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Prevalence and Clinical Characteristics of Aquagenic Pruritus among Medical and Pharmacy Students in Lomé (Togo). 多哥洛美市医药学专业学生水源性瘙痒症的患病率及临床特点
IF 1.5
Dermatology Research and Practice Pub Date : 2020-05-21 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8420123
Julienne Noude Teclessou, Koussake Kombate, Abla Sefako Akakpo, Abas Mouhari-Toure, Julie Zoua, Panawe Kassang, Bayaki Saka, Palokinam Pitche
{"title":"Prevalence and Clinical Characteristics of Aquagenic Pruritus among Medical and Pharmacy Students in Lomé (Togo).","authors":"Julienne Noude Teclessou,&nbsp;Koussake Kombate,&nbsp;Abla Sefako Akakpo,&nbsp;Abas Mouhari-Toure,&nbsp;Julie Zoua,&nbsp;Panawe Kassang,&nbsp;Bayaki Saka,&nbsp;Palokinam Pitche","doi":"10.1155/2020/8420123","DOIUrl":"https://doi.org/10.1155/2020/8420123","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to determine the prevalence and clinical characteristics of aquagenic pruritus (AP) in medical students in Lomé (Togo).</p><p><strong>Methods: </strong>This was a prospective and descriptive study conducted among medical students in Lomé from June 1<sup>st</sup> to August 30<sup>th</sup>, 2019. The data collection questionnaire was anonymous composed of sociodemographic variables, bathing habits, and history of allergy responding to the concept of aquagenic pruritus and its characteristics.</p><p><strong>Results: </strong>In our study, 129/591 medical students had AP, giving a prevalence of AP to 21.8%. The average age of students with AP was 23.9 years, and the M/F sex ratio was 1.5. AP was not present after each bath in 100% of the medical students who suffered from it and lasted an average of 9.09 minutes. It was characteristically pruritic (60.5%) or tingling (38.0%) and localized (45.0%) or generalized (55.0%) in respondents with history of AP. There was a significant association between the presence of AP and a personal history of allergic rhinitis (<i>p</i> < 0.01) and the presence of AP and a family AP (<i>p</i> < 0.01). Twenty-six (20.2%) respondents with AP feared taking a bath. Bathing with warm or lukewarm water (29.5%) or applying menthol ointment (27.1%) were the main precautions taken to reduce AP.</p><p><strong>Conclusion: </strong>Aquagenic pruritus is a common condition in medical students in Togo. It occurs mainly in males and can be familial.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2020-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8420123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38029536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial. 1%纳米姜黄素凝胶和0.1%曲安奈德漱口水联合治疗口腔扁平苔藓:随机双盲安慰剂对照临床试验
IF 1.5
Dermatology Research and Practice Pub Date : 2020-05-20 eCollection Date: 2020-01-01 DOI: 10.1155/2020/4298193
Mahin Bakhshi, Shahzad Gholami, Arash Mahboubi, Mahmoud Reza Jaafari, Mahshid Namdari
{"title":"Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial.","authors":"Mahin Bakhshi,&nbsp;Shahzad Gholami,&nbsp;Arash Mahboubi,&nbsp;Mahmoud Reza Jaafari,&nbsp;Mahshid Namdari","doi":"10.1155/2020/4298193","DOIUrl":"https://doi.org/10.1155/2020/4298193","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the efficacy of a combination of 1% nanocurcumin gel with 0.1% triamcinolone acetonide mouth rinse for oral lichen planus (OLP).</p><p><strong>Materials and methods: </strong>This double-blind randomized clinical trial was conducted on 31 patients with erosive or ulcerative OLP. All patients received 0.1% triamcinolone mouth rinse and were then randomly divided into two groups for combination therapy with (I) %1 nanocurcumin gel or (II) placebo gel. The reticular-erosive-ulcerative (REU) score was calculated at baseline and at two and four weeks after the intervention. The changes in the mean REU score and the efficacy index were calculated to determine the level of improvement after two and four weeks. Data were analyzed using independent <i>t</i>-test, repeated measures ANCOVA, Mann-Whitney test, and chi-square test. <i>P</i> < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>There were 14 patients in the nanocurcumin and 17 patients in the placebo group. A significantly higher decrease in the mean REU score was observed in the nanocurcumin compared with the placebo group (<i>P</i> < 0.001). The efficacy index was significantly higher in the nanocurcumin group (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Application of 1% nanocurcumin in combination with 0.1% triamcinolone acetonide can serve as an effective treatment strategy to enhance the level of improvement of lesions compared with the use of triamcinolone acetonide alone.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2020-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/4298193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38029535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Cutaneous Lesions in Iranian Neonates and Their Relationships with Maternal-Neonatal Factors: A Prospective Cross-Sectional Study. 伊朗新生儿皮肤病变及其与母婴因素的关系:一项前瞻性横断面研究。
IF 1.5
Dermatology Research and Practice Pub Date : 2020-05-05 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8410165
Hossein Firouzi, Iman Jalalimehr, Zahra Ostadi, Siavash Rahimi
{"title":"Cutaneous Lesions in Iranian Neonates and Their Relationships with Maternal-Neonatal Factors: A Prospective Cross-Sectional Study.","authors":"Hossein Firouzi,&nbsp;Iman Jalalimehr,&nbsp;Zahra Ostadi,&nbsp;Siavash Rahimi","doi":"10.1155/2020/8410165","DOIUrl":"https://doi.org/10.1155/2020/8410165","url":null,"abstract":"<p><p>Cutaneous lesions are common in the neonatal period and mostly physiological, transient, and self-limited; uncommonly, they are pathological and require treatment and cooperation between neonatologists and dermatologists. Particular conditions, like prematurity, can influence the onset, type, and evolution of cutaneous manifestations. Of the several articles in the literature about skin findings in newborns, only a few were performed in Iran. We aimed to investigate dermatological findings in a sample of neonates within the first three days of life and to evaluate the association between skin lesions and neonatal- or maternal-related variables. A total of 1202 newborns, hospitalized in the Department of Pediatrics of Imam Sajjad Hospital of Ramsar and Shahid Rajaee Hospital of Tonekabon, Iran, for two years, were examined. All skin findings were recorded, and information on neonatal and maternal variables was collected and analyzed to detect statistically significant associations. Skin lesions were present in 958 newborns (79.8%). The prevalence of milia, erythema toxicum, salmon patch, and Mongolian spots were 45.2%, 43%, 37.3%, and 37%, respectively. Natural vaginal delivery, use of medication, term gestation, and maternal disease were associated with a higher incidence of cutaneous lesions in neonates. Milia, erythema toxicum, Mongolian spots, and genital hyperpigmentation were seen more frequently in the male gender. Conversely, skin desquamation was seen more frequently in females. Among maternal diseases, gestational diabetes mellitus, urinary tract infection, preeclampsia, hypertension, psychiatric disorders, and uterine infection were associated with a higher prevalence of cutaneous lesions. Neonatal cutaneous lesions are a common source of concern in parents and inexperienced physicians. Therefore, prompt recognition of neonatal cutaneous lesions is essential in order to avoid unnecessary diagnostic and therapeutic procedures.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2020-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8410165","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37950499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin® with Marilex® in Pattern Hair Loss and Telogen Effluvium. 特定蛋白聚糖在头发生长和脱发中的整体作用:蛋白聚糖替代疗法与nurkrin®和Marilex®在脱发和休止期脱发中的生物活性背后的机制。
IF 1.5
Dermatology Research and Practice Pub Date : 2020-05-05 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8125081
Jan Wadstein, Erling Thom, Aida Gadzhigoroeva
{"title":"Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin® with Marilex® in Pattern Hair Loss and Telogen Effluvium.","authors":"Jan Wadstein,&nbsp;Erling Thom,&nbsp;Aida Gadzhigoroeva","doi":"10.1155/2020/8125081","DOIUrl":"https://doi.org/10.1155/2020/8125081","url":null,"abstract":"<p><p>Follicular proteoglycans are key players with structural, functional, and regulatory roles in the growth and cycling behaviour of the hair follicles. The expression pattern of specific proteoglycans is strongly correlated with follicular phase transitions, which further affirms their functional involvement. Research shows that bioactive proteoglycans, e.g., versican and decorin, can actively trigger follicular phase shift by their anagen-inducing, anagen-maintaining, and immunoregulatory properties. This emerging insight has led to the recognition of \"dysregulated proteoglycan metabolism\" as a plausible causal or mediating pathology in hair growth disorders in both men and women. In support of this, declined expression of proteoglycans has been reported in cases of anagen shortening and follicular miniaturisation. To facilitate scientific communication, we propose designating this pathology \"follicular hypoglycania (FHG),\" which results from an impaired ability of follicular cells to replenish and maintain a minimum relative concentration of key proteoglycans during anagen. Lasting FHG may advance to structural decay, called proteoglycan follicular atrophy (PFA). This process is suggested to be an integral pathogenetic factor in pattern hair loss (PHL) and telogen effluvium (TE). To address FHG and PFA, a proteoglycan replacement therapy (PRT) program using oral administration of a marine-derived extract (Nourkrin® with Marilex®, produced by Pharma Medico Aps, Aarhus, Denmark) containing specific proteoglycans has been developed. In clinical studies, this treatment significantly reduced hair fall, promoted hair growth, and improved quality of life in patients with male- and female-pattern hair loss. Accordingly, PRT (using Nourkrin® with Marilex®) can be recommended as an add-on treatment or monotherapy in patients with PHL and TE.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2020-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8125081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37950500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Onychomycosis in Psoriatic Patients with Nail Disorders: Aetiological Agents and Immunosuppressive Therapy. 银屑病伴指甲疾病患者的甲真菌病:病因和免疫抑制治疗。
IF 1.5
Dermatology Research and Practice Pub Date : 2020-05-02 eCollection Date: 2020-01-01 DOI: 10.1155/2020/7209518
Núbia Carvalho Pena de Oliveira Praeiro Alves, Tomaz de Aquino Moreira, Lucivânia Duarte Silva Malvino, José Joaquim Rodrigues, Roberto Ranza, Lúcio Borges de Araújo, Reginaldo Dos Santos Pedroso
{"title":"Onychomycosis in Psoriatic Patients with Nail Disorders: Aetiological Agents and Immunosuppressive Therapy.","authors":"Núbia Carvalho Pena de Oliveira Praeiro Alves,&nbsp;Tomaz de Aquino Moreira,&nbsp;Lucivânia Duarte Silva Malvino,&nbsp;José Joaquim Rodrigues,&nbsp;Roberto Ranza,&nbsp;Lúcio Borges de Araújo,&nbsp;Reginaldo Dos Santos Pedroso","doi":"10.1155/2020/7209518","DOIUrl":"https://doi.org/10.1155/2020/7209518","url":null,"abstract":"<p><p>Psoriasis and psoriatic arthritis are chronic, relapsing, immune-based diseases. Psoriatic patients may have nail involvement in 50 to 80% of cases, and this may reach 85% in patients with joint disease, in spite of the fact that the relationship between psoriasis and onychomycosis is not well established. The aim of this study was to investigate the occurrence of onychomycosis in patients with nail disorders and diagnosis of psoriasis and psoriatic arthritis. This was a cross-sectional study in which 38 patients diagnosed with psoriasis and/or psoriatic arthritis were interviewed and had altered nail samples analysed by mycological and histopathological exams. Twenty-two (57.89%) patients had a confirmed diagnosis for onychomycosis. Seventeen (44.8%) had a positive direct mycological examination, 16 (42.1%) had positive cultures, and 12 (31.6%) were positive for fungi by histopathological examination. Dermatophytes were identified in nine (56.3%) cultures, and of these, eight were <i>Trichophyton rubrum</i> and one <i>T. tonsurans</i>. Yeasts were isolated in seven patients (43.75%), which included four <i>Candida parapsilosis</i> and three <i>C. albicans</i>. Six patients (15.78%) were not using immunosuppressive therapy, and the others were using methotrexate, etanercept, adalimumab, infliximab, secukinumab, or golimumab, in monotherapy or in combination with other drugs. The confirmed onychomycosis rate in patients using methotrexate alone was 92.8% (<i>n</i> = 13). We concluded that it is possible that there is a positive relationship between psoriatic disease and onychomycosis. And we highlight that it is also worth investigating in the future the possible role of immunosuppressive therapy (mainly methotrexate) as a predisposing factor for the development of fungal infections in psoriatic patients.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2020-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/7209518","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37937409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients. 痤疮患者脂联素单核苷酸多态性与异维甲酸副作用的关系。
IF 1.5
Dermatology Research and Practice Pub Date : 2020-04-29 eCollection Date: 2020-01-01 DOI: 10.1155/2020/3176521
Munir Garba, Omar F Khabour, Karem H Alzoubi, Ahmed Abu-Siniyeh, Firas Al-Qarqaz
{"title":"The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients.","authors":"Munir Garba,&nbsp;Omar F Khabour,&nbsp;Karem H Alzoubi,&nbsp;Ahmed Abu-Siniyeh,&nbsp;Firas Al-Qarqaz","doi":"10.1155/2020/3176521","DOIUrl":"https://doi.org/10.1155/2020/3176521","url":null,"abstract":"<p><strong>Background: </strong>Acne is a common condition of pilosebaceous follicle especially among young. Clinically, the most used medication in the treatment of moderate to severe acne is oral isotretinoin. However, interindividual variability in therapeutic response to isotretinoin and many side effects such as musculoskeletal pain, headache, and alteration in lipid profile can be seen with this treatment.</p><p><strong>Aim: </strong>In this study, the effect of genetic polymorphisms, rs2241766 and rs1501299, of the adiponectin gene was investigated in relation to the side effects of isotretinoin-treated young adult acne patients (<i>n</i> = 230).</p><p><strong>Methods: </strong>Several biochemical parameters were measured at baseline and after treatments with isotretinoin. The ADIPOQ gene SNPs, rs2241766 and rs1501299, were genotyped in 230 patients.</p><p><strong>Results: </strong>Alterations in lipid profile with a significant increase of ALT (<i>P</i>=0.007) were detected after isotretinoin treatment. Moreover, percentage change in HDL following isotretinoin treatment was significantly associated with rs1501299 (<i>P</i>=0.008). On the other hand, no associations between examined SNPs and side effects of isotretinoin and other lipid parameters (total cholesterol, LDL, and triglycerides) or liver function enzymes (ALT and AST) were detected.</p><p><strong>Conclusions: </strong>Current findings showed that rs1501299 of the ADIPOQ gene might be associated with changes in HDL level in acne patients following treatment with isotretinoin.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2020-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/3176521","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37937408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Systemic Glutathione as a Skin-Whitening Agent in Adult. 体制性谷胱甘肽在成人皮肤增白剂中的作用。
IF 1.5
Dermatology Research and Practice Pub Date : 2020-04-24 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8547960
I B S Sitohang, S Ninditya
{"title":"Systemic Glutathione as a Skin-Whitening Agent in Adult.","authors":"I B S Sitohang,&nbsp;S Ninditya","doi":"10.1155/2020/8547960","DOIUrl":"https://doi.org/10.1155/2020/8547960","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the efficacy and safety profiles of systemic glutathione as a skin-whitening agent in adults from several randomized controlled trials (RCTs).</p><p><strong>Methods: </strong>This study is an evidence-based case report with literature search conducted on Clinical Key, Cochrane, Journal of the American Academy of Dermatology, Taylor and Francis Online, ScienceDirect, and PubMed databases. Three relevant RCTs were extracted and assessed for validity, importance, and applicability.</p><p><strong>Results: </strong>From 3 included trials, one of the studies opposed glutathione as a skin-whitening agent. However, the other two showed significant results only to some parts of the body or to certain age groups. As a skin-whitening agent, studies showed that glutathione yielded other cosmetic benefits as it may improve skin elasticity and reduce skin wrinkles. Furthermore, glutathione was well tolerated in oral preparations, but not in parenteral preparations.</p><p><strong>Conclusions: </strong>Highest-evidence literatures showed that glutathione is not beneficial enough as a skin-whitening agent as it was only effective in some parts of the body and did not elicit long-lasting effects. However, its safety profiles in oral preparations were well tolerated. More researches regarding the time needed for skin color to return to its original state following drug withdrawal need to be conducted as it is yet to be discovered.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2020-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8547960","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37904594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Consensus on the Clinical Approach to Moderate-to-Severe Atopic Dermatitis in Spain: A Delphi Survey. 西班牙中重度特应性皮炎临床治疗方法共识:德尔菲调查。
IF 1.5
Dermatology Research and Practice Pub Date : 2020-04-07 eCollection Date: 2020-01-01 DOI: 10.1155/2020/1524293
Joaquín Sastre, Esther Serra Baldrich, José Carlos Armario Hita, L Herráez, Ignacio Jáuregui, Ana Martín-Santiago, Javier Ortiz de Frutos, Juan Francisco Silvestre, Antonio Valero
{"title":"Consensus on the Clinical Approach to Moderate-to-Severe Atopic Dermatitis in Spain: A Delphi Survey.","authors":"Joaquín Sastre, Esther Serra Baldrich, José Carlos Armario Hita, L Herráez, Ignacio Jáuregui, Ana Martín-Santiago, Javier Ortiz de Frutos, Juan Francisco Silvestre, Antonio Valero","doi":"10.1155/2020/1524293","DOIUrl":"10.1155/2020/1524293","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this study was to gather information on the current assessment and management of patients with moderate-to-severe AD in routine daily practice.</p><p><strong>Methods: </strong>A cross-sectional two-round Delphi survey with the participation of dermatologists and allergologists throughout Spain was conducted. They completed a 46-item questionnaire, and consensus was defined when responses of ≥80% of participants coincided in the categories of a 5-point Likert scale for that item.</p><p><strong>Results: </strong>A total of 105 specialists (aged 40-59 years) completed the two rounds. Participants agreed regarding the consideration of AD as a multifaceted disease and the differences in clinical presentation of AD according to the patient's age. It is recommendable to perform a skin biopsy to exclude early stage T-cell cutaneous lymphoma, psoriasis, or dermatitis herpetiformis, among others (99.1%). Also, consensus was reached regarding the use of the SCORAD index to quantify the severity of the disease (86.7%), the use of wet wraps to increase the effect of topical corticosteroids (90.4%), the usefulness of proactive treatment during follow-up (85.6%) and tacrolimus ointment (91.2%) to reduce new flares, and the fact that crisaborole is not the treatment of choice for severe AD (92.4%). AD was not considered a contraindication for immunotherapy in patients with allergic respiratory diseases (92.4%). In patients with severe AD, the use of immune response modifier drugs (97.6%) or phototherapy (92.8%) does not sufficiently cover their treatment needs. Consensus was also obtained regarding the role of the new biologic drugs (93.6%) targeting cytokines involved in the Th2 inflammatory pathway (92.0%) and the potential role of dupilumab as first-line treatment (90.4%) in moderate-to-severe AD patients.</p><p><strong>Conclusion: </strong>This study contributes a reference framework to the care of AD patients. There is no diagnostic test or biomarkers to direct treatment or to assess the severity of the disease, and many therapeutic challenges remain.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2020-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37858929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Tracnil™ Administration in Patients with Dermatological Manifestations of PCOS: An Open-Label Single-Arm Study. 一项开放标签单臂研究:Tracnil™治疗皮肤症状的PCOS患者的疗效和安全性
IF 1.5
Dermatology Research and Practice Pub Date : 2020-03-24 eCollection Date: 2020-01-01 DOI: 10.1155/2020/7019126
Ezhil Arasan Ramanan, Sailatha Ravi, K R Radha Anbu, Margaret Michael
{"title":"Efficacy and Safety of Tracnil™ Administration in Patients with Dermatological Manifestations of PCOS: An Open-Label Single-Arm Study.","authors":"Ezhil Arasan Ramanan,&nbsp;Sailatha Ravi,&nbsp;K R Radha Anbu,&nbsp;Margaret Michael","doi":"10.1155/2020/7019126","DOIUrl":"https://doi.org/10.1155/2020/7019126","url":null,"abstract":"<p><p>Myo-inositol's role in improving acne by reducing hyperandrogenism has been demonstrated in PCOS patients. Inositol and associated molecules display inhibitory properties against 5-<i>α</i> reductase, COX-2, and lipase enzymes in addition to their antimicrobial and anti-inflammatory properties. However, the role of myo-inositol is not well established in women patients with normal hormone levels but with clinical manifestations of PCOS. In this study, we evaluate the efficacy of Tracnil™, a combination of myo-inositol with folic acid and vitamin D3, in resolving acne in overweight women of menstruation age displaying normal hormone levels. It is a single-arm study conducted at 2 centers including 33 women with acne, hirsutism, and menstrual irregularities. Acne and hirsutism were assessed by manual lesion count, modified Cook's scale, and modified Ferriman-Gallwey hirsutism score (mFGHS). Hormone levels and safety parameters were assessed throughout the study. Our results show that Tracnil™ monotherapy could drastically reduce acne-related lesions of both inflammatory and noninflammatory types as quickly as 8 weeks. Additionally, it improves hirsutism and menstrual irregularities. Adverse reactions were negligible during the whole study period with no drastic side effects reflected by a modulatory effect on hormone levels. Despite the subjects having normal hormone levels, the acne treatment with myo-inositol and vitamin D3 shows improvement in hirsutism and regularization of menstrual cycle. Therefore, we attribute the mechanism of action of Tracnil™ to modulation of receptor sensitivity to sex hormones or other downstream processing events. Tracnil™ may be considered as a first-line treatment for dermatological manifestations of PCOS even in the absence of significant hormonal abnormalities. This treatment is practically implementable in a dermatologists's office practise.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2020-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/7019126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37809209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Sunscreen Use among a Population of Saudi University Students. 沙特大学生防晒霜使用情况调查
IF 1.5
Dermatology Research and Practice Pub Date : 2020-03-16 eCollection Date: 2020-01-01 DOI: 10.1155/2020/4732721
Mohammed I AlJasser, Abdullah Aljumah, Mohannad Alzaydi, Abdullah Alassaf, Suliman Alassafi, Maha T Alassafi, Mohammed Almedlej, Emad Masuadi
{"title":"Sunscreen Use among a Population of Saudi University Students.","authors":"Mohammed I AlJasser,&nbsp;Abdullah Aljumah,&nbsp;Mohannad Alzaydi,&nbsp;Abdullah Alassaf,&nbsp;Suliman Alassafi,&nbsp;Maha T Alassafi,&nbsp;Mohammed Almedlej,&nbsp;Emad Masuadi","doi":"10.1155/2020/4732721","DOIUrl":"https://doi.org/10.1155/2020/4732721","url":null,"abstract":"<p><strong>Results: </strong>A total of 1,011 students were enrolled. Approximately half were males (<i>n</i> = 510). Half of the students used sunscreen (<i>n</i> = 515, 51%). Female gender, high family income, previous history of sunburn, tanning bed use, and use of other sun protection methods were factors independently associated with sunscreen use. The main reasons for using sunscreen were prevention of sunburns, dark spots, skin cancer, and overall skin darkening. Eighty percent of participants used other methods of sun protection. Sunscreen with a sun protection factor (SPF) > 30 was used in 59% of students. However, the majority did not know if the sunscreen they use provided broad-spectrum coverage or not. Only 35% of students apply sunscreen in both sunny and cloudy days. Most students apply sunscreen less than 10 minutes before going out and do not repeat the application throughout the day. More than 90% of students seem to apply insufficient amount of sunscreen.</p><p><strong>Conclusion: </strong>Almost half of the population in the study use sunscreen. We have identified several areas of improper use of sunscreen. Increasing the awareness of effective sunscreen use in our community might be needed.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2020-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/4732721","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37807813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
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