Endocrinologia japonica最新文献_第9页

In vivo effect of pituitary adenylate cyclase activating polypeptide 38 (PACAP 38) on the secretion of luteinizing hormone (LH) in male rats. 垂体腺苷酸环化酶激活多肽38 (pacap38)对雄性大鼠体内促黄体生成素(LH)分泌的影响。

Endocrinologia japonica Pub Date : 1992-02-01 DOI: 10.1507/endocrj1954.39.153

Y Osuga, N Mitsuhashi, M Mizuno

{"title":"In vivo effect of pituitary adenylate cyclase activating polypeptide 38 (PACAP 38) on the secretion of luteinizing hormone (LH) in male rats.","authors":"Y Osuga, N Mitsuhashi, M Mizuno","doi":"10.1507/endocrj1954.39.153","DOIUrl":"https://doi.org/10.1507/endocrj1954.39.153","url":null,"abstract":"In view of the recent demonstrations that pituitary adenylate cyclase activating polypeptide (PACAP) 38 stimulates the release of LH from superfused pituitary cells and that the hypothalamus and anterior pituitary have highly selective binding sites for the peptide, we have surveyed the effect of intraatrial injections of PACAP 38 and vasoactive intestinal peptide (VIP), which has 68% homology with PACAP 38, in intact adult male rats. Furthermore the effect of intracerebroventricular (icv) injection of PACAP 38 was investigated. Intraatrial (10, 30, 100 micrograms) and icv (8, 32 micrograms) administration of PACAP 38 stimulated LH release significantly (P less than 0.01) in a dose-related fashion. Icv injection at a dose of 0.8 microgram was ineffective. The time course pattern of LH release by intraatrial injection and that by icv injection was similar, but the LH levels increased by intraatrial injection were much higher than that by icv injection. Intraatrial administration of VIP had almost no effect on LH release. These findings suggested that PACAP 38 stimulates LH release in vivo.","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"39 1","pages":"153-6"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.39.153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12773209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 61

Disordered expression of adrenal steroidogenic P450 mRNAs in incidentally discovered nonfunctioning adrenal adenoma. 偶然发现的无功能肾上腺腺瘤中肾上腺甾体原性P450 mrna的表达紊乱。

Endocrinologia japonica Pub Date : 1992-02-01 DOI: 10.1507/endocrj1954.39.73

A Ogo, M Haji, M Ohashi, R Takayanagi, T Yanase, H Nawata

{"title":"Disordered expression of adrenal steroidogenic P450 mRNAs in incidentally discovered nonfunctioning adrenal adenoma.","authors":"A Ogo, M Haji, M Ohashi, R Takayanagi, T Yanase, H Nawata","doi":"10.1507/endocrj1954.39.73","DOIUrl":"https://doi.org/10.1507/endocrj1954.39.73","url":null,"abstract":"In order to elucidate the steroidogenesis of clinically nonfunctioning adrenocortical adenoma, we studied the aldosterone, cortisol (F) and dehydroepiandrosterone (DHEA) content and the expression of mRNA of cytochrome P450 for side chain cleavage (P450scc), 17 alpha-hydroxylase (P450c17). 21-hydroxylase (P450c21) and 11 beta-hydroxylase (P450c11) in four clinically nonfunctioning adrenocortical adenomas discovered incidentally in asymptomatic patients (Cases 1, 2, 3 and 4). The results were compared with those in normal adrenal glands. In the adenomas from cases 1 and 2, the abundance of steroidogenic P450s mRNA were similar to those in normal adrenal glands, except P450c11 mRNA expression in the adenoma from case 1 which was slightly higher than normal. The steroid content was normal level, except for higher F in the adenoma from case 1 and lower aldosterone in case 2 adenoma than normal. The adenoma from case 3 contained much less P450scc, P450c17 and P450c21 mRNA, while the amount of P450c11 mRNA was slightly greater than in normal adrenals. The adenoma showed normal aldosterone, high F and low DHEA content compared with normal adrenal glands. In the adenoma from case 4, the accumulation of all four P450 mRNAs decreased, whereas aldosterone, F and DHEA content in the adenoma was similar to that of normal adrenal glands. These data indicated that nonfunctioning adrenocortical adenoma showed similar or decreased expression of steroidogenic P450 mRNAs that the normal adrenal gland. This decreased expression of steroidogenic P450 mRNAs may be at least partly concerned with the absence of clinical symptoms in patients with nonfunctioning adenoma.","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"39 1","pages":"73-80"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.39.73","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12703554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Spontaneous growth hormone secretion in healthy prepubertal children of normal stature. 正常身材的健康青春期前儿童的自发生长激素分泌。

Endocrinologia japonica Pub Date : 1992-02-01 DOI: 10.1507/endocrj1954.39.9

T Hasegawa, Y Hasegawa, T Yokoyama, S Koto, Y Tsuchiya

{"title":"Spontaneous growth hormone secretion in healthy prepubertal children of normal stature.","authors":"T Hasegawa, Y Hasegawa, T Yokoyama, S Koto, Y Tsuchiya","doi":"10.1507/endocrj1954.39.9","DOIUrl":"https://doi.org/10.1507/endocrj1954.39.9","url":null,"abstract":"To evaluate the dynamics of growth hormone (GH) secretion in healthy prepubertal children of normal stature, we determined spontaneous GH secretion by measuring GH every 30 min in 21 Japanese subjects, age: 5.4 +/- 2.3 (1.6-10.6) years; height: -1.4 +/- 1.1 (-1.98-1.77) SD. The 24-h mean GH concentration was 4.8 +/- 1.5 ng/ml. The 24-h mean GH was similar in boys and girls (mean +/- SD: 4.8 +/- 1.7 vs 4.7 +/- 1.1 ng/ml). No correlation was found between chronological age and the 24-h mean GH. The 24-h mean GH was closely correlated with GH pulse amplitude (r = 0.94; P less than 0.001), but not with the number of GH pulses. The 24-h mean GH was also highly correlated with 3-h mean GH after sleep and 3-h peak GH after sleep (r = 0.86; P less than 0.001 and r = 0.72; P less than 0.001, respectively). Our data suggest that in healthy prepubertal children of normal stature, (1) spontaneous GH secretion is independent of sex and age, (2) the amount of spontaneous GH secretion is controlled by pulse amplitude, not by number of pulses. (3) 3-h mean GH and 3-h peak GH after sleep might represent 24-h total spontaneous GH secretion.","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"39 1","pages":"9-12"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.39.9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12773832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Effect of pravastatin on serum lipids, apolipoproteins and lipoprotein (a) in patients with non-insulin dependent diabetes mellitus. 普伐他汀对非胰岛素依赖型糖尿病患者血脂、载脂蛋白和脂蛋白(a)的影响。

Endocrinologia japonica Pub Date : 1992-02-01 DOI: 10.1507/endocrj1954.39.45

F Umeda, J Watanabe, K Inoue, A Hisatomi, K Mimura, T Yamauchi, Y Sako, M Kunisaki, Y Tajiri, H Nawata

{"title":"Effect of pravastatin on serum lipids, apolipoproteins and lipoprotein (a) in patients with non-insulin dependent diabetes mellitus.","authors":"F Umeda, J Watanabe, K Inoue, A Hisatomi, K Mimura, T Yamauchi, Y Sako, M Kunisaki, Y Tajiri, H Nawata","doi":"10.1507/endocrj1954.39.45","DOIUrl":"https://doi.org/10.1507/endocrj1954.39.45","url":null,"abstract":"In 43 patients with non-insulin dependent diabetes mellitus (NIDDM) associated with hypercholesterolemia, the effect of pravastatin, a potent HMG CoA-reductase inhibitor, on serum lipids, apolipoproteins and lipoprotein (a) was examined. After 1 to 3 months administration of 10 mg per day of pravastatin, the serum levels of total cholesterol, triglycerides and low-density lipoprotein cholesterol (LDL-C) were significantly decreased, while the serum level of high density lipoprotein cholesterol (HDL-C) was significantly increased in patients with NIDDM. The levels of apolipoproteins B (apo B) and E were significantly decreased, while apolipoprotein AI (apo A-I) was not changed by the administration of pravastatin. The atherogenic indices (LDL-C/HDL-C and apo B/apo A-I) were significantly decreased by the administration of this drug. The serum lipoprotein (a), which was increased in the diabetic patients, was not affected by the pravastatin treatment. Plasma glucose and hemoglobin A1c levels were not affected by the treatment. We concluded that pravastatin is a potentially useful agent in the treatment of hypercholesterolemia in patients with NIDDM.","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"39 1","pages":"45-50"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.39.45","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12703552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Gestational profiles of rat placental lactogen-II (rPL-II) and growth hormone (GH) in maternal and fetal serum, amniotic fluid, and placental tissue. 大鼠胎盘乳原- ii (rPL-II)和生长激素(GH)在母胎血清、羊水和胎盘组织中的妊娠谱

Endocrinologia japonica Pub Date : 1991-12-01 DOI: 10.1507/endocrj1954.38.589

K Kishi, M Hirashiba, Y Hasegawa

{"title":"Gestational profiles of rat placental lactogen-II (rPL-II) and growth hormone (GH) in maternal and fetal serum, amniotic fluid, and placental tissue.","authors":"K Kishi, M Hirashiba, Y Hasegawa","doi":"10.1507/endocrj1954.38.589","DOIUrl":"https://doi.org/10.1507/endocrj1954.38.589","url":null,"abstract":"Rat placental lactogen-II (rPL-II) and growth hormone (rGH) in maternal and fetal serum, amniotic fluid, and placental tissue were measured by a homologous radioimmunoassay during the last half of pregnancy. rPL-II appeared first in maternal circulation and the placental tissue on day 11 of pregnancy. The maternal serum rPL-II concentration increased progressively and reached the peak value (684 +/- 76 ng/ml) on day 19, and declined thereafter up to term. rPL-II content in the tissue had a similar pattern to the maternal serum profile of rPL-II, while its concentration in the tissue increased dramatically on day 12 and remained high until day 19. Fetal serum rPL-II was detected on days 17 and 18, though its concentration was much lower (ranged between 3-10 ng/ml) than that of maternal serum. rPL-II in amniotic fluid was also detectable only on days 12-14 of pregnancy, and the peak value on day 13 was 22% of the maternal serum rPL-II concentration. The rGH concentration increased gradually as pregnancy advanced with a decline on the day before parturition. Although rGH in fetal serum increased on day 20 with a decline on the following day, it was slightly detectable in amniotic fluid on the last two days of pregnancy. The molecular profile of rPL-II in amniotic fluid and maternal serum of day 13 pregnant rats were examined by Western blotting. Anti-rPL-II serum detected two proteins with molecular weights (mol wt) of 19.5K and 20.5K in amniotic fluid and one protein with a mol wt of 20.5K in maternal serum under nonreducing conditions.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"38 6","pages":"589-95"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.38.589","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12984732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Blocking type immunoglobulins in patients with nongoitrous primary hypothyroidism in area of iodine deficiency. 阻断型免疫球蛋白在非甲状腺性原发性甲状腺功能减退缺乏症患者中的应用。

Endocrinologia japonica Pub Date : 1991-12-01 DOI: 10.1507/endocrj1954.38.661

T Tang, Y G Wang, K Tsuboi, M Irie, T Ma, S H Ingbar

{"title":"Blocking type immunoglobulins in patients with nongoitrous primary hypothyroidism in area of iodine deficiency.","authors":"T Tang, Y G Wang, K Tsuboi, M Irie, T Ma, S H Ingbar","doi":"10.1507/endocrj1954.38.661","DOIUrl":"https://doi.org/10.1507/endocrj1954.38.661","url":null,"abstract":"We have evaluated the role of circulating serum immunoglobulins (IgG) which inhibit the growth of thyroid in the etiology of thyroid atrophy in endemic cretinism. Twenty nongoitrous cretins (13 women and 7 men, age range: 9-33) were classified on the basis of clinical criteria for cretinism in China. They were born and living in an iodine deficient area, Xinjiang, northwest China. Antimicrosomal antibody titers were negative in all serum. Nine patients (seven women and two men; age range: 11-23) were biologically primary hypothyroid. Seven subjects were of a myxedematous form and two subjects were of a mixed form. We have studied thyroid-growth inhibiting immunoglobulin (TGII) activity that was measured as an inhibitory effect of 4 mg/ml IgG on TSH-induced [3H]-thymidine incorporation into the DNA of a rat thyroid follicular cell line, FRTL5 cells. Six (five women and one man) out of the nine patients with primary hypothyroidism (66.7 percent) had TGII. We also measured other growth-blocking IgG that inhibited [3H]-thymidine incorporation into DNA stimulated by insulin-like growth factor-I (IGF-I), a growth factor working through a cAMP-independent pathway. Five (three women and two men) out of nine patients (55.6 percent) with nongoitrous primary hypothyroidism had IGF-I-blocking IgG. These results indicate that TGII plays an important role in atrophy of the thyroid in spite of increased serum TSH concentrations, and IgG which inhibits thyroid growth stimulated by IGF-I also might play a role in thyroid atrophy in some endemic cretins.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"38 6","pages":"661-5"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.38.661","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12984669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A case of renin producing leiomyosarcoma originating in the lung. 肾素产生性平滑肌肉瘤发源于肺部1例。

Endocrinologia japonica Pub Date : 1991-12-01 DOI: 10.1507/endocrj1954.38.603

K Kawai, A Fukamizu, Y Kawakami, M Matsumura, K Mitsui, K Murakami, K Yamashita

{"title":"A case of renin producing leiomyosarcoma originating in the lung.","authors":"K Kawai, A Fukamizu, Y Kawakami, M Matsumura, K Mitsui, K Murakami, K Yamashita","doi":"10.1507/endocrj1954.38.603","DOIUrl":"https://doi.org/10.1507/endocrj1954.38.603","url":null,"abstract":"A 54-year-old woman was referred to our hospital for the treatment of a tumor of the right chest wall. Clinical examination revealed hypertension, hypokalemia, metabolic alkalosis, hyperaldosteronism and hyperreninemia. Computed tomography and an abdominal echogram indicated a tumor in the right phrenic area and two tumors in the retroperitoneum near the pancreas head. After the surgical resection of these tumors, the primary reninism was diminished. The pathological diagnosis of these tumors was leiomyosarcoma. Plasma active and inactive (trypsin-activated) renin activities (PRA) were 85.7 and 38.9 ng angiotensin I/ml/h, respectively. These PRA did not respond to either postural stimulation or suppression by the volume expansion. Active and inactive renin activities in a right phrenic area tumor were 208 and 32 ng angiotensin I/mg protein /h, respectively. Those of an abdominal tumor were 196 and 30 ng angiotensin I/mg protein/h, respectively. Renin mRNA identical in molecular size to that of the human kidney was identified by northern blot analysis. This is the first case report of renin producing leiomyosarcoma derived from the lung, which is characterized by relatively lower plasma prorenin concentrations.","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"38 6","pages":"603-9"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.38.603","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12984733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Serum free triiodothyronine to free thyroxine ratio enables early prediction of the outcome of antithyroid drug therapy in patients with Graves' hyperthyroidism. 血清游离三碘甲状腺原氨酸与游离甲状腺素的比值可以早期预测Graves甲亢患者抗甲状腺药物治疗的结果。

Endocrinologia japonica Pub Date : 1991-12-01 DOI: 10.1507/endocrj1954.38.683

J Tajiri, S Noguchi, M Morita, M Tamaru, N Murakami, R Kato

{"title":"Serum free triiodothyronine to free thyroxine ratio enables early prediction of the outcome of antithyroid drug therapy in patients with Graves' hyperthyroidism.","authors":"J Tajiri, S Noguchi, M Morita, M Tamaru, N Murakami, R Kato","doi":"10.1507/endocrj1954.38.683","DOIUrl":"https://doi.org/10.1507/endocrj1954.38.683","url":null,"abstract":"This study scrutinizes the correlation between serum free triiodothyronine (FT3) to free thyroxine (FT4) ratios and the eventual outcome of antithyroid drug (ATD) therapy in patients with Graves' disease. Forty-four patients with Graves' thyrotoxicosis were treated with methylmercaptoimidazole (methimazole). During the follow-up, 16 patients relapsed in the short period of one to five months after cessation of the drug (relapse group), and 28 patients remained in remission when checked at 12 to 20 months after treatment (remission group). Serum FT3 to FT4 ratios [(pg/ml/ng/dl) x 10] were less than 55 throughout ATD therapy in 27 of the 28 remission patients whereas the ratios of the relapse group exceeded 55 from the early phase of methimazole treatment in 10 of 16 patients. In eight of these 10 patients the increased ratios were detected within three months of therapy (1 month, 3 patients; 2 months, 4 patients; 3 months, 1 patient). The ratios for the remaining two patients rose above 55 at the fifth and sixth months. There was no statistical difference between the remission and relapse groups in the FT3 to FT4 ratios either before nor at the completion of the treatment. However, a clear difference could be measured at a point during the therapy. Those in whom this difference was pronounced later underwent relapse.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"38 6","pages":"683-7"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.38.683","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12890628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Downward regulation of plasma LH by LHRH agonist, leuprolide acetate, resulting in inhibited renal growth and function in the castrated male rat. LHRH激动剂醋酸leuprolide下调血浆LH，导致阉割雄性大鼠肾脏生长和功能受到抑制。

Endocrinologia japonica Pub Date : 1991-12-01 DOI: 10.1507/endocrj1954.38.693

K Nomura, Y Sato, M Watanabe, N Horiba, M Ujihara, S Toraya, H Demura

{"title":"Downward regulation of plasma LH by LHRH agonist, leuprolide acetate, resulting in inhibited renal growth and function in the castrated male rat.","authors":"K Nomura, Y Sato, M Watanabe, N Horiba, M Ujihara, S Toraya, H Demura","doi":"10.1507/endocrj1954.38.693","DOIUrl":"https://doi.org/10.1507/endocrj1954.38.693","url":null,"abstract":"We previously reported that ovine and porcine luteinizing hormone (LH) stimulated kidney growth in castrated hypophysectomized rats. Our present study focuses on the physiological role of the renotropic activity of LH isoforms. Plasma LH levels were decreased to 10% of that of castrated control rats by injections of a slow-releasing LHRH agonist, leuprolide acetate, from microcapsules. Compared to controls, which were injected with microcapsules only, the kidney weight in leuprolide-treated castrated rats decreased 12%. Renal protein and DNA contents decreased significantly. Body, liver and spleen weights were not changed by the treatment, however. This effect on the kidney was not observed in castrated hypophysectomized rats, suggesting that leuprolide affected the kidneys indirectly, rather than directly, by suppressing LH secretion. In leuprolide-treated castrated rats, urinary fractional excretion of sodium (FENa) increased, indicating suppressed renal function at the proximal tubules. We concluded that the secretion of renotropically active LH isoforms was regulated at least partially by LHRH and played a physiological role in growth and the function of the proximal tubules.","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"38 6","pages":"693-7"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.38.693","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12984672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Application of MEN 203 as a polymorphic DNA probe in screening multiple endocrine neoplasia 2a. men203作为多态DNA探针在多发性内分泌肿瘤2a筛查中的应用。

Endocrinologia japonica Pub Date : 1991-12-01 DOI: 10.1507/endocrj1954.38.583

K Kojima, Y Totsuka

引用次数: 0