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Neuroimmune mechanisms of neuropsychiatric systemic lupus erythematosus 神经精神系统性红斑狼疮的神经免疫机制
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2025-10-01 Epub Date: 2025-07-18 DOI: 10.1016/j.coi.2025.102608
Stacie L Lin , Michael C Carroll
{"title":"Neuroimmune mechanisms of neuropsychiatric systemic lupus erythematosus","authors":"Stacie L Lin ,&nbsp;Michael C Carroll","doi":"10.1016/j.coi.2025.102608","DOIUrl":"10.1016/j.coi.2025.102608","url":null,"abstract":"<div><div>In systemic lupus erythematosus (SLE), chronic autoimmunity and sustained inflammation can lead to the development of neuropsychiatric lupus (NPSLE) in up to 80% of patients. Elevated interferon-alpha (IFNα) is detected in serum and cerebrospinal fluid, making it a major focus in studies investigating the mediators of NPSLE. Others have emphasized the role of autoantibodies, such as anti-dsDNA, which have been shown to cross-react with neurotransmitter receptors and directly damage neurons. In this review, we present an integrative framework in which immune complexes deposited in the neurovasculature trigger local IFNα production in the brain. We discuss how complement activation amplifies inflammation by recruiting monocytes and promoting transcriptional shifts in glial cells toward reactive and neurotoxic states. Together, cellular and soluble immune effectors converge to disrupt neuronal function and drive the behavioral symptoms characteristic of NPSLE.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"96 ","pages":"Article 102608"},"PeriodicalIF":6.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144656227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implication of epigenetic factors in development and recurrence of psoriasis 表观遗传因素在银屑病发展和复发中的意义
IF 5.8 2区 医学
Current Opinion in Immunology Pub Date : 2025-10-01 Epub Date: 2025-08-14 DOI: 10.1016/j.coi.2025.102636
Jingyi Tang, Erle Dang, Gang Wang
{"title":"Implication of epigenetic factors in development and recurrence of psoriasis","authors":"Jingyi Tang,&nbsp;Erle Dang,&nbsp;Gang Wang","doi":"10.1016/j.coi.2025.102636","DOIUrl":"10.1016/j.coi.2025.102636","url":null,"abstract":"<div><div>Psoriasis is a chronic autoimmune skin disease characterized by abnormal proliferation and differentiation of keratinocytes, with a complex pathogenesis often linked to environmental and genetic factors. Although many treatments are available, the disease still exhibits a high recurrence rate. Epigenetic regulation appears to bridge external stimuli and genetic abnormalities in the development of psoriasis. Skin-resident cells may contribute to disease recurrence through an ‘inflammatory memory’ formed through epigenetic modifications. This review focuses on skin-resident cells in psoriasis, elucidating their roles in disease progression and recurrence from an epigenetic perspective, providing scientific evidence for targeted therapies.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"96 ","pages":"Article 102636"},"PeriodicalIF":5.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144829092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Friend or foe? — Janus Langerhans cells in skin immunity and promising clinical application 是敌是友？-朗格汉斯细胞在皮肤免疫中的应用前景
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2025-10-01 Epub Date: 2025-07-18 DOI: 10.1016/j.coi.2025.102615
Mengjiao Chen , Shiyi Yan , Jun Li , Juan Tao
{"title":"Friend or foe? — Janus Langerhans cells in skin immunity and promising clinical application","authors":"Mengjiao Chen ,&nbsp;Shiyi Yan ,&nbsp;Jun Li ,&nbsp;Juan Tao","doi":"10.1016/j.coi.2025.102615","DOIUrl":"10.1016/j.coi.2025.102615","url":null,"abstract":"<div><div>Langerhans cells (LCs), the professional antigen-presenting cells in the epidermis, serve as the first line of defense in the skin's immune system. With advancements in detection technologies and the development of diverse animal models, LCs have been shown to exhibit heterogeneous origins, phenotypes, and functions, which are regulated in a context-dependent manner by various cytokines and transcription factors. This heterogeneity enables LCs to either promote or suppress immune responses depending on the microenvironment. As research advances in elucidating the regulatory mechanisms underlying LC phenotypes and functions across various pathological conditions, clinical studies targeting LCs are gradually progressing. This review summarizes commonly used experimental animal models in LC research, highlights the phenotypic diversity of LCs in various diseases, and discusses their dual roles in disease progression. With our understanding of LC heterogeneity deepening, we anticipate elucidating the characteristic of distinct LC subgroups, thereby establishing a solid foundation for LC-targeted precision immunotherapy.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"96 ","pages":"Article 102615"},"PeriodicalIF":6.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent progress in understanding of allergic transfusion reaction 过敏性输血反应的最新研究进展
IF 5.8 2区 医学
Current Opinion in Immunology Pub Date : 2025-10-01 Epub Date: 2025-08-20 DOI: 10.1016/j.coi.2025.102644
Fumiya Hirayama , Ayumu Kuroishi , Nobuki Matsuyama , Kazuta Yasui , Yoshihiro Takihara
{"title":"Recent progress in understanding of allergic transfusion reaction","authors":"Fumiya Hirayama ,&nbsp;Ayumu Kuroishi ,&nbsp;Nobuki Matsuyama ,&nbsp;Kazuta Yasui ,&nbsp;Yoshihiro Takihara","doi":"10.1016/j.coi.2025.102644","DOIUrl":"10.1016/j.coi.2025.102644","url":null,"abstract":"<div><div>Allergic transfusion reactions (ATRs) are among the most common adverse nonhemolytic transfusion reactions. However, since ATR is diagnosed based only on clinical observations, contrary to other allergic diseases, the causal relationship between a given ATR and the corresponding transfusion remains ambiguous in most cases. Although the prevailing theory suggests that immunoglobulin E (IgE)-mediated type I allergies are the primary cause of ATRs, the IgE-mediated pathway has rarely been demonstrated. Furthermore, despite accumulating reports suggesting the role of allergic predispositions to food and inhaled antigens, the etiology of ATR has yet to be fully elucidated. The recent introduction of the basophil activation test (BAT) and passive immune BAT into transfusion medicine has provided novel insights into these issues.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"96 ","pages":"Article 102644"},"PeriodicalIF":5.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can we cure autoimmune hepatitis? 我们能治愈自身免疫性肝炎吗？
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2025-10-01 Epub Date: 2025-07-14 DOI: 10.1016/j.coi.2025.102609
Maria Serena Longhi , Lina Zhang , Giorgina Mieli-Vergani , Diego Vergani
{"title":"Can we cure autoimmune hepatitis?","authors":"Maria Serena Longhi ,&nbsp;Lina Zhang ,&nbsp;Giorgina Mieli-Vergani ,&nbsp;Diego Vergani","doi":"10.1016/j.coi.2025.102609","DOIUrl":"10.1016/j.coi.2025.102609","url":null,"abstract":"<div><div>Autoimmune hepatitis (AIH) is an organ-specific autoimmune disorder mainly affecting females and characterized by seropositivity for autoantibodies, hypergammaglobulinemia, and histological evidence of interface hepatitis. Liver damage in AIH is perpetrated by multiple immune cell subsets, including B, T lymphocytes, and macrophages. Dysfunction of regulatory T cells (Tregs), an immune subset central to immunotolerance, plays an important permissive role by enabling effector lymphocytes to act unopposed and perpetuate autoimmune liver injury. Corticosteroids and azathioprine are the mainstay of treatment, resulting in disease remission in 80–90% of cases. Second- and third-line treatment, including mycophenolate mofetil, calcineurin inhibitors, and anti-B lymphocyte strategies, are used in difficult-to-treat cases or intolerant patients. Although controlling inflammation, these immunosuppressants are associated with significant side effects that impact patients’ quality of life and adherence to treatment and, importantly, do not enable immune tolerance reconstitution. Strategies based on adoptive transfer of or <em>ex vivo</em> expansion of Tregs would enable limiting effector cell immunity while reconstituting immune tolerance. Additional studies into the mechanisms resulting in Treg dysfunction at both systemic and tissue levels are warranted to engineer more potent, stable, and long-lasting Tregs to be used in immunotherapy. Restoring Treg pool would be a key step forward toward the cure of this autoimmune condition and other autoimmune diseases with similar pathogenesis.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"96 ","pages":"Article 102609"},"PeriodicalIF":6.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic regulation of inflammation dynamics during wound healing: a subtle yet profound shift in histone modifications 伤口愈合过程中炎症动态的表观遗传调控：组蛋白修饰的微妙而深刻的转变
IF 5.8 2区 医学
Current Opinion in Immunology Pub Date : 2025-10-01 Epub Date: 2025-08-06 DOI: 10.1016/j.coi.2025.102635
Jingyu Xiao , Mengjiao Chen , Yamin Zhang , Juan Tao
{"title":"Epigenetic regulation of inflammation dynamics during wound healing: a subtle yet profound shift in histone modifications","authors":"Jingyu Xiao ,&nbsp;Mengjiao Chen ,&nbsp;Yamin Zhang ,&nbsp;Juan Tao","doi":"10.1016/j.coi.2025.102635","DOIUrl":"10.1016/j.coi.2025.102635","url":null,"abstract":"<div><div>Wound healing represents a dynamic process centered on the temporally coordinated inflammatory, proliferative, and remodeling phases. The inflammatory response exhibits a double-edged role: a moderate response is essential for normal healing, but excessive or persistent response impedes repair processes. In normal wound healing, histone modifications precisely regulate inflammatory responses from initiation to resolution, mainly manifested through early-stage modulation of NETs and late-stage intervention in macrophage polarization. In chronic non-healing wounds such as diabetic wounds, venous ulcers, and pressure ulcers, the specific pathological microenvironment regulates the inflammatory response of immune cells through various histone modifications, resulting in a greater intensity and longer duration of the inflammation. Herein, we summarize the critical roles of histone modifications in normal and chronic non-healing wounds, highlighting the subtle alterations of histone methylation and acetylation in macrophages that lead to macrophage reprogramming and inflammation regulation, thus providing the promise of precision therapy for chronic non-healing wounds.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"96 ","pages":"Article 102635"},"PeriodicalIF":5.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Red blood cell alloimmunization immunogenetic risk factor 红细胞异体免疫免疫遗传危险因素
IF 5.8 2区 医学
Current Opinion in Immunology Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1016/j.coi.2025.102634
Pascal Pedini , Jacques Chiaroni , Christophe Picard
{"title":"Red blood cell alloimmunization immunogenetic risk factor","authors":"Pascal Pedini ,&nbsp;Jacques Chiaroni ,&nbsp;Christophe Picard","doi":"10.1016/j.coi.2025.102634","DOIUrl":"10.1016/j.coi.2025.102634","url":null,"abstract":"<div><div>Alloimmunization to blood group antigens is the result of a humoral immune response initiated by exposure to foreign antigens absent from the recipient's red blood cells (RBCs). Interestingly, not all individuals who receive mismatched RBC transfusions develop alloantibodies. Increasing evidence points to the role of the classical human leukocyte antigen (HLA) system in modulating this immune response. More recently, polymorphisms in nonclassical HLA molecules have been implicated in the regulation of inflammatory responses, particularly in patients with sickle cell disease. The role of natural fetomaternal microchimerism may also be a factor to consider in explaining individual variability in alloimmune response.</div><div>The genetic diversity of both RBC antigens and HLA across ethnic groups underscores the need for high-throughput sequencing technologies to improve donor–recipient matching. In the future, genotyping strategies should aim not only to assess individual risk for alloantibody development but also to guide the selection of compatible RBC units, thereby reducing the likelihood of alloimmunization.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"96 ","pages":"Article 102634"},"PeriodicalIF":5.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunological complications of blood transfusion: current insights and advances 输血的免疫学并发症：当前的见解和进展
IF 5.8 2区 医学
Current Opinion in Immunology Pub Date : 2025-10-01 Epub Date: 2025-07-29 DOI: 10.1016/j.coi.2025.102617
Naveen Bansal , Manish Raturi , Charu Singh , Yashik Bansal
{"title":"Immunological complications of blood transfusion: current insights and advances","authors":"Naveen Bansal ,&nbsp;Manish Raturi ,&nbsp;Charu Singh ,&nbsp;Yashik Bansal","doi":"10.1016/j.coi.2025.102617","DOIUrl":"10.1016/j.coi.2025.102617","url":null,"abstract":"<div><div>Blood transfusion is integral to modern medicine but carries significant immunological risks. This review outlines key immune-mediated complications, including acute hemolytic transfusion reactions from ABO incompatibility, and febrile nonhemolytic reactions caused by cytokines or antileukocyte antibodies. Other reactions include allergic responses, anaphylaxis (notably in IgA-deficient patients), and transfusion-related acute lung injury — the leading cause of transfusion-related mortality. Delayed hemolytic reactions, alloimmunization-induced platelet refractoriness, transfusion-associated graft-versus-host disease, and post-transfusion purpura also contribute to morbidity. Transfusion-related immunomodulation may increase infection and cancer recurrence risks. Preventive measures such as leukoreduction, irradiation, extended antigen matching, and restrictive transfusion strategies are crucial. This review article emphasis the importance on the need for strict adherence to protocols, enhanced hemovigilance, and education, especially in resource-limited settings. This review article summarizes the various immunological complications of blood transfusion and the recent advances in their etiopathogenesis, prevention, mitigation, and future research direction.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"96 ","pages":"Article 102617"},"PeriodicalIF":5.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary sclerosing cholangitis: what is new in the therapeutic landscape 原发性硬化性胆管炎：治疗领域的新进展
IF 6.6 2区 医学
Current Opinion in Immunology Pub Date : 2025-10-01 Epub Date: 2025-07-18 DOI: 10.1016/j.coi.2025.102613
Armando Curto , Laura Cristoferi , Marco Carbone , Andrea Galli , Pietro Invernizzi
{"title":"Primary sclerosing cholangitis: what is new in the therapeutic landscape","authors":"Armando Curto ,&nbsp;Laura Cristoferi ,&nbsp;Marco Carbone ,&nbsp;Andrea Galli ,&nbsp;Pietro Invernizzi","doi":"10.1016/j.coi.2025.102613","DOIUrl":"10.1016/j.coi.2025.102613","url":null,"abstract":"<div><div>Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease affecting the intra- and extra-hepatic bile ducts, leading to progressive inflammation and fibrosis. Its pathogenesis is complex and involves genetic predisposition, environmental triggers, and their interaction through the gut–liver axis, mediated by the microbiota. To date, no approved therapies modify the natural history of PSC, and liver transplantation remains the only curative option.</div><div>This review provides an overview of current investigational therapies for PSC, emphasizing their mechanisms of action and relevance to the underlying disease biology. It also examines key challenges in therapeutic development, including the lack of validated surrogate end points, clinical heterogeneity, and the confounding effects of concomitant inflammatory bowel disease treatments factors that complicate trial design and interpretation.</div><div>Clarifying these aspects is essential to support the development of effective, targeted therapies for this complex and currently untreatable condition.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"96 ","pages":"Article 102613"},"PeriodicalIF":6.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144656225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transfusion-related acute lung injury: experimental models to study pathogenesis and therapeutic strategies 输血相关性急性肺损伤：实验模型研究发病机制和治疗策略
IF 5.8 2区 医学
Current Opinion in Immunology Pub Date : 2025-10-01 Epub Date: 2025-08-26 DOI: 10.1016/j.coi.2025.102650
Farahnaz Rayatdoost , Rick Kapur
{"title":"Transfusion-related acute lung injury: experimental models to study pathogenesis and therapeutic strategies","authors":"Farahnaz Rayatdoost ,&nbsp;Rick Kapur","doi":"10.1016/j.coi.2025.102650","DOIUrl":"10.1016/j.coi.2025.102650","url":null,"abstract":"<div><div>Transfusion-related acute lung injury (TRALI) is a life-threatening complication of blood transfusion, with mortality rates exceeding 40% in critically ill patients. Despite its clinical severity, TRALI pathogenesis remains unclear, leaving clinicians struggling to fully understand and manage it due to its unpredictable onset, complex causes, and lack of available treatments. Recent advances in experimental models, including <em>in vitro</em>, <em>ex vivo</em>, and <em>in vivo</em> models, have revealed novel mechanisms such as neutrophil extracellular trap formation, gut–microbiota crosstalk, and endothelial and neutrophil-derived reactive oxygen species, as well as some preclinical therapeutic advancements. This review synthesizes mechanistic insights from experimental models, critically evaluates their translational applicability, and proposes a roadmap for personalized prevention strategies, including biomarker-driven transfusion protocols.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"96 ","pages":"Article 102650"},"PeriodicalIF":5.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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