Diagnostic Cytopathology最新文献

{"title":"Predictors of Malignancy in Patients With a Repeated Diagnosis of Bethesda Category in Thyroid Nodules Who Underwent Surgery","authors":"Veli Vural,&nbsp;Hasan Calis,&nbsp;Burhan Mayir,&nbsp;Ilhan Tasdoven,&nbsp;Bulent Comcali,&nbsp;Osman Cem Yilmaz,&nbsp;Tolga Dinc,&nbsp;Ozgur Dandin,&nbsp;Guldeniz Karadeniz Cakmak,&nbsp;Ali Ugur Emre,&nbsp;Nusret Yilmaz,&nbsp;Cumhur Arici","doi":"10.1002/dc.25463","DOIUrl":"10.1002/dc.25463","url":null,"abstract":"<div>\u0000 \u0000 <p>Fine Needle Aspiration Biopsy (FNAB) is a diagnostic modality commonly utilized in thyroid nodules, and the incorporation of the Bethesda System further enhances its diagnostic performance. However, category III nodules according to the Bethesda System are challenging due to their suspicious cytology, which renders an indeterminate risk of malignancy and requires repeated FNAB. Previous studies emphasize the possible advantage of repeated FNAB and some clinical and radiological markers in stratification of malignancy risk, though the exact predictive factors for malignancy among Bethesda III cases remain inadequately known. The aim of this study is to focus on the analysis of clinical and radiological predictors influencing malignancy risk in patients with repeated Bethesda III diagnoses. In this retrospective study, the authors reviewed three hospitals from 2015 to 2022 and retrospectively identified 120 patients with a repeat FNAB diagnosis of Bethesda III who underwent thyroid surgery. Demographic, clinical, and ultrasound data were collected, and logistic regression was performed to identify independent predictors of malignancy. The rate of malignancy was 39.2%, which was much higher than in previous reports. There were strong associations with gender, male gender, and increased risk of malignancy, with a cumulative odds ratio of 3.67. These findings suggest that repeat FNAB in association with patient-specific factors and nodule-specific factors, such as gender and ultrasound findings, may improve the prediction of the risk of malignancy in Bethesda III thyroid nodules. This could translate into better clinical decision-making, avoiding unnecessary surgery, and improved outcomes for the patient overall.</p>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 7","pages":"344-350"},"PeriodicalIF":1.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Series and Literature Review of Angiosarcoma With Malignant Effusion—A Challenging Cytologic Diagnosis With Dire Prognostic Implications","authors":"Jamie C. Y. Lam,&nbsp;Iris Y. H. Liu,&nbsp;Joanna K. M. Ng,&nbsp;Joshua J. X. Li","doi":"10.1002/dc.25471","DOIUrl":"10.1002/dc.25471","url":null,"abstract":"<p>Angiosarcoma with malignant effusion is an uncommon yet clinically aggressive presentation, which poses as a diagnostic pitfall with its overlapping cytomorphologic features with metastatic adenocarcinoma. In this article, two cases reported in the literature were reviewed for cytology, immunocytochemistry, and clinical course. Key clinical hints, useful cytological features, and immunocytochemical markers in the diagnostic approach of this entity are presented.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 7","pages":"E119-E126"},"PeriodicalIF":1.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dc.25471","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FNAC Diagnosis of Rare Port-Site Metastasis in Gallbladder Cancer Post-Cholecystectomy","authors":"Arushi Gupta,&nbsp;Durre Aden,&nbsp;Sabina Khan,&nbsp;Nehal Ahmad","doi":"10.1002/dc.25469","DOIUrl":"10.1002/dc.25469","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Port-site metastasis (PSM) following laparoscopic cholecystectomy (LC) for unsuspected gallbladder carcinoma (GBC) is a rare occurrence. Fine Needle Aspiration Cytology is a simple and time-saving technique, thus it has proven useful in diagnosing such metastases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Report</h3>\u0000 \u0000 <p>We present a case of a 45-year-old female who developed painful, multinodular epigastric swellings 2 years post-LC, initially performed for presumed benign cholelithiasis. FNAC of the port-site swelling revealed hypercellular smears with malignant epithelial cells, leading to a diagnosis of poorly differentiated malignancy. Follow-up imaging and histopathology confirmed incidental primary gallbladder carcinoma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Port site metastasis in gallbladder carcinoma has a poor prognosis; thus, early detection and intervention are essential. Advanced imaging and FNAC under guidance serve as critical tools for early diagnosis, especially in cases lacking prior histological examination.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case highlights the critical role of vigilant post-surgical monitoring and comprehensive histopathological analysis following cholecystectomy, especially in areas with a higher incidence of gallbladder carcinoma. FNAC also plays a valuable diagnostic modality for early detection and management of Port site metastasis in unsuspected gallbladder carcinoma cases.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 6","pages":"E115-E118"},"PeriodicalIF":1.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tzanck Smear: Old Handy Tool in Modern Dermatology","authors":"Sachin Chaudhari,&nbsp;Nisha Meshram,&nbsp;Milind Bhatkule,&nbsp;Ankita Srivastava,&nbsp;Rasika Gadkari","doi":"10.1002/dc.25470","DOIUrl":"10.1002/dc.25470","url":null,"abstract":"<div>\u0000 \u0000 <p>Tzanck smears, first introduced by Arnault Tzanck, are widely used in dermatology for the cytodiagnosis of cutaneous lesions. In the current era of evidence-based medicine with the availability of more confirmatory sophisticated tests, the use of this bedside tool is limited. In this article, the authors tried to assess the utility of Tzanck smear in various dermatological disorders. Findings in the Pemphigus group of disorders were studied in detail with complete and incomplete changes. Results were compared with histopathology, anti-desmoglein antibody status, and in combination. Further subtle features of the acantholytic cells were studied in detail. The sensitivity and specificity with histopathology and anti-desmoglein antibodies were 80.70%, 68.18% and 82.75%,100%. When patients were having either follow-up of histopathology or anti-desmoglein antibodies, each sensitivity was 81.01% and specificity was 87.50%. Complete acantholytic cells were predominant in 39.18%, and incomplete cells were predominant in 60.32% of cases. Rounding was the most consistent feature followed by nuclear enlargement. Streptocytes, dyskeratosis, and tadpole cells were also seen in a few cases. Other diagnoses of viral infections, like molluscum contagiosum (4 cases) and Herpes virus cytopathic effects (25 cases), were also observed in the study. Finally, Tzanck smear is still useful in dermatology, which can aid in rapid diagnosis and starting early treatment. Incomplete acantholytic cells, when seen in smear, help to pick up Pemphigus disorders even if all the classical features are not seen.</p>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 7","pages":"333-343"},"PeriodicalIF":1.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Prevalence and Genotype Distribution of High-Risk Human Papillomavirus in Varamin (Iran)","authors":"Mahboubeh Jamshidi,&nbsp;Shohreh Zare Karizi,&nbsp;Hoda Baghizadeh,&nbsp;Vahid Ezzatizadeh,&nbsp;Fatemeh Shasti Karimi,&nbsp;Ghasem Khazaee,&nbsp;Zahra Salehi,&nbsp;Amir Javadi,&nbsp;Amitis Ramezani,&nbsp;Mona Sadat Larijani,&nbsp;Amir Houshang Nejadeh","doi":"10.1002/dc.25465","DOIUrl":"10.1002/dc.25465","url":null,"abstract":"<div>\u0000 \u0000 <p>Cervical cancer is the fourth most common type of female malignancy worldwide. Although appropriate algorithms are available for precise HPV testing in order to manage women with abnormal Papanicolaou smears, region-to-region adoption is really critical. The present study aimed at cervical cell cytology assessment as well as HPV genotyping in cervical specimens. A total of 1047 samples of the women who attended for the routine referral indications were examined in four laboratories in Varamin City (Tehran Province) from April 2021 to May 2022. Genetic analysis of cervical cells was performed by PCR and reverse dot blotting. A total of 994 samples were also investigated with Pap staining, and analysis was performed based on the Bethesda 2014 system. Among the total participants with a mean age of 34.2 years, HPV prevalence was detected in 40.12%. The highest HPV infection was determined inthe 31–40-year-old population. Furthermore, 22.15% of the detected HPVs belonged to high-risk genotypes. The most frequent high-risk HPV genotype was HPV-16, accounting for 6.78%. In addition, 951 (95.67%) women had normal NILM cytology test results, whereas 43 (4.32%) demonstrated ASC-US lesions. HPV-16 was the most prevalent type in ASC-US lesions. Furthermore, there was a significant association between the high-risk HPVs and changes in the Pap smear results (<i>p</i> &lt; 0.001). Considering the high prevalence of high-risk HPV genotypes in the studied population, the genotyping technique is recommended as a priority to determine potential HPV infection, rather than liquid Pap smear analysis as a complementary approach to liquid Pap smear analysis to enhance cervical cancer screening strategies. The findings of this study can contribute to policymaking by providing updated local data on HPV prevalence, which may support vaccination strategies and screening programs in Iran.</p>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 7","pages":"325-332"},"PeriodicalIF":1.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Papillomavirus Prevalence and Genotype Distribution Among Women With Cervical Cytological Abnormalities in Urumqi, Xinjiang, China","authors":"Jing Ma,&nbsp;Min Yang,&nbsp;Guohong Huang","doi":"10.1002/dc.25467","DOIUrl":"10.1002/dc.25467","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the genotype distribution and viral loads of human papillomavirus (HPV) among women with cervical cytological abnormalities in Urumqi, Xinjiang, China.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The HPV genotyping and viral loads were detected in 9351 patients who underwent the ThinPrep cytology test (TCT) using quantitative real-time polymerase chain reaction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Result</h3>\u0000 \u0000 <p>The overall HPV infection rate was 21.63%, with a predominance of single and high-risk HPV (hrHPV) infection. The ethnic stratification showed that the infection rates were 17.01% (265/1558) in Uyghur, 21.76% (84/386) in Kazakh, 22.20% (103/464) in Hui, and 22.79% (1490/6539) in Han. The major hrHPV genotype was HPV53 in Kazakh and HPV16 in Uyghur, Han, and Hui ethnic groups. The age-stratified data suggested that the highest HPV infection rate in Han, Hui, and Kazakh women was among 25–34 year-olds, but in the 35–44 year-old group for Uyghur. The infection rates of HPV16 in cervicitis, ASCUS, LSIL, and HSIL groups were significantly different among the five ethnic groups; the viral load of HPV16 showed a positive correlation with the severity of cervical lesions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Variations exist in HPV infection and age distribution among different ethnic groups in Xinjiang, while the HPV16 viral load can guide risk stratification of cervical lesion progression.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 7","pages":"315-324"},"PeriodicalIF":1.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of SOX17 Immunohistochemical Stain in Serous Fluid Cytology Cell Block Specimens","authors":"Neharika Shrestha,&nbsp;Xulang Zhang,&nbsp;Syed M. Gilani","doi":"10.1002/dc.25468","DOIUrl":"10.1002/dc.25468","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The identification of metastatic tumors in serous fluid cytology specimens (SFCS) has always been a challenge. In this study, we explored SOX17 as an immunohistochemical (IHC) marker for the diagnosis of metastatic gynecologic tumors in body fluid specimens.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We selected 97 tumor cases, including 85 SFCS with adequate cell block material (from gynecologic primary, <i>n</i> = 30 and others, <i>n</i> = 55) and 12 histology specimens (thymic and thyroid tumors). SOX17 IHC was performed on all selected cases, and results were interpreted as positive or negative. Positive results were further characterized by intensity (nuclear staining) as weak (1+), moderate (2+), and strong (3+) and percentage of positive cells as focal (&lt; 10%), patchy (10%–50%) and diffuse (&gt; 50%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In SFCS of gynecologic primary tumors, SOX17 exhibited strong nuclear staining in 28 out of 30 tumors, with two cases showing moderate staining. All non-gynecologic metastatic tumors in effusion cytology specimens were SOX17-negative except for one case of renal cell carcinoma, which displayed a moderate patchy staining pattern. All histology cases consisting of thymic and thyroid tumors were negative for SOX17.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In this study, all tumors of gynecologic tract origin in effusion SFCS were SOX17 positive, while all other non-gynecologic tumors were negative for SOX17 except for one case. This finding suggests that SOX17 IHC is an excellent addition to the IHC panel while working up tumors at metastatic sites, specifically when gynecologic primary tumors are in the differential diagnosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 6","pages":"304-307"},"PeriodicalIF":1.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Poor Performance of Applicator Tampon-Based Self-Collection for Liquid-Based Cytology Among Women Attending a Tertiary Hospital in South Africa”","authors":"","doi":"10.1002/dc.25466","DOIUrl":"10.1002/dc.25466","url":null,"abstract":"<p>T. A. Tiiti, V. V. Nkwinika, T. L. Mashishi, K. A. Molefi, T. L. Msibi, M. Khaba, J. Bogers, and R.L. Lebelo, “Poor Performance of Applicator Tampon-Based Self-Collection for Liquid-Based Cytology Among Women Attending a Tertiary Hospital in South Africa,” <i>Diagnostic Cytopathology</i> 53 (2025): 150–160, https://doi.org/10.1002/dc.25429.</p><p>The authors identified an oversight regarding the staining method used for cytology slides. The manuscript incorrectly states that slides were stained with Hematoxylin and Eosin (H&amp;E), whereas the correct staining method was Papanicolaou (Pap) stain.</p><p>\u0000 <b>In the abstract, methods section, lines 3–4 (page 1/11)</b>\u0000 </p><p>Current Statement: LBC slides were prepared using the ThinPrep 5000 processor and manually stained with Hematoxylin and Eosin (H&amp;E).</p><p>Correct to: LBC slides were prepared using the ThinPrep 5000 processor and manually stained with Papanicolaou (Pap) stain.</p><p>\u0000 <b>Section 4: LBC lines 1–6 (Page 3/11)</b>\u0000 </p><p>Current Statement: The automated ThinPrep 5000 processor (Hologic Inc.) processed LBC samples following the manufacturer's instructions. All slides were manually stained using Hematoxylin and Eosin (H&amp;E) stains at the Department of Anatomical Pathology, National Health Laboratory Service (NHLS) at Sefako Makgatho Health Sciences University.</p><p>Correct to: The automated ThinPrep 5000 processor (Hologic Inc.) processed LBC samples following the manufacturer's instructions. All slides were manually stained using Papanicolaou (Pap) stains at the Department of Anatomical Pathology, National Health Laboratory Service (NHLS) at Sefako Makgatho Health Sciences University.</p><p>We apologize for this error.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 5","pages":"262"},"PeriodicalIF":1.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dc.25466","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Risk of Malignancy by Application of the Proposed IAC–IARC–WHO Cytopathology System for Classification and Reporting of Soft Tissue Lesions: An Experience From Tertiary Care Center From India","authors":"Mukund Sable,&nbsp;M. Shameema Farween,&nbsp;Pritinanda Mishra,&nbsp;Suvendu Purkait,&nbsp;Pavithra Ayyanar,&nbsp;Amit Kumar Adhya,&nbsp;Madhusmita Sethy,&nbsp;Susama Patra","doi":"10.1002/dc.25464","DOIUrl":"10.1002/dc.25464","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Soft tissue lesions encompass a diverse category of diseases from benign to malignant, and their morphology might overlap; therefore, accurate categorization is needed to approach the reporting of soft tissue cytology. The cytology of these lesions is helpful in detecting the features of malignancy, which helps in guiding further management. In this study, we applied the proposed IAC–IARC–WHO cytopathology system to assess the risk of malignancy (ROM) and diagnostic accuracy (DA) for the determination of its clinical and diagnostic utility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Materials</h3>\u0000 \u0000 <p>This was a 5-year retrospective study of fine needle aspirations (FNA) of soft tissue, which were categorized according to the proposed IAC–IARC–WHO system. Cytological diagnoses were correlated with the corresponding histopathological diagnoses to assess diagnostic accuracy and ROM for each diagnostic category and to evaluate the diagnostic utility of FNAC by analyzing the sensitivity, specificity, and accuracy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 1509 FNAC cases of soft tissue lesions were classified under the proposed six categories of the IAC–IARC–WHO system. Final histology was compared with cytology in 250 cases. Considering malignant diagnosis as a positive result, the overall sensitivity, specificity, and accuracy of FNAC were found to be 58.14%, 99.03%, and 92%, respectively. ROM was calculated in each category, which had a wide range from 7.6% to 100%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We have validated the IAC–IARC–WHO system for soft tissue cytology and found it to be effective with the sensitivity and specificity results. FNA categorization is helpful for better communication between cytopathologists and clinicians, ensuring better reproducibility, which is crucial for guiding further diagnostic workup and surgical management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 6","pages":"290-303"},"PeriodicalIF":1.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of P16 Protein Detection in the Screening for High-Grade Squamous Intraepithelial and Higher Lesions of the Cervix by the Combined Detection of HR-HPV and TCT","authors":"Jiayu Zhou,&nbsp;Mi Tang,&nbsp;Chunhua Lin,&nbsp;Wei Chen","doi":"10.1002/dc.25461","DOIUrl":"10.1002/dc.25461","url":null,"abstract":"<p>Liquid-based thin layer cytology (TCT) and HR-HPV detection are the most important screening methods for cervical cancer. These two methods have limited sensitivity and specificity, so some cervical lesions are still missed or misdiagnosed. This paper mainly discusses the value of P16 protein detection in cervical cancer screening. In particular, it is effective and practical in high-grade squamous epithelial and above cervical lesions (CINII+). In this retrospective study, the diagnostic specificity and positive predictive value (PPV) of P16 protein detection for cervical CINII+ lesions were significantly higher than that of TCT and HR-HPV detection, and the accuracy was the highest. P16 protein detection can also reduce the rate of missed diagnoses in HR-HPV-negative patients and reduce unnecessary colposcopic biopsies. Our data highlight the feasibility and significance of P16 protein detection in cervical disease screening.</p>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 6","pages":"283-289"},"PeriodicalIF":1.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dc.25461","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}