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Current Opinion in Immunology最新文献

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Metabolic footprint and logic through the T cell life cycle T 细胞生命周期中的代谢足迹和逻辑。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-21 DOI: 10.1016/j.coi.2024.102487
Tingting Fan, Rushil Shah, Ruoning Wang
{"title":"Metabolic footprint and logic through the T cell life cycle","authors":"Tingting Fan,&nbsp;Rushil Shah,&nbsp;Ruoning Wang","doi":"10.1016/j.coi.2024.102487","DOIUrl":"10.1016/j.coi.2024.102487","url":null,"abstract":"<div><div>A simple definition of life is a system that can self-replicate (proliferation) and self-sustain (metabolism). At the cellular level, metabolism has evolved to drive proliferation, which requires energy and building blocks to duplicate cellular biomass before division. T lymphocytes (or T cells) are required for adaptive immune responses, protecting us against invading and malignant agents capable of hyper-replication. To gain a competitive advantage over these agents, activated T cells can duplicate their biomass and divide into two daughter cells in as short as 2–6 hours, considered the fastest cell division among all cell types in vertebrates. Thus, the primary task of cellular metabolism has evolved to commit available resources to drive T cell hyperproliferation. Beyond that, the T cell life cycle involves an ordered series of fate-determining events that drive cells to transition between discrete cell states. At the life stages not involved in hyperproliferation, T cells engage metabolic programs that are more flexible to sustain viability and maintenance and sometimes are fine-tuned to support specific cellular activities. Here, we focus on the central carbon metabolism, which is most relevant to cell proliferation. We provide examples of how the changes in the central carbon metabolism may or may not change the fate of T cells and further explore a few conceptual frameworks, such as metabolic flexibility, the Goldilocks Principle, overflow metabolism, and effector-signaling metabolites, in the context of T cell fate transitions.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102487"},"PeriodicalIF":6.6,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952791524000773/pdfft?md5=53eec91d31cb362d95c62f0974622792&pid=1-s2.0-S0952791524000773-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142304521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rethinking Toll-like receptor signalling 对 Toll 样受体信号的再思考
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-16 DOI: 10.1016/j.coi.2024.102460
Clare E Bryant
{"title":"Rethinking Toll-like receptor signalling","authors":"Clare E Bryant","doi":"10.1016/j.coi.2024.102460","DOIUrl":"10.1016/j.coi.2024.102460","url":null,"abstract":"<div><p>Since the discovery of Toll and Toll-like receptors (TLRs) in the 90s, an extensive body of research has been performed to determine how Pattern Recognition Receptors (PRRs) recognise ‘ligands’ and signal. The families of PRRs now include membrane and cytosolic proteins, which broadly signal by forming large protein platforms or supramolecular organising centres (SMOCs). The concept of SMOC-driven signalling has led to the development of a set of assumptions, particularly for TLRs, based on experimental data, to explain the physiological consequences of PRR activation. Recent research suggests that at least some of these assumptions should be reconsidered, especially as many of these receptors are important therapeutic targets for drug development, so understanding the mechanisms by which they signal is critical.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102460"},"PeriodicalIF":6.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952791524000505/pdfft?md5=06675d4a32ef2587f4ce04c1ff7422c0&pid=1-s2.0-S0952791524000505-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiome modulation of antigen presentation in tolerance and inflammation 微生物组在耐受和炎症中对抗原递呈的调节作用
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-14 DOI: 10.1016/j.coi.2024.102471
Yiming He , Gayatree Mohapatra , Sahana Asokan , Samuel Philip Nobs , Eran Elinav
{"title":"Microbiome modulation of antigen presentation in tolerance and inflammation","authors":"Yiming He ,&nbsp;Gayatree Mohapatra ,&nbsp;Sahana Asokan ,&nbsp;Samuel Philip Nobs ,&nbsp;Eran Elinav","doi":"10.1016/j.coi.2024.102471","DOIUrl":"10.1016/j.coi.2024.102471","url":null,"abstract":"<div><p>The microbiome regulates mammalian immune responses from early life to adulthood. Antigen presentation, orchestrating these responses, integrates commensal and pathogenic signals. However, the temporal and spatial specificity of microbiome impacts on antigen presentation and downstream tolerance versus inflammation remain incompletely understood. Herein, we review the influences of antigen presentation of microbiome-related epitopes on immunity; impacts of microbiome-based modulation of antigen presentation on innate and adaptive immune responses; and their ramifications on homeostasis and immune-related disease, ranging from auto-inflammation to tumorigenesis. We highlight mechanisms driving these influences, such as ‘molecular mimicry’, in which microbiome auto-antigen presentation aberrantly triggers an immune response driving autoimmunity or influences conferred by microbiome-derived metabolites on antigen-presenting cells in inflammatory bowel disease. We discuss unknowns, controversies, and challenges associated with the study of microbiome regulation of antigen presentation while demonstrating how increasing knowledge may contribute to the development of microbiome-based therapeutics modulating immune responses in a variety of clinical contexts.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102471"},"PeriodicalIF":6.6,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
T follicular helper cells in food allergy 食物过敏中的 T 滤泡辅助细胞
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-14 DOI: 10.1016/j.coi.2024.102461
Jennifer S Chen , Donguk Lee , Uthaman Gowthaman
{"title":"T follicular helper cells in food allergy","authors":"Jennifer S Chen ,&nbsp;Donguk Lee ,&nbsp;Uthaman Gowthaman","doi":"10.1016/j.coi.2024.102461","DOIUrl":"10.1016/j.coi.2024.102461","url":null,"abstract":"<div><p>T follicular helper (Tfh) cells help direct the production of antibodies by B cells. In addition to promoting antibody responses to vaccination and infection, Tfh cells have been found to mediate antibody production to food antigens. Work over the past decade has delineated the specific phenotypes of Tfh cells that induce antibodies to food while also clarifying the divergent Tfh cell requirement for different food-specific antibody isotypes. Furthermore, Tfh and antibody responses to food can occur at multiple barrier sites — namely, skin, airway, and gut. Depending on the context of food antigen exposure, the immune response to food at these sites can be protective, as in the case of tolerance or immunotherapy, or pathogenic, as in the case of allergy. This review will highlight recent advances in our understanding of how Tfh cells promote antibodies to food as well as future avenues for continued discovery.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102461"},"PeriodicalIF":6.6,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Powerful microscopy technologies decode spatially organized cellular networks that drive response to immunotherapy in humans 强大的显微镜技术解码了驱动人体免疫疗法反应的空间组织细胞网络
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-14 DOI: 10.1016/j.coi.2024.102463
Jonathan H Chen , Liad Elmelech , Alexander L Tang , Nir Hacohen
{"title":"Powerful microscopy technologies decode spatially organized cellular networks that drive response to immunotherapy in humans","authors":"Jonathan H Chen ,&nbsp;Liad Elmelech ,&nbsp;Alexander L Tang ,&nbsp;Nir Hacohen","doi":"10.1016/j.coi.2024.102463","DOIUrl":"10.1016/j.coi.2024.102463","url":null,"abstract":"<div><p>In tumors, immune cells organize into networks of different sizes and composition, including complex tertiary lymphoid structures and recently identified networks centered around the chemokines CXCL9/10/11 and CCL19. New commercially available highly multiplexed microscopy using cyclical RNA <em>in situ</em> hybridization and antibody-based approaches have the potential to establish the organization of the immune response in human tissue and serve as a foundation for future immunology research.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102463"},"PeriodicalIF":6.6,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142230245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Linking signal input, cell state, and spatial context to inflammatory responses 将信号输入、细胞状态和空间环境与炎症反应联系起来
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-11 DOI: 10.1016/j.coi.2024.102462
Rachel A Gottschalk , Ronald N Germain
{"title":"Linking signal input, cell state, and spatial context to inflammatory responses","authors":"Rachel A Gottschalk ,&nbsp;Ronald N Germain","doi":"10.1016/j.coi.2024.102462","DOIUrl":"10.1016/j.coi.2024.102462","url":null,"abstract":"<div><p>Signal integration is central to a causal understanding of appropriately scaled inflammatory responses. Here, we discuss recent progress in our understanding of the stimulus–response linkages downstream of pro-inflammatory inputs, with special attention to (1) the impact of cell state on the specificity of evoked gene expression and (2) the critical role of the spatial context of stimulus exposure. Advances in these directions are emerging from new tools for inferring cell–cell interactions and the activities of cytokines and transcription factors in complex microenvironments, enabling analysis of signal integration in tissue settings<em>.</em> Building on data-driven elucidation of factors driving inflammatory outcomes, mechanistic modeling can then contribute to a quantitative understanding of regulatory events that balance protective versus pathological inflammation.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102462"},"PeriodicalIF":6.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene: environment interactions in immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 infection 严重急性呼吸系统综合征冠状病毒 2 感染的免疫和炎症反应中基因与环境的相互作用。
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-06 DOI: 10.1016/j.coi.2024.102459
Yunxiang Yang, Alessia Azzuolo, Nassima Fodil, Philippe Gros
{"title":"Gene: environment interactions in immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 infection","authors":"Yunxiang Yang,&nbsp;Alessia Azzuolo,&nbsp;Nassima Fodil,&nbsp;Philippe Gros","doi":"10.1016/j.coi.2024.102459","DOIUrl":"10.1016/j.coi.2024.102459","url":null,"abstract":"<div><p>Despite its devastating human cost, the rapid spread and global establishment of the severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic had the benefit of providing unique insights into the intricate interplay between genetic, environmental, and socioeconomic factors, which collectively impact susceptibility to infection with SARS-CoV-2. Preceding the implementation of broad vaccination programs and assuming the absence of significant acquired immunity, examining the innate vulnerability to the virus becomes essential. There is indeed considerable heterogeneity observed at both the population and individual levels for various SARS-CoV-2 infection phenotypes, including emergence, progression, and survival from the coronavirus disease 2019 (COVID-19) syndrome. Particularly intriguing is the seemingly milder course of COVID-19 disease reported for the African continent early during the pandemic. This was characterized by significantly lower mortality rates in SARS-CoV-2 patients compared with the European and American continents and globally. We will discuss some of the demographic and socioeconomic factors that may have contributed to these observations. We review the mapped COVID-19 genetic architecture, including the remarkable association of type I interferon as a single protective mechanism and a major determinant of susceptibility. Furthermore, we speculate on potential ‘environmental’ modulators of penetrance and expressivity of intrinsic vulnerability factors, with a focus on the microbiome and associated metabolomes. Additionally, this review explores the potential immunomodulatory contribution of helminth parasites to the human host immune and inflammatory responses to respiratory viral infections.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"90 ","pages":"Article 102459"},"PeriodicalIF":6.6,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952791524000499/pdfft?md5=fb32fa09490ad1683df372ef85988b46&pid=1-s2.0-S0952791524000499-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Friendly fire: recognition of self by the innate immune system 友谊之火：先天免疫系统识别自我
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-09-03 DOI: 10.1016/j.coi.2024.102457
Veit Hornung , Moritz M Gaidt
{"title":"Friendly fire: recognition of self by the innate immune system","authors":"Veit Hornung ,&nbsp;Moritz M Gaidt","doi":"10.1016/j.coi.2024.102457","DOIUrl":"10.1016/j.coi.2024.102457","url":null,"abstract":"<div><p>The innate immune system employs two different strategies to detect pathogens: first, it recognizes microbial components as ligands of pattern recognition receptors (pattern-triggered immunity [PTI]), and second, it detects the activities of pathogen-encoded effectors (effector-triggered immunity [ETI]). Recently, these pathogen-centric concepts were expanded to include sensing of self-derived signals during cellular distress or damage (damage-triggered immunity [DTI]). This extension relied on broadening the PTI model to include damage-associated molecular patterns (DAMPs). However, applying the pattern recognition framework of PTI to DTI overlooks the critical role of sterile activation of ETI pathways. We argue that both PTI and ETI pathways are prone to erroneous detection of self, which is largely attributable to ‘friendly fire’ rather than protective immune activation. This erroneous activation is inherent to the trade-off between sensitivity and specificity of immune sensing and might be tolerated because its detrimental effects emerge late in life, a phenomenon known as antagonistic pleiotropy.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"90 ","pages":"Article 102457"},"PeriodicalIF":6.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142128499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroimmune recognition of allergens 神经免疫识别过敏原
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-08-29 DOI: 10.1016/j.coi.2024.102458
Isaac M Chiu , Caroline L Sokol
{"title":"Neuroimmune recognition of allergens","authors":"Isaac M Chiu ,&nbsp;Caroline L Sokol","doi":"10.1016/j.coi.2024.102458","DOIUrl":"10.1016/j.coi.2024.102458","url":null,"abstract":"<div><p>Interactions between the nervous system and the immune system play crucial roles in initiating and directing the type 2 immune response. Sensory neurons can initiate innate and adaptive type 2 immunity through their ability to detect allergens and promote dendritic cell and mast cell responses. Neurons also indirectly promote type 2 inflammation through suppression of type 1 immune responses. Type 2 cytokines promote neuronal function by directly activating or sensitizing neurons. This positive neuroimmune feedback loop may not only enhance allergic inflammation but also promote the system-wide responses of aversion, anaphylaxis, and allergen polysensitization that are characteristic of allergic immunity.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"90 ","pages":"Article 102458"},"PeriodicalIF":6.6,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining the niche for stem-like CD8+ T cell formation and function 确定干样 CD8+ T 细胞形成和功能的生态位
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2024-08-01 DOI: 10.1016/j.coi.2024.102454
Benjamin J Broomfield , Joanna R Groom
{"title":"Defining the niche for stem-like CD8+ T cell formation and function","authors":"Benjamin J Broomfield ,&nbsp;Joanna R Groom","doi":"10.1016/j.coi.2024.102454","DOIUrl":"10.1016/j.coi.2024.102454","url":null,"abstract":"<div><p>TCF-1<sup>+</sup> CD8<sup>+</sup> T cell populations have emerged as critical determinants for long-lived immunological memory. This cell population has stem-like properties and is implicated in improved disease outcomes by driving sustained killing of infected cells and maintaining the immune-cancer equilibrium. During an immune response, several factors, including antigen deposition and affinity, the inflammatory milieu, and T cell priming dynamics, aggregate to skew CD8<sup>+</sup> T cell differentiation. Although these mechanisms are altered between acute and chronic disease settings, phenotypically similar stem-like TCF-1<sup>+</sup> CD8<sup>+</sup> T cell states are formed in each of these settings. Here, we characterize the specialized microenvironments within lymph nodes and the tumor microenvironment, which foster the generation or re-activation of stem-like TCF-1<sup>+</sup> CD8<sup>+</sup> T cell populations. We highlight the potential for targeting the stem-like CD8<sup>+</sup> T cell niche to enhance vaccination and cancer immunotherapy and to track the trajectory of stem-like CD8<sup>+</sup> T cells as biomarkers of therapeutic efficacy.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"89 ","pages":"Article 102454"},"PeriodicalIF":6.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141997309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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