahsen-van der Grinten, Nicole Reisch, Philippe Touraine, Henrik Falhammar

{"title":"Cardiometabolic Aspects of Congenital Adrenal Hyperplasia.","authors":"Robert Krysiak, Hedi L Claahsen-van der Grinten, Nicole Reisch, Philippe Touraine, Henrik Falhammar","doi":"10.1210/endrev/bnae026","DOIUrl":"10.1210/endrev/bnae026","url":null,"abstract":"Treatment of classic congenital adrenal hyperplasia (CAH) is directed at replacing deficient hormones and reducing androgen excess. However, even in the era of early diagnosis and lifelong hormonal substitution, the presence of CAH is still associated with numerous complications and also with increased mortality. The aim of this article was to create an authoritative and balanced review concerning cardiometabolic risk in patients with CAH. The authors searched all major databases and scanned reference lists of all potentially eligible articles to find relevant articles. The risk was compared with that in other forms of adrenal insufficiency. The reviewed articles, most of which were published recently, provided conflicting results, which can be partially explained by differences in the inclusion criteria and treatment, small sample sizes, and gene-environment interactions. However, many studies showed that the presence of CAH is associated with an increased risk of weight gain, worsening of insulin sensitivity, high blood pressure, endothelial dysfunction, early atherosclerotic changes in the vascular wall, and left ventricular diastolic dysfunction. These complications were more consistently reported in patients with classic than nonclassic CAH and were in part related to hormonal and functional abnormalities associated with this disorder and/or to the impact of overtreatment and undertreatment. An analysis of available studies suggests that individuals with classic CAH are at increased cardiometabolic risk. Excess cardiovascular and metabolic morbidity is likely multifactorial, related to glucocorticoid overtreatment, imperfect adrenal hormone replacement therapy, androgen excess, and adrenomedullary failure. Cardiometabolic effects of new therapeutic approaches require future targeted studies.","PeriodicalId":11544,"journal":{"name":"Endocrine reviews","volume":" ","pages":"80-148"},"PeriodicalIF":22.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11720181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Cortisol Awakening Response: Regulation and Functional Significance. 皮质醇觉醒反应：调节和功能意义。

IF 22 1区医学

Endocrine reviews Pub Date : 2025-01-10 DOI: 10.1210/endrev/bnae024

Tobias Stalder, Henrik Oster, James L Abelson, Katharina Huthsteiner, Tim Klucken, Angela Clow

{"title":"The Cortisol Awakening Response: Regulation and Functional Significance.","authors":"Tobias Stalder, Henrik Oster, James L Abelson, Katharina Huthsteiner, Tim Klucken, Angela Clow","doi":"10.1210/endrev/bnae024","DOIUrl":"10.1210/endrev/bnae024","url":null,"abstract":"In healthy individuals, the majority of cortisol secretion occurs within several hours surrounding morning awakening. A highly studied component of this secretory period is the cortisol awakening response (CAR), the rapid increase in cortisol levels across the first 30 to 45 minutes after morning awakening. This strong cortisol burst at the start of the active phase has been proposed to be functional in preparing the organism for the challenges of the upcoming day. Here, we review evidence on key regulatory and functional processes of the CAR and develop an integrative model of its functional role. Specifically, we propose that, in healthy individuals, the CAR is closely regulated by an intricate dual-control system, which draws upon key circadian, environmental, and neurocognitive processes to best predict the daily need for cortisol-related action. Fine-tuned CAR expression, in turn, is then assumed to induce potent glucocorticoid action via rapid nongenomic and slower genomic pathways (eg, affecting circadian clock gene expression) to support and modulate daily activity through relevant metabolic, immunological, and neurocognitive systems. We propose that this concerted action is adaptive in mediating two main functions: a primary process to mobilize resources to meet activity-related demands and a secondary process to help the organism counterregulate adverse prior-day emotional experiences.","PeriodicalId":11544,"journal":{"name":"Endocrine reviews","volume":" ","pages":"43-59"},"PeriodicalIF":22.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postbiotic Impact on Host Metabolism and Immunity Provides Therapeutic Potential in Metabolic Disease. 后生物对宿主新陈代谢和免疫的影响为代谢性疾病的治疗提供了潜力。

IF 22 1区医学

Endocrine reviews Pub Date : 2025-01-10 DOI: 10.1210/endrev/bnae025

Han Fang, Rodrigo Rodrigues E-Lacerda, Nicole G Barra, Dana Kukje Zada, Nazli Robin, Alina Mehra, Jonathan D Schertzer

{"title":"Postbiotic Impact on Host Metabolism and Immunity Provides Therapeutic Potential in Metabolic Disease.","authors":"Han Fang, Rodrigo Rodrigues E-Lacerda, Nicole G Barra, Dana Kukje Zada, Nazli Robin, Alina Mehra, Jonathan D Schertzer","doi":"10.1210/endrev/bnae025","DOIUrl":"10.1210/endrev/bnae025","url":null,"abstract":"The gut microbiota influences aspects of metabolic disease, including tissue inflammation, adiposity, blood glucose, insulin, and endocrine control of metabolism. Prebiotics or probiotics are often sought to combat metabolic disease. However, prebiotics lack specificity and can have deleterious bacterial community effects. Probiotics require live bacteria to find a colonization niche sufficient to influence host immunity or metabolism. Postbiotics encompass bacterial-derived components and molecules, which are well-positioned to alter host immunometabolism without relying on colonization efficiency or causing widespread effects on the existing microbiota. Here, we summarize the potential for beneficial and detrimental effects of specific postbiotics related to metabolic disease and the underlying mechanisms of action. Bacterial cell wall components, such as lipopolysaccharides, muropeptides, lipoteichoic acids and flagellin, have context-dependent effects on host metabolism by engaging specific immune responses. Specific types of postbiotics within broad classes of compounds, such as lipopolysaccharides and muropeptides, can have opposing effects on endocrine control of host metabolism, where certain postbiotics are insulin sensitizers and others promote insulin resistance. Bacterial metabolites, such as short-chain fatty acids, bile acids, lactate, glycerol, succinate, ethanolamine, and ethanol, can be substrates for host metabolism. Postbiotics can fuel host metabolic pathways directly or influence endocrine control of metabolism through immunomodulation or mimicking host-derived hormones. The interaction of postbiotics in the host-microbe relationship should be considered during metabolic inflammation and metabolic disease.","PeriodicalId":11544,"journal":{"name":"Endocrine reviews","volume":" ","pages":"60-79"},"PeriodicalIF":22.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11720174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adiponectin and Adiponectin Receptors in Atherosclerosis. 动脉粥样硬化中的脂肪连接素和脂肪连接素受体

IF 22 1区医学

Endocrine reviews Pub Date : 2025-01-10 DOI: 10.1210/endrev/bnae021

Ioanna Gianopoulos, Christos S Mantzoros, Stella S Daskalopoulou

{"title":"Adiponectin and Adiponectin Receptors in Atherosclerosis.","authors":"Ioanna Gianopoulos, Christos S Mantzoros, Stella S Daskalopoulou","doi":"10.1210/endrev/bnae021","DOIUrl":"10.1210/endrev/bnae021","url":null,"abstract":"Adiponectin is an abundantly secreted hormone that communicates information between the adipose tissue, and the immune and cardiovascular systems. In metabolically healthy individuals, adiponectin is usually found at high levels and helps improve insulin responsiveness of peripheral tissues, glucose tolerance, and fatty acid oxidation. Beyond its metabolic functions in insulin-sensitive tissues, adiponectin plays a prominent role in attenuating the development of atherosclerotic plaques, partially through regulating macrophage-mediated responses. In this context, adiponectin binds to its receptors, adiponectin receptor 1 (AdipoR1) and AdipoR2 on the cell surface of macrophages to activate a downstream signaling cascade and induce specific atheroprotective functions. Notably, macrophages modulate the stability of the plaque through their ability to switch between proinflammatory responders, and anti-inflammatory proresolving mediators. Traditionally, the extremes of the macrophage polarization spectrum span from M1 proinflammatory and M2 anti-inflammatory phenotypes. Previous evidence has demonstrated that the adiponectin-AdipoR pathway influences M1-M2 macrophage polarization; adiponectin promotes a shift toward an M2-like state, whereas AdipoR1- and AdipoR2-specific contributions are more nuanced. To explore these concepts in depth, we discuss in this review the effect of adiponectin and AdipoR1/R2 on 1) metabolic and immune responses, and 2) M1-M2 macrophage polarization, including their ability to attenuate atherosclerotic plaque inflammation, and their potential as therapeutic targets for clinical applications.","PeriodicalId":11544,"journal":{"name":"Endocrine reviews","volume":" ","pages":"1-25"},"PeriodicalIF":22.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11720176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure and Function of Somatostatin and Its Receptors in Endocrinology. 内分泌学中的促生长素及其受体的结构和功能。

IF 22 1区医学

Endocrine reviews Pub Date : 2025-01-10 DOI: 10.1210/endrev/bnae022

Bo Zhang, Li Xue, Zhe Bao Wu

{"title":"Structure and Function of Somatostatin and Its Receptors in Endocrinology.","authors":"Bo Zhang, Li Xue, Zhe Bao Wu","doi":"10.1210/endrev/bnae022","DOIUrl":"10.1210/endrev/bnae022","url":null,"abstract":"Somatostatin analogs, such as octreotide, lanreotide, and pasireotide, which function as somatostatin receptor ligands (SRLs), are the main drugs used for the treatment of acromegaly. These ligands are also used as important molecules for radiation therapy and imaging of neuroendocrine tumors. Somatostatin receptors (SSTRs) are canonical G protein-coupled proteins that play a role in metabolism, growth, and pathological conditions such as hormone disorders, neurological diseases, and cancers. Cryogenic electron microscopy combined with the protein structure prediction platform AlphaFold has been used to determine the 3-dimensional structures of many proteins. Recently, several groups published a series of papers illustrating the 3-dimensional structure of SSTR2, including that of the inactive/activated SSTR2-G protein complex bound to different ligands. The results revealed the residues that contribute to the ligand binding pocket and demonstrated that Trp8-Lys9 (the W-K motif) in somatostatin analogs is the key motif in stabilizing the bottom part of the binding pocket. In this review, we discuss the recent findings related to the structural analysis of SSTRs and SRLs, the relationships between the structural data and clinical findings, and the future development of novel structure-based therapies.","PeriodicalId":11544,"journal":{"name":"Endocrine reviews","volume":" ","pages":"26-42"},"PeriodicalIF":22.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Developments in Parasellar Tumors and Potential Therapeutic Implications. 寄生虫肿瘤的分子发展及潜在治疗意义。

IF 22 1区医学

Endocrine reviews Pub Date : 2024-11-22 DOI: 10.1210/endrev/bnae020

Paraskevi Xekouki, Vasiliki Venetsanaki, Georgios Kyriakopoulos, Krystallenia Alexandraki, Anna Angelousi, Gregory Kaltsas

{"title":"Molecular Developments in Parasellar Tumors and Potential Therapeutic Implications.","authors":"Paraskevi Xekouki, Vasiliki Venetsanaki, Georgios Kyriakopoulos, Krystallenia Alexandraki, Anna Angelousi, Gregory Kaltsas","doi":"10.1210/endrev/bnae020","DOIUrl":"10.1210/endrev/bnae020","url":null,"abstract":"The parasellar region is the anatomical area around the sella turcica that represents a crucial crossroad for important adjacent structures. Several distinct tumors can primarily originate from this area, the most common being meningiomas, gliomas, embryonal cell tumors, germ cell tumors, and craniopharyngiomas. In addition, a number of systemic and inflammatory disorders can also affect the parasellar region, most commonly involving the pituitary. These lesions have different pathologic characteristics and malignant potential according to the new World Health Organization CNS5 2021 classification. Signs and symptoms may be nonspecific and are mostly related to a mass effect on the surrounding anatomical structures and/or impairment of endocrine function, whereas the vast majority lack a secretory component. The mutational signature analysis based on advances in molecular techniques has recently enabled the identification of specific gene mutations or signaling pathway aberrations. These developments may serve as a powerful means to delineate the pathophysiology of these lesions and serve as a diagnostic, prognostic, and therapeutic tool, particularly for high-risk populations. Treatment options include surgery alone or in combination with radiotherapy, chemotherapy, and disease-specific medical therapy, in order to prevent recurrence or further tumor growth along with replacement of coexistent pituitary hormonal deficiencies. In this comprehensive review, we present the current state-of-the-art developments in the histopathology and molecular biology of parasellar lesions, which often represent a diagnostic and therapeutic challenge, that may be utilized by a dedicated multidisciplinary team for the diagnosis, monitoring, and treatment of these lesions.","PeriodicalId":11544,"journal":{"name":"Endocrine reviews","volume":" ","pages":"880-911"},"PeriodicalIF":22.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141765738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0