Diagnostic Cytopathology最新文献

{"title":"Correction to “Middle Ear Adenoma: Cytohistologic Features and Differential Diagnosis”","authors":"","doi":"10.1002/dc.25413","DOIUrl":"10.1002/dc.25413","url":null,"abstract":"<p>A. Almajnooni, M. Vega, L. Cheng, P. Gattuso, and M. K. Allen-Proctor, “Middle Ear Adenoma: Cytohistologic Features and Differential Diagnosis,” <i>Diagnostic Cytopathology</i> 51, no. 4 (2023): E137–E141, https://doi.org/10.1002/dc.25103.</p><p>There is a missing affiliation for the first author (Almajnooni, A.). The missing affiliation is: Department of Pathology, Qunfudah College of Medicine, Umm Al-Qura University, Makkah, Saudia Arabia.</p><p>We apologize for this error.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"52 12","pages":"793"},"PeriodicalIF":1.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dc.25413","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study of the Paris System and Common Reporting System for Urine Cytology With Cyto-Histology Correlation: A Study of 829 Urine Cytology Specimens","authors":"Anju Khairwa,&nbsp; Swati,&nbsp;Prerna Mahajan,&nbsp;Preeti Diwaker,&nbsp;Khan Amir Maroof","doi":"10.1002/dc.25414","DOIUrl":"10.1002/dc.25414","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The Paris System (TPS) diligently detects high-grade urothelial carcinoma (HGUC) and creates a uniform, standardized, reproducible reporting system for urine cytology. However, many centres might still use a common reporting system (CRS). The study aims to compare TPS and CRS for urine cytology with histology correlation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>It was a cross-sectional study done from July 2016 to December 2022.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study included 829 urine cytology samples (96% voided urine) from 478 patients. Histology correlation was available for 138 (16.6%) samples of 115 patients. The frequency of NHGUC, AUC, HGUC and SHGUC was 40.6%, 17.4%, 12.2% and 5.5%, respectively, in TPS. In contrast, in CRS, the frequency of NM, AUS, SM and PM was 69.2%, 13.3%, 4.5% and 13.0%, respectively. TPS and CRS had 64% agreement overall with the kappa test (κ-value 0.479, moderate strength). The agreement between TPS and CRS was 39.8% for NHGUC, 10.97% for AUC and 10.85% for HGUC. After combining a few TPS categories, the agreement increased to 87.7% (κ-value 0.7640, good strength). Histological concordance for AUC, HGUC and NHGUC was 75%, 31.8% and 31.3% in TPS, and it was 50% and 33.3% for AUS and PM, respectively, in CRS. The sensitivity and specificity of TPS and CRS against histology were 37.5% vs. 26.0%, <i>p</i> = 0.0005 and 76.5% vs. 85.3%, <i>p</i> = 0.0083, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>TPS and CRS have moderate strength of agreement for urine cytology. TPS was more sensitive than CRS. It may be easy for institutes to transition to a newer TPS system if they still use a CRS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 2","pages":"51-57"},"PeriodicalIF":1.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fine Needle Aspiration Cytology of Pancreatoblastoma in Adult/Adolescent Patients, One With Histology Mimicking NUT Carcinoma","authors":"Zhengfan Xu,&nbsp;Sameer Chhetri Aryal,&nbsp;Kelsey McHugh,&nbsp;Brian K. Theisen,&nbsp;Lisi Yuan","doi":"10.1002/dc.25412","DOIUrl":"10.1002/dc.25412","url":null,"abstract":"<div>\u0000 \u0000 <p>Pancreatoblastoma is a rare malignant neoplasm. Cytologic diagnosis is challenging due to the tumor's heterogeneity and requirement of the presence of squamoid nests. Commonly affects children, but the tumor rarely is seen in adult patients. We are reporting three cases from two patients. First patient was a 38-year-old male with a mass in the pancreatic body and numerous hepatic lesions. Fine-needle aspiration (FNA) of the pancreas showed a biphasic malignancy, predominantly composed of a primitive component with intermingled squamoid nests. Subsequent Liver FNA from the same patient showed a similar biphasic malignancy. NUT carcinoma was the top differential and was ruled out by molecular testing. Second patient was a 24-year-old female with a history of pancreatoblastoma related to Gardner's syndrome initially diagnosed in 2015 at age 17, status post distal pancreatectomy and chemotherapy. Celiac lymph node FNA in 2021 showed few cohesive clusters of atypical epithelioid cells, which were highlighted by beta-catenin. Lastly, the literature was reviewed; differential diagnosis and ancillary testing were discussed.</p>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 2","pages":"E17-E22"},"PeriodicalIF":1.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Agreement in Whole Slide Digital Images of Cervical Cytology and Cell Blocks","authors":"Giovanni Negri,&nbsp;Martina Tauber,&nbsp;Maurizio Pinamonti,&nbsp;Luca Golinelli,&nbsp;Maja Garofalo,&nbsp;Fabio Vittadello,&nbsp;Arrigo Capitanio","doi":"10.1002/dc.25411","DOIUrl":"10.1002/dc.25411","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cell blocks (CB) are an established technique in non-gynecological cytology, but experience in gynecological cytology is still relatively limited. In this study, we compared the diagnostic agreement between liquid-based cytology (LBC) and CB using whole slide digital imaging (WSI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>WSI of 82 specimens (41 LBC and 41 CB) were evaluated independently by three observers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The overall agreement was 0.463 for all 82 cases including both LBC and CB, 0.439 for LBC alone, and 0.484 for CB alone. Agreement was highest for HSIL, NILM, cancers and lower for borderline (ASC-US, ASC-H). There was no significant difference in agreement between LBC and CB.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>WSI of CB can be used for the diagnosis of cervical lesions and may be particularly useful in cases with high atypical cellularity or large hyperchromatic cell groups.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 1","pages":"43-47"},"PeriodicalIF":1.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pitfalls in Urine Cytology: A Case of Fumarate Hydratase-Deficient Renal Cell Carcinoma Initially Diagnosed as High-Grade Urothelial Carcinoma","authors":"Kai Cheng,&nbsp;Xuelian Zhang,&nbsp;Xiaodie Zhou,&nbsp;Xiaotong Wang,&nbsp;Wei Bao,&nbsp;Qiu Rao","doi":"10.1002/dc.25409","DOIUrl":"10.1002/dc.25409","url":null,"abstract":"<div>\u0000 \u0000 <p>Fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) is a rare, aggressive, hereditary subtype of renal cancer that requires careful diagnostic considerations. We report a case of a 33-year-old Asian woman who presented with a 20-day history of hematuria. Imaging studies revealed a solid tumor in the lower pole of the right kidney with lymph node metastases. Urinary cytology revealed benign squamous cells, inflammatory cells, and atypical epithelial cells, suggestive of high-grade urothelial carcinoma. Following a right nephrectomy, the tumor displayed papillary structures composed of cells exhibiting atypical, elongated nuclei with eosinophilic nucleoli and peripheral halos. Immunohistochemical staining demonstrated negative FH expression. Genetic analysis identified a somatic missense mutation in the FH gene, confirming the diagnosis of FH-deficient RCC. This case highlights the importance of integrating cytological, histological, and genetic analyses for accurate diagnosis of FH-deficient RCC.</p>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 1","pages":"E11-E16"},"PeriodicalIF":1.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity, Specificity, and Cost–Benefit Effect Between Primary Human Papillomavirus Testing, Primary Liquid-Based Cytology, and Co-Testing Algorithms for Cervical Lesions","authors":"Chang Gok Woo,&nbsp;Seung-Myoung Son,&nbsp;Hye-Kyung Hwang,&nbsp;Jung-Sil Bae,&nbsp;Ok-Jun Lee,&nbsp;Ho-Chang Lee","doi":"10.1002/dc.25410","DOIUrl":"10.1002/dc.25410","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cytology has long been a major screening method for cervical cancer prevention. Human papillomavirus (HPV) testing has recently been introduced for cervical cancer screening, and HPV tests become a major screening method in some countries. To seek the optimal strategy considering the cost-effectiveness for cervical cancer screening, we compared the performance of primary LBC, primary HPV test, and LBC plus HPV co-test in real practice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>From March 2016 to June 2018, 3742 patients were included in this study. Liquid-based cytology (LBC), HPV test, and histopathological assessment were performed in 3727, 1063, and 508 cases, respectively. The sensitivity, specificity, and cost–benefit effects of primary HPV, primary LBC, and co-test algorithms were simulated for 317 cases with LBC, HPV, and histopathological results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>On the LBC, 13.0% of the cases were diagnosed with atypical squamous cells of undetermined significance or higher grade lesions. In the HPV test, high-risk HPV was found in 43.5%, and 11.9% was positive for HPV type 16 or 18. Among the three simulated algorithms, the co-test demonstrated the best sensitivity (97.5%) and the lowest specificity (50.3%). The primary LBC demonstrated the best specificity (53.5%) and a slightly better sensitivity, compare with the primary HPV (95.1% vs. 93.8%). Using the primary LBC algorithm, 82.0% can be determined without additional HPV test, whereas 50.1% could be determined without additional LBC using the primary HPV algorithm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The primary LBC algorithm for uterine cervical cancer (UCC) screening is comparable to the primary HPV algorithm and has the best cost–benefit effect among the three algorithms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 1","pages":"35-42"},"PeriodicalIF":1.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dc.25410","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Commentary on “Pitfalls in the Cytological Diagnosis of Nodal Hodgkin Lymphoma”","authors":"Uma Handa,&nbsp;Rasheeda Mohamedali,&nbsp;Rajpal Singh Punia,&nbsp;Simrandeep Singh,&nbsp;Ranjeev Bhagat,&nbsp;Phiza Aggarwal,&nbsp;Manveen Kaur","doi":"10.1002/dc.25408","DOIUrl":"10.1002/dc.25408","url":null,"abstract":"","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"52 12","pages":"791-792"},"PeriodicalIF":1.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunostaining on Destained Smears in Hodgkin Lymphoma","authors":"Elisabetta Maffei,&nbsp;Pio Zeppa,&nbsp;Valentina Giudice,&nbsp;Immacolata Cozzolino","doi":"10.1002/dc.25407","DOIUrl":"10.1002/dc.25407","url":null,"abstract":"","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"52 12","pages":"789-790"},"PeriodicalIF":1.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superficial CD34 Positive Fibroblastic Tumor: A Rare Entity With Cytological and Histopathological Correlation","authors":"Abhiruchi Sharma,&nbsp;Bembem Khuraijam,&nbsp;Nita Khurana,&nbsp;Neha Pandey,&nbsp;Chandra Bhushan Singh","doi":"10.1002/dc.25406","DOIUrl":"10.1002/dc.25406","url":null,"abstract":"<div>\u0000 \u0000 <p>Superficial CD34-positive fibroblastic tumor (SPFT) is an extremely rare neoplasm of borderline (intermediate) category. To the best of our knowledge, less than 40 cases have been reported in the English literature. It is imperative to understand and emphasize its cytological features as fine needle aspiration cytology (FNAC) is still considered a first line of investigation in such cases in many countries including India. We present a case of a young male aged 27 years who presented to the General Surgery OPD with a history of slow-growing mass over right thigh for 7 years. FNAC and subsequent histopathological examination revealed a diagnosis of SPFT.</p>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 1","pages":"E5-E10"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of the WHO System for Reporting Lung Cytopathology: A Retrospective Analysis","authors":"V. Shakthivel,&nbsp;Charanjeet Ahluwalia,&nbsp;Sana Ahuja,&nbsp;Sunil Ranga","doi":"10.1002/dc.25405","DOIUrl":"10.1002/dc.25405","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Lung cancer is the leading cause of cancer-related deaths globally, with early diagnosis crucial for improving survival. The 2023 WHO reporting system for lung cytopathology aims to standardize diagnostic criteria. This study assesses the system's diagnostic accuracy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This retrospective study analyzed 207 respiratory tract cytology samples (bronchoalveolar lavage/bronchial washing and endobronchial ultrasound-guided transbronchial needle aspiration) from January 2023 to June 2024. Samples were classified into five WHO categories: Nondiagnostic, Benign, Atypical, Suspicious for Malignancy, and Malignant. Histological correlation was performed where available. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy were calculated using histological diagnosis as the reference.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients ranged from 27 to 87 years old, with a male-to-female ratio of 5.8:1. Sample distribution: Nondiagnostic (3.4%), Benign (63.7%), Atypical (6.3%), Suspicious for Malignancy (16.9%), and Malignant (9.6%). Histological correlation was available for 46.3% of cases. Risk of malignancy (ROM) was 25% for Nondiagnostic, 25.7% for Benign, 44.4% for Atypical, 93.5% for Suspicious for Malignancy, and 100% for Malignant. Highest sensitivity (84.75%) and NPV (74.29%) were achieved when Atypical, Suspicious for Malignancy, and Malignant categories were considered positive for malignancy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The 2023 WHO reporting system for lung cytopathology offers a standardized and accurate diagnostic framework, enhancing patient management. Further studies are recommended to validate these results.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 1","pages":"27-34"},"PeriodicalIF":1.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}