Dermatology Research and Practice最新文献

{"title":"<i>Moringa oleifera L</i>. Extracts as Bioactive Ingredients That Increase Safety of Body Wash Cosmetics.","authors":"Zofia Nizioł-Łukaszewska,&nbsp;Dominika Furman-Toczek,&nbsp;Tomasz Bujak,&nbsp;Tomasz Wasilewski,&nbsp;Zofia Hordyjewicz-Baran","doi":"10.1155/2020/8197902","DOIUrl":"https://doi.org/10.1155/2020/8197902","url":null,"abstract":"<p><p>The work attempts to obtain a multifunctional plant extract derived from Moringa tree leaves. Obtained results indicate a strong antioxidant potential of the tested extracts. It was shown that <i>Moringa oleifera</i> leaf extract is a rich source of flavonoid and phenolic compounds. Furthermore, it shows a strong antioxidant activity by scavenging free radicals. <i>In vitro</i> toxicity studies showed that the tested extracts in concentrations up to 5% showed a positive effect on cell proliferation and metabolism and may contribute to the reduction of oxidative stress in cells. It was noted that the tested model formulation of cosmetic (1% SCS) with the addition of different types of extracts might contribute to the reduction of skin irritation and improve the safety of the product.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"8197902"},"PeriodicalIF":1.5,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8197902","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38186142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Public Knowledge and Attitudes towards Vitiligo: A Survey in Mekelle City, Northern Ethiopia.","authors":"Afewerki Gebremeskel Tsadik,&nbsp;Mezgebe Zeru Teklemedhin,&nbsp;Tesfay Mehari Atey,&nbsp;Meles Tekie Gidey,&nbsp;Desilu Mahari Desta","doi":"10.1155/2020/3495165","DOIUrl":"https://doi.org/10.1155/2020/3495165","url":null,"abstract":"<p><strong>Background: </strong>The overall well-being, sense of stigmatization, and treatment outcome of persons with vitiligo are largely dependent on their social acceptance and this is linked with perception and attitude of this disease in a given population. Therefore, this study assessed the knowledge and attitude of the public towards vitiligo.</p><p><strong>Methods: </strong>A cross-sectional survey was carried out using a self-reported questionnaire distributed to adults living in Mekelle city, Northern Ethiopia from August to November 2019. Individuals who were 18 to 65 years of age and not suffering from vitiligo were included in the study. A self-administered questionnaire that contains a demographic, knowledge, and attitudes parts was used to collect data. Data were entered using Epi Data® version 3.1 and analyzed using SPSS® version 21.</p><p><strong>Results: </strong>Of the total 368 subjects, 300 completed the questionnaires giving 81.5% response rate. The mean age was 30 ± 8.3 years and the male-to-female ratio was 1.14 : 1. Friends or families were reported as the most common source of information (70%) about vitiligo. The overall vitiligo knowledge was sufficient in 68.3% of the participants. Higher vitiligo-related knowledge scores were recorded by people older than 30 and below 50, those of secondary school graduated or more, urban-dwellers, persons who had heard about vitiligo, and persons having families or friends affected by vitiligo. Attitudes towards vitiligo were positive in 43.3% of participants. This was more prevalent among employed persons, those of secondary school graduated or more, and persons having families or friends affected by vitiligo. Moreover, sufficient knowledge was significantly related to positive attitudes towards the disease (<i>p</i> < 0.0001).</p><p><strong>Conclusion: </strong>Even though the majority of the respondents had sufficient knowledge, we still found misconceptions and negative attitudes towards vitiligo. Therefore, it is still crucial to educate the public about vitiligo to ultimately improve the well-being of patients with vitiligo.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"3495165"},"PeriodicalIF":1.5,"publicationDate":"2020-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/3495165","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38058963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinico-Epidemiological Profile and Treatment Pattern of Vitiligo in Selected Dermatological Clinics of Mekelle City, Northern Ethiopia.","authors":"Afewerki Gebremeskel Tsadik, Goitom Fitsum Legesse, Desilu Mahari Desta, Brhane Teklebrhan Assefa, Hailekiros Gebretsadik Kidanemariam, Meles Tekie Gidey","doi":"10.1155/2020/3625753","DOIUrl":"10.1155/2020/3625753","url":null,"abstract":"<p><strong>Background: </strong>Vitiligo is not a well-studied disease in Ethiopia. Therefore, this study assessed its clinico-epidemiological profile and treatment patterns.</p><p><strong>Methods: </strong>An institutional-based cross-sectional study was conducted in conveniently selected dermatologic clinics of Mekelle city, Ethiopia. A two-phased study was conducted, in which the first was to determine prevalence of vitiligo while the second phase was to describe the clinico-epidemiological profile and treatment pattern of vitiligo. Four-hundred three randomly selected dermatological patients were included in the first phase study. The second phase study included vitiligo cases from the first phase study and additional vitiligo cases found in a two months period prospective study.</p><p><strong>Results: </strong>Of the 403 randomly selected dermatological patients who presented in the year 2017 to 2019, the prevalence of vitiligo was 13.15%. Of the 79 cases with vitiligo, nearly two-thirds (50, 63.3%) were males with five years as the median age at onset of the disease. Positive family history of vitiligo was recorded in about one-third (25, 31.6%) of the cases. Limbs (48, 44.5%) followed by the head and neck (26, 24%) were the most commonly affected parts of the body at the onset of the disease. The most prevalent clinical form of vitiligo was vulgaris (39.2%) followed by the focal type (26.6%). Emotional upset (24, 33.8%) and physical traumas (23, 32.4%) were the frequently reported triggering factors of vitiligo. Three-fourths (75.5%) of the cases had prescriptions of topical corticosteroids, and 24.5% of them had prescriptions of sun screen lotion.</p><p><strong>Conclusion: </strong>The prevalence of vitiligo was found to be high. The clinico-epidemiological profile of vitiligo in Ethiopia was similar with that found globally. However, treatment options of vitiligo were very limited in Ethiopia.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"3625753"},"PeriodicalIF":1.5,"publicationDate":"2020-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38059649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of General Anesthesia in Pediatric Skin Procedures with Projection on Tumescent Anesthesia.","authors":"Abdulmajeed Alajlan,&nbsp;Bader M Alhabeeb,&nbsp;Ali M Alhazmi,&nbsp;Osama A Alobaid,&nbsp;Ahmed A Alharthi,&nbsp;Nada I Al-Habib,&nbsp;Ahmed M El-Malky","doi":"10.1155/2020/9327152","DOIUrl":"https://doi.org/10.1155/2020/9327152","url":null,"abstract":"<p><strong>Background: </strong>Uses of general anaesthesia in outpatient invasive procedures have increased, especially in dermatology. Being uncooperative, children often require general anaesthesia, since surgical skin operations are mostly painful.</p><p><strong>Aim: </strong>The purpose of this study is to evaluate the safety, significant adverse events, and the complication rates related to general anaesthesia, when used among pediatric population undergoing skin procedures.</p><p><strong>Methods: </strong>We conducted a first retrospective cohort study of patient chart review during the period from September 1, 2017 through September 2019. All patients admitted for pediatric skin procedures during this period have participated in our study. We reviewed selected charts to document any unexpected admissions, adverse events, or complications. Surgical outcomes and anaesthesia complications were reviewed by three anesthesiologists. We assessed inter-rater reliability.</p><p><strong>Results: </strong>A total of 211 procedures were reported for 211 patients with 19 diagnoses. No adverse events related to anaesthesia were recognized, apart from minor complications noticed in twelve patients. The kappa value range is between 0.78 and 1.00 (95% C.I., 0.46809 to 1.00).</p><p><strong>Conclusion: </strong>Dermatologist and pediatricians can safely do necessary procedures under general anaesthesia with the supervision of pediatric-trained anesthesiologists while considering other safety and risk precautions and the pediatric age group.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"9327152"},"PeriodicalIF":1.5,"publicationDate":"2020-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/9327152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38060141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Clinical Characteristics of Aquagenic Pruritus among Medical and Pharmacy Students in Lomé (Togo).","authors":"Julienne Noude Teclessou,&nbsp;Koussake Kombate,&nbsp;Abla Sefako Akakpo,&nbsp;Abas Mouhari-Toure,&nbsp;Julie Zoua,&nbsp;Panawe Kassang,&nbsp;Bayaki Saka,&nbsp;Palokinam Pitche","doi":"10.1155/2020/8420123","DOIUrl":"https://doi.org/10.1155/2020/8420123","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to determine the prevalence and clinical characteristics of aquagenic pruritus (AP) in medical students in Lomé (Togo).</p><p><strong>Methods: </strong>This was a prospective and descriptive study conducted among medical students in Lomé from June 1^st to August 30^th, 2019. The data collection questionnaire was anonymous composed of sociodemographic variables, bathing habits, and history of allergy responding to the concept of aquagenic pruritus and its characteristics.</p><p><strong>Results: </strong>In our study, 129/591 medical students had AP, giving a prevalence of AP to 21.8%. The average age of students with AP was 23.9 years, and the M/F sex ratio was 1.5. AP was not present after each bath in 100% of the medical students who suffered from it and lasted an average of 9.09 minutes. It was characteristically pruritic (60.5%) or tingling (38.0%) and localized (45.0%) or generalized (55.0%) in respondents with history of AP. There was a significant association between the presence of AP and a personal history of allergic rhinitis (<i>p</i> < 0.01) and the presence of AP and a family AP (<i>p</i> < 0.01). Twenty-six (20.2%) respondents with AP feared taking a bath. Bathing with warm or lukewarm water (29.5%) or applying menthol ointment (27.1%) were the main precautions taken to reduce AP.</p><p><strong>Conclusion: </strong>Aquagenic pruritus is a common condition in medical students in Togo. It occurs mainly in males and can be familial.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"8420123"},"PeriodicalIF":1.5,"publicationDate":"2020-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8420123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38029536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial.","authors":"Mahin Bakhshi,&nbsp;Shahzad Gholami,&nbsp;Arash Mahboubi,&nbsp;Mahmoud Reza Jaafari,&nbsp;Mahshid Namdari","doi":"10.1155/2020/4298193","DOIUrl":"https://doi.org/10.1155/2020/4298193","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the efficacy of a combination of 1% nanocurcumin gel with 0.1% triamcinolone acetonide mouth rinse for oral lichen planus (OLP).</p><p><strong>Materials and methods: </strong>This double-blind randomized clinical trial was conducted on 31 patients with erosive or ulcerative OLP. All patients received 0.1% triamcinolone mouth rinse and were then randomly divided into two groups for combination therapy with (I) %1 nanocurcumin gel or (II) placebo gel. The reticular-erosive-ulcerative (REU) score was calculated at baseline and at two and four weeks after the intervention. The changes in the mean REU score and the efficacy index were calculated to determine the level of improvement after two and four weeks. Data were analyzed using independent <i>t</i>-test, repeated measures ANCOVA, Mann-Whitney test, and chi-square test. <i>P</i> < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>There were 14 patients in the nanocurcumin and 17 patients in the placebo group. A significantly higher decrease in the mean REU score was observed in the nanocurcumin compared with the placebo group (<i>P</i> < 0.001). The efficacy index was significantly higher in the nanocurcumin group (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Application of 1% nanocurcumin in combination with 0.1% triamcinolone acetonide can serve as an effective treatment strategy to enhance the level of improvement of lesions compared with the use of triamcinolone acetonide alone.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"4298193"},"PeriodicalIF":1.5,"publicationDate":"2020-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/4298193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38029535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous Lesions in Iranian Neonates and Their Relationships with Maternal-Neonatal Factors: A Prospective Cross-Sectional Study.","authors":"Hossein Firouzi,&nbsp;Iman Jalalimehr,&nbsp;Zahra Ostadi,&nbsp;Siavash Rahimi","doi":"10.1155/2020/8410165","DOIUrl":"https://doi.org/10.1155/2020/8410165","url":null,"abstract":"<p><p>Cutaneous lesions are common in the neonatal period and mostly physiological, transient, and self-limited; uncommonly, they are pathological and require treatment and cooperation between neonatologists and dermatologists. Particular conditions, like prematurity, can influence the onset, type, and evolution of cutaneous manifestations. Of the several articles in the literature about skin findings in newborns, only a few were performed in Iran. We aimed to investigate dermatological findings in a sample of neonates within the first three days of life and to evaluate the association between skin lesions and neonatal- or maternal-related variables. A total of 1202 newborns, hospitalized in the Department of Pediatrics of Imam Sajjad Hospital of Ramsar and Shahid Rajaee Hospital of Tonekabon, Iran, for two years, were examined. All skin findings were recorded, and information on neonatal and maternal variables was collected and analyzed to detect statistically significant associations. Skin lesions were present in 958 newborns (79.8%). The prevalence of milia, erythema toxicum, salmon patch, and Mongolian spots were 45.2%, 43%, 37.3%, and 37%, respectively. Natural vaginal delivery, use of medication, term gestation, and maternal disease were associated with a higher incidence of cutaneous lesions in neonates. Milia, erythema toxicum, Mongolian spots, and genital hyperpigmentation were seen more frequently in the male gender. Conversely, skin desquamation was seen more frequently in females. Among maternal diseases, gestational diabetes mellitus, urinary tract infection, preeclampsia, hypertension, psychiatric disorders, and uterine infection were associated with a higher prevalence of cutaneous lesions. Neonatal cutaneous lesions are a common source of concern in parents and inexperienced physicians. Therefore, prompt recognition of neonatal cutaneous lesions is essential in order to avoid unnecessary diagnostic and therapeutic procedures.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"8410165"},"PeriodicalIF":1.5,"publicationDate":"2020-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8410165","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37950499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin® with Marilex® in Pattern Hair Loss and Telogen Effluvium.","authors":"Jan Wadstein,&nbsp;Erling Thom,&nbsp;Aida Gadzhigoroeva","doi":"10.1155/2020/8125081","DOIUrl":"https://doi.org/10.1155/2020/8125081","url":null,"abstract":"<p><p>Follicular proteoglycans are key players with structural, functional, and regulatory roles in the growth and cycling behaviour of the hair follicles. The expression pattern of specific proteoglycans is strongly correlated with follicular phase transitions, which further affirms their functional involvement. Research shows that bioactive proteoglycans, e.g., versican and decorin, can actively trigger follicular phase shift by their anagen-inducing, anagen-maintaining, and immunoregulatory properties. This emerging insight has led to the recognition of \"dysregulated proteoglycan metabolism\" as a plausible causal or mediating pathology in hair growth disorders in both men and women. In support of this, declined expression of proteoglycans has been reported in cases of anagen shortening and follicular miniaturisation. To facilitate scientific communication, we propose designating this pathology \"follicular hypoglycania (FHG),\" which results from an impaired ability of follicular cells to replenish and maintain a minimum relative concentration of key proteoglycans during anagen. Lasting FHG may advance to structural decay, called proteoglycan follicular atrophy (PFA). This process is suggested to be an integral pathogenetic factor in pattern hair loss (PHL) and telogen effluvium (TE). To address FHG and PFA, a proteoglycan replacement therapy (PRT) program using oral administration of a marine-derived extract (Nourkrin® with Marilex®, produced by Pharma Medico Aps, Aarhus, Denmark) containing specific proteoglycans has been developed. In clinical studies, this treatment significantly reduced hair fall, promoted hair growth, and improved quality of life in patients with male- and female-pattern hair loss. Accordingly, PRT (using Nourkrin® with Marilex®) can be recommended as an add-on treatment or monotherapy in patients with PHL and TE.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"8125081"},"PeriodicalIF":1.5,"publicationDate":"2020-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8125081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37950500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Onychomycosis in Psoriatic Patients with Nail Disorders: Aetiological Agents and Immunosuppressive Therapy.","authors":"Núbia Carvalho Pena de Oliveira Praeiro Alves,&nbsp;Tomaz de Aquino Moreira,&nbsp;Lucivânia Duarte Silva Malvino,&nbsp;José Joaquim Rodrigues,&nbsp;Roberto Ranza,&nbsp;Lúcio Borges de Araújo,&nbsp;Reginaldo Dos Santos Pedroso","doi":"10.1155/2020/7209518","DOIUrl":"https://doi.org/10.1155/2020/7209518","url":null,"abstract":"<p><p>Psoriasis and psoriatic arthritis are chronic, relapsing, immune-based diseases. Psoriatic patients may have nail involvement in 50 to 80% of cases, and this may reach 85% in patients with joint disease, in spite of the fact that the relationship between psoriasis and onychomycosis is not well established. The aim of this study was to investigate the occurrence of onychomycosis in patients with nail disorders and diagnosis of psoriasis and psoriatic arthritis. This was a cross-sectional study in which 38 patients diagnosed with psoriasis and/or psoriatic arthritis were interviewed and had altered nail samples analysed by mycological and histopathological exams. Twenty-two (57.89%) patients had a confirmed diagnosis for onychomycosis. Seventeen (44.8%) had a positive direct mycological examination, 16 (42.1%) had positive cultures, and 12 (31.6%) were positive for fungi by histopathological examination. Dermatophytes were identified in nine (56.3%) cultures, and of these, eight were <i>Trichophyton rubrum</i> and one <i>T. tonsurans</i>. Yeasts were isolated in seven patients (43.75%), which included four <i>Candida parapsilosis</i> and three <i>C. albicans</i>. Six patients (15.78%) were not using immunosuppressive therapy, and the others were using methotrexate, etanercept, adalimumab, infliximab, secukinumab, or golimumab, in monotherapy or in combination with other drugs. The confirmed onychomycosis rate in patients using methotrexate alone was 92.8% (<i>n</i> = 13). We concluded that it is possible that there is a positive relationship between psoriatic disease and onychomycosis. And we highlight that it is also worth investigating in the future the possible role of immunosuppressive therapy (mainly methotrexate) as a predisposing factor for the development of fungal infections in psoriatic patients.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"7209518"},"PeriodicalIF":1.5,"publicationDate":"2020-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/7209518","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37937409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients.","authors":"Munir Garba,&nbsp;Omar F Khabour,&nbsp;Karem H Alzoubi,&nbsp;Ahmed Abu-Siniyeh,&nbsp;Firas Al-Qarqaz","doi":"10.1155/2020/3176521","DOIUrl":"https://doi.org/10.1155/2020/3176521","url":null,"abstract":"<p><strong>Background: </strong>Acne is a common condition of pilosebaceous follicle especially among young. Clinically, the most used medication in the treatment of moderate to severe acne is oral isotretinoin. However, interindividual variability in therapeutic response to isotretinoin and many side effects such as musculoskeletal pain, headache, and alteration in lipid profile can be seen with this treatment.</p><p><strong>Aim: </strong>In this study, the effect of genetic polymorphisms, rs2241766 and rs1501299, of the adiponectin gene was investigated in relation to the side effects of isotretinoin-treated young adult acne patients (<i>n</i> = 230).</p><p><strong>Methods: </strong>Several biochemical parameters were measured at baseline and after treatments with isotretinoin. The ADIPOQ gene SNPs, rs2241766 and rs1501299, were genotyped in 230 patients.</p><p><strong>Results: </strong>Alterations in lipid profile with a significant increase of ALT (<i>P</i>=0.007) were detected after isotretinoin treatment. Moreover, percentage change in HDL following isotretinoin treatment was significantly associated with rs1501299 (<i>P</i>=0.008). On the other hand, no associations between examined SNPs and side effects of isotretinoin and other lipid parameters (total cholesterol, LDL, and triglycerides) or liver function enzymes (ALT and AST) were detected.</p><p><strong>Conclusions: </strong>Current findings showed that rs1501299 of the ADIPOQ gene might be associated with changes in HDL level in acne patients following treatment with isotretinoin.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"3176521"},"PeriodicalIF":1.5,"publicationDate":"2020-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/3176521","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37937408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}