Dermatology Research and Practice最新文献

{"title":"Comorbidities and Environmental Factors Associated with Atopic Dermatitis in Children and Adults in Dermatology-Venereology in Cotonou, Benin.","authors":"Bérénice Dégboé,&nbsp;Félix Atadokpèdé,&nbsp;Christabelle Nguessie,&nbsp;Alida Kouassi,&nbsp;Nadège Elégbédé,&nbsp;Nina Maffo,&nbsp;Fabrice Akpadjan,&nbsp;Hugues Adégbidi","doi":"10.1155/2021/1502721","DOIUrl":"https://doi.org/10.1155/2021/1502721","url":null,"abstract":"<p><strong>Introduction: </strong>The objective of this work was to document the comorbidities and environmental factors associated with atopic dermatitis (AD) in dermatology Venereology in Cotonou.</p><p><strong>Methods: </strong>A cross-sectional, prospective, and analytical study included, from January 2016 to December 2018, in the Dermatology-Venereology Department of the National Teaching Hospital Hubert Koutoukou Maga (CNHU-HKM) of Cotonou, children and adults after free and informed consent, in whom the diagnosis of AD was retained according to the criteria of the United Kingdom Working Party. Severity was assessed using SCORAD (severity scoring of atopic dermatitis).</p><p><strong>Results: </strong>The overall prevalence of AD was 7.7%. AD was more frequent in children (56.8% and 40.6%) and adults (59.8% and 37.4%) from urban and periurban areas (0.003 < <i>p</i> < 0.034). It was more frequent in children who regularly dewormed and those with complete vaccination (0.001 < <i>p</i> < 0.01). In 54.8% of children and 58.9% of adults, flare-ups occurred during the warm season. The main associated comorbidities were rhinitis and conjunctivitis in both children (49.7% and 36.1%, respectively) and adults (32.7% and 26.2%, respectively). The main triggering factors in children were heat (43.2%), pneumallergens (28.4%), and skin irritants (22.6%). In adults, we noted skin irritants (58.9%), heat (47.7%), and psychological factors (34.6%). In adults, the use of detergent soaps was associated with lichenified and severe AD (0.003 < <i>p</i> < 0.006) and that of lightening soaps with acute AD (<i>p</i>=0.042).</p><p><strong>Conclusion: </strong>AD in the Dermatology-Venereology Department of the CNHU-HKM of Cotonou was associated with comorbidities. It was influenced by environmental factors related to the tropical climate and by skin irritants or allergens.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39807864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interrelationships between Skin Structure, Function, and Microbiome of Pregnant Females and Their Newborns: Study Protocol for a Prospective Cohort Study.","authors":"Doris Wilborn,&nbsp;Jan Kottner,&nbsp;Kathrin Hillmann,&nbsp;Sa Xu,&nbsp;Frank Konietschke,&nbsp;Ulrike Blume-Peytavi","doi":"10.1155/2021/4163705","DOIUrl":"https://doi.org/10.1155/2021/4163705","url":null,"abstract":"<p><strong>Background: </strong>Pregnancy leads to several skin changes, but evidence about structural and functional skin changes is scarce. Findings on skin structure and function in children in their first year reveal rapid skin maturation, but evidence indicates that in particular, water holding and transport mechanisms are different from adults. Important questions include whether maternal cutaneous properties predict infant skin condition, and if so, how. This is especially relevant for the skin's microbiome because it closely interacts with the host and is assumed to play a role in many skin diseases. Therefore, the study objective is to explore characteristics of skin and hair of pregnant women and their newborns during pregnancy and in the first six months after delivery and their associations.</p><p><strong>Methods: </strong>The study has an observational longitudinal design. We are recruiting pregnant females between 18 and 45 years using advertisement campaigns in waiting areas of gynecologists and hospital's outpatient services. A final sample size of <i>n</i> = 100 women is the target. We perform noninvasive, standardized skin, hair, and skin microbiome measurements. We establish the baseline visit during pregnancy until at the latest four weeks before delivery. We schedule follow-up visits four weeks and six months after birth for mothers and their newborns. We will calculate descriptive statistical methods using frequencies and associations over time depending on scale levels of the measurements. <i>Discussion</i>. The majority of previous studies that have investigated infants' skin microbiome and its associations used cross-sectional designs and focused on selected characteristics in small samples. In our longitudinal study, we will characterize a broad range of individual and environmental characteristics of mothers and their newborns to evaluate interrelationships with skin parameters and their changes over time. Considering the combination of these multiple variables and levels will allow for a deeper understanding of the complex interrelationship of the newborn's skin maturation. This trial is registered with ClinicalTrials.gov (Identifier: NCT04759924).</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39786294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Literature Review: The History of Psychological Impact of Illness amongst People with Leprosy (PwL) in Countries across the Globe.","authors":"Pati Aji Achdiat,&nbsp;Eko Fuji Ariyanto,&nbsp;Michael Nobel Simanjuntak","doi":"10.1155/2021/5519608","DOIUrl":"https://doi.org/10.1155/2021/5519608","url":null,"abstract":"<p><strong>Background: </strong>Leprosy is a chronic infectious disease for which effective therapy has been long since invented. Thus, the morbidity has been decreased as technology has advanced, but the permanent disability has continuously generated stigma for centuries. The stigma causes the emergence of a poor psychological impact on people with leprosy (PwL). These impacts make new PwL reluctant to get appropriate therapy for their initial symptoms and are, thus, troublesome in accomplishing the goals of the leprosy elimination program. The aim of this review is to provide the history of psychological impact amongst PwL in countries across the globe.</p><p><strong>Methods: </strong>This is a literature review study. A keyword-based search was conducted in digital libraries. Articles reporting on PwL's psychology and related issues, such as quality of life, opportunity of building a marriage, and getting hired, were included. The data were presented based on a leprosy history timeline with cutoff points, namely, the invention of promin (1941) and multidrug treatment (1970).</p><p><strong>Results: </strong>In total, 38 studies were included in this review. These studies showed that PwL's knowledge towards leprosy has been increasing; nevertheless, their attitude is still lacking. The emotional response was described by various negative feelings that had persistently occurred. These poor psychological impacts were followed by poor treatment-seeking behavior and resulted in low quality of life.</p><p><strong>Conclusions: </strong>From year to year, the PwL's knowledge about leprosy has been getting better; nevertheless, their attitude towards the disease is still poor. The emotional response, social participation, and quality of life of PwL are persistently poor due to the persistent stigma.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39747339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intralesional Bleomycin for the Treatment of Resistant Palmoplantar and Periungual Warts.","authors":"Suchana Marahatta, Dhan Keshar Khadka, Sudha Agrawal, Arpana Rijal","doi":"10.1155/2021/8655004","DOIUrl":"10.1155/2021/8655004","url":null,"abstract":"<p><strong>Introduction: </strong>Periungual, palmar, and plantar warts are difficult to treat with poor treatment response. Intralesional (IL) bleomycin has shown promising results for their treatment in a few reports. However, we need further evidence before opting it for treating difficult sites and resistant warts. Hence, we conducted this study to assess the efficacy and safety of IL bleomycin for the treatment of resistant palmoplantar and periungual warts.</p><p><strong>Methods: </strong>In this retrospective study, we included all patients who were given IL bleomycin for warts over a year. Maximum three sittings of bleomycin (1 mg/ml) were given monthly, and they were followed up for 3 months after the procedure. The response was categorized as complete, near-complete, significant, moderate, mild, and no clearance for 100%, 75-99%, 50-74%, 25-49%, 1-25%, and 0% clearance, respectively.</p><p><strong>Results: </strong>Out of 29 patients, follow-up details were available only in 19 patients (53 warts). The mean duration was 2.5 ± 1.47 years. The number of past interventions ranged from 2-4. Wart clearance after the first intervention was complete in 36.84%, near-complete in 26.31%, significant in 26.31%, and moderate in 10.53%. Wart clearance after the last intervention was complete in 89.47% and near-complete in 10.52% of patients. However, during 3 months of follow-up after the last injection, 15.78% had a recurrence. None of them had severe local and systemic side effects.</p><p><strong>Conclusions: </strong>IL bleomycin could be a better treatment option for the treatment of resistant and difficult warts. However, we observed a higher recurrence rate even in a shorter follow-up. Hence, we need further studies with larger samples.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39565636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicoepidemiology of Skin Diseases in Children Seen at the University Hospital Center Morafeno, Toamasina, Madagascar.","authors":"Irina Mamisoa Ranaivo,&nbsp;Fandresena Arilala Sendrasoa,&nbsp;Malalaniaina Andrianarison,&nbsp;Moril Sata,&nbsp;Onivola Raharolahy,&nbsp;Dimby Stephane Ralandison,&nbsp;Lala Soavina Ramarozatovo,&nbsp;Fahafahantsoa Rapelanoro Rabenja","doi":"10.1155/2021/6456448","DOIUrl":"https://doi.org/10.1155/2021/6456448","url":null,"abstract":"<p><strong>Introduction: </strong>The child's skin diseases are common and very diverse. Many studies concerning pediatric dermatoses have been carried out in Africa and the rest of the world. Few epidemioclinical data reflect these skin diseases in children, especially in the east coast of Madagascar. We aim to describe the pattern skin diseases among children seen at the University Hospital Center Morafeno, Toamasina, Madagascar. <i>Patients and Methods</i>. A retrospective study over a 3-year period from January 2017 to December 2019 was conducted in children seen in the Dermatology Department of University Hospital Center Morafeno, Toamasina, with skin diseases.</p><p><strong>Results: </strong>During the study period, 347 children out of the 1584 new patients were retained with a sex ratio of 0.86. The mean age was 6.4 years old. The main diseases identified were skin infectious diseases (43, 23%), allergic dermatoses (24.21%), and autonomous dermatosis (15.56%).</p><p><strong>Conclusion: </strong>Our study revealed the importance of infectious and allergic dermatoses in Toamasina. It is necessary to carry out simple preventive actions such as hygiene.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39430026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trichloroacetic Acid Peeling for Treating Photoaging: A Systematic Review.","authors":"Irma Bernadette S Sitohang,&nbsp;Lili Legiawati,&nbsp;Lis Surachmiati Suseno,&nbsp;Fadhila Dea Safira","doi":"10.1155/2021/3085670","DOIUrl":"https://doi.org/10.1155/2021/3085670","url":null,"abstract":"<p><p>Photoaging can significantly contribute to lower quality of life. Medium-deep peeling using trichloroacetic acid allows controlled keratocoagulation through the dermis and into the dermal papillary layer that is effective for skin rejuvenation. The purpose of this article is to give updates regarding the efficacy, possible adverse events, and patient satisfaction of trichloroacetic acid (TCA) peeling for skin rejuvenation by assessing various photoaging parameters. A systematic review of prospective trial articles collected from PubMed, MEDLINE, EMBASE, Cochrane, and Scopus databases was conducted on November 2, 2020. Treatment efficacy was assessed based on the photoaging parameters used by each study. Adverse events and patient satisfaction as the secondary outcome were assessed based on patients-perceived improvements. Five studies included three randomized comparison studies and two prospective cohort studies. These studies show that TCA peeling significantly improve the cosmesis of photoaged facial skin. Low concentration is effective for superficial sun damage. Medium-depth peels using a higher concentration of TCA or as combination therapy are effective as skin resurfacing agents to reduce wrinkles. Some adverse effects may occur but usually resolve within weeks. Overall patients were satisfied with the treatment result. An equivalent basic skin preparation such as topical retinoic acid skin priming prior to intervention is necessary for more objective comparison. Further research studies with a larger sample size and longer follow-up period are required. This evidence suggests that TCA peeling is effective in photoaging treatment, either as monotherapy or as combination therapy with other modalities.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39421067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitude, and Practice (KAP) Survey toward Skin Cancer among Ecuadorian Population.","authors":"Victor H Pinos-León,&nbsp;César Sandoval,&nbsp;Franklin Cabrera,&nbsp;Esmeraldas Terán,&nbsp;Ana Garnica,&nbsp;Ana Kellendonk,&nbsp;Mery Alvear,&nbsp;Carla Rosero,&nbsp;Lorena Vaca,&nbsp;Jorge Bonifaz,&nbsp;Anita Buestán,&nbsp;Claudia Armas,&nbsp;Raquel Trujillo,&nbsp;Patricio Freire,&nbsp;Tamara León,&nbsp;Giselle Erazo,&nbsp;Liliana García,&nbsp;Marcela Alzate,&nbsp;Vicente Toapanta,&nbsp;Myriam Ortega,&nbsp;Daniela Caicedo,&nbsp;Alicia Pereira,&nbsp;Lenin Gómez-Barreno,&nbsp;Juan S Izquierdo-Condoy,&nbsp;Merry Charlie,&nbsp;Esteban Ortiz-Prado,&nbsp;Katherine Simbaña-Rivera","doi":"10.1155/2021/5539149","DOIUrl":"https://doi.org/10.1155/2021/5539149","url":null,"abstract":"<p><strong>Background: </strong>Skin cancer is one of the most common cancers, and melanoma is a highly preventable cancer. In Ecuador, few studies have evaluated the awareness levels of the population about the disease. For this reason, the objective of this study was to measure the level of knowledge, attitudes, and practices regarding skin cancer and its determining factors.</p><p><strong>Methods: </strong>A cross-sectional analysis using an online self-assessment questionnaire containing 40 questions was delivered. A total of 537 participants were included in this study. Knowledge, attitude, and practice scores were assigned to each participant based on the number of correct or appropriate responses. Logistic regression analysis was used to calculate crude and adjusted odds ratios.</p><p><strong>Results: </strong>In total, 75% of participants referenced knowledge of the harmful effects related to noncontrolled solar exposure. Concerning sunscreen, 76.7% knew the reason for using it. The female group was 1.68 times more likely to get a higher score than the male group, and the groups between 61-70 and 71-80 years were 0.30 and 0.17 times less likely to get a higher score compared with the less than 20-years-old group, respectively.</p><p><strong>Conclusions: </strong>The findings of this study indicate the requirement to increase the population's knowledge about skin cancer and possible protection measures. For this reason, the prevention and health promotion programs at a national level from primary healthcare centers are recommended. Due to the limitation of the representativeness of the sample, the use of more studies among Ecuadorian residents of the low socioeconomic level and replication in different provinces of Ecuador is justified.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39312962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contributing Factors and Outcome after Cryotherapy of Molluscum Contagiosum among Patients Attending Tertiary Hospital, Northern Tanzania: A Descriptive Prospective Cohort Study.","authors":"Peter J Chapa,&nbsp;Daudi R Mavura,&nbsp;Rune Philemon,&nbsp;Lulyritha Kini,&nbsp;Elisante J Masenga","doi":"10.1155/2021/9653651","DOIUrl":"https://doi.org/10.1155/2021/9653651","url":null,"abstract":"<p><strong>Background: </strong>Molluscum contagiosum (MC) is a benign infection caused by a member of the Poxviridae family, molluscum contagiosum virus (MCV). The contributing factors for MCV infection are different in different populations and study areas. Few studies have been conducted to determine the effectiveness of cryotherapy in the treatment of MC. The study's objectives were to determine contributing factors and outcome after cryotherapy of MC among patients attending a tertiary hospital in Northern Tanzania.</p><p><strong>Methods: </strong>A hospital-based cohort study was conducted at the Regional Dermatology Training Centre (RDTC) from September 2018 to August 2019, involving all patients clinically diagnosed with MC. We used a consecutive sampling method to recruit study participants. We treated all participants with cryotherapy and assessed them after two weeks. Data were collected using a structured questionnaire and analyzed using Statistical Package for the Social Sciences (SPSS) software version 21.</p><p><strong>Results: </strong>There were 49 patients with MC who agreed to participate in this study with a median age of 8 (IQR 3-22). We found 18.4% of patients with active atopic dermatitis (AD) had MC while those with a history of atopic diseases (Ad) were 32%, and 22.4% had a history of using immunosuppressive drugs. The clearance rate of cryotherapy on MC lesions was found to be 94%. Hypopigmentation was the commonest adverse effect.</p><p><strong>Conclusion: </strong>The findings of this study show that AD and immunosuppression may be contributing to MC development. Based on the clearance rate results, cryotherapy has shown to be effective and may be used in the treatment of MC.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39223969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Inflammatory and Restorative Effects of Olives in Topical Application.","authors":"Mahdiyeh Taheri, Leila Amiri-Farahani","doi":"10.1155/2021/9927976","DOIUrl":"10.1155/2021/9927976","url":null,"abstract":"<p><strong>Methods: </strong>A literature search was conducted (1990-2021) in Medline, Embase, CINAHL, Google Scholar, Science Direct, SID, IranDoc, and Magiran databases. From the 102 reviewed articles, 17 articles were selected to be included in the current article.</p><p><strong>Results: </strong>Various forms of olive have long been used to accelerate the healing of various wounds and skin damage such as diabetic foot ulcers, atopic dermatitis, diaper dermatitis, episiotomy wound, and nipple ulcer but there are still no credible documents or articles that provide reliable evidence of topical use.</p><p><strong>Conclusion: </strong>According to the information obtained from the articles reviewed, olive oil appears to be an effective, safe, and available treatment. This study suggests that olive oil is an alternative remedy to minimize the frequent use of chemical-based treatments. More research may be beneficial to reach certainty in terms of curative properties of olive oil in similar or different injuries in different populations.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39180694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and Safety of Abrocitinib in Patients with Moderate-to-Severe Atopic Dermatitis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.","authors":"Hammad Ali Fadlalmola,&nbsp;Muayad Saud Albadrani,&nbsp;Amal Mohamed Elhusein,&nbsp;Wahieba E Mohamedsalih,&nbsp;Veerabhadra D S Swamy,&nbsp;Daniel Mon Mamanao","doi":"10.1155/2021/8382761","DOIUrl":"https://doi.org/10.1155/2021/8382761","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD) is a complex, chronic, inflammatory skin disease characterized by pruritic, intense itching, and eczematous lesions affecting about 25% of children and 2% to 3% of adults worldwide. Abrocitinib is a selective inhibitor of Janus kinase-1 (JAK1) enzyme inhibiting the inflammatory process. Therefore, we aimed to assess the efficacy and safety of abrocitinib for moderate-to-severe AD.</p><p><strong>Methods: </strong>We systematically searched PubMed, Cochrane, Web of Science, Scopus, and EczemATrials till Feb 1, 2021, for reliable trials. The analysis was conducted using an inverse-variance method. The results were pooled as mean difference/event rate and 95% confidence interval.</p><p><strong>Results: </strong>Abrocitinib 100 mg and 200 mg were associated with higher IGA response, EASI-50% responders, EASI-75% responders, EASI-90% responders, number of participants with at least 4-point improvements in NRS, and quality of life measured by DLQI and CDLQI than placebo. Also, 100 mg and 200 mg were associated with lower SCORAD index, %BSA, PSAAD index, and POEM index than placebo. Abrocitinib 100 mg and 200 mg were not associated with adverse events such as upper respiratory tract infection, nasopharyngitis, dermatitis, atopic, any serious adverse events, and death.</p><p><strong>Conclusion: </strong>Abrocitinib in dose 100 mg or 200 mg is an effective, well-tolerated, and promising drug in treating patients with moderate-to-severe atopic dermatitis. However, the analysis favored the efficacy of abrocitinib 200 mg over 100 mg, but side effects such as nausea and headache are likely to occur more with 200 mg.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39180693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}