Dermatology Research and Practice最新文献

{"title":"The Efficacy of Amniotic Membrane Stem Cell (AMSC) Metabolite Product and Vitamin E for Wrinkles, Spots, and Pores in Photoaging.","authors":"Rahmadewi Rahmadewi,&nbsp;Retha Retha,&nbsp;Dyah Ayu Pitasari,&nbsp;Vidyani Adiningtyas Kusumastanto,&nbsp;Agatha Anindita Ayu Ardhaninggar,&nbsp;Irmadita Citrashanty,&nbsp;Maylita Sari,&nbsp;Menul Ayu Umborowati,&nbsp;Cita Rosita Sigit Prakoeswa","doi":"10.1155/2020/1584541","DOIUrl":"https://doi.org/10.1155/2020/1584541","url":null,"abstract":"<p><strong>Background: </strong>It is expected that a combination of amniotic membrane stem cell metabolite product (AMSC-MP) and vitamin E after fractional CO₂ laser as laser-assisted drug delivery (LADD) will provide better effects in photoaging treatment as the combination reaches the target. This promises an option for photoaging therapy in the future.</p><p><strong>Materials and methods: </strong>Sixty women with photoaged skins were involved in this experimental study. They were then divided into two groups. The treatment group received a topical combination of AMSC-MP and vitamin E, and the control group received AMSC-MP alone after fractional CO₂ laser. The treatment was repeated three times.</p><p><strong>Result: </strong>The Janus assessment results showed a significant difference in pores in the third observation, and the average pore improvements in the treatment group were better than the control group. Wrinkle, UV spot, and polar spot did not show any significant difference.</p><p><strong>Conclusion: </strong>A combination of the amniotic membrane stem cell metabolite product (AMSC-MP) and vitamin E after fractional CO₂ laser as LADD only improves pores in photoaged skins.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"1584541"},"PeriodicalIF":1.5,"publicationDate":"2020-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/1584541","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38363711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of the Dermatological Manifestations of Coronavirus Disease 2019 (COVID-19).","authors":"Farah Marraha, Ibtissam Al Faker, Salim Gallouj","doi":"10.1155/2020/9360476","DOIUrl":"10.1155/2020/9360476","url":null,"abstract":"<p><p>Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has affected 210 countries and territories around the world. The virus has spread rapidly, and the disease is still extending up to now. The pathophysiology for SARS-CoV-2 has not been well elucidated, and diverse hypotheses to date have been proposed. Initially, no skin manifestations were observed among patients with COVID-19, but recently a few cases have been described. In this review, we discuss these various cutaneous manifestations and skin problems related to personal protective equipment, as well as different cutaneous anti-COVID-19 drug-associated reactions. We also focus on the currently proposed managements of these rare manifestations.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"9360476"},"PeriodicalIF":1.5,"publicationDate":"2020-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38313288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of a New Artificial Dermis as a Successful Tool in Face and Scalp Reconstruction for Skin Cancer: Analysis of the Efficacy, Safety, and Aesthetic Outcomes.","authors":"Fedele Lembo,&nbsp;Liberato Roberto Cecchino,&nbsp;Domenico Parisi,&nbsp;Aurelio Portincasa","doi":"10.1155/2020/4874035","DOIUrl":"https://doi.org/10.1155/2020/4874035","url":null,"abstract":"<p><p>Radical ablative surgery is the gold standard treatment of head skin cancer. The authors expose their experience with a new artificial dermis (Pelnac®), analyzing retrospectively the overall morbidity and aesthetic outcomes. 16 consecutive patients underwent two surgical procedures under local anesthesia. The first involved the tumor removal and application of the ADM. In the second, the exposed tissue was covered with a split-thickness skin graft. On follow-up (6 months), tumor recurrences, quality of scars (using the Vancouver Scar Scale), and patient reported outcomes (using FACE-Q Skin Cancer Module) were evaluated. 10 were males and 6 females, with a mean age of 73 years (61-89). The follow-up ranged from 12 to 48 months (mean: 30). The sites of skin tumor were scalp (12 cases), forehead (2), cheek (1), and zygomatic area (1). Nine patients underwent previous local surgery; two received radiotherapy. The average length of hospital stay was 3.2 days. The mean surface area of the defect was 59.15 cm² (16.9-89.5). In three cases, the surgical bed was bone without periosteum. The malignant tumors excised were basal cell carcinoma (68.75%), squamous cell carcinoma (18.75%), malignant melanoma (6.25%), and sarcoma (6.25%). The mean operating time was 41 minutes for the first operation (25-55) and 34 for the second (25-48). No significant problems were observed and 15 patients (93.75%) had 100 percent intake of graft. The mean time of healing was 39 days (32-45). At 6 months post-op, no tumor recurrence. Satisfactory cosmetic and functional results were obtained in all patients as shown by the VSS Scale and FACEQ skin cancer module mean scores. We believe that the artificial dermis is a reliable alternative to flaps and should be considered an excellent option in head reconstruction for skin cancer, especially in critical patients (old, with large and deep defects, with recurrent tumors, required radiotherapy).</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"4874035"},"PeriodicalIF":1.5,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/4874035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38239407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Efficacy and Safety of Two Cryotherapy Protocols in the Treatment of Common Viral Warts: A Prospective Observational Study.","authors":"Jihan M Muhaidat,&nbsp;Firas A Al-Qarqaz,&nbsp;Diala M Alshiyab,&nbsp;Hadeel S Alkofahi,&nbsp;Yousef Khader,&nbsp;Mawaddah Y Ababneh","doi":"10.1155/2020/2309309","DOIUrl":"https://doi.org/10.1155/2020/2309309","url":null,"abstract":"<p><strong>Background: </strong>Cryotherapy (freezing by liquid nitrogen) is an effective and widely used method for treatment of common warts. Patients often need multiple sessions at variable intervals. Protocols used by different dermatologists vary in terms of freezing time, the number of cycles, and the intervals between sessions.</p><p><strong>Aim: </strong>To compare the efficacy (cure rates) and safety (complications, early and late) of two cryotherapy treatment protocols for common viral warts.</p><p><strong>Method: </strong>A prospective observational study was conducted; it involved 80 patients with common warts on the hands and feet who were treated with cryotherapy done by two dermatologists who use different protocols; group 1 (45 patients) were treated by a single cycle of 10 seconds of freezing at 2 weekly intervals, and group 2 (35 patients) received a single cycle of 20 seconds of freezing at 4-weeks intervals. The two protocols were compared in terms of cure rate and complications 1-2 months after the final treatment. Recurrence rate and late complications were assessed at 9-12 months after the final treatment.</p><p><strong>Results: </strong>Group 1 patients achieved higher cure rate than group 2, 77.8% and 54.3%, respectively (<i>P</i>=0.001). Early (blistering) and late complications (dyspigmentation and scarring) were comparable in both groups. Pain score associated with protocol 1 (5.2/10) was less than protocol 2 (6.4/10) (<i>P</i>=0.004). Recurrence rate (17%) was comparable in both groups. Association between cure rate and duration of warts (<i>P</i>=0.022) and also association between cure rate and the mean number of warts (<i>P</i>=0.001) were demonstrated.</p><p><strong>Conclusions: </strong>Cryotherapy is an effective and safe treatment for common viral warts of hands and feet. The impact of shorter intervals on cure rate was more significant than increasing freezing time with longer intervals between freezing sessions. The study was approved by the local IRB committee (285-2018).</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"2309309"},"PeriodicalIF":1.5,"publicationDate":"2020-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/2309309","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38239406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Moringa oleifera L</i>. Extracts as Bioactive Ingredients That Increase Safety of Body Wash Cosmetics.","authors":"Zofia Nizioł-Łukaszewska,&nbsp;Dominika Furman-Toczek,&nbsp;Tomasz Bujak,&nbsp;Tomasz Wasilewski,&nbsp;Zofia Hordyjewicz-Baran","doi":"10.1155/2020/8197902","DOIUrl":"https://doi.org/10.1155/2020/8197902","url":null,"abstract":"<p><p>The work attempts to obtain a multifunctional plant extract derived from Moringa tree leaves. Obtained results indicate a strong antioxidant potential of the tested extracts. It was shown that <i>Moringa oleifera</i> leaf extract is a rich source of flavonoid and phenolic compounds. Furthermore, it shows a strong antioxidant activity by scavenging free radicals. <i>In vitro</i> toxicity studies showed that the tested extracts in concentrations up to 5% showed a positive effect on cell proliferation and metabolism and may contribute to the reduction of oxidative stress in cells. It was noted that the tested model formulation of cosmetic (1% SCS) with the addition of different types of extracts might contribute to the reduction of skin irritation and improve the safety of the product.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"8197902"},"PeriodicalIF":1.5,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8197902","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38186142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Public Knowledge and Attitudes towards Vitiligo: A Survey in Mekelle City, Northern Ethiopia.","authors":"Afewerki Gebremeskel Tsadik,&nbsp;Mezgebe Zeru Teklemedhin,&nbsp;Tesfay Mehari Atey,&nbsp;Meles Tekie Gidey,&nbsp;Desilu Mahari Desta","doi":"10.1155/2020/3495165","DOIUrl":"https://doi.org/10.1155/2020/3495165","url":null,"abstract":"<p><strong>Background: </strong>The overall well-being, sense of stigmatization, and treatment outcome of persons with vitiligo are largely dependent on their social acceptance and this is linked with perception and attitude of this disease in a given population. Therefore, this study assessed the knowledge and attitude of the public towards vitiligo.</p><p><strong>Methods: </strong>A cross-sectional survey was carried out using a self-reported questionnaire distributed to adults living in Mekelle city, Northern Ethiopia from August to November 2019. Individuals who were 18 to 65 years of age and not suffering from vitiligo were included in the study. A self-administered questionnaire that contains a demographic, knowledge, and attitudes parts was used to collect data. Data were entered using Epi Data® version 3.1 and analyzed using SPSS® version 21.</p><p><strong>Results: </strong>Of the total 368 subjects, 300 completed the questionnaires giving 81.5% response rate. The mean age was 30 ± 8.3 years and the male-to-female ratio was 1.14 : 1. Friends or families were reported as the most common source of information (70%) about vitiligo. The overall vitiligo knowledge was sufficient in 68.3% of the participants. Higher vitiligo-related knowledge scores were recorded by people older than 30 and below 50, those of secondary school graduated or more, urban-dwellers, persons who had heard about vitiligo, and persons having families or friends affected by vitiligo. Attitudes towards vitiligo were positive in 43.3% of participants. This was more prevalent among employed persons, those of secondary school graduated or more, and persons having families or friends affected by vitiligo. Moreover, sufficient knowledge was significantly related to positive attitudes towards the disease (<i>p</i> < 0.0001).</p><p><strong>Conclusion: </strong>Even though the majority of the respondents had sufficient knowledge, we still found misconceptions and negative attitudes towards vitiligo. Therefore, it is still crucial to educate the public about vitiligo to ultimately improve the well-being of patients with vitiligo.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"3495165"},"PeriodicalIF":1.5,"publicationDate":"2020-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/3495165","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38058963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinico-Epidemiological Profile and Treatment Pattern of Vitiligo in Selected Dermatological Clinics of Mekelle City, Northern Ethiopia.","authors":"Afewerki Gebremeskel Tsadik, Goitom Fitsum Legesse, Desilu Mahari Desta, Brhane Teklebrhan Assefa, Hailekiros Gebretsadik Kidanemariam, Meles Tekie Gidey","doi":"10.1155/2020/3625753","DOIUrl":"10.1155/2020/3625753","url":null,"abstract":"<p><strong>Background: </strong>Vitiligo is not a well-studied disease in Ethiopia. Therefore, this study assessed its clinico-epidemiological profile and treatment patterns.</p><p><strong>Methods: </strong>An institutional-based cross-sectional study was conducted in conveniently selected dermatologic clinics of Mekelle city, Ethiopia. A two-phased study was conducted, in which the first was to determine prevalence of vitiligo while the second phase was to describe the clinico-epidemiological profile and treatment pattern of vitiligo. Four-hundred three randomly selected dermatological patients were included in the first phase study. The second phase study included vitiligo cases from the first phase study and additional vitiligo cases found in a two months period prospective study.</p><p><strong>Results: </strong>Of the 403 randomly selected dermatological patients who presented in the year 2017 to 2019, the prevalence of vitiligo was 13.15%. Of the 79 cases with vitiligo, nearly two-thirds (50, 63.3%) were males with five years as the median age at onset of the disease. Positive family history of vitiligo was recorded in about one-third (25, 31.6%) of the cases. Limbs (48, 44.5%) followed by the head and neck (26, 24%) were the most commonly affected parts of the body at the onset of the disease. The most prevalent clinical form of vitiligo was vulgaris (39.2%) followed by the focal type (26.6%). Emotional upset (24, 33.8%) and physical traumas (23, 32.4%) were the frequently reported triggering factors of vitiligo. Three-fourths (75.5%) of the cases had prescriptions of topical corticosteroids, and 24.5% of them had prescriptions of sun screen lotion.</p><p><strong>Conclusion: </strong>The prevalence of vitiligo was found to be high. The clinico-epidemiological profile of vitiligo in Ethiopia was similar with that found globally. However, treatment options of vitiligo were very limited in Ethiopia.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"3625753"},"PeriodicalIF":1.5,"publicationDate":"2020-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38059649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of General Anesthesia in Pediatric Skin Procedures with Projection on Tumescent Anesthesia.","authors":"Abdulmajeed Alajlan,&nbsp;Bader M Alhabeeb,&nbsp;Ali M Alhazmi,&nbsp;Osama A Alobaid,&nbsp;Ahmed A Alharthi,&nbsp;Nada I Al-Habib,&nbsp;Ahmed M El-Malky","doi":"10.1155/2020/9327152","DOIUrl":"https://doi.org/10.1155/2020/9327152","url":null,"abstract":"<p><strong>Background: </strong>Uses of general anaesthesia in outpatient invasive procedures have increased, especially in dermatology. Being uncooperative, children often require general anaesthesia, since surgical skin operations are mostly painful.</p><p><strong>Aim: </strong>The purpose of this study is to evaluate the safety, significant adverse events, and the complication rates related to general anaesthesia, when used among pediatric population undergoing skin procedures.</p><p><strong>Methods: </strong>We conducted a first retrospective cohort study of patient chart review during the period from September 1, 2017 through September 2019. All patients admitted for pediatric skin procedures during this period have participated in our study. We reviewed selected charts to document any unexpected admissions, adverse events, or complications. Surgical outcomes and anaesthesia complications were reviewed by three anesthesiologists. We assessed inter-rater reliability.</p><p><strong>Results: </strong>A total of 211 procedures were reported for 211 patients with 19 diagnoses. No adverse events related to anaesthesia were recognized, apart from minor complications noticed in twelve patients. The kappa value range is between 0.78 and 1.00 (95% C.I., 0.46809 to 1.00).</p><p><strong>Conclusion: </strong>Dermatologist and pediatricians can safely do necessary procedures under general anaesthesia with the supervision of pediatric-trained anesthesiologists while considering other safety and risk precautions and the pediatric age group.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"9327152"},"PeriodicalIF":1.5,"publicationDate":"2020-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/9327152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38060141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Clinical Characteristics of Aquagenic Pruritus among Medical and Pharmacy Students in Lomé (Togo).","authors":"Julienne Noude Teclessou,&nbsp;Koussake Kombate,&nbsp;Abla Sefako Akakpo,&nbsp;Abas Mouhari-Toure,&nbsp;Julie Zoua,&nbsp;Panawe Kassang,&nbsp;Bayaki Saka,&nbsp;Palokinam Pitche","doi":"10.1155/2020/8420123","DOIUrl":"https://doi.org/10.1155/2020/8420123","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to determine the prevalence and clinical characteristics of aquagenic pruritus (AP) in medical students in Lomé (Togo).</p><p><strong>Methods: </strong>This was a prospective and descriptive study conducted among medical students in Lomé from June 1^st to August 30^th, 2019. The data collection questionnaire was anonymous composed of sociodemographic variables, bathing habits, and history of allergy responding to the concept of aquagenic pruritus and its characteristics.</p><p><strong>Results: </strong>In our study, 129/591 medical students had AP, giving a prevalence of AP to 21.8%. The average age of students with AP was 23.9 years, and the M/F sex ratio was 1.5. AP was not present after each bath in 100% of the medical students who suffered from it and lasted an average of 9.09 minutes. It was characteristically pruritic (60.5%) or tingling (38.0%) and localized (45.0%) or generalized (55.0%) in respondents with history of AP. There was a significant association between the presence of AP and a personal history of allergic rhinitis (<i>p</i> < 0.01) and the presence of AP and a family AP (<i>p</i> < 0.01). Twenty-six (20.2%) respondents with AP feared taking a bath. Bathing with warm or lukewarm water (29.5%) or applying menthol ointment (27.1%) were the main precautions taken to reduce AP.</p><p><strong>Conclusion: </strong>Aquagenic pruritus is a common condition in medical students in Togo. It occurs mainly in males and can be familial.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"8420123"},"PeriodicalIF":1.5,"publicationDate":"2020-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8420123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38029536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial.","authors":"Mahin Bakhshi,&nbsp;Shahzad Gholami,&nbsp;Arash Mahboubi,&nbsp;Mahmoud Reza Jaafari,&nbsp;Mahshid Namdari","doi":"10.1155/2020/4298193","DOIUrl":"https://doi.org/10.1155/2020/4298193","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the efficacy of a combination of 1% nanocurcumin gel with 0.1% triamcinolone acetonide mouth rinse for oral lichen planus (OLP).</p><p><strong>Materials and methods: </strong>This double-blind randomized clinical trial was conducted on 31 patients with erosive or ulcerative OLP. All patients received 0.1% triamcinolone mouth rinse and were then randomly divided into two groups for combination therapy with (I) %1 nanocurcumin gel or (II) placebo gel. The reticular-erosive-ulcerative (REU) score was calculated at baseline and at two and four weeks after the intervention. The changes in the mean REU score and the efficacy index were calculated to determine the level of improvement after two and four weeks. Data were analyzed using independent <i>t</i>-test, repeated measures ANCOVA, Mann-Whitney test, and chi-square test. <i>P</i> < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>There were 14 patients in the nanocurcumin and 17 patients in the placebo group. A significantly higher decrease in the mean REU score was observed in the nanocurcumin compared with the placebo group (<i>P</i> < 0.001). The efficacy index was significantly higher in the nanocurcumin group (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Application of 1% nanocurcumin in combination with 0.1% triamcinolone acetonide can serve as an effective treatment strategy to enhance the level of improvement of lesions compared with the use of triamcinolone acetonide alone.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"4298193"},"PeriodicalIF":1.5,"publicationDate":"2020-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/4298193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38029535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}