Dermatology Research and Practice最新文献

{"title":"Epidemiological Patterns of Skin Disease in Saudi Arabia: A Systematic Review and Meta-Analysis.","authors":"Mohammad Almohideb","doi":"10.1155/2020/5281957","DOIUrl":"https://doi.org/10.1155/2020/5281957","url":null,"abstract":"<p><strong>Background: </strong>Large epidemiological studies on patterns of skin diseases in Saudi Arabia are scarce. Therefore, this systematic review and meta-analysis was conducted to gather available epidemiologic data describing the pattern of skin diseases in different geographical areas in Saudi Arabia.</p><p><strong>Methods: </strong>A comprehensive literature search of articles was conducted in PubMed, SCOPUS, and Web of Science through October 2019. We included all published cross-sectional studies that provided data on relevant incidence or prevalence of skin disease in Saudi Arabia. The risk of bias within the included cross-sectional studies was assessed using the Hoy tool for the prevalence studies. All statistical analysis was performed using the Comprehensive Meta-analysis software.</p><p><strong>Results: </strong>The present meta-analysis included 14 studies that reported the frequency of the skin disease patterns in different regions in Saudi Arabia with a total sample size of 30436 patients with an overall low risk of bias. The diseases of skin appendages and dermatitis were the most commonly reported skin diseases in Saudi Arabia (24.8% (95% CI, 24.3-25.3) and 24% (95% CI, 23.6%-24.6%), respectively). Skin infection represented about 18.5% (95% CI, 18.1%-19%), while the papulosquamous disorders represented 5.3% (95% CI, 5%-5.6%) of the skin diseases in Saudi Arabia. Skin cancers were pooled from only two studies. Basal cell carcinoma and squamous cell carcinoma were the most common malignant neoplasm in Saudi Arabia (51.4% and 22.5% of the malignant neoplasm, respectively), while malignant melanoma represents only 3.8% of the malignant skin cancer.</p><p><strong>Conclusion: </strong>Adnexal disorders and dermatitis are the most common skin disease in Saudi Arabia, followed by skin infection and pigmentary disorders. While skin cancer is more frequent than other countries, awareness campaigns should be initiated to increase knowledge about the harmful effect of long-term sun exposure.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"5281957"},"PeriodicalIF":1.5,"publicationDate":"2020-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/5281957","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38711223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Atopy in the Prevalence of Contact Sensitization: The Experience of a Greek Referral Center.","authors":"Anna Tagka,&nbsp;George I Lambrou,&nbsp;Electra Nicolaidou,&nbsp;Stamatios G Gregoriou,&nbsp;Alexandra Katsarou-Katsari,&nbsp;Dimitrios Rigopoulos","doi":"10.1155/2020/3946084","DOIUrl":"https://doi.org/10.1155/2020/3946084","url":null,"abstract":"<p><p>Contact dermatitis is a well-known skin condition, which is related to stimuli and environmental exposure to chemicals, affecting all ages as well as both genders. In the present work, we attempt to investigate the patterns of contact sensitization, with respect to the personal history of atopy (AT), in Greece in a large number of allergens, using patch testing. The retrospective analysis included clinical routine data of 1978 patients collected from 2014 to 2016 in the Laboratory of Patch Testing, National Referral Centre of Occupational Dermatoses. Sensitization, in all cases, was tested with 28 allergens of the European baseline series as adjusted to our local circumstances and clinical experience. A total population of 1978 patients was evaluated, with a male-to-female ratio of 0.45 (1359 females/619 males). From our patient cohort, 693 (35%) patients were evaluated with a history of atopy, while 1285 (65%) were nonatopic. The five most prevalent allergens in the total population without AT were nickel sulphate 5% (15.47%), fragrance mix (I) 8% (9.10%), balsam of Peru (6.47%), cobalt chloride 1% (4.70%), and thiomersal 0.1% (4.10%). Respectively, in the total population with AT, the five most prevalent allergens were nickel sulphate 5% (10.36%), fragrance mix (I) 8% (5.11%), balsam of Peru (3.29%), thiomersal 0.1% (3.03%), and cobalt chloride 1% (2.78%). Contact dermatitis surveillance is of great importance towards the clinical and systematic understanding of the disease. Further studies should be directed towards that end, in order to facilitate more effective health policies.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"3946084"},"PeriodicalIF":1.5,"publicationDate":"2020-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/3946084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38556916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxic Epidermal Necrolysis (TEN)/Stevens-Johnson Syndrome (SJS) Epidemiology and Mortality Rate at King Fahad Specialist Hospital (KFSH) in Qassim Region of Saudi Arabia: A Retrospective Study.","authors":"Abdullah Alajaji,&nbsp;Jagannath Chandra Shekaran,&nbsp;Omar Mohammed Aldhabbah,&nbsp;Hajar Abdullah Alhindi,&nbsp;Nouf Salem Almazyad,&nbsp;Ziyad Abdulrahman Aljutayli,&nbsp;Saleh Abaalkhail,&nbsp;Saleh Alfouzan","doi":"10.1155/2020/7524726","DOIUrl":"https://doi.org/10.1155/2020/7524726","url":null,"abstract":"<p><strong>Background: </strong>Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are life-threatening conditions caused by drug reactions. There are multiple causative drugs and different risk factors associated with SJS/TEN.</p><p><strong>Objectives: </strong>To study the epidemiology of SJS/TEN and associated mortality rate in Qassim region, Saudi Arabia. <i>Methodology</i>. A retrospective chart review of all patients with the diagnosis of SJS/TEN who were admitted to King Fahad Specialist Hospital (KFSH) in Qassim region, Saudi Arabia, for the period between Jan 2014 to Jan 2019. The Careware information health system is used at KFSH, and patients were identified searching the diagnosis SJS/TEN.</p><p><strong>Results: </strong>Total of 10 patients with diagnosis of SJS/TEN were admitted to KFSH for the period from Jan 2014 to Jan 2019. Antibiotics were the culprit in 5 out of 10 patients. 9 out of 10 patients survived with good outcome. One patient with the diagnosis of TEN died, given extensive skin involvement complicated by sepsis.</p><p><strong>Conclusion: </strong>Despite the limitation of this study given small sample size, this is the first study of its kind that discusses the epidemiology of SJS/TEN in Saudi Arabia. We found the estimated incidence rate of SJS/TEN in Qassim region to be 7.6 cases per million person-years. Antibiotics and antiepileptics were the culprits in 8 out of 10 patients.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"7524726"},"PeriodicalIF":1.5,"publicationDate":"2020-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/7524726","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38556917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Analysis between Household Hygiene and Sanitation and Nutritional Status and Female Leprosy in Gresik Regency.","authors":"Flora Ramona Sigit Prakoeswa, Afik Zakie Ilhami, Ratna Luthfia, Aviola Syania Putri, Hardyanto Soebono, Dominicus Husada, Hari Basuki Notobroto, Muhammad Yulianto Listiawan, Anang Endaryanto, Cita Rosita Sigit Prakoeswa","doi":"10.1155/2020/4379825","DOIUrl":"10.1155/2020/4379825","url":null,"abstract":"<p><p>Leprosy, also known as morbus Hansen's disease, is a chronic disease caused by <i>M. leprae</i>. Leprosy attacks various parts of the body including nerves and skin. The most important factor in the occurrence of leprosy is the sources of transmission and contact, both from patients and the environment. Household conditions where the person lives and the nutritional status of the individual can be a risk factor for leprosy. Household hygiene and sanitation can be seen from several aspects, like the physical environment of the house, clean water facilities, personal hygiene, availability of latrines, waste disposal facilities, and garbage disposal. This study was aimed to determine the correlation between household hygiene sanitation and nutritional status with females with leprosy in Gresik Regency. This case-control study was conducted in December 2019 in Gresik Regency. The subjects of this study were 74 respondents taken by consecutive sampling techniques. Retrieval of data was carried out using observations from the healthy house component questionnaire, personal hygiene questionnaire, and direct measurement. Data were analyzed using the chi-square test. The results showed significant correlation between physical environment of the house (<i>p</i>=0.001, OR = 0.104), clean water facilities (<i>p</i>=0.008, OR = 0.261), availability of latrines (<i>p</i>=0.018, OR = 0.209), waste disposal facilities (<i>p</i>=0.015, OR = 0.291), and personal hygiene (<i>p</i>=0.001, OR = 2.850) and female leprosy in Gresik Regency. There is no correlation between nutritional status (<i>p</i>=0.085, OR = 0.422) and wastewater disposal waste (<i>p</i>=0.183, OR = 0.486) and female leprosy in this study.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"4379825"},"PeriodicalIF":1.5,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38596049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pemphigus Vulgaris: A Clinical Study of 31 Cases (2004-2014) in Morocco.","authors":"Titou Hicham,&nbsp;Fatima Zahra Chahnoun,&nbsp;Tarik Hanafi,&nbsp;Naoufal Hjira,&nbsp;Boui Mohammed","doi":"10.1155/2020/8535109","DOIUrl":"https://doi.org/10.1155/2020/8535109","url":null,"abstract":"<p><strong>Background: </strong>Pemphigus vulgaris is a rare bullous autoimmune dermatosis whose evolution and prognosis are unpredictable.</p><p><strong>Aim: </strong>The objective was to analyze long-term outcomes in patients with pemphigus vulgaris by identifying the factors that are able to influence prognosis, in particular the phenotype of pemphigus vulgaris, age at onset, multiplicity of mucosal involvement, relapse and remission rates, and survival functions.</p><p><strong>Methods: </strong>A retrospective analysis of a cohort of 31 patients followed for pemphigus vulgaris during the period from January 2004 to January 2014. Inclusion criteria were a diagnosis of pemphigus vulgaris confirmed by histopathology and direct immunofluorescence (DIF) and a period of follow-up of at least five years from the diagnosis. The following information was collected by a single investigator.</p><p><strong>Results: </strong>In total, 67.7% of patients presented a mucocutaneous pemphigus vulgaris. Male-female sex ratio was 2.4. The median duration of patient's follow-up was estimated at 7 (6-9) years. Multiple mucosal involvement in the oral cavity and at other mucosal sites was significantly associated with severe mucocutaneous pemphigus vulgaris (<i>p</i>=0.01). Multiple relapses were significantly associated with the disease severity (<i>p</i>=0.04).</p><p><strong>Conclusion: </strong>Poor prognosis factors were severe mucocutaneous type of pemphigus vulgaris and multiple mucosal involvement in the oral cavity and at other mucosal sites.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"8535109"},"PeriodicalIF":1.5,"publicationDate":"2020-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8535109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38408982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Chronic Urticaria and <i>Helicobacter pylori</i> Infection among Patients Attending a Tertiary Hospital in Tanzania.","authors":"Magdalena F Dennis, Daudi R Mavura, Luryritha Kini, Rune Philemon, Elisante J Masenga","doi":"10.1155/2020/5932038","DOIUrl":"10.1155/2020/5932038","url":null,"abstract":"<p><strong>Background: </strong>Chronic urticaria (CU) is a common skin disease; however, its etiology is rarely recognized. Infection due to <i>Helicobacter pylori</i> (<i>H</i>. <i>pylori</i>) has been shown in some studies to play a significant role in the pathogenesis of CU.</p><p><strong>Objective: </strong>This study was conducted to determine the association between CU and <i>H</i>. <i>pylori</i> infection among patients attending the Regional Dermatology Training Center, Northern Tanzania, from October 2018 to April 2019. <i>Methodology</i>. A matched case-control study that included 55 cases and 55 controls matched by age and sex was conducted. Data were collected through direct interviews, and the results of laboratory investigations were recorded in the extraction sheet. An enzyme-linked immunosorbent assay test was used to detect <i>H</i>. <i>pylori</i> antigen in the stool samples. Conditional logistic regression was used to measure the association between CU and <i>H</i>. <i>pylori</i>.</p><p><strong>Results: </strong>The total number of participants in this study was 110 patients (55 cases and 55 controls), whereby the median age was 31 (IQR 27-45) among controls versus 34 (IQR: 22-46) years among the cases. Both cases and controls had the same number of females and males. There was no significant association between CU and baseline characteristics of the participants. There was an association between CU and <i>H</i>. <i>pylori</i> infection, such that subjects with CU had a higher number of positive <i>H</i>. <i>pylori</i> test (15/55 = 27%) versus controls (6/55 = 10.1%) (<i>p</i> = 0.0225). The adjusted odds of CU among patients who were positive for <i>H</i>. <i>pylori</i> were sixfolds higher (OR = 6.9; CI: 1.3-36.2; <i>p</i> = 0.021) than those of patients who were negative for <i>H. pylori.</i></p><p><strong>Conclusion: </strong>There was a strong and significant association between CU and <i>H</i>. <i>pylori</i> infection. We recommend investigating for <i>H</i>. <i>pylori</i> in all cases of CU and conducting further trials on <i>H</i>. <i>pylori</i> eradication.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"5932038"},"PeriodicalIF":1.5,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38499452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy of Amniotic Membrane Stem Cell (AMSC) Metabolite Product and Vitamin E for Wrinkles, Spots, and Pores in Photoaging.","authors":"Rahmadewi Rahmadewi,&nbsp;Retha Retha,&nbsp;Dyah Ayu Pitasari,&nbsp;Vidyani Adiningtyas Kusumastanto,&nbsp;Agatha Anindita Ayu Ardhaninggar,&nbsp;Irmadita Citrashanty,&nbsp;Maylita Sari,&nbsp;Menul Ayu Umborowati,&nbsp;Cita Rosita Sigit Prakoeswa","doi":"10.1155/2020/1584541","DOIUrl":"https://doi.org/10.1155/2020/1584541","url":null,"abstract":"<p><strong>Background: </strong>It is expected that a combination of amniotic membrane stem cell metabolite product (AMSC-MP) and vitamin E after fractional CO₂ laser as laser-assisted drug delivery (LADD) will provide better effects in photoaging treatment as the combination reaches the target. This promises an option for photoaging therapy in the future.</p><p><strong>Materials and methods: </strong>Sixty women with photoaged skins were involved in this experimental study. They were then divided into two groups. The treatment group received a topical combination of AMSC-MP and vitamin E, and the control group received AMSC-MP alone after fractional CO₂ laser. The treatment was repeated three times.</p><p><strong>Result: </strong>The Janus assessment results showed a significant difference in pores in the third observation, and the average pore improvements in the treatment group were better than the control group. Wrinkle, UV spot, and polar spot did not show any significant difference.</p><p><strong>Conclusion: </strong>A combination of the amniotic membrane stem cell metabolite product (AMSC-MP) and vitamin E after fractional CO₂ laser as LADD only improves pores in photoaged skins.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"1584541"},"PeriodicalIF":1.5,"publicationDate":"2020-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/1584541","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38363711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of the Dermatological Manifestations of Coronavirus Disease 2019 (COVID-19).","authors":"Farah Marraha, Ibtissam Al Faker, Salim Gallouj","doi":"10.1155/2020/9360476","DOIUrl":"10.1155/2020/9360476","url":null,"abstract":"<p><p>Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has affected 210 countries and territories around the world. The virus has spread rapidly, and the disease is still extending up to now. The pathophysiology for SARS-CoV-2 has not been well elucidated, and diverse hypotheses to date have been proposed. Initially, no skin manifestations were observed among patients with COVID-19, but recently a few cases have been described. In this review, we discuss these various cutaneous manifestations and skin problems related to personal protective equipment, as well as different cutaneous anti-COVID-19 drug-associated reactions. We also focus on the currently proposed managements of these rare manifestations.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"9360476"},"PeriodicalIF":1.5,"publicationDate":"2020-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38313288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of a New Artificial Dermis as a Successful Tool in Face and Scalp Reconstruction for Skin Cancer: Analysis of the Efficacy, Safety, and Aesthetic Outcomes.","authors":"Fedele Lembo,&nbsp;Liberato Roberto Cecchino,&nbsp;Domenico Parisi,&nbsp;Aurelio Portincasa","doi":"10.1155/2020/4874035","DOIUrl":"https://doi.org/10.1155/2020/4874035","url":null,"abstract":"<p><p>Radical ablative surgery is the gold standard treatment of head skin cancer. The authors expose their experience with a new artificial dermis (Pelnac®), analyzing retrospectively the overall morbidity and aesthetic outcomes. 16 consecutive patients underwent two surgical procedures under local anesthesia. The first involved the tumor removal and application of the ADM. In the second, the exposed tissue was covered with a split-thickness skin graft. On follow-up (6 months), tumor recurrences, quality of scars (using the Vancouver Scar Scale), and patient reported outcomes (using FACE-Q Skin Cancer Module) were evaluated. 10 were males and 6 females, with a mean age of 73 years (61-89). The follow-up ranged from 12 to 48 months (mean: 30). The sites of skin tumor were scalp (12 cases), forehead (2), cheek (1), and zygomatic area (1). Nine patients underwent previous local surgery; two received radiotherapy. The average length of hospital stay was 3.2 days. The mean surface area of the defect was 59.15 cm² (16.9-89.5). In three cases, the surgical bed was bone without periosteum. The malignant tumors excised were basal cell carcinoma (68.75%), squamous cell carcinoma (18.75%), malignant melanoma (6.25%), and sarcoma (6.25%). The mean operating time was 41 minutes for the first operation (25-55) and 34 for the second (25-48). No significant problems were observed and 15 patients (93.75%) had 100 percent intake of graft. The mean time of healing was 39 days (32-45). At 6 months post-op, no tumor recurrence. Satisfactory cosmetic and functional results were obtained in all patients as shown by the VSS Scale and FACEQ skin cancer module mean scores. We believe that the artificial dermis is a reliable alternative to flaps and should be considered an excellent option in head reconstruction for skin cancer, especially in critical patients (old, with large and deep defects, with recurrent tumors, required radiotherapy).</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"4874035"},"PeriodicalIF":1.5,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/4874035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38239407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Efficacy and Safety of Two Cryotherapy Protocols in the Treatment of Common Viral Warts: A Prospective Observational Study.","authors":"Jihan M Muhaidat,&nbsp;Firas A Al-Qarqaz,&nbsp;Diala M Alshiyab,&nbsp;Hadeel S Alkofahi,&nbsp;Yousef Khader,&nbsp;Mawaddah Y Ababneh","doi":"10.1155/2020/2309309","DOIUrl":"https://doi.org/10.1155/2020/2309309","url":null,"abstract":"<p><strong>Background: </strong>Cryotherapy (freezing by liquid nitrogen) is an effective and widely used method for treatment of common warts. Patients often need multiple sessions at variable intervals. Protocols used by different dermatologists vary in terms of freezing time, the number of cycles, and the intervals between sessions.</p><p><strong>Aim: </strong>To compare the efficacy (cure rates) and safety (complications, early and late) of two cryotherapy treatment protocols for common viral warts.</p><p><strong>Method: </strong>A prospective observational study was conducted; it involved 80 patients with common warts on the hands and feet who were treated with cryotherapy done by two dermatologists who use different protocols; group 1 (45 patients) were treated by a single cycle of 10 seconds of freezing at 2 weekly intervals, and group 2 (35 patients) received a single cycle of 20 seconds of freezing at 4-weeks intervals. The two protocols were compared in terms of cure rate and complications 1-2 months after the final treatment. Recurrence rate and late complications were assessed at 9-12 months after the final treatment.</p><p><strong>Results: </strong>Group 1 patients achieved higher cure rate than group 2, 77.8% and 54.3%, respectively (<i>P</i>=0.001). Early (blistering) and late complications (dyspigmentation and scarring) were comparable in both groups. Pain score associated with protocol 1 (5.2/10) was less than protocol 2 (6.4/10) (<i>P</i>=0.004). Recurrence rate (17%) was comparable in both groups. Association between cure rate and duration of warts (<i>P</i>=0.022) and also association between cure rate and the mean number of warts (<i>P</i>=0.001) were demonstrated.</p><p><strong>Conclusions: </strong>Cryotherapy is an effective and safe treatment for common viral warts of hands and feet. The impact of shorter intervals on cure rate was more significant than increasing freezing time with longer intervals between freezing sessions. The study was approved by the local IRB committee (285-2018).</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2020 ","pages":"2309309"},"PeriodicalIF":1.5,"publicationDate":"2020-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/2309309","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38239406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}