Diagnostic Agreement in Whole Slide Digital Images of Cervical Cytology and Cell Blocks

IF 1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Diagnostic Cytopathology Pub Date : 2024-10-11 DOI:10.1002/dc.25411

Giovanni Negri, Martina Tauber, Maurizio Pinamonti, Luca Golinelli, Maja Garofalo, Fabio Vittadello, Arrigo Capitanio

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引用次数: 0

Abstract

Background

Cell blocks (CB) are an established technique in non-gynecological cytology, but experience in gynecological cytology is still relatively limited. In this study, we compared the diagnostic agreement between liquid-based cytology (LBC) and CB using whole slide digital imaging (WSI).

Methods

WSI of 82 specimens (41 LBC and 41 CB) were evaluated independently by three observers.

Results

The overall agreement was 0.463 for all 82 cases including both LBC and CB, 0.439 for LBC alone, and 0.484 for CB alone. Agreement was highest for HSIL, NILM, cancers and lower for borderline (ASC-US, ASC-H). There was no significant difference in agreement between LBC and CB.

Conclusions

WSI of CB can be used for the diagnosis of cervical lesions and may be particularly useful in cases with high atypical cellularity or large hyperchromatic cell groups.

查看原文本刊更多论文

宫颈细胞学和细胞块全切片数字图像的诊断一致性。

背景：细胞块（CB）是非妇科细胞学中一项成熟的技术，但在妇科细胞学中的应用仍相对有限。在这项研究中，我们使用全玻片数字成像（WSI）技术比较了液基细胞学（LBC）和细胞阻断术的诊断一致性：方法：由三名观察者对 82 份标本（41 份 LBC 和 41 份 CB）的 WSI 进行独立评估：所有 82 个病例（包括 LBC 和 CB）的总体一致性为 0.463，仅 LBC 的一致性为 0.439，仅 CB 的一致性为 0.484。HSIL、NILM和癌症的一致性最高，而边缘（ASC-US、ASC-H）的一致性较低。LBC和CB的一致性无明显差异：CB的WSI可用于宫颈病变的诊断，尤其适用于非典型细胞较多或大的高色素细胞群的病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic Cytopathology 医学-病理学

CiteScore

2.60

自引率

7.70%

发文量

163

审稿时长

3-6 weeks

期刊介绍： Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology, with special emphasis on the practical, clinical aspects of the discipline. The editors invite original scientific articles, as well as special review articles, feature articles, and letters to the editor, from laboratory professionals engaged in the practice of cytopathology. Manuscripts are accepted for publication on the basis of scientific merit, practical significance, and suitability for publication in a journal dedicated to this discipline. Original articles can be considered only with the understanding that they have never been published before and that they have not been submitted for simultaneous review to another publication.