I.P. Pavlov Russian Medical Biological Herald最新文献

{"title":"Pathogenetic Aspects of Bronchial Asthma Phenotyping","authors":"Yuriy Yu. Byalovskiy, Sergey I. Glotov, I. Rakitina, A. Ermachkova","doi":"10.17816/pavlovj181606","DOIUrl":"https://doi.org/10.17816/pavlovj181606","url":null,"abstract":"INTRODUCTION: During a many-year history of its study, bronchial asthma (BA) has gone through the stages of numerous classifications. The introduction of specific biological therapy of BA permitted to speak about the phenotypes of the disease. \u0000AIM: Presentation of the main pathophysiological mechanisms for isolation of endotypes and phenotypes of BA. \u0000The diagnosis of phenotype of BA is based on the pathophysiological mechanisms of its development, which permit to evaluate the dynamics of the disease, make the diagnosis and predict the course of the disease. The most complicated aspect of BA phenotyping is severe forms of the disease characterized by a combination of different phenotypes. This impedes evaluation of specific pathogenetic mechanisms and administration of the optimal therapy for the patient. \u0000CONCLUSION: The diagnosis of BA phenotypes permits to identify specific pathogenetic mechanisms and thereby personalize the treatment.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"55 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140733490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological and Epizootological Characteristics of Tick-Borne Viral Encephalitis and Tick-Borne Borreliosis in European Part of Russia","authors":"N. D. Okunev, T. D. Zdol'nik","doi":"10.17816/pavlovj568883","DOIUrl":"https://doi.org/10.17816/pavlovj568883","url":null,"abstract":"INTRODUCTION: Tick-borne borreliosis (TBB) andtick-borne viral encephalitis (TBVE) are widely spread in the world and in Russia and have a high socioeconomic significance. The morbidity of the population with these infections is to a large extent determined by the epizootological situation formed in the natural conditions of certain natural climatic zones. \u0000AIM: To obtain modern epidemiological and epizootological characteristics of TBB and TBVE in the territorial formations of the European part of Russia with different natural and climatic conditions. \u0000MATERIALS AND METHODS: The work used the materials of the Governmental reports ‘On the state of sanitary and epidemiological welfare of the population’ of the territorial departments of Rospotrebnadzor in the European part of Russia in 2012–2021. \u0000RESULTS: The maximum incidence of TBB and TBVE (5.00 and 1.83 per 100 thousand population) is characteristic of the territory of the Northwestern Federal District (NWFD) of Russia with the natural and climatic conditions of the taiga zone. The second and third positions are occupied by the Central (4.53 and 0.34 per 100 thousand) and the Volga (3.59 and 1.11 per 100 thousand) federal districts whose territories include several natural zones. In the Southern and North Caucasian federal districts where a significant part of the territory is located in the steppe and forest-steppe zone, the incidence of TBB is 0.63 and 0.16 per 100 thousand, respectively, the incidence of TBVE is practically not recorded. The incidence of TBB and TBVE in the population correlates with the proportion of people bitten by ticks — in the Northwestern Federal District the correlation coefficient was 0.89 and 0.74, in the Central Federal District — 0.65 and 0.68, in the Volga Federal District — 0.90 and 0.92. The ratio of infection of ticks removed from people in the Northwestern Federal District with agents of TBB and TBVE was 9.7:1.0. The total annual average area of acaricide treatments has a maximum value in the Central Federal District — 14333.6 hectares. In the territorial formations of the European part of Russia with the largest acaricide treatment area, an inverse correlation was found between this indicator and the proportion of people bitten by ticks (r = -0.40). \u0000CONCLUSIONS: The epidemiological and epizootological characteristics of TBB and TBVE in 2012–2021 in the territorial formations of the European part of Russia indicate the influence of conditions of certain natural and climatic zonesof these territorieson the formation of epizootic foci and the incidence of these infections in the population, which should be taken into account when planning and implementing anti-epidemic measures.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"18 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140732560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teleneurorehabilitation in Neurologic Disorders and Diseases: Potentials, Effectiveness and Barriers","authors":"Anna N. Belova, Alexey N. Kuznetsov, V. O. Sushin, A. M. Rezenova, M. A. Shabanova, G. E. Sheyko, Roman D. Ananyev","doi":"10.17816/pavlovj364502","DOIUrl":"https://doi.org/10.17816/pavlovj364502","url":null,"abstract":"INTRODUCTION: One of the important problems of modern rehabilitation is loss of the results achieved at different stages of rehabilitation because of interruption of the recovery processes and absence of home-based rehabilitation after discharge from a medical center. The maximal effect after rehabilitation can be achieved only on condition that an integrated continuous approach is provided including distant format through use of modern digital devices and technologies to ensure the double feedback between the patient and the doctor. In this context, telemedicine acquires special significance. Teleneurorehabilitation (TNR) is a field of telemedicine ensuring accessibility and continuity of rehabilitation care to patients living in geographically remote areas. \u0000AIM: Reporting of brief information on the possibilities of using TNR technologies in neurologic disorders and diseases. \u0000The review includes general concepts of TNR: conditions of realization range of technical means, principles and types of remote rehabilitation interventions. Brief information is given on the possibilities of using remote technologies in motor and cognitive disorders. The effectiveness of TNR and barriers to its implementation are considered. \u0000CONCLUSION: A large number of studies prove the technical feasibility of TNR, however, the development and maintenance of a viable model of remote rehabilitation care integrated into the existing health care system requires scientific justification of the effectiveness and economic benefits of specific technologies in specific forms of neurologic pathology. The creation of an evidence base will permit to realize the potential of TNR and make the remote form of rehabilitation a new standard of medical care not only in the era of the pandemic of a new coronavirus infection, but also after the pandemic.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"47 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140733937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathomorphological Features of Placenta in Different Degrees of Severity of New Coronavirus Infection Suffered During Pregnancy","authors":"Y. Kuklis, I. Medyannikova, E. Protsenko, L. V. Kulida, Ol'ga P. Sariyeva","doi":"10.17816/pavlovj340807","DOIUrl":"https://doi.org/10.17816/pavlovj340807","url":null,"abstract":"INTRODUCTION: A wide spread of infection caused by SARS-CoV-2 coronavirus (Severe Acute Respiratory Syndrome-related coronavirus 2 associated with a severe acute respiratory syndrome) in the population, high risks of infection in pregnant women and the lack of understanding of the mechanisms of invasion of the agent into the placenta and its effect on the perinatal outcomes, dictate the need for targeted investigation of the morphofunctional features of placentas of puerperia’s who have suffered this infection. \u0000AIM: To identify pathomorphological alterations in placentas in a mild, moderate and severe course of the new coronavirus infection in women during pregnancy. \u0000MATERIALS AND METHODS: A morphological survey research of 63 placentas of women who have suffered SARS-CoV-2 infection during pregnancy was conducted. The material was divided into groups with mild (n = 16), moderate (n = 35) and severe (n = 12) course of the disease. The control group included 25 placentas from women with physiological pregnancy. After standard fixation and histological preparation of the material, the tissue sections of 4 µm to 5 µm thickness were stained with hematoxylin and eosin. \u0000RESULTS: It has been established that the new coronavirus infection runs with general pathological alterations in the placentas. In a mild course of the infectious process, inflammation in the basal (12.5%) and parietal (25.0%) decidual membrane, disorders in maternal (6.3%) and fetal (6.3%) hemocirculation were diagnosed. A moderate course of the disease was characterized by predominance of placentas with impaired differentiation of chorionic villi by dissociation type (74.3%, p = 0.0001) and of mononuclear deciduitis (57.1%, p = 0.008). In a severe course of SARS-CoV-2 infection, abnormalities in the form of placenta (58.3%, p = 0.004) and in the attachment of the umbilicus (58.3%, p = 0.03), villous infarctions (33.3%, p = 0.05), thrombosis in the maternal (63.7%, p = 0.005) and fetal (57.3%, p = 0.005) parts of vascular bed were noted. \u0000CONCLUSION: Thus, the mild course of SARS-CoV-2 infection is characterized by chronic inflammation in the structural components of the placenta, the moderate course — by the dissociated development of cotyledons, the severe course — by disorders in hemocirculation in the form of infarctions and thrombosis.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"3 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140733318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphometric Features of Different Types of Bifurcations in the Splenic Intraorgan Arterial System in Individuals of Different Gender and Age","authors":"A. S. Dadashev, O. Zenin, Ilia S. Miltykh, E. Kafarov","doi":"10.17816/pavlovj321742","DOIUrl":"https://doi.org/10.17816/pavlovj321742","url":null,"abstract":"INTRODUCTION: A promising direction that has recently emerged in morphology is investigation of the arterial bed of various human organs as fractal or quasi-fractal systems. Conceptual models have been developed permitting a quantitative description of the vascular bed features. This approach will help to create a morphometric standard of the intraorgan blood flow, which will be useful in objective diagnosis of probable deviations from the normal structure. \u0000AIM: To identify the morphometric features of various types of bifurcations of the splenic intraorgan arterial bed in individuals of different gender and age. \u0000MATERIALS AND METHODS: The characteristics of the splenic intraorgan arterial bed have been studied in 67 individuals who died suddenly and from accidental causes at the age of 21 to 60 years. The arterial bed was represented as connected graphs with vertices corresponding to the bifurcation points of arteries, and edges to the arterial segments. The diameter and length of an arterial segment were measured on corrosion preparations. Based on the morphometry data, the following parameters were determined: generation number, division level, form factor FF1, branching factor ƞ and asymmetry factor γ. Statistical analysis was carried out using the R language. \u0000RESULTS: The total number of examined arterial bifurcations was 6,840. The examined bifurcations were located at 20 division levels and presented 8 generations. In the structure of the vascular bed, bifurcations of neutral kind (0) predominated with the relative quantity 51%. The least numerous was type 2 bifurcations — 9%. The intermediate position was taken by open (1) bifurcations accounting for about 40% in the vascular bed structure. \u0000CONCLUSIONS: The intraorgan arterial bed of the spleen is a quasi-fractal system consisting of three types of bifurcations — open, neutral and closed. A relative number of different types of bifurcations differs depending on gender and age and is also related to the generation number and division level.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"8 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140732781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular Stiffness in Senile Patients with Chronic Heart Failure","authors":"Dmitriy S. Grachev, Vadim S. Petrov, Kamila I. Namazova, Tat'yana A. Maksyakova, Viktoriya I. Tokareva","doi":"10.17816/pavlovj375266","DOIUrl":"https://doi.org/10.17816/pavlovj375266","url":null,"abstract":"INTRODUCTION: The study of vascular stiffness is a method of assessing the risk of cardiovascular diseases. One of methods of assessing arterial stiffness is theсardio-ankle vascular index (CAVI), which reflects the extent of structural lesion of vessels. This index has prospects in application for studying vascular stiffness in senile individuals with chronic heart failure (CHF) to identify new predictors of the cardiovascular risk. \u0000AIM: To study the parameters of vascular stiffness (cardio-vascular and ankle-brachial indices) in senile patients (75–89 years) with CHF using the volume sphygmography method. \u0000MATERIALS AND METHODS: The study included 120 patients (87 women and 33 men) with CHF of senile age (mean age 81.3 ± 4.2 years). In all patients, the electrocardiography and sphygmography data were analyzed with assessment of the CAVI and ankle-brachial index. \u0000RESULTS: In patients with IV functional class (FC) CHF, the highest CAVI was found on the right exceeding the parameters of II FC CHF and III FC CHF groups by 0.57 and 1.02 units, respectively (p 0.05). The CAVI on the left in patients with IV FC CHF was higher in comparison with II FC CHF and III FC CHF groups by 0.47 and 0.6 units, respectively. There were also identified correlation relationships of vascular stiffness with the age of patients, functional class of chronic heart failure and echocardiographic parameters: left ventricle ejection fraction, left ventricle end-diastolic diameter, left-ventricle end-systolic diameter (p 0.05). \u0000CONCLUSION: The cardio-ankle vascular index can be used to assess vascular stiffness in senile patients with CHF and can help determine the risk of cardiovascular diseases. Further studies are needed on a larger sample of patients.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140733180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opinion of Obstetricians and Gynecologists on Problems of Rehabilitation of Women with Early Reproductive Losses","authors":"Oksana S. Aleshkina, Oleg E. Konovalov","doi":"10.17816/pavlovj566777","DOIUrl":"https://doi.org/10.17816/pavlovj566777","url":null,"abstract":"INTRODUCTION: One of the most important problems is preserving reproductive potential of the population, which requires development of principally new approaches and organizational solutions. \u0000AIM: To study the opinion of obstetricians and gynecologists on preventability of early reproductive losses and rehabilitation of women after them. \u0000MATERIALS AND METHODS: A sociological survey covered 128 obstetricians and gynecologists working in women’s consultation clinics, specialized gynecological clinics and gynecological departments of multidisciplinary hospitals of Ryazan. Mathematical processing of the results was performed using variation statistics methods. \u0000RESULTS: More than half (60.3%) of the surveyed doctors believe that early pregnancy losses (EPL) in women are conventionally preventable; 28.6% of respondents think they are incompletely preventable and absolutely unpreventable; 11% of respondents found it difficult to answer. A vast majority of respondents (92.1%) were of the opinion that women with EPL need additional health monitoring and rehabilitation. Concerning the opinion of doctors of the awareness of women of necessity for rehabilitation after EPL, 23.6% of surveyed doctors considered them sufficiently informed, 52.7% — insufficiently informed, 12.8%— completely uninformed, and 10.9% found it difficult to answer. The average score on the 5-point scale of the extent of motivation of women for rehabilitation after EPL was 3.72. \u0000CONCLUSION: The results of the study are recommended to be considered when taking organizational and managerial decisions on improving complex medical and socio-psychological rehabilitation of women after EPL.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"22 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140733034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Effect of Therapy with Intensive Pulsed Light on Psychoemotional State of Patients with Erythematotelangiectatic Rosacea","authors":"E. E. Zhiltsova, Kseniya V. Mezhevaya","doi":"10.17816/pavlovj342053","DOIUrl":"https://doi.org/10.17816/pavlovj342053","url":null,"abstract":"INTRODUCTION: Rosacea, or acne rosacea, is a polyetiological disease that affects the facial area, less commonly the neck and the area of decollete. The disease has diverse clinical manifestations. Erythematotelangiectatic rosacea is characterized by persistent erythema, telangiectasia of different diameters, edema of skin. Patients subjectively feel burning, heat and itching. These symptoms often lead to changes in the psychoemotional state of patients, depression, apathy. \u0000АIM: To evaluate the effect of intensive pulsed light therapy on the severity of psychoemotional problems in patients with erythematotelangiectatic type of rosacea. \u0000MATERIALS AND METHODS: Sixty-two patients were followed up. The patients were divided into 2 groups. In the first group, local therapy with azelaic acid gel was used; in the second group, a combined therapy was conducted with azelaic acid gel and intensive pulsed light on M-22 apparatus (Lumenis Ltd., Israel). Before and after a course of treatment patients were surveyed using the Dermatology Life Quality Index questionnaire. \u0000RESULTS: After a course of the combined treatment, the second group showed an improvement of skin condition and a considerable reduction of the anxiety level in comparison with the first group where monotherapy with azelaic acid was conducted. \u0000CONCLUSION: Therapy with intense pulsed light reduces the number of telangiectasias and brightness of erythema, which alleviates the severity of psychological problems in patients with rosacea.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"48 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140733462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenetic Mechanisms of Peristalsis Disorders in Chronic Constipation","authors":"Tat'yana I. Shevchenko, D. S. Shvorob, Arina A. Abramyan, I. S. Grekov","doi":"10.17816/pavlovj321316","DOIUrl":"https://doi.org/10.17816/pavlovj321316","url":null,"abstract":"INTRODUCTION: Chronic constipation is one of the most pressing problems in the contemporary coloproctology, which is observed in 14%–16% of the population of developed countries. The causes of chronic constipation widely vary from functional to organic. Pathogenesis of this syndrome is based on peristalsis disorders. \u0000AIM: Analysis and systematization of the relevant literature data on pathogenetic mechanisms of disorders in peristalsis in chronic constipation. \u0000Peristalsis is controlled by the influence of the sympathetic and parasympathetic divisions of the autonomic nervous system on the enteric nervous system. The latter, in turn, is regulated by a complex interaction of nerve cells (afferent, motor, mechanosensitive neurons, interneurons, glial cells) with auxiliary cells (enterochromaffin, interstitial, mast cells, fibroblasts, immune cells, endothelium). The intercellular relations provide homeostasis of ions, hormones and neurotransmitters. \u0000CONCLUSION: A disorder in any of the numerous regulatory mechanisms can lead to chronic constipation, and understanding of many-sided pathways of the pathogenesis of the disease will permit to justify and apply the best treatment methods.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"47 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140733773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrastructural Features of Rabbits’ Cornea in Phacoemulsification Using New Method of Adaptive Control of Infusion","authors":"B. M. Aznabayev, L. A. Musina, T. Ismagilov, Timur R. Mukhamadeyev, T. I. Dibayev","doi":"10.17816/pavlovj544169","DOIUrl":"https://doi.org/10.17816/pavlovj544169","url":null,"abstract":"INTRODUCTION: Employees of the Department of Ophthalmology of Bashkir State Medical University, jointly with engineers of the Department of Microsurgical Equipment of Optimedservice, have developed a new method of adaptive control of infusion during phacoemulsification (PE) permitting to control the infusion flow depending on the changes in the rate of aspiration and infusion flows characteristic of a certain hydrodynamic situation, and also on the vacuum level in the aspiration line. An important aspect of safety of the new method is histological and electron microscopic examination of rabbits’ cornea in different periods after experimental PE. \u0000AIM: To evaluate histological and electron microscopic features of the rabbits’ cornea after experimental PE using a new method of adaptive control of infusion. \u0000MATERIALS AND METHODS: The experiment was conducted on 15 eyes of Chinchilla rabbits using a new method of adaptive control of infusion on the basis of Optimed Profi surgical system (Optimedservice, Russia). Histological and electron microscopic examinations of the cornea were performed on the 1st, 7th and 30th day after surgery. \u0000RESULTS: On the 1st day after surgery, according to the study data, signs of moderate edema of the corneal stroma with mild separation of collagen fiber bundles were observed. In the cell cytoplasm, signs of dystrophic processes in the epithelial cells were noticeable in the form of vacuoles of different sizes. On the 7th day after surgery, signs of alteration in the rabbits’ cornea reduced. In 30th days after surgery, based on the data of histological and electron microscopic examinations, the cornea fully corresponded to norm. \u0000CONCLUSION: The identified histological and electron microscopic alterations considerably diminish on the 7th day after surgery, and on the 30th day the ultrastructure of the cornea corresponds to the norm.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140733173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}