Endocrinologia japonica最新文献_第8页

A case of Graves' disease and papillary thyroid carcinoma with predominant production of thyroid-stimulation-blocking antibodies (TSBAb) persisted after total thyroidectomy. 格雷夫斯病合并甲状腺乳头状癌，甲状腺刺激阻断抗体(TSBAb)在全甲状腺切除术后持续产生。

Endocrinologia japonica Pub Date : 1992-02-01 DOI: 10.1507/endocrj1954.39.133

S Nakamura, M Ishiyama-Takuno, J Kosaka, K Kondo, Y Horiya, S Hara, H Shima, T Shiraki

引用次数: 5

Biochemical analysis of the bone of SHC rats with spontaneous hypercholesterolemia and renal dysfunction. 自发性高胆固醇血症和肾功能不全SHC大鼠骨生化分析。

Endocrinologia japonica Pub Date : 1992-02-01 DOI: 10.1507/endocrj1954.39.147

K Sudo, K Shiota, T Masaki, R Tsukuda, T Fujita

{"title":"Biochemical analysis of the bone of SHC rats with spontaneous hypercholesterolemia and renal dysfunction.","authors":"K Sudo, K Shiota, T Masaki, R Tsukuda, T Fujita","doi":"10.1507/endocrj1954.39.147","DOIUrl":"https://doi.org/10.1507/endocrj1954.39.147","url":null,"abstract":"Spontaneously hypercholesterolemic (SHC) rats exhibit severe abnormalities in renal function and bone metabolism at old ages, in addition to hypercholesterolemia. SHC rats were also found to show endocrine abnormalities such as hyperthyroidism from young ages. In this study, biochemical and microdensitometric analyses were carried out using femurs to characterize further the abnormality in bone metabolism: whether biochemical markers of the bone may be affected by these abnormalities. At 6 weeks of age, the ashed weight and calcium content of the dried femurs were slightly lower in SHC rats than in age-matched Sprague-Dawley (SD) rats. None of the markers of microdensitometric analysis was changed. At 24 weeks of age, the ashed weight of dried femurs and the density of the marrow region of femurs were lower in the SHC rats. The results indicate that SHC rats exhibit severe abnormality in bone metabolism leading to biochemical changes in the bone at old ages whereas changes in bone markers were minimal at young ages before the onset of severe renal dysfunction.","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"39 1","pages":"147-51"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.39.147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12773207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of the outcome of postoperative hypocalcemia in Graves' disease. Graves病术后低血钙预后的预测。

Endocrinologia japonica Pub Date : 1992-02-01 DOI: 10.1507/endocrj1954.39.103

T Murakami, J Tajiri, S Noguchi, N Murakami, R Kato, Y Taniguchi, Y Ohta

{"title":"Prediction of the outcome of postoperative hypocalcemia in Graves' disease.","authors":"T Murakami, J Tajiri, S Noguchi, N Murakami, R Kato, Y Taniguchi, Y Ohta","doi":"10.1507/endocrj1954.39.103","DOIUrl":"https://doi.org/10.1507/endocrj1954.39.103","url":null,"abstract":"Symptomatic hypocalcemia sometimes follows subtotal thyroidectomy for Graves' disease. Irreversible damage to the parathyroids contributes to permanent hypocalcemia and the mechanism for a transient hypocalcemia is thought to be different from that of a permanent one. However, sensitive assays for parathyroid hormones (PTH), which had recently become available, revealed that levels of PTH decrease in patients with transient hypocalcemia. In order to differentiate a prolonged hypocalcemia from a transient one, calcium and inorganic phosphate concentrations in serum as well as in urine, and whole molecule-PTH levels were determined in 18 Graves' disease patients with postoperative hypocalcemia just after the initial symptoms for hypocalcemia appeared. In 13 patients, medication was withdrawn within one month since serum calcium levels had returned to normal (transient hypocalcemia). In five other patients, medication was required for six months or more to maintain normocalcemia (prolonged hypocalcemia). The same parameters were determined after surgery in eight Graves' disease patients without hypocalcemia. Urinary inorganic phosphate concentrations in patients with prolonged hypocalcemia (0.02 +/- 0.01 mmol/mmol Cr) were significantly lower (P less than 0.01) than those in patients with transient hypocalcemia (1.59 +/- 1.59 mmol/mmol Cr) or those in control patients (1.27 +/- 0.70 mmol/mmol Cr). Preoperative concentrations of calcium and inorganic phosphate in serum and urine, and serum alkaline-phosphatase activities were also determined. However, there were no significant differences in these parameters between patients with prolonged and those with transient hypocalcemia. It is concluded that prolonged hypocalcemia is discriminated from the transient type by determining the urinary inorganic phosphate at the time of appearance of the initial symptoms for hypocalcemia.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"39 1","pages":"103-7"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.39.103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12773993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The renotropic effect of ovine luteinizing hormone on subtotally nephrectomized rats. 羊黄体生成素对肾大部切除大鼠的促肾作用。

Endocrinologia japonica Pub Date : 1992-02-01 DOI: 10.1507/endocrj1954.39.109

T Takeuchi, E Higashihara, K Nomura, N Moriyama, Y Aso, H Demura

{"title":"The renotropic effect of ovine luteinizing hormone on subtotally nephrectomized rats.","authors":"T Takeuchi, E Higashihara, K Nomura, N Moriyama, Y Aso, H Demura","doi":"10.1507/endocrj1954.39.109","DOIUrl":"https://doi.org/10.1507/endocrj1954.39.109","url":null,"abstract":"Some of luteinizing hormone (LH) isoforms can stimulate renal growth. The objective of this study is to determine whether the administration of LH modifies subtotal nephrectomy-induced chronic renal failure. Castrated 3/4-nephrectomized male rats were divided into four groups of seven each and fed a low-protein (6%) diet. Ovine LH with renotropic activity (40 micrograms/day) or vehicle only (control) was given for three weeks or six weeks. Compared with controls, remnant kidney weights (% body weight) in LH-treated rats had increased significantly at three weeks (0.385 +/- 0.019 vs 0.443 +/- 0.052, P less than 0.02), but not at six weeks (0.281 +/- 0.004 vs 0.272 +/- 0.013). 24 h creatinine clearance (ml/day/100 g body weight) increased significantly both by three weeks (242 +/- 58 vs 301 +/- 36, P less than 0.05), and six weeks (323 +/- 55 vs 395 +/- 10, P less than 0.01). Urinary thromboxane B2 excretion increased in LH-treated rats, suggesting that hemodynamic changes may play a role in increasing creatinine clearance. Our results suggest that renotropically active oLH stimulated the glomerular function in castrated rats with reduced renal mass. Further study may clarify its clinical usefulness.","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"39 1","pages":"109-14"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.39.109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12773994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Impaired water diuresis in a patient with pseudo-Bartter syndrome. 伪巴特综合征患者的水利尿功能受损。

Endocrinologia japonica Pub Date : 1992-02-01 DOI: 10.1507/endocrj1954.39.65

M Shoji, T Kimura, K Ota, M Inoue, K Sato, M Ohta, T Yamamoto, T Furuyama, K Abe, K Yoshinaga

{"title":"Impaired water diuresis in a patient with pseudo-Bartter syndrome.","authors":"M Shoji, T Kimura, K Ota, M Inoue, K Sato, M Ohta, T Yamamoto, T Furuyama, K Abe, K Yoshinaga","doi":"10.1507/endocrj1954.39.65","DOIUrl":"https://doi.org/10.1507/endocrj1954.39.65","url":null,"abstract":"A 32-year-old man was diagnosed as having pseudo-Bartter syndrome due to surreptitious habitual vomiting and to maldigestion related to decayed teeth. His chief complaints were muscle pain and weakness. In this case, metabolic alkalosis, hypokalemia, hypochloremia, increased plasma renin activity and aldosterone levels were noticed with marked decreases in urinary chloride excretion. Creatinine clearance (GFR) and renal plasma flow (RPF) were also decreased. Blood pressure was normal, but the pressor response to angiotensin II was attenuated. Before treatment with 0.9% saline infusion, plasma vasopressin (AVP) was not suppressed sufficiently by lowering the plasma osmolality (Posm) with an oral water load (WL), but it normally responded to a rise in Posm due to hypertonic saline infusion. Moreover, plasma AVP was normally suppressed by WL after the replenishment of saline. Plasma atrial natriuretic peptide (ANP) was low before WL, but increased normally in response to WL. However, inconsistent with the normal response in this case, decreases in plasma AVP failed to dilute urinary osmolality and to increase urine flow, irrespective of the levels of plasma ANP. These results indicate that chronic inanition due to surreptitious vomiting causes impaired renal diluting ability through decreases in GFR and RPF, irrespective of the levels of plasma AVP and ANP.","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"39 1","pages":"65-71"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.39.65","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12703553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A case of asymptomatic cortisol producing adrenal adenoma. 无症状皮质醇产生肾上腺腺瘤1例。

Endocrinologia japonica Pub Date : 1992-02-01 DOI: 10.1507/endocrj1954.39.19

M Noritake, K Morimoto, H Kosano, Y Nemoto, N Kugai, M Takao, M Murai, S Tamai, K Tanaka, N Nagata

{"title":"A case of asymptomatic cortisol producing adrenal adenoma.","authors":"M Noritake, K Morimoto, H Kosano, Y Nemoto, N Kugai, M Takao, M Murai, S Tamai, K Tanaka, N Nagata","doi":"10.1507/endocrj1954.39.19","DOIUrl":"https://doi.org/10.1507/endocrj1954.39.19","url":null,"abstract":"We describe a man without the clinical findings of Cushing's syndrome, but who harbored an incidentally found cortisol-producing adrenal adenoma. On adrenal 131I-adsterol imaging, there was good uptake to the nodule, but no visualization of the contralateral adrenal. No abnormalities were found in the basal plasma cortisol, ACTH, urinary free cortisol and 17OHCS. However, dynamic hormone assessment revealed the existence of abnormal cortisol secretion: no suppression to dexamethasone, incomplete response to human corticotropin-releasing hormone, and lack of diurnal variation in plasma cortisol. Left adrenalectomy was performed with the diagnosis of cortisol-producing adrenal tumor. The pathological finding was an adrenal adenoma, and the perifusion of the excised tissues revealed a negligible response of the tumor tissue to ACTH though the residual normal cortex responded. Postoperative course was uneventful without replacement therapy with cortisol. It is suggested that the tumor autonomously produced a small amount of cortisol not only insufficient to provide clinical Cushing's syndrome, but also to provide typical suppression of hypothalamo-pituitary corticotroph-adrenal system.","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"39 1","pages":"19-24"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.39.19","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12773210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Thyroid function before and after induced abortion in normal pregnant women. 正常孕妇人工流产前后甲状腺功能的比较。

Endocrinologia japonica Pub Date : 1992-02-01 DOI: 10.1507/endocrj1954.39.13

H Hara, Y Ban, Y Morita, R Sato

引用次数: 2

Splenic macrophages enhance prolactin and luteinizing hormone action in rat luteal cell cultures. 脾巨噬细胞增强大鼠黄体细胞培养中催乳素和黄体生成素的作用。

Endocrinologia japonica Pub Date : 1992-02-01 DOI: 10.1507/endocrj1954.39.51

S Matsuyama, K Shiota, C Tachi, M Nishihara, M Takahashi

{"title":"Splenic macrophages enhance prolactin and luteinizing hormone action in rat luteal cell cultures.","authors":"S Matsuyama, K Shiota, C Tachi, M Nishihara, M Takahashi","doi":"10.1507/endocrj1954.39.51","DOIUrl":"https://doi.org/10.1507/endocrj1954.39.51","url":null,"abstract":"We have reported that splenic macrophages play a role in the regulation of progestin secretion in rats. In this study, splenic macrophages were obtained from cycling rats at different estrous cycle stages and co-cultured with luteal cells from mid-pseudopregnant rats in the absence/presence of prolactin (PRL) or luteinizing hormone (LH). The effect of macrophages on the luteotropic action of PRL and LH was evaluated with 2 parameters, i.e. an increase in total progestin output (progesterone plus 20 alpha-hydroxyprgn-4-en-one [20 alpha-OHP]), and an increase in the progesterone to 20 alpha-OHP (P/20 alpha-OHP) secretion ratio. Splenic macrophages obtained from proestrous or metestrous rats enhanced the PRL action to increase the P/20 alpha-OHP secretion ratio, but those from estrous or diestrous donors did not. Only macrophages from proestrous donors enhanced the PRL action to increase the total progestin output. In contrast, the LH action increasing the P/20 alpha-OHP secretion ratio was enhanced by splenic macrophages regardless of the donors' estrous cycle stages. The LH action increasing the total progestin output was enhanced only by proestrous or metestrous macrophages. Therefore, if luteal cells are co-cultured with proestrous macrophages, the luteotropic actions of PRL and LH can be fully expressed. These results indicate that splenic macrophages directly act on luteal cells and enhance the luteotropic action of PRL and LH, and that this function of splenic macrophages is modified somehow according to the donors' estrous cycle stages.","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"39 1","pages":"51-7"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.39.51","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12773212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Endocrinological evaluation of GH deficient patient with acromegaloidism showing excessive growth. 生长激素缺乏伴肢端肥大症患者生长过度的内分泌学评价。

Endocrinologia japonica Pub Date : 1992-02-01 DOI: 10.1507/endocrj1954.39.59

N Iwatani, M Kodama, T Miike

引用次数: 3

Cyclosporine A inhibits the secretion of certain anterior pituitary hormones in patients with nephrotic syndrome. 环孢素A抑制肾病综合征患者某些垂体前叶激素的分泌。

Endocrinologia japonica Pub Date : 1992-02-01 DOI: 10.1507/endocrj1954.39.129

Y Nagai, H Miyakoshi, K Ohsawa, Y Ieki, T Takamura, K Kobayashi

{"title":"Cyclosporine A inhibits the secretion of certain anterior pituitary hormones in patients with nephrotic syndrome.","authors":"Y Nagai, H Miyakoshi, K Ohsawa, Y Ieki, T Takamura, K Kobayashi","doi":"10.1507/endocrj1954.39.129","DOIUrl":"https://doi.org/10.1507/endocrj1954.39.129","url":null,"abstract":"To clarify the effects of cyclosporine A (CsA) on the secretion of serum thyrotropin (TSH), prolactin (PRL), luteinizing hormone (LH) and follicular stimulating hormone (FSH), we performed TRH and LH-RH testing in 4 patients with the nephrotic syndrome before and after the administration of CsA, 6 mg/kg/day for 4 to 12 weeks. Prior to CsA all patients responded normally to TRH with respect to TSH and PRL secretion. Two patients showed normal response of LH and FSH to LH-RH stimulation while the response in 2 other patients, who were both menopausal, was exaggerated. By the third or fourth week of CsA administration the basal and peak TSH and PRL values declined significantly in all patients in response to TRH stimulation while those of LH and FSH showed only a modest decrease in response to LH-RH stimulation. Two to 4 weeks after the cessation of CsA the response of TSH, PRL and FSH returned to the pretreatment level. These observations suggest that: 1) CsA exerts an inhibitory effect on the secretion of at least TSH and PRL in humans, and 2) the effect of CsA on the pituitary may be partially reversible after the cessation of the therapy.","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"39 1","pages":"129-32"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.39.129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12774000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7