Dermatology Research and Practice最新文献

{"title":"Chronic Urticaria and Its Impact on the Quality of Life of Nepalese Patients.","authors":"Sushil Paudel,&nbsp;Niraj Parajuli,&nbsp;Rabindra Prasad Sharma,&nbsp;Sudip Dahal,&nbsp;Sudarshan Paudel","doi":"10.1155/2020/6694191","DOIUrl":"https://doi.org/10.1155/2020/6694191","url":null,"abstract":"<p><p>Chronic urticaria (CU) is a skin condition characterized by sudden and recurrent episodes of wheals, angioedema, or both and commonly associated with itching for a duration of more than six weeks. The available data indicate that urticaria markedly affects both objective functioning and subjective well-being of patients. A review of patients' records with chronic urticaria attending Civil Service Hospital from January 2018 to December 2019 was done. A detailed demographic data of all patients with chronic urticaria was also retrieved. Dermatology Life Quality Index questionnaire (DLQI) Nepalese version was used for the assessment of the impact of disease on life quality. Mann-Whitney <i>U</i>-test was applied to compare means, and principle component analysis for factor analysis was used. A total of 149 patients were included, with a male-to-female ratio of 1 : 1.9. The mean age of the study population was 32.86 ± 12.837 years. The mean DLQI score was 8.30 ± 6.73 with men having a significantly greater score than women (<i>p</i> < 0.02). DLQI scores negatively correlated with age (<i>p</i> < 0.01). There was a high internal consistency among items (Cronbach's alpha 0.89), and all items had satisfactory correlation with each other as well. Principle component extraction revealed that there were two underlying factors in the DLQI questionnaire on measuring quality of life in chronic urticaria. Males had a greater impairment in quality of life than females due to chronic urticaria. Most severe impairment was seen in symptoms/feelings subdomain. It also revealed that there were two different underlying factors in DLQI questionnaire.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"6694191"},"PeriodicalIF":1.5,"publicationDate":"2020-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/6694191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38366718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cutaneous Leishmaniasis and the Sand Fly: Knowledge and Beliefs of the Population in Central Morocco (El Hajeb).","authors":"Karima El-Mouhdi,&nbsp;Abdelkader Chahlaoui,&nbsp;Mohammed Fekhaoui","doi":"10.1155/2020/1896210","DOIUrl":"https://doi.org/10.1155/2020/1896210","url":null,"abstract":"<p><strong>Background: </strong>Cutaneous leishmaniasis is a neglected parasitic dermal disease transmitted to humans through the bite of an infected female sand fly. Morocco hopes to eliminate all forms of leishmaniasis by 2030. These dermatoses pose a real public health problem in the country. Although the information is available on the disease, individual knowledge of cutaneous leishmaniasis and sand fly is not yet developed. Exploring people's beliefs and popular behaviours about cutaneous leishmaniasis and its vector allows health officials to know the sociocultural aspects of the disease and to improve prevention and control actions.</p><p><strong>Objectives: </strong>To identify the knowledge of cutaneous leishmaniasis and its vector in the population in central Morocco.</p><p><strong>Methods: </strong>Based on the epidemiological data of leishmaniases in the province of El Hajeb, we conducted a field survey and personal interviews in April and May 2019, among 281 persons belonging to the localities where leishmaniases were registered.</p><p><strong>Results: </strong>Our results show that the participants use the concept of \"Chniwla\" (61.6%) for sand fly and the concept of \"Hboub Chniwla\" (50.8%) for cutaneous leishmaniasis; 24.6% of the respondents do not know how the disease is transmitted to humans and 43.7% use traditional treatments and home remedies to cure themselves. 44% of participants believe that sand fly does not transmit the disease to humans and only 6.4% were aware of their responsibility in vector control.</p><p><strong>Conclusions: </strong>The study concluded that there is a need to simplify the scientific terminology in the health education of citizens regarding these dermatoses and their vector by integrating the popular concepts obtained in this study to raise public awareness and facilitate their involvement as active actors in the prevention of cutaneous leishmaniasis.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"1896210"},"PeriodicalIF":1.5,"publicationDate":"2020-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/1896210","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38680665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal Variation in Patch Test Results with European Baseline Series.","authors":"Aïcha Brahem,&nbsp;Haifa Aroui,&nbsp;Asma Gaddour,&nbsp;Asma Chouchene,&nbsp;Asma Aloui,&nbsp;Imen Kacem,&nbsp;Maher Maoua,&nbsp;Houda Kalboussi,&nbsp;Olfa ElMaalel,&nbsp;Souhail Chatti,&nbsp;Faten Dabbabi,&nbsp;Nejib Mrizek","doi":"10.1155/2020/8316753","DOIUrl":"https://doi.org/10.1155/2020/8316753","url":null,"abstract":"<p><strong>Aim: </strong>To study the influence of season on patch tests results.</p><p><strong>Methods: </strong>We conducted a retrospective epidemiological study which concerned all the patients of the Tunisian center, who consulted in the Dermato-Allergology Unit of Occupational Medicine Department of Farhat Hached University Hospital-Sousse (Tunisia) over a period of 07 years. All the patients were tested by the European Standard Battery allergens (BSE).</p><p><strong>Results: </strong>The data of 1000 patch tests were analyzed during the study period. More than half of the patch tests (58.6%) was positive. In winter, 63% of patch tests showed a positive reaction versus 52% of patch tests in summer without a statistically significant association. However, results of lanolin alcohols, epoxy resin, and Sesquiterpene lactone mix varied significantly with season. Atopy was significantly associated with 18.8% of positive reactions in winter and only with 5.2% of positive reactions in summer (<i>p</i> = 0.015).</p><p><strong>Conclusion: </strong>Seasonal variations in patch tests results were more significant with some allergens of European Standard Battery and in atopic patients.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"8316753"},"PeriodicalIF":1.5,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8316753","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38675842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin Diseases among the Old Age Residents in a Nursing Home: A Neglected Problem.","authors":"Abbas Darjani, Narges Alizadeh, Elahe Rafiei, Meysam Moulaei, Seyed Hamed Naseri Alavi, Hojat Eftekhari, Rana Rafiei, Kaveh Gharaei-Nejad, Zahra Mohtasham-Amiri","doi":"10.1155/2020/8849355","DOIUrl":"10.1155/2020/8849355","url":null,"abstract":"<p><strong>Background: </strong>Geriatric health care has become a worldwide concern, but a few statistical studies were carried out about skin diseases in this age group in the nursing home of Iran.</p><p><strong>Aims: </strong>In this study, we set out to determine the frequency as well as the age and gender distribution of dermatological diseases in nursing home old age residents.</p><p><strong>Methods: </strong>In a cross-sectional study, all patients over 60 years who were living in a charity nursing home complex of Rasht in 2017 participated in this study. Baseline information on sociodemographic variables, past medical history, and medication were gathered by medical staff during a face-to-face interview. Full-body skin examination was done by dermatologists. Biopsy, and pathological and laboratory methods were used to confirm the diagnosis of suspected lesions or disease.</p><p><strong>Results: </strong>In this study, 259 people underwent the study. 52.9% were male, and their mean age was 73.5 years (SD = 9.1 years). Hypertension (20.9%); diabetes mellitus (9.7%), and hypothyroidism (2.3%) were the most common underlying diseases. Most of them (85.7%) had age-related skin changes. The benign neoplasm was the most common skin disease among patients (68.3%), followed by infectious diseases (46.3%) and erythemo-squamous (31.6%). None of them had precancerous lesions or skin cancers. There were not any differences between skin disorders and gender or age groups in this study.</p><p><strong>Conclusion: </strong>Our study suggests that skin manifestations and diseases are common among nursing home old age residents in this area. Therefore, this should constitute one of the top priorities of aged care physicians and nurses.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"8849355"},"PeriodicalIF":1.5,"publicationDate":"2020-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38623535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Patterns of Skin Disease in Saudi Arabia: A Systematic Review and Meta-Analysis.","authors":"Mohammad Almohideb","doi":"10.1155/2020/5281957","DOIUrl":"https://doi.org/10.1155/2020/5281957","url":null,"abstract":"<p><strong>Background: </strong>Large epidemiological studies on patterns of skin diseases in Saudi Arabia are scarce. Therefore, this systematic review and meta-analysis was conducted to gather available epidemiologic data describing the pattern of skin diseases in different geographical areas in Saudi Arabia.</p><p><strong>Methods: </strong>A comprehensive literature search of articles was conducted in PubMed, SCOPUS, and Web of Science through October 2019. We included all published cross-sectional studies that provided data on relevant incidence or prevalence of skin disease in Saudi Arabia. The risk of bias within the included cross-sectional studies was assessed using the Hoy tool for the prevalence studies. All statistical analysis was performed using the Comprehensive Meta-analysis software.</p><p><strong>Results: </strong>The present meta-analysis included 14 studies that reported the frequency of the skin disease patterns in different regions in Saudi Arabia with a total sample size of 30436 patients with an overall low risk of bias. The diseases of skin appendages and dermatitis were the most commonly reported skin diseases in Saudi Arabia (24.8% (95% CI, 24.3-25.3) and 24% (95% CI, 23.6%-24.6%), respectively). Skin infection represented about 18.5% (95% CI, 18.1%-19%), while the papulosquamous disorders represented 5.3% (95% CI, 5%-5.6%) of the skin diseases in Saudi Arabia. Skin cancers were pooled from only two studies. Basal cell carcinoma and squamous cell carcinoma were the most common malignant neoplasm in Saudi Arabia (51.4% and 22.5% of the malignant neoplasm, respectively), while malignant melanoma represents only 3.8% of the malignant skin cancer.</p><p><strong>Conclusion: </strong>Adnexal disorders and dermatitis are the most common skin disease in Saudi Arabia, followed by skin infection and pigmentary disorders. While skin cancer is more frequent than other countries, awareness campaigns should be initiated to increase knowledge about the harmful effect of long-term sun exposure.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"5281957"},"PeriodicalIF":1.5,"publicationDate":"2020-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/5281957","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38711223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Atopy in the Prevalence of Contact Sensitization: The Experience of a Greek Referral Center.","authors":"Anna Tagka,&nbsp;George I Lambrou,&nbsp;Electra Nicolaidou,&nbsp;Stamatios G Gregoriou,&nbsp;Alexandra Katsarou-Katsari,&nbsp;Dimitrios Rigopoulos","doi":"10.1155/2020/3946084","DOIUrl":"https://doi.org/10.1155/2020/3946084","url":null,"abstract":"<p><p>Contact dermatitis is a well-known skin condition, which is related to stimuli and environmental exposure to chemicals, affecting all ages as well as both genders. In the present work, we attempt to investigate the patterns of contact sensitization, with respect to the personal history of atopy (AT), in Greece in a large number of allergens, using patch testing. The retrospective analysis included clinical routine data of 1978 patients collected from 2014 to 2016 in the Laboratory of Patch Testing, National Referral Centre of Occupational Dermatoses. Sensitization, in all cases, was tested with 28 allergens of the European baseline series as adjusted to our local circumstances and clinical experience. A total population of 1978 patients was evaluated, with a male-to-female ratio of 0.45 (1359 females/619 males). From our patient cohort, 693 (35%) patients were evaluated with a history of atopy, while 1285 (65%) were nonatopic. The five most prevalent allergens in the total population without AT were nickel sulphate 5% (15.47%), fragrance mix (I) 8% (9.10%), balsam of Peru (6.47%), cobalt chloride 1% (4.70%), and thiomersal 0.1% (4.10%). Respectively, in the total population with AT, the five most prevalent allergens were nickel sulphate 5% (10.36%), fragrance mix (I) 8% (5.11%), balsam of Peru (3.29%), thiomersal 0.1% (3.03%), and cobalt chloride 1% (2.78%). Contact dermatitis surveillance is of great importance towards the clinical and systematic understanding of the disease. Further studies should be directed towards that end, in order to facilitate more effective health policies.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"3946084"},"PeriodicalIF":1.5,"publicationDate":"2020-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/3946084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38556916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxic Epidermal Necrolysis (TEN)/Stevens-Johnson Syndrome (SJS) Epidemiology and Mortality Rate at King Fahad Specialist Hospital (KFSH) in Qassim Region of Saudi Arabia: A Retrospective Study.","authors":"Abdullah Alajaji,&nbsp;Jagannath Chandra Shekaran,&nbsp;Omar Mohammed Aldhabbah,&nbsp;Hajar Abdullah Alhindi,&nbsp;Nouf Salem Almazyad,&nbsp;Ziyad Abdulrahman Aljutayli,&nbsp;Saleh Abaalkhail,&nbsp;Saleh Alfouzan","doi":"10.1155/2020/7524726","DOIUrl":"https://doi.org/10.1155/2020/7524726","url":null,"abstract":"<p><strong>Background: </strong>Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are life-threatening conditions caused by drug reactions. There are multiple causative drugs and different risk factors associated with SJS/TEN.</p><p><strong>Objectives: </strong>To study the epidemiology of SJS/TEN and associated mortality rate in Qassim region, Saudi Arabia. <i>Methodology</i>. A retrospective chart review of all patients with the diagnosis of SJS/TEN who were admitted to King Fahad Specialist Hospital (KFSH) in Qassim region, Saudi Arabia, for the period between Jan 2014 to Jan 2019. The Careware information health system is used at KFSH, and patients were identified searching the diagnosis SJS/TEN.</p><p><strong>Results: </strong>Total of 10 patients with diagnosis of SJS/TEN were admitted to KFSH for the period from Jan 2014 to Jan 2019. Antibiotics were the culprit in 5 out of 10 patients. 9 out of 10 patients survived with good outcome. One patient with the diagnosis of TEN died, given extensive skin involvement complicated by sepsis.</p><p><strong>Conclusion: </strong>Despite the limitation of this study given small sample size, this is the first study of its kind that discusses the epidemiology of SJS/TEN in Saudi Arabia. We found the estimated incidence rate of SJS/TEN in Qassim region to be 7.6 cases per million person-years. Antibiotics and antiepileptics were the culprits in 8 out of 10 patients.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"7524726"},"PeriodicalIF":1.5,"publicationDate":"2020-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/7524726","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38556917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Analysis between Household Hygiene and Sanitation and Nutritional Status and Female Leprosy in Gresik Regency.","authors":"Flora Ramona Sigit Prakoeswa, Afik Zakie Ilhami, Ratna Luthfia, Aviola Syania Putri, Hardyanto Soebono, Dominicus Husada, Hari Basuki Notobroto, Muhammad Yulianto Listiawan, Anang Endaryanto, Cita Rosita Sigit Prakoeswa","doi":"10.1155/2020/4379825","DOIUrl":"10.1155/2020/4379825","url":null,"abstract":"<p><p>Leprosy, also known as morbus Hansen's disease, is a chronic disease caused by <i>M. leprae</i>. Leprosy attacks various parts of the body including nerves and skin. The most important factor in the occurrence of leprosy is the sources of transmission and contact, both from patients and the environment. Household conditions where the person lives and the nutritional status of the individual can be a risk factor for leprosy. Household hygiene and sanitation can be seen from several aspects, like the physical environment of the house, clean water facilities, personal hygiene, availability of latrines, waste disposal facilities, and garbage disposal. This study was aimed to determine the correlation between household hygiene sanitation and nutritional status with females with leprosy in Gresik Regency. This case-control study was conducted in December 2019 in Gresik Regency. The subjects of this study were 74 respondents taken by consecutive sampling techniques. Retrieval of data was carried out using observations from the healthy house component questionnaire, personal hygiene questionnaire, and direct measurement. Data were analyzed using the chi-square test. The results showed significant correlation between physical environment of the house (<i>p</i>=0.001, OR = 0.104), clean water facilities (<i>p</i>=0.008, OR = 0.261), availability of latrines (<i>p</i>=0.018, OR = 0.209), waste disposal facilities (<i>p</i>=0.015, OR = 0.291), and personal hygiene (<i>p</i>=0.001, OR = 2.850) and female leprosy in Gresik Regency. There is no correlation between nutritional status (<i>p</i>=0.085, OR = 0.422) and wastewater disposal waste (<i>p</i>=0.183, OR = 0.486) and female leprosy in this study.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"4379825"},"PeriodicalIF":1.5,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38596049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pemphigus Vulgaris: A Clinical Study of 31 Cases (2004-2014) in Morocco.","authors":"Titou Hicham,&nbsp;Fatima Zahra Chahnoun,&nbsp;Tarik Hanafi,&nbsp;Naoufal Hjira,&nbsp;Boui Mohammed","doi":"10.1155/2020/8535109","DOIUrl":"https://doi.org/10.1155/2020/8535109","url":null,"abstract":"<p><strong>Background: </strong>Pemphigus vulgaris is a rare bullous autoimmune dermatosis whose evolution and prognosis are unpredictable.</p><p><strong>Aim: </strong>The objective was to analyze long-term outcomes in patients with pemphigus vulgaris by identifying the factors that are able to influence prognosis, in particular the phenotype of pemphigus vulgaris, age at onset, multiplicity of mucosal involvement, relapse and remission rates, and survival functions.</p><p><strong>Methods: </strong>A retrospective analysis of a cohort of 31 patients followed for pemphigus vulgaris during the period from January 2004 to January 2014. Inclusion criteria were a diagnosis of pemphigus vulgaris confirmed by histopathology and direct immunofluorescence (DIF) and a period of follow-up of at least five years from the diagnosis. The following information was collected by a single investigator.</p><p><strong>Results: </strong>In total, 67.7% of patients presented a mucocutaneous pemphigus vulgaris. Male-female sex ratio was 2.4. The median duration of patient's follow-up was estimated at 7 (6-9) years. Multiple mucosal involvement in the oral cavity and at other mucosal sites was significantly associated with severe mucocutaneous pemphigus vulgaris (<i>p</i>=0.01). Multiple relapses were significantly associated with the disease severity (<i>p</i>=0.04).</p><p><strong>Conclusion: </strong>Poor prognosis factors were severe mucocutaneous type of pemphigus vulgaris and multiple mucosal involvement in the oral cavity and at other mucosal sites.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"8535109"},"PeriodicalIF":1.5,"publicationDate":"2020-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8535109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38408982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Chronic Urticaria and <i>Helicobacter pylori</i> Infection among Patients Attending a Tertiary Hospital in Tanzania.","authors":"Magdalena F Dennis, Daudi R Mavura, Luryritha Kini, Rune Philemon, Elisante J Masenga","doi":"10.1155/2020/5932038","DOIUrl":"10.1155/2020/5932038","url":null,"abstract":"<p><strong>Background: </strong>Chronic urticaria (CU) is a common skin disease; however, its etiology is rarely recognized. Infection due to <i>Helicobacter pylori</i> (<i>H</i>. <i>pylori</i>) has been shown in some studies to play a significant role in the pathogenesis of CU.</p><p><strong>Objective: </strong>This study was conducted to determine the association between CU and <i>H</i>. <i>pylori</i> infection among patients attending the Regional Dermatology Training Center, Northern Tanzania, from October 2018 to April 2019. <i>Methodology</i>. A matched case-control study that included 55 cases and 55 controls matched by age and sex was conducted. Data were collected through direct interviews, and the results of laboratory investigations were recorded in the extraction sheet. An enzyme-linked immunosorbent assay test was used to detect <i>H</i>. <i>pylori</i> antigen in the stool samples. Conditional logistic regression was used to measure the association between CU and <i>H</i>. <i>pylori</i>.</p><p><strong>Results: </strong>The total number of participants in this study was 110 patients (55 cases and 55 controls), whereby the median age was 31 (IQR 27-45) among controls versus 34 (IQR: 22-46) years among the cases. Both cases and controls had the same number of females and males. There was no significant association between CU and baseline characteristics of the participants. There was an association between CU and <i>H</i>. <i>pylori</i> infection, such that subjects with CU had a higher number of positive <i>H</i>. <i>pylori</i> test (15/55 = 27%) versus controls (6/55 = 10.1%) (<i>p</i> = 0.0225). The adjusted odds of CU among patients who were positive for <i>H</i>. <i>pylori</i> were sixfolds higher (OR = 6.9; CI: 1.3-36.2; <i>p</i> = 0.021) than those of patients who were negative for <i>H. pylori.</i></p><p><strong>Conclusion: </strong>There was a strong and significant association between CU and <i>H</i>. <i>pylori</i> infection. We recommend investigating for <i>H</i>. <i>pylori</i> in all cases of CU and conducting further trials on <i>H</i>. <i>pylori</i> eradication.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"5932038"},"PeriodicalIF":1.5,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38499452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}