Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005.最新文献_第8页

Advanced Analysis of Wearable Sensor Data to Adjust Medication Intake in Patients with Parkinson's Disease 可穿戴传感器数据调整帕金森病患者药物摄入的高级分析

Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005. Pub Date : 2005-03-16 DOI: 10.1109/CNE.2005.1419591

D. Sherrill, Richard Hughes, Sara S. Salles, Theresa Lie-Nemeth, Metin Akay, David G. Standaert, Paolo Bonato

{"title":"Advanced Analysis of Wearable Sensor Data to Adjust Medication Intake in Patients with Parkinson's Disease","authors":"D. Sherrill, Richard Hughes, Sara S. Salles, Theresa Lie-Nemeth, Metin Akay, David G. Standaert, Paolo Bonato","doi":"10.1109/CNE.2005.1419591","DOIUrl":"https://doi.org/10.1109/CNE.2005.1419591","url":null,"abstract":"The objective of this pilot work is to identify characteristics and measure severity of motor fluctuations in patients with Parkinson's disease (PD) based on wearable sensor data. Improved methods of assessing longitudinal changes in PD would enable optimization of treatment and maximization of patient function. We hypothesize that motor fluctuations accompanying late-stage PD present with predictable features of accelerometer signals recorded during execution of standardized motor tasks. Six patients (age 46-75) with diagnosis of idiopathic PD and levodopa-related motor fluctuations were studied. Subjects performed motor tasks in a \"practically-defined OFF\" state, and then at 30 minute intervals after medication intake. At each interval, data from 8 uniaxial accelerometers on the upper and lower limbs were recorded continuously, and subjects were videotaped. Features representing motion characteristics such as intensity, rate, regularity, and coordination were derived from the sensor data, and clinical scores were assigned for each task by review of the videotapes. Cluster analysis was performed on feature sets that were expected to reflect severity of parkinsonian symptoms (e.g. bradykinesia) and motor complications (e.g. dyskinesias). Two-dimensional data projections revealed clusters corresponding to the degree of dyskinesia and bradykinesia indicated by clinical scores. These preliminary results support our hypothesis that wearable sensors are sensitive to changing patterns of movement throughout the medication intake cycle, and that automated recognition of motor states using these recordings is feasible","PeriodicalId":113815,"journal":{"name":"Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005.","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128395513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The effect of training of cultured neuronal networks, can they learn ? 培养神经元网络的训练效果，它们能学习吗?

Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005. Pub Date : 2005-03-16 DOI: 10.1109/CNE.2005.1419624

W. StaverenvanG., J. Buitenweg, E. Marani, W. Rutten

引用次数: 9

Analysis of In-vitro Neurite Extension for Neurotrophic Electrode Design 神经营养电极设计中体外神经突延伸的分析

Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005. Pub Date : 2005-03-16 DOI: 10.1109/CNE.2005.1419639

L. Satish, D. Gandhi, R. Das, P. Rousche

{"title":"Analysis of In-vitro Neurite Extension for Neurotrophic Electrode Design","authors":"L. Satish, D. Gandhi, R. Das, P. Rousche","doi":"10.1109/CNE.2005.1419639","DOIUrl":"https://doi.org/10.1109/CNE.2005.1419639","url":null,"abstract":"Stimulation of nervous tissue using implantable electrode systems has been suggested for a wide range of clinical problems including depression, migraine headaches, systemic pain, deafness, blindness, bladder function etc. Several of these problems would require the long-term implantation of multi-channel electrode systems in close proximity to the appropriate neural tissue within the central nervous system. In this work, we continue our attempt to apply and quantify neurotrophic tissue engineering techniques in an in-vitro test system that can guide the future functional improvement of implanted electrodes for clinical use. Our model system consists of cultured PC-12 cells and polyimide microtubes. The microtubes act as conduits to capture neurite extension. This is a model for the demonstrated neurite extension that occurs in known neurotrophic electrode systems such as the cone electrode developed by Kennedy et al. The tubes also can act as vessels for the transport of neurotrophic agents that could attract candidate neurons close to the electrode site. In this study, we quantify neurite extension induced via nerve growth factor (NGF). We show that NGFadsorbed gelatin sponges can be used to create an effective NGF gradient to induce directional neurite growth in this system","PeriodicalId":113815,"journal":{"name":"Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005.","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134220286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Imaging Locations of Neurons vs. Glia in Low Density Culture 低密度培养中神经元与胶质细胞的成像位置

Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005. Pub Date : 2005-03-16 DOI: 10.1109/CNE.2005.1419623

Y. Nam, B. Wheeler

引用次数: 3

The Detection of Seizure Vulnerable Period from Epidural EEG Recordings of Epilepsy Rat 癫痫大鼠硬膜外脑电图记录检测癫痫易损期

Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005. Pub Date : 2005-03-16 DOI: 10.1109/CNE.2005.1419719

Wenyan Jia, Xuan Liu, Xiaorong Gao, Liang Guo, Yang Lei, Y. Ku, Shangkai Gao

引用次数: 0

Combining fMRI with Video Automated Perimetry in Patients with Brain-based Visual Impairments 脑基视觉障碍患者的功能磁共振成像与视频自动视野测量相结合

Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005. Pub Date : 2005-03-16 DOI: 10.1109/CNE.2005.1419695

M. Maciejewski, K. Ropella, E. DeYoe

{"title":"Combining fMRI with Video Automated Perimetry in Patients with Brain-based Visual Impairments","authors":"M. Maciejewski, K. Ropella, E. DeYoe","doi":"10.1109/CNE.2005.1419695","DOIUrl":"https://doi.org/10.1109/CNE.2005.1419695","url":null,"abstract":"For clinical diagnosis of brain-related vision deficits, it is advantageous to obtain behavioral visual field perimetry in conjunction with functional magnetic resonance imaging (fMRI) maps of visual cortex function. Ideally, these data should be obtained simultaneously to ensure that both measures are closely correlated. To facilitate this goal, we have developed a video automated perimeter (VAP) that will allow conventional or custom visual field testing inside the fMRI environment. To validate the system, data were obtained using both the VAP and a conventional Humphrey field analyzer (HFA) for 4 patients having localized visual field defects. Flashing spots of 0.4deg were presented on a grid of 76 test points (identical to the Humphrey 30-2 grid) using a modified staircase protocol to estimate detection thresholds. Overall, detection thresholds obtained with the two systems were similar though the VAP was 2 dB less sensitive, on average. Most importantly, though, the spatial pattern of visual sensitivity matched well in the two tests with a median cross correlation coefficient of 0.71, comparable to correlations obtained between repeated runs using the HFA. Thus the VAP system provides visual field maps comparable to those obtained with Humphrey perimetry but that can be administered between runs while the patient is in the MRI scanner, thus reducing test time and ensuring that both measures are obtained under closely matched conditions","PeriodicalId":113815,"journal":{"name":"Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005.","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133439591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MEG Responses to Speech and Stimuli With Speechlike Modulations 具有类言语调节的言语和刺激的脑电反应

Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005. Pub Date : 2005-03-16 DOI: 10.1109/CNE.2005.1419544

Juanjuan Xiang, Yadong Wang, J. Simon

{"title":"MEG Responses to Speech and Stimuli With Speechlike Modulations","authors":"Juanjuan Xiang, Yadong Wang, J. Simon","doi":"10.1109/CNE.2005.1419544","DOIUrl":"https://doi.org/10.1109/CNE.2005.1419544","url":null,"abstract":"Acoustic signals can be decomposed into the product of an envelope and its fine structure. The envelope features are critical to speech recognition. Results from human behavioral and psychophysical experiments indicate that magnetoencephalography (MEG) responses can significantly phase-lock to the temporal envelope of an auditory stimulus, and speech comprehension is correlated with this phase locking. The goal of this study is to explore the properties of neural response to the speech and stimuli with complex temporal envelopes. Five auditory stimuli with the same envelope, generated from natural speech, and the same stimuli but with the envelope artificially sped up were presented to two subjects. Auditory evoked responses were recorded with a whole-head 160-channel MEG system. Independent component analysis (ICA), principle component analysis (PCA) and equivalent current dipole fitting were performed to separate and identify the neural sources (and artifacts). The result shows that the location, orientation, and strength of the neural sources are robust across all stimuli, with correlation between auditory responses and the temporal envelope of the stimuli. These results provide support for the premise that neurons in the auditory cortex are particularly sensitive to the envelope and can phase-lock to stimuli with complex temporal and spectrotemporal envelopes","PeriodicalId":113815,"journal":{"name":"Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005.","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130124151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

An Abnormal EEG Simulation Based on The Chay Model of An Excitable Neuron 基于可兴奋神经元Chay模型的异常脑电图模拟

Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005. Pub Date : 2005-03-16 DOI: 10.1109/CNE.2005.1419547

Manling Ge, Guoya Dong, Hui Meng, Lei Wang, Shuo Yang, Bao-shan Wang, CuiPing Zhao

引用次数: 1

Scale-Space Processing and Clustering for Efficient Multi-Electrode Data Analysis of Large-size Neuronal Ensembles 大规模神经元集成中高效多电极数据分析的尺度空间处理和聚类

Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005. Pub Date : 2005-03-16 DOI: 10.1109/CNE.2005.1419595

K. Oweiss, Rong Jin, Y. Suhail

{"title":"Scale-Space Processing and Clustering for Efficient Multi-Electrode Data Analysis of Large-size Neuronal Ensembles","authors":"K. Oweiss, Rong Jin, Y. Suhail","doi":"10.1109/CNE.2005.1419595","DOIUrl":"https://doi.org/10.1109/CNE.2005.1419595","url":null,"abstract":"Identifying clusters of neurons with correlated activity in large-size neuronal ensembles from high-density multielectrode array recordings is an emerging problem in computational neuroscience. A new engineering approach is proposed that relies on representing multiple neural spike trains in a scale-space in which a spectral clustering algorithm is able to identify clusters of correlated firing within different behavioral contexts (temporal bin-width choices). The method constitutes a natural extension to the multiscale representation of the neural data obtained from the array-based multiresolution spike detection and sorting algorithms previously developed. The advantage of the proposed method is its ability to efficiently identify populations of recorded neurons with correlated activity independent of the temporal scale from which rate functions are typically estimated. Moreover, it relies on simultaneously maximizing cluster aggregation based on similarity as well as cluster segregation based on dissimilarity across any number of neuronal spike trains. We compare the performance to the classical A-means and the probabilistic (Bayesian) clustering algorithms on a complex synthesized data set to illustrate the substantial gain in clustering accuracy","PeriodicalId":113815,"journal":{"name":"Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005.","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114457196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Modeling Biological Noise in Firing and Bursting Neurons in the Presence of an Electromagnetic Field 电磁场作用下放电和爆破神经元的生物噪声建模

Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005. Pub Date : 2005-03-16 DOI: 10.1109/CNE.2005.1419600

M. Giannì, F. Maggio, M. Liberti, A. Paffi, F. Apollonio, G. D'Inzeo

引用次数: 3