Advanced Materials最新文献_第5页

Advances and Prospects in Multifunctional Composite Fibrous Materials Utilizing Porous Organic Polymers. 多孔有机聚合物多功能复合纤维材料的研究进展与展望。

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-10-01 DOI: 10.1002/adma.202513138

Wenliang Song,Yuheng Wen,Yujang Cho,Xinzeyu Zhang,Dandan Kang,Euichul Shin,Deng-Guang Yu,Guisheng Li,Yaozu Liao,Il-Doo Kim

{"title":"Advances and Prospects in Multifunctional Composite Fibrous Materials Utilizing Porous Organic Polymers.","authors":"Wenliang Song,Yuheng Wen,Yujang Cho,Xinzeyu Zhang,Dandan Kang,Euichul Shin,Deng-Guang Yu,Guisheng Li,Yaozu Liao,Il-Doo Kim","doi":"10.1002/adma.202513138","DOIUrl":"https://doi.org/10.1002/adma.202513138","url":null,"abstract":"Porous organic polymers (POPs) offer exceptional surface area, tunable pore sizes, and versatile chemical functionality, making them attractive for a range of advanced applications. However, their conventional powdered form limits processability, structural integration, and practical deployment. Integrating POPs into fibrous matrices through electrospinning, a scalable and versatile technique for producing nonwoven fibers, helps overcome these limitations and enables the creation of new material architecture. The resulting POP-incorporated fibrous materials (POP-FMs) combine the intrinsic advantages of POPs with enhanced mechanical integrity, tailored surface properties, and improved mass transport characteristics. These features expand the potential of POP-FMs in areas such as catalysis, environmental remediation, sensing, and biomedical fields. This review discusses recent progress in the design and synthesis of electrospinning-compatible POPs, strategies for fabricating POP-FM composites, and the structure-property relationships that govern their performance. Key challenges and future directions are also explored, underscoring the potential of POP-FMs as next-generation functional materials.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"28 1","pages":"e13138"},"PeriodicalIF":29.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering the Quantitative Relationship Between the Photocatalytic Activity and the Built-In Electric Field of Heterojunction. 解读异质结光催化活性与内嵌电场的定量关系。

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-10-01 DOI: 10.1002/adma.202505900

Chengwei Qiu,Jinni Shen,Haifeng Li,Yuhua Zhong,Jianhan Lin,Qing Wu,Dongmiao Li,Bing Wang,Ying Wang,Xuxu Wang,Xianzhi Fu,Zizhong Zhang

{"title":"Deciphering the Quantitative Relationship Between the Photocatalytic Activity and the Built-In Electric Field of Heterojunction.","authors":"Chengwei Qiu,Jinni Shen,Haifeng Li,Yuhua Zhong,Jianhan Lin,Qing Wu,Dongmiao Li,Bing Wang,Ying Wang,Xuxu Wang,Xianzhi Fu,Zizhong Zhang","doi":"10.1002/adma.202505900","DOIUrl":"https://doi.org/10.1002/adma.202505900","url":null,"abstract":"The principle of heterojunction in physics has been extensively referenced in heterogeneous photocatalysis, but it appears to have been utilized qualitatively more as a concept than as a method. The reason is that the quantitative correlation between the intensity of the built-in electric field (BIEF) and photocatalytic activity has not been established, primarily due to the challenges in directly measuring the BIEF of nanosized photocatalysts. To address this, both powder-type and single-crystal-type SiC@WO3-x-T heterostructures are prepared to quantitatively investigate the dependence of photocatalytic CO2 reduction activities on BIEF intensity. A strong linear correlation between the effective photoelectron number (NEPN) for CO2 reduction and the BIEF intensity is revealed for the first time. Specifically, NEPN increases by 0.25 µmol g-1 when Vbi (built-in potential) increases by 1 kV for the powder sample. In contrast, for the single-crystal sample, NEPN rises by 0.16 µmol with a 1 kV cm-1 increase in Ebi (built-in electric field). This study not only bridges a critical gap in heterojunction photocatalysis research but also demonstrates a method to amplify the built-in electric field by engineering the interface species, thereby enhancing the photocatalytic performance.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"18 1","pages":"e05900"},"PeriodicalIF":29.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triplet Exciton-Enhanced Photosynthesis of Hydrogen Peroxide Enabled by Topologically Tuned Covalent Organic Frameworks. 拓扑调谐共价有机框架激活过氧化氢的三重激子增强光合作用。

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-10-01 DOI: 10.1002/adma.202511092

Can Huang,Youzi Zhang,Rongchen Shen,Lei Hao,Bin Qi,Guijie Liang,Peng Zhang,Xin Li,Xuanhua Li

{"title":"Triplet Exciton-Enhanced Photosynthesis of Hydrogen Peroxide Enabled by Topologically Tuned Covalent Organic Frameworks.","authors":"Can Huang,Youzi Zhang,Rongchen Shen,Lei Hao,Bin Qi,Guijie Liang,Peng Zhang,Xin Li,Xuanhua Li","doi":"10.1002/adma.202511092","DOIUrl":"https://doi.org/10.1002/adma.202511092","url":null,"abstract":"Artificial photosynthesis technology can utilize water, oxygen, and solar energy to produce hydrogen peroxide (H2O2), an environmentally friendly oxidant and a clean fuel. However, H2O2 photosynthesis mainly follows photogenerated electrons/holes pathway, which suffers from high thermodynamic barriers and competing reactions. Triplet excitons can spontaneously convert O2 into singlet oxygen (1O2) intermediate and bypass these challenges, but demonstrating its effects on photocatalysis is still scarce. Here, this study designs twist pyrimidine-based covalent organic frameworks with excellent triplet exciton production using a topological tuning strategy. The twist configuration modulates the molecular orbital overlap between singlet and triplet states and achieves a 1.8 × 107 enhancement in the intersystem crossing rate, obtaining excitation of triplet excitons and the generation of 1O2, rather than exciting photogenerated electrons and holes. A novel triplet exciton-1O2 H2O2 photosynthesis pathway is achieved and demonstrates a 38.6% reduction in the generation barrier compared to typical redox pathway, obtaining record activity with rates of 10.80 mmol g-1 h-1 in an O2 atmosphere and 7.82 mmol g-1 h-1 in air, without the need for a sacrificial agent. The solar-to-chemical conversion efficiency is 1.25%.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"34 1","pages":"e11092"},"PeriodicalIF":29.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating High-Efficient Delamination and Structural Reconstruction Boosting Direct Regeneration of Spent Cathode Materials. 高效分层与结构重构相结合，促进废阴极材料直接再生。

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-10-01 DOI: 10.1002/adma.202510888

Jiajun Li,Ruyu Shi,Xinru Wu,Hongtai Li,Zhuozhao Wu,Junxiong Wang,Yanfei Zhu,Guangmin Zhou

{"title":"Integrating High-Efficient Delamination and Structural Reconstruction Boosting Direct Regeneration of Spent Cathode Materials.","authors":"Jiajun Li,Ruyu Shi,Xinru Wu,Hongtai Li,Zhuozhao Wu,Junxiong Wang,Yanfei Zhu,Guangmin Zhou","doi":"10.1002/adma.202510888","DOIUrl":"https://doi.org/10.1002/adma.202510888","url":null,"abstract":"Direct regeneration presents a promising solution for tackling spent lithium-ion batteries due to its environmental and economic advantages. Nonetheless, the effectiveness of direct regeneration hinges on the efficient and precise separation of cathode materials from current collectors. Current separation methods not only suffer from incomplete separation and low delamination efficiency but also risk inflicting damage to the already degraded surface structure of cathode materials, which further renders the direct regeneration less effective. Herein, an approach is introduced that synergistically achieves high-efficient delamination and surface reconstruction of spent LiNi0.5Co0.2Mn0.3O2 (NCM523) by catalytically activating potassium peroxymonosulfate. This approach achieves delamination of cathode materials from current collectors with a separation efficiency over 99% within only 2 min. Moreover, the surface reconstruction is simultaneously accomplished during the delamination process, building fast lithium-ion diffusion pathway, greatly reducing the lithium-ion migration barrier. Consequently, the NCM523 regenerated through this method successfully restores its capacity to commercial level at 152 mAh·g-1 and maintains outstanding cycling stability, retaining 75% of its capacity after 1000 cycles. The findings underscore the necessity of complete separation of cathode materials from current collectors and surface structural reconstruction in direct regeneration and offer critical insights into optimizing sustainable recycling processes for spent lithium-ion batteries.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"183 1","pages":"e10888"},"PeriodicalIF":29.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive Materials-Mediated Regulation of Bone Marrow Microenvironment: Mechanistic Insights and Therapeutic Potentials. 生物活性物质介导的骨髓微环境调控：机制见解和治疗潜力。

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-10-01 DOI: 10.1002/adma.202511497

Yizhi Li,Luli Ji,Jiaze Yu,Fuwei Zhu,Yuanyuan Xiang,Xiaogang Wang,Jing Wang,Changsheng Liu

{"title":"Bioactive Materials-Mediated Regulation of Bone Marrow Microenvironment: Mechanistic Insights and Therapeutic Potentials.","authors":"Yizhi Li,Luli Ji,Jiaze Yu,Fuwei Zhu,Yuanyuan Xiang,Xiaogang Wang,Jing Wang,Changsheng Liu","doi":"10.1002/adma.202511497","DOIUrl":"https://doi.org/10.1002/adma.202511497","url":null,"abstract":"The bone marrow microenvironment(BME) maintains bone homeostasis through multi-cellular cooperation and signal crosstalk, its dysregulation drives pathological bone loss. In recent years, Materiobiology, a scientific discipline studying how biomaterial properties affect biological functions, has opened new avenues for the precise regulation of this complex microenvironment. Biomaterials enable sophisticated regulation of the BME through biomimetic design and functionalization strategies. They not only activate osteoblast signaling pathways to promote bone formation but also inhibit osteoclast differentiation and bone resorption functions. Additionally, they integrate nerve and vascular regeneration processes with immunomodulatory mechanisms to optimize stem cell behavior and improve the tissue repair microenvironment. This review comprehensively summarizes advances in biomaterial-mediated BME regulation, emphasizing interdisciplinary integration and intelligent material development to overcome the limitations of conventional therapies. The innovation of intelligent materials lies in their ability to mimic biological systems. Recent research has leveraged generative design models to engineer new thiol-containing antimicrobial peptides. These approaches achieve spatiotemporal coordination of cellular interactions and functional reconstruction during bone regeneration. Future efforts need to address challenges in material stability, personalized adaptation, and clinical translation, promoting cross-scale therapeutic innovation from molecular intervention to tissue regeneration, providing revolutionary solutions for bone metabolic diseases and complex defect repair.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"71 1","pages":"e11497"},"PeriodicalIF":29.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inorganic Oxide Phosphors-PDMS Composite Platforms: Recent Breakthroughs and Challenges in Multifunctional Emerging Applications. 无机氧化磷- pdms复合平台：多功能新兴应用的最新突破和挑战。

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-10-01 DOI: 10.1002/adma.202510954

Chengjun Zhang,Yongbin Hua,Zhongkai Yu,Yue Xu,Mengchao Shen,Li Li,Jae Su Yu,Wen-Xing Yang

{"title":"Inorganic Oxide Phosphors-PDMS Composite Platforms: Recent Breakthroughs and Challenges in Multifunctional Emerging Applications.","authors":"Chengjun Zhang,Yongbin Hua,Zhongkai Yu,Yue Xu,Mengchao Shen,Li Li,Jae Su Yu,Wen-Xing Yang","doi":"10.1002/adma.202510954","DOIUrl":"https://doi.org/10.1002/adma.202510954","url":null,"abstract":"Inorganic oxide phosphors-polydimethylsiloxane (PDMS) composite platform integrates inorganic oxide materials with a PDMS matrix, providing unique optical properties along with flexibility and humidity resistance, making it promising for applications in the forefront of advanced optoelectronics. In this respect, this review focuses on the emerging applications enabled by inorganic oxide phosphors-PDMS composite films and comprehensively summarizes the progress and challenges. At the beginning, the luminescence mechanism of inorganic phosphors, covering photoluminescence (downconversion, upconversion, and long persistent luminescence) and mechanoluminescence, as well as their recent research trends, is elaborated on the diversity of phosphor luminescence characteristics and the achievements of cutting-edge exploration. Afterward, this review further delves into the preparation methods of PDMS films, laying a technological foundation for the innovative applications of photoluminescent films in display technology, anti-counterfeiting, message encryption, and flexible optical temperature sensors, as well as the mechanoluminescent films for biomedical/biomechanical testing and stress sensing technology. Eventually, the present challenges and future prospects are discussed to advance their potential in real-world applications. This review is expected to inspire experts in the field to break through bottlenecks and expand the new frontiers of applications of inorganic oxide phosphors-PDMS composite films.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"102 1","pages":"e10954"},"PeriodicalIF":29.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging Scales in Solar-Driven Water Splitting: Pathways to System Integration. 桥接尺度在太阳能驱动的水分解：途径系统集成。

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-10-01 DOI: 10.1002/adma.202506690

Chengyang Feng,Miao Hu,Jumanah Alharbi,Magnus Rueping,Huabin Zhang

{"title":"Bridging Scales in Solar-Driven Water Splitting: Pathways to System Integration.","authors":"Chengyang Feng,Miao Hu,Jumanah Alharbi,Magnus Rueping,Huabin Zhang","doi":"10.1002/adma.202506690","DOIUrl":"https://doi.org/10.1002/adma.202506690","url":null,"abstract":"Artificial photosynthesis, which converts and stores solar energy as chemical energy, holds immense potential for promoting sustainable development and achieving carbon neutrality. Solar-driven water splitting offers an ideal method for storing solar energy, with one of the most promising approaches based on efficient particulate photocatalysts. In recent years, significant progress has been made in particulate photocatalyst-based water splitting systems, from fundamental scientific research to exploratory practical applications. However, to date, no photocatalytic water splitting system has achieved the efficiency required for practical applications. The development of high-performance photocatalysts and optimized photocatalytic systems is urgently needed. This review examines the crucial factors limiting the activity of photocatalysts for overall water splitting and summarizes design strategies to enhance photocatalyst performance and overcome these barriers. The design and modification strategies for high-efficiency photocatalysts are highlighted, including bandgap regulation, localized surface plasmon resonance, morphology control, crystal facet engineering, heterostructures, cocatalysts, and external-field association. Additionally, the scalability of using particulate photocatalysts for overall water splitting driven by natural sunlight is discussed. Finally, insights into advanced strategies for improving the performance of particulate photocatalysts are provided, and perspectives on the future development of solar water splitting systems for commercial applications are offered.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"31 1","pages":"e06690"},"PeriodicalIF":29.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organic Cation Methylation Design of Hybrid Eu(II)-based Halide Scintillators for Improved X-Ray Detection and Imaging. 用于改进x射线探测和成像的Eu（II）基杂化卤化物闪烁体的有机阳离子甲基化设计。

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-09-30 DOI: 10.1002/adma.202510379

Liang Li,Yuzhen Wang,Jiance Jin,Kai Han,Shuai Zhang,Zhiguo Xia

{"title":"Organic Cation Methylation Design of Hybrid Eu(II)-based Halide Scintillators for Improved X-Ray Detection and Imaging.","authors":"Liang Li,Yuzhen Wang,Jiance Jin,Kai Han,Shuai Zhang,Zhiguo Xia","doi":"10.1002/adma.202510379","DOIUrl":"https://doi.org/10.1002/adma.202510379","url":null,"abstract":"Organic-inorganic hybrid scintillators (OIHSs) have emerged as promising candidates for X-ray imaging. However, inhibiting the concentration quenching effect and reducing vacancy defects remain major challenges for high-performance OIHSs. Herein, a modification strategy of organic cation methylation is introduced to prepare PDMIMEuX3 (PDMIM-X, PDMIM = 1-Propyl-2,3-dimethylimidazolium, X = Br, I) upon PMIMEuX3 (PMIM-X, PMIM = 1-Propyl-3-methylimidazolium). Benefiting from the increased Eu-Eu chain spacing and structural rigidity by the steric effect of inserted cationic methylation, PDMIM-X suppresses nonradiative recombination between luminescent centers and the halogen vacancy defects. Particularly, PDMIM-Br designed via such a cation methylation exhibits high light output, which is 3.57 and 9.7 times higher than that of commercial Lu3Al5O12:Ce and original PMIM-Br, respectively, and thus it also demonstrates a low detection limit of 42.61 nGy s-1. Moreover, leveraging the capability of rapid in situ solution processing, a transparent and large-area PDMIM-Br@film is prepared with a spatial resolution of 21.1 lp mm-1 for X-ray imaging. This study developed high-performance OIHSs and further provided an effective strategy via materials design to improve the detection and imaging capabilities.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"104 1","pages":"e10379"},"PeriodicalIF":29.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-Atom Anchored on Perovskite With Strong Metal-Oxide Interaction for Efficient High Temperature CO2 Electrolysis. 钙钛矿上单原子锚定与强金属-氧化物相互作用的高效高温CO2电解。

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-09-30 DOI: 10.1002/adma.202512310

Feng Hu,Beibei He,Kongfa Chen,Wenjia Ma,Yonglong Huang,Sunce Zhao,Yu Chen,Ling Zhao

{"title":"Single-Atom Anchored on Perovskite With Strong Metal-Oxide Interaction for Efficient High Temperature CO2 Electrolysis.","authors":"Feng Hu,Beibei He,Kongfa Chen,Wenjia Ma,Yonglong Huang,Sunce Zhao,Yu Chen,Ling Zhao","doi":"10.1002/adma.202512310","DOIUrl":"https://doi.org/10.1002/adma.202512310","url":null,"abstract":"Efficient electrochemical CO2 reduction remains a grand challenge in advancing carbon-neutral energy technologies. Here, an efficient solid-state approach for the fabrication of a novel single-atom Ir anchored Sr2Fe1.5Mo0.5O6-δ (SFM) perovskite electrocatalyst, designed for high temperature CO2 electrolysis in solid oxide electrolysis cells (SOECs) is reported. The resulting four-coordinated Ir-O-Fe/Mo configuration induces pronounced interfacial electronic reconstruction and strong metal-oxide interaction, substantially lowering the energy barrier for CO2 electrolysis, as indicated by extended X-ray absorption fine structure (EXAFS) analysis and density functional theory (DFT) calculations. When employed as a cathode in SOECs, the 2Ir/SFM (2 wt.% Ir) electrocatalyst achieves a high current density of 1.63 A cm-2 at 1.5 V and 800 °C, along with excellent Faradaic efficiency and long-term operational stability. These findings offer atomistic insights into the structure-performance relationship of single-atom/perovskite heterostructures, underscoring the commercial potential of SOECs for CO2 electrolysis.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"17 1","pages":"e12310"},"PeriodicalIF":29.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heat-Responsive Phase-Change Cream Broadly Enhances Transdermal Delivery Through a Mild Photothermal Strategy. 热响应相变霜通过温和的光热策略广泛增强透皮给药。

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-09-30 DOI: 10.1002/adma.202416017

Rui Geng,Wanyue Xiao,Duohang Bi,Fei Zhang,Jun Zhou,Yijing Liu,Jintao Zhu

{"title":"Heat-Responsive Phase-Change Cream Broadly Enhances Transdermal Delivery Through a Mild Photothermal Strategy.","authors":"Rui Geng,Wanyue Xiao,Duohang Bi,Fei Zhang,Jun Zhou,Yijing Liu,Jintao Zhu","doi":"10.1002/adma.202416017","DOIUrl":"https://doi.org/10.1002/adma.202416017","url":null,"abstract":"High-temperature-mediated transdermal delivery often relies on extreme heating to disrupt the skin barrier, but these approaches risk tissue damage and drug denaturation. Mild thermal stimulation promises safer uptake, yet achieving precise temperature control is inconvenient, and its transdermal efficacy and mechanisms remain unclear. A heat-responsive cream made from a stearic acid-lauric acid eutectic, polydopamine (PDA) nanoparticles, glycerin, and drugs is introduced. This cream maintains skin temperature ∼40 °C under simulated sunlight by absorbing excess heat through phase change, preventing overheating while preserving the effectiveness of the drug without requiring manual adjustments. Mild photothermal treatment boosted penetration of PDA nanoparticles (2.4-406.9 nm) by 5.5-7.1-fold, and achieved 28.9-, 24.6-, and 10.7-fold increase of fluorescent signals in dermis for rhodamine B (RB), RB-labeled 5 or 20 kDa dextran versus nonheated controls, respectively. Mechanistic studies revealed that the photothermal effect enhances transdermal delivery by inducing micropores on the skin and through the transappendageal route. Moreover, insulin delivered through this strategy reduced blood glucose by 75% in diabetic mice, and co-delivery of PDA NPs with methotrexate significantly improved psoriasis lesions. This self-regulating platform uniquely unites precise thermal control and dual-pathway enhancement, offering a generalizable route for enhancing transdermal delivery efficiency.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"37 1","pages":"e16017"},"PeriodicalIF":29.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0