Dermatology Research and Practice最新文献

{"title":"Trichloroacetic Acid Peeling for Treating Photoaging: A Systematic Review.","authors":"Irma Bernadette S Sitohang,&nbsp;Lili Legiawati,&nbsp;Lis Surachmiati Suseno,&nbsp;Fadhila Dea Safira","doi":"10.1155/2021/3085670","DOIUrl":"https://doi.org/10.1155/2021/3085670","url":null,"abstract":"<p><p>Photoaging can significantly contribute to lower quality of life. Medium-deep peeling using trichloroacetic acid allows controlled keratocoagulation through the dermis and into the dermal papillary layer that is effective for skin rejuvenation. The purpose of this article is to give updates regarding the efficacy, possible adverse events, and patient satisfaction of trichloroacetic acid (TCA) peeling for skin rejuvenation by assessing various photoaging parameters. A systematic review of prospective trial articles collected from PubMed, MEDLINE, EMBASE, Cochrane, and Scopus databases was conducted on November 2, 2020. Treatment efficacy was assessed based on the photoaging parameters used by each study. Adverse events and patient satisfaction as the secondary outcome were assessed based on patients-perceived improvements. Five studies included three randomized comparison studies and two prospective cohort studies. These studies show that TCA peeling significantly improve the cosmesis of photoaged facial skin. Low concentration is effective for superficial sun damage. Medium-depth peels using a higher concentration of TCA or as combination therapy are effective as skin resurfacing agents to reduce wrinkles. Some adverse effects may occur but usually resolve within weeks. Overall patients were satisfied with the treatment result. An equivalent basic skin preparation such as topical retinoic acid skin priming prior to intervention is necessary for more objective comparison. Further research studies with a larger sample size and longer follow-up period are required. This evidence suggests that TCA peeling is effective in photoaging treatment, either as monotherapy or as combination therapy with other modalities.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2021 ","pages":"3085670"},"PeriodicalIF":1.5,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39421067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitude, and Practice (KAP) Survey toward Skin Cancer among Ecuadorian Population.","authors":"Victor H Pinos-León,&nbsp;César Sandoval,&nbsp;Franklin Cabrera,&nbsp;Esmeraldas Terán,&nbsp;Ana Garnica,&nbsp;Ana Kellendonk,&nbsp;Mery Alvear,&nbsp;Carla Rosero,&nbsp;Lorena Vaca,&nbsp;Jorge Bonifaz,&nbsp;Anita Buestán,&nbsp;Claudia Armas,&nbsp;Raquel Trujillo,&nbsp;Patricio Freire,&nbsp;Tamara León,&nbsp;Giselle Erazo,&nbsp;Liliana García,&nbsp;Marcela Alzate,&nbsp;Vicente Toapanta,&nbsp;Myriam Ortega,&nbsp;Daniela Caicedo,&nbsp;Alicia Pereira,&nbsp;Lenin Gómez-Barreno,&nbsp;Juan S Izquierdo-Condoy,&nbsp;Merry Charlie,&nbsp;Esteban Ortiz-Prado,&nbsp;Katherine Simbaña-Rivera","doi":"10.1155/2021/5539149","DOIUrl":"https://doi.org/10.1155/2021/5539149","url":null,"abstract":"<p><strong>Background: </strong>Skin cancer is one of the most common cancers, and melanoma is a highly preventable cancer. In Ecuador, few studies have evaluated the awareness levels of the population about the disease. For this reason, the objective of this study was to measure the level of knowledge, attitudes, and practices regarding skin cancer and its determining factors.</p><p><strong>Methods: </strong>A cross-sectional analysis using an online self-assessment questionnaire containing 40 questions was delivered. A total of 537 participants were included in this study. Knowledge, attitude, and practice scores were assigned to each participant based on the number of correct or appropriate responses. Logistic regression analysis was used to calculate crude and adjusted odds ratios.</p><p><strong>Results: </strong>In total, 75% of participants referenced knowledge of the harmful effects related to noncontrolled solar exposure. Concerning sunscreen, 76.7% knew the reason for using it. The female group was 1.68 times more likely to get a higher score than the male group, and the groups between 61-70 and 71-80 years were 0.30 and 0.17 times less likely to get a higher score compared with the less than 20-years-old group, respectively.</p><p><strong>Conclusions: </strong>The findings of this study indicate the requirement to increase the population's knowledge about skin cancer and possible protection measures. For this reason, the prevention and health promotion programs at a national level from primary healthcare centers are recommended. Due to the limitation of the representativeness of the sample, the use of more studies among Ecuadorian residents of the low socioeconomic level and replication in different provinces of Ecuador is justified.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2021 ","pages":"5539149"},"PeriodicalIF":1.5,"publicationDate":"2021-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39312962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contributing Factors and Outcome after Cryotherapy of Molluscum Contagiosum among Patients Attending Tertiary Hospital, Northern Tanzania: A Descriptive Prospective Cohort Study.","authors":"Peter J Chapa,&nbsp;Daudi R Mavura,&nbsp;Rune Philemon,&nbsp;Lulyritha Kini,&nbsp;Elisante J Masenga","doi":"10.1155/2021/9653651","DOIUrl":"https://doi.org/10.1155/2021/9653651","url":null,"abstract":"<p><strong>Background: </strong>Molluscum contagiosum (MC) is a benign infection caused by a member of the Poxviridae family, molluscum contagiosum virus (MCV). The contributing factors for MCV infection are different in different populations and study areas. Few studies have been conducted to determine the effectiveness of cryotherapy in the treatment of MC. The study's objectives were to determine contributing factors and outcome after cryotherapy of MC among patients attending a tertiary hospital in Northern Tanzania.</p><p><strong>Methods: </strong>A hospital-based cohort study was conducted at the Regional Dermatology Training Centre (RDTC) from September 2018 to August 2019, involving all patients clinically diagnosed with MC. We used a consecutive sampling method to recruit study participants. We treated all participants with cryotherapy and assessed them after two weeks. Data were collected using a structured questionnaire and analyzed using Statistical Package for the Social Sciences (SPSS) software version 21.</p><p><strong>Results: </strong>There were 49 patients with MC who agreed to participate in this study with a median age of 8 (IQR 3-22). We found 18.4% of patients with active atopic dermatitis (AD) had MC while those with a history of atopic diseases (Ad) were 32%, and 22.4% had a history of using immunosuppressive drugs. The clearance rate of cryotherapy on MC lesions was found to be 94%. Hypopigmentation was the commonest adverse effect.</p><p><strong>Conclusion: </strong>The findings of this study show that AD and immunosuppression may be contributing to MC development. Based on the clearance rate results, cryotherapy has shown to be effective and may be used in the treatment of MC.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2021 ","pages":"9653651"},"PeriodicalIF":1.5,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39223969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Inflammatory and Restorative Effects of Olives in Topical Application.","authors":"Mahdiyeh Taheri, Leila Amiri-Farahani","doi":"10.1155/2021/9927976","DOIUrl":"10.1155/2021/9927976","url":null,"abstract":"<p><strong>Methods: </strong>A literature search was conducted (1990-2021) in Medline, Embase, CINAHL, Google Scholar, Science Direct, SID, IranDoc, and Magiran databases. From the 102 reviewed articles, 17 articles were selected to be included in the current article.</p><p><strong>Results: </strong>Various forms of olive have long been used to accelerate the healing of various wounds and skin damage such as diabetic foot ulcers, atopic dermatitis, diaper dermatitis, episiotomy wound, and nipple ulcer but there are still no credible documents or articles that provide reliable evidence of topical use.</p><p><strong>Conclusion: </strong>According to the information obtained from the articles reviewed, olive oil appears to be an effective, safe, and available treatment. This study suggests that olive oil is an alternative remedy to minimize the frequent use of chemical-based treatments. More research may be beneficial to reach certainty in terms of curative properties of olive oil in similar or different injuries in different populations.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2021 ","pages":"9927976"},"PeriodicalIF":1.5,"publicationDate":"2021-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39180694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and Safety of Abrocitinib in Patients with Moderate-to-Severe Atopic Dermatitis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.","authors":"Hammad Ali Fadlalmola,&nbsp;Muayad Saud Albadrani,&nbsp;Amal Mohamed Elhusein,&nbsp;Wahieba E Mohamedsalih,&nbsp;Veerabhadra D S Swamy,&nbsp;Daniel Mon Mamanao","doi":"10.1155/2021/8382761","DOIUrl":"https://doi.org/10.1155/2021/8382761","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD) is a complex, chronic, inflammatory skin disease characterized by pruritic, intense itching, and eczematous lesions affecting about 25% of children and 2% to 3% of adults worldwide. Abrocitinib is a selective inhibitor of Janus kinase-1 (JAK1) enzyme inhibiting the inflammatory process. Therefore, we aimed to assess the efficacy and safety of abrocitinib for moderate-to-severe AD.</p><p><strong>Methods: </strong>We systematically searched PubMed, Cochrane, Web of Science, Scopus, and EczemATrials till Feb 1, 2021, for reliable trials. The analysis was conducted using an inverse-variance method. The results were pooled as mean difference/event rate and 95% confidence interval.</p><p><strong>Results: </strong>Abrocitinib 100 mg and 200 mg were associated with higher IGA response, EASI-50% responders, EASI-75% responders, EASI-90% responders, number of participants with at least 4-point improvements in NRS, and quality of life measured by DLQI and CDLQI than placebo. Also, 100 mg and 200 mg were associated with lower SCORAD index, %BSA, PSAAD index, and POEM index than placebo. Abrocitinib 100 mg and 200 mg were not associated with adverse events such as upper respiratory tract infection, nasopharyngitis, dermatitis, atopic, any serious adverse events, and death.</p><p><strong>Conclusion: </strong>Abrocitinib in dose 100 mg or 200 mg is an effective, well-tolerated, and promising drug in treating patients with moderate-to-severe atopic dermatitis. However, the analysis favored the efficacy of abrocitinib 200 mg over 100 mg, but side effects such as nausea and headache are likely to occur more with 200 mg.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2021 ","pages":"8382761"},"PeriodicalIF":1.5,"publicationDate":"2021-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39180693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of IL-17A Serum Levels in Patients with Nonmelanoma Skin Cancer.","authors":"Mehdi Ghahartars,&nbsp;Fatemeh Sedaghat,&nbsp;Elham Khajavi,&nbsp;Amir Ali Nejat,&nbsp;Mahyar Malekzadeh,&nbsp;Abbas Ghaderi,&nbsp;Mohammad Javad Fattahi","doi":"10.1155/2021/5540163","DOIUrl":"https://doi.org/10.1155/2021/5540163","url":null,"abstract":"<p><strong>Background: </strong>Role of interleukin 17A (IL-17A) in carcinogenesis and cancer growth is controversial. Although some researches support its antitumor activity, some others suggest that it promotes the growth and development of different types of cancer including skin cancer by activation of STAT3. Although the function of the cytokines such as IL-17A has been extensively studied in various types of cancer, nonmelanoma skin cancer (NMSC) has not received much attention. Therefore, the present study was aimed to investigate the serum levels of IL-17A in NMSC patients.</p><p><strong>Methods: </strong>This cross-sectional study was performed on 60 patients with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) as well as 57 age-sex matched healthy individuals as control group. Measurement of IL-17A serum levels in both case and control groups was performed by a commercially reliable sandwich enzyme-linked immunosorbent assay (ELISA) kit.</p><p><strong>Results: </strong>In this study, we observed that IL-17A serum levels in NMSC patients were significantly higher than the control group (<i>P</i> < 0.001). Also, both BCC and SCC patients had higher levels of IL-17A in their sera in comparison to the controls (<i>P</i>=0.001 and <i>P</i> < 0.001, respectively). However, there was no significant difference between SCC and BCC patients regarding serum levels of IL-17A.</p><p><strong>Conclusion: </strong>According to our results, it can be concluded that IL-17A may play a role in inducing the growth and progression of NMSC and it can be used as a therapeutic target in these patients in future.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2021 ","pages":"5540163"},"PeriodicalIF":1.5,"publicationDate":"2021-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39166201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin Diseases in a Pediatric Hospital of Nepal.","authors":"Roushan Jahan,&nbsp;Shreedhar Khanal,&nbsp;Shraddha Shrestha,&nbsp;Niraj Parajuli","doi":"10.1155/2021/6619936","DOIUrl":"https://doi.org/10.1155/2021/6619936","url":null,"abstract":"<p><p>The skin diseases of pediatric population are varied which change according to age and season. There is a rarity of studies on pediatric skin conditions from Nepal. This observational study from the only tertiary care referral pediatric center of the country highlighted the burden of pediatric skin diseases in Nepalese population. All new cases of pediatric patients less than 14 years of age consulting the pediatric dermatological OPD of Kanti Children's Hospital from January 2017 to December 2017 were included in this study. Demographic details of all the patients such as age and sex were recorded. The diagnosis was made clinically in most instances and appropriate laboratory and histopathological examination were performed wherever necessary. A total of 7683 pediatric patients were included in the study. Among these, there were 4574 (59.53%) males and 3109 (40.47%) females. The most common skin condition was infections among 2463 (32.12%) followed by eczematous conditions in 1711(22.27%) and hypersensitivity reactions in 1510 (19.65%). Infections were more common during the summer months. Overall, both infectious and noninfectious skin diseases were significantly more common during the warmer (summer and spring) months as compared to colder (autumn and winter) months (<i>p</i> < 0.001). This study shows that the pediatric dermatoses are common in Nepalese population.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2021 ","pages":"6619936"},"PeriodicalIF":1.5,"publicationDate":"2021-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39162923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Diagnosis has a High Negative Predictive Value in Evaluation of Malignant Skin Lesions.","authors":"Maral Seyed Ahadi,&nbsp;Alireza Firooz,&nbsp;Hoda Rahimi,&nbsp;Mehrdad Jafari,&nbsp;Zohreh Tehranchinia","doi":"10.1155/2021/6618990","DOIUrl":"https://doi.org/10.1155/2021/6618990","url":null,"abstract":"<p><strong>Background: </strong>The increasing incidence of skin cancers in fair-skinned population and its relatively good response to treatment make its accurate diagnosis of great importance. We evaluated the accuracy of clinical diagnosis of malignant skin lesions by comparing the clinical diagnosis with histological diagnosis as the gold standard.</p><p><strong>Materials and methods: </strong>In this retrospective study, we assessed all the pathology reports from specimens sent to a university hospital laboratory in 3 consecutive years from March 2008 to March 2010. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and positive and negative likelihood ratios were calculated for clinical diagnosis of malignant skin lesions stratified by their histological subtype.</p><p><strong>Results: </strong>A total 4,123 specimen were evaluated. The sensitivity and specificity for clinical diagnosis of malignancy were 90.48% and 82.85%, respectively, whereas the negative predictive value was shown to be 99.06%. The positive and negative likelihood ratios were 5.23 and 0.11, respectively.</p><p><strong>Conclusion: </strong>Pathological assessment of skin lesions remains the cornerstone of skin cancer diagnosis. The high NPV and the relatively low PPV indicate that clinical diagnosis is more efficient in ruling out malignancies rather than diagnosing them.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2021 ","pages":"6618990"},"PeriodicalIF":1.5,"publicationDate":"2021-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38986979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Circulatory Interleukin-17A Levels in Patients with Progressive and Leukotrichial Vitiligo.","authors":"Thai Van Thanh Le,&nbsp;Huy Ngoc Phan,&nbsp;Tran Ngoc Dang,&nbsp;Le Duy Pham","doi":"10.1155/2021/5524566","DOIUrl":"https://doi.org/10.1155/2021/5524566","url":null,"abstract":"<p><strong>Background: </strong>Vitiligo is a chronic condition characterized by skin depigmentation. Although not life-threatening, it significantly impacts quality of life. The pathophysiology of vitiligo remains poorly understood, and treatment options are limited. Mounting evidence supports the importance of autoreactive T cells and, particularly interleukin-17A- (IL-17A-) secreting Th17 cells, in vitiligo. IL-17A targeting has been proven successful in various inflammatory dermatological conditions, including psoriasis and lupus erythematosus.</p><p><strong>Objective: </strong>We evaluated the relationship between serum levels of IL-17A and the clinicopathological characteristics of Vietnamese vitiligo patients.</p><p><strong>Methods: </strong>In this cross-sectional study, we analyzed data from 52 nonsegmental vitiligo patients and 50 age- and sex-matched healthy individuals. Serum levels of IL-17A were measured using an enzyme-linked immunosorbent assay. We evaluated the correlation between IL-17A levels and clinical characteristics including leukotrichia, disease duration, vitiligo activity, and body surface area involvement.</p><p><strong>Results: </strong>Patients with progressive vitiligo had significantly higher IL-17A levels than patients with stable vitiligo (<i>P</i> = 0.014) or healthy individuals (<i>P</i> = 0.002). In addition, serum IL-17A levels were higher in vitiligo patients with leukotrichia than in patients without it (<i>P</i> = 0.04). Furthermore, serum IL-17A levels were negatively correlated with age (<i>r</i> = -0.39, <i>P</i> = 0.004) and age of onset (<i>r</i> = -0.33, <i>P</i> = 0.016) in vitiligo patients.</p><p><strong>Conclusions: </strong>Higher serum levels of IL-17A in patients with progressive vitiligo and leukotrichia suggest a potential role of IL-17A in melanocyte destruction in the epidermis and the follicular matrix.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2021 ","pages":"5524566"},"PeriodicalIF":1.5,"publicationDate":"2021-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38963730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cosmetic Syndrome Correction with Calcium Hydroxylapatite-Based Filler in Patients with Connective Tissue Dysplasia.","authors":"Maria Shirshakova,&nbsp;Elena Morozova,&nbsp;Daria Sokolova,&nbsp;Svetlana Pervykh,&nbsp;Lyailya Kayumova","doi":"10.1155/2021/6673058","DOIUrl":"https://doi.org/10.1155/2021/6673058","url":null,"abstract":"<p><p>Undifferentiated connective tissue dysplasia is one of the most common diseases of nowadays, which does not fit into the group of hereditary syndromes. This condition is diagnosed in 20-50% of the population at any age. The study aimed to correct the facial soft tissues of patients with undifferentiated connective tissue dysplasia through the cosmetic procedure of calcium hydroxylapatite injection. In 2018, a 36-year-old patient addressed the beauty salon with signs of undifferentiated connective tissue dysplasia, such as severe asymmetry of the face, infraorbital and nasolabial sulci, and thin and easily folding skin. Signs were observed from the age of 22, i.e., for 14 years. The therapy was performed using special features of the correction of facial soft tissue changes in patients with connective tissue dysplasia (CTD) using calcium hydroxylapatite-based products (Radiesse®, Merz North America, Inc., USA). Particular attention is given to the need for early correction to prevent premature skin aging related to this condition. After 14 days, a significant improvement of the patient's skin condition was noted after the passing of two procedures. Her condition was estimated as consistent with T1-2P0G0A1Zh1 P1M1K1 and corresponded to grade I age-related changes in the superficial soft tissues. The performed treatment showed high efficacy in case of mild connective tissue dysplasia diagnosis. The results showed that when collecting information from anamnesis, the diagnostic criteria for dysplasia should be considered. If the criteria are met, the cosmetological correction with collagen stimulators becomes possible.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2021 ","pages":"6673058"},"PeriodicalIF":1.5,"publicationDate":"2021-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38873408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}