I.P. Pavlov Russian Medical Biological Herald最新文献

{"title":"Influence of Timing of Stenting on Condition of Venous Valves of Lower Extremities, Frequency and Severity of Development of Post-Thrombotic Disease","authors":"V. V. Boyarintsev, E.V. Barinov, A. S. Pankov, V.E. Barinov, Mekhridzhamal B. Bazarova, Sergey V. Zhuravlev, I. Zolotukhin","doi":"10.17816/pavlovj630006","DOIUrl":"https://doi.org/10.17816/pavlovj630006","url":null,"abstract":"INTRODUCTION: Acute deep vein thrombosis (DVT) of the lower extremities (LE) is a life-threatening condition, accompanied by high rates of disability among people of working age. Despite early detection of DVT and the use of recommended antithrombotic therapy, damage to the venous wall, development of valvular reflux and post-thrombotic disease (PTD) inevitably occur. The clinical picture of PTD becomes evident after the development of valve incompetence, which leads to vertical venous reflux and chronic venous hypertension. Timely elimination of venous obstruction can preserve the functionality of valve structures, which will subsequently help reduce the frequency and severity of PTD. \u0000AIM: To evaluate the impact of the timing of stenting on the condition of the venous valves, the frequency and severity of the development of PTD in patients with acute DVT of LE. \u0000MATERIALS AND METHODS: A prospective interventional study included 49 patients with acute iliofemoral thrombosis. After selective thrombolysis, 25 patients underwent early (within 7 days) and 24 patients underwent delayed (7–30 days) stenting. The incidence and severity of PTD was assessed on the Villalta scale at 3, 6 and 12 months. The effect of treatment on the condition of the venous valves of the LE was assessed at 12 months. On ultrasound examination, reflux was assessed using a scoring system. \u0000RESULTS: At 12 months, 2 (8%), 13 (52%), and 10 (40%) patients who underwent delayed stenting, developed severe, moderate, or mild PTD, respectively. In the early stenting group, 6 (25%) patients had no symptoms of PTD, 15 (62.5%) and 3 (12.5%) developed mild and moderate PTD, respectively (p = 0.0005). At 12 months, in the early stenting group, the absence of reflux was recorded in 6 (25%) patients, 4 (17%) patients had valve reflux in the femoral segment, and 14 (58%) in the popliteal segment. In the delayed stenting group, valvular incompetence of both segments was detected in 12 (48%) patients; in 4 (16%) and 9 (36%) patients, the valves of the femoral and popliteal veins were preserved; there were no patients without reflux in both segments. Treatment results for this indicator were better if early stenting was performed (p = 0.0005). \u0000CONCLUSION: Early stenting after selective thrombolysis in patients with proximal DVT of LE leads to a decrease in the incidence and severity of symptoms of PTD, and can reduce the incidence of reflux in the deep veins.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"17 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141661720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive Behavior of Adolescent Girls: Analysis of Risk Factors, Prospects of Prevention and Education","authors":"O. V. Lukasheva, K. Makarov, V. A. Bortsov, Tatyana M. Sokolova, Tat'yana A. Yur'yeva","doi":"10.17816/pavlovj626329","DOIUrl":"https://doi.org/10.17816/pavlovj626329","url":null,"abstract":"INTRODUCTION: Caring of reproductive health of children and adolescents in the society, especially of adolescent girls as a group most vulnerable to risks in the reproductive sphere, continues to be of high importance. The studies confirm that education and awareness about reproductive health can reduce the probability of problems occurring. The existing legal regulations emphasize the importance of providing accurate and timely information of reproductive health. \u0000AIM: Scientific justification of the strategy of forming safe reproductive behavior of adolescent girls on the basis of the peculiarities of their current reproductive behavior taking into account the opinion of specialists in the fields of education and healthcare. \u0000MATERIALS AND METHODS: To assess the peculiarities of reproductive behavior of adolescent girls, an anonymous questionnaire survey of 400 adolescent girls was conducted. To determine the expectations of the participants of the sex education process, as well as the main directions of preventive work and education, a survey of 400 parents of adolescent girls, 86 pediatricians, 34 obstetricians-gynecologists and 420 teachers was conducted. For all groups of participants, author’s questionnaires were developed. \u0000RESULTS: The reproductive behavior of adolescent girls living in the territory of the Novosibirsk region, is characterized by early start of sex life (15.90 ± 0.14 years), promiscuity (1.70 ± 1.10 partners), refusal to use effective means of contraception. Parents of adolescent girls emphasize the leading role of the family in sex education, suggesting participation of doctors and teachers in the process, but remain dissatisfied with the intensity of preventive measures. A similar problem is emphasized by specialists in the healthcare and education systems who indicate the possibility of conducting preventive work with adolescent girls remotely. In the opinion of pediatricians and obstetricians-gynecologists, providing preventive information on the reproductive health and behavior, will not only create safe reproductive behavior for modern adolescents, but is also an effective strategy of improving the system of reproductive health protection. \u0000CONCLUSION: The study identified features of the reproductive behavior of adolescent girls that characterize it as risky. The results emphasize the need for an integrated approach to assessing and maintaining the health of adolescent girls, and also focus attention on the importance of educational work in this age group. The study serves as a basis for further preventive strategies in the field of reproductive health and education.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"79 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141662996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-Oculography: New Method of Determination of Human Gaze Point Position in Space","authors":"Pavel V. Arakcheyev, Valeriy L. Bezdelov, E. V. Buryi, Denis A. Semerenko, A. L. Shlemenkov","doi":"10.17816/pavlovj274768","DOIUrl":"https://doi.org/10.17816/pavlovj274768","url":null,"abstract":"INTRODUCTION: Oculography — a method of recording movement of eyeballs of a human or animal by analyzing changes in electrical potentials recorded by two electrodes fixed on skin near the eye socket is used to solve various problems. Among them are the determination of pronounced nystagmus, of characteristic changes of oculomotor reactions in different conditions of observing video images. Of interest is the determination of the position of gaze point (GP) and of the area of increased attention in three-dimensional space. This information is associated with the cognitive system of the observer and is of interest not only to physiologists, but also to specialists of related fields. . \u0000AIM: To experimentally prove the effectiveness of the developed method of 3D-oculography providing determination of the GP position in space. \u0000MATERIALS AND METHODS: The possibility of restoring GP position based on the analysis of recorded oculograms even in the presence of additive noise induced by the external electromagnetic fields, is proven by the numeric modeling method. Direct experimental studies were conducted with recording oculograms of a human observer on a previously verified equipment. A ZB-2 oculograph was used, the data obtained were verified by the method of average values. \u0000RESULTS: The obtained modeling results permitted to determine the maximal values of dispersion of additive noise and amplitude shifts of signals, which make possible satisfactory restoration of the coordinates of the GP and parameters of its movement trajectory. The qualitative correspondence of the experimental results to the results of numerical modeling was proven. The correspondence between trajectories of the observed object moving in space and trajectories of GP movement synthesized from counts of recorded oculograms was confirmed. \u0000CONCLUSION: Multichannel record of oculographic signals permits restoring parameters of the GP trajectory. Creating systems for recording these signals requires minimization of the noise level. An increase in dispersion of the noise component of the signal leads to most significant errors in calculating the coordinates of trajectory points.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"22 3‐4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141835455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levels of Corticosterone and Glucose in Blood of Rats under Conditions of Chronic Unpredictable Stress of Different Duration","authors":"D. Skripkina, A. Abramova, Batozhab B. Shoibonov, Irina V. Alekseyeva, E. Nikenina, S.S. Pertsov","doi":"10.17816/pavlovj627521","DOIUrl":"https://doi.org/10.17816/pavlovj627521","url":null,"abstract":"INTRODUCTION: Mammals are almost constantly exposed to a variety of stressors. The changes in the concentration of corticosterone and the level of glucose in blood of animals under such conditions seems relevant for understanding the influence of repeated stress effects on endocrine and metabolic processes. \u0000AIM: To study the concentrations of corticosterone and glucose in blood of rats in different time periods of prolonged low-intensity unpredictable stress. \u0000MATERIALS AND METHODS: Experiments were carried out on 42 male Wistar rats. Individuals of the experimental groups were subjected to 7-day cycles of alternating stressors using a modified model of chronic unpredictable mild stress with presentation of different stressors. The concentration of corticosterone and glucose in blood was determined at 1, 2, 3 and 4 weeks of observation. \u0000RESULTS: A pronounced decrease in corticosterone levels was found in rats at 1 week of stress exposure, followed by a slow recovery by the end of 4th week. Blood glucose level increased at 2 weeks of exposure. \u0000CONCLUSION: The data obtained illustrate the specificity of changes in the levels of glucose and corticosterone in the blood of mammals in different time periods of chronic stress. These changes characterize the dysregulation of the integrative physiological systems in relatively early periods of chronic stress with the subsequent development of adaptation in the later stages of repeated stress exposures.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"70 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141662719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 Epidemic on Morbidity and Mortality of Cancer Patients in the Ryazan Region","authors":"E. P. Kulikov, A. I. Sudakov, Aleksey V. Grigor’yev, S. A. Mertsalov, I.B. Sudakov, Anastasiya A. Grishina","doi":"10.17816/pavlovj456450","DOIUrl":"https://doi.org/10.17816/pavlovj456450","url":null,"abstract":"INTRODUCTION: In 2020, humanity faced a pandemic of a new infection a Severe Acute Respiratory Syndrome-related Corona Virus 2 (SARS-CoV-2) that had a significant impact on the economic, social, including medical, aspects of our life. Against the background of these changes, oncological diseases, like many other comorbid pathologies, seemed to fade into insignificance. But, as we understand, they have not lost their relevance, but only ‘retreated to the shadow’ for a while. Study of the basic statistical indicators used for evaluating the prevalence of cancer pathology and the results of the work of oncological service, helps analyze and understand the processes occurring in conditions of reorientation of medical measures for combating the pandemic. \u0000AIM: To study changes in the main indicators of the oncology service of the Ryazan region during the COronaVIrus Disease 2019 (COVID-2019) epidemic. \u0000MATERIALS AND METHODS: The main statistical indicators of morbidity, detestability and mortality from malignant neoplasms (MNs) in the Ryazan region were analyzed on the basis of statistical forms of federal statistical observation No. 7 (Form No. 7) ‘Record of MNs’, reports and data of cancer registry for 2012–2022. The most relevant statistical indicators were analyzed, data on most common and relevant tumor localizations were separately considered. \u0000RESULTS: At the height of COVID-19 pandemics in 2020–2021, a sharp reduction of the total number of identified MN cases was observed a seeming decline of ‘mortality’. At the same time, there was an increase in the proportion of patients with advanced IV stage pathology of lungs, stomach, and colorectal cancer, which, in turn, led in some cases to increase in one-year mortality, and to general increase in mortality among cancer patients. To note, despite a complicated situation associated with non-observance of the terms of the periodic medical examinations, reprofiling of a number of medical organizations and increased load on the primary medical care organizations, the oncology service of the Ryazan region showed a not that catastrophic impairment of the main statistical indicators, and of some of them a proportion of detection of early stages, results of treatment of tumors of visual localization even a positive dynamics. In 2022, officially registered cancer incidence rates in our region returned to previous values comparable to 2019. \u0000CONCLUSION: The experience of recent years should help in developing measures to prevent both the spread of similar epidemiological diseases and measures to prevent a decline of the quality of specialized medical care, in particular, in the field of oncology.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"24 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141660427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peculiarities of Frequency-Following Response in Healthy Individuals when Listening to Complex Sounds","authors":"Lyubov' B. Oknina, A. A. Slezkin, Y. Vologdina, A. O. Kantserova, Ekaterina V. Strel'nikova, D. I. Pitskhelauri","doi":"10.17816/pavlovj320947","DOIUrl":"https://doi.org/10.17816/pavlovj320947","url":null,"abstract":"INTRODUCTION: Studies of recent years showed that functional disorders in the brainstem may be one of factors causing inability to perceive speech by normal-hearing individuals. Frequency-following response (FFR) is an auditory evoked potential emerging in different regions of the brain in response to a sound or a change in the sound frequency. The initiation of this potential is associated with the correct processing of auditory information in the subcortical structures of the brain. However, until the moment, there is no regulatory framework that could permit use of this potential in routine examinations. \u0000AIM: To identify and analyze the peculiarities of FFR in healthy adult individuals when listening to a complex sound. \u0000MATERIALS AND METHODS: The study included 29 healthy subjects aged from 18 to 48 years (mean age 28 ± 10 years). Electrical activity of the brain was recorded from 32 electrodes. Sampling frequency 2000 Hz, transmission frequency 0.1 Hz–500 Hz. The stimulus was a 30-s sound that included simple sounds of five different frequencies (600 Hz, 800 Hz, 1000 Hz, 2000 Hz, 4000 Hz) changing in a random order every 100 ms. FFR was isolated in each frequency change in the complex sound. The resulting FFR included two peaks, for each amplitude, latency, and dipole sources were calculated. \u0000RESULTS: FFR was obtained in all the subjects and included two peaks. In some subjects, FFR peaks had a statistically higher amplitude and lower latency. In subjects with a higher amplitude FFR peaks, three dipoles were identified for the first peak: in the brainstem and in the cortex of the right hemisphere (Brodmann areas 6 and 39). For the second peak, one dipole was identified in the cortex (Brodmann area 19). In subjects with low amplitude FFR peaks, for the first peak one source in the brainstem was identified. For the second peak, two dipoles were identified: in the posterior cingulate cortex (Brodmann area 23) and in the medial thalamus. \u0000CONCLUSION: The data obtained suggest that the method of recording and analyzing FFR can be used to assess the functional integrity and correct participation of the midbrain in the perception of auditory stimuli. The peculiarities of amplitude-time parameters of its peaks probably reflect the individual ability to finely differentiate stimuli.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"28 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141662458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior Abdominal Wall Endometriosis: A Series of Case Reports","authors":"Elena A. Baklygina, Vadim V. Pchelintsev, Aleksey V. Markin","doi":"10.17816/pavlovj109638","DOIUrl":"https://doi.org/10.17816/pavlovj109638","url":null,"abstract":"INTRODUCTION: Endometriosis is a chronic, hormone-dependent, progressive and recurrent disease characterized by the existence of tissue outside the uterine cavity, similar to endometrium in the morphological and functional properties. This disease is gaining increasing medical and social significance due to its severe clinical manifestations and recurrent course, as well as a negative impact on the quality of life and working capacity of women. The incidence of abdominal wall endometriosis (AWE) that is referred to extragenital localization, is 0.3% to 3.5%. In most cases, it develops after cesarean section, less often after other gynecological operations (hysterectomy, removal of endometrioid ovarian cysts). Its recognition presents certain difficulties due to the necessity of differential diagnosis with postoperative hernias, ligature abscesses, hematomas and use of additional imaging methods. In this context, of interest is to study the clinical and history data, localization and management tactics for female patients with the anterior abdominal wall endometriosis. \u0000AIM: Investigation of clinical presentation, diagnosis, treatment of one of the rarest and least studied forms of extragenital localization of endometriosis — AWE — and improvement of management tactics for patients with this pathology. \u0000MATERIALS AND METHODS: A clinical analysis of AWE cases with several variants of its invasion was carried out in 7 female patients. \u0000RESULTS: The age of the patients ranged from 27 to 39 years (median — 33 years). All the seven patients had a past cesarean section; the period after surgical delivery ranged from 3 to 7 years. Six patients reported pain in the area of the postoperative scar associated with the menstrual cycle, 1 noted the presence of a palpable formation of the anterior abdominal wall. During surgical treatment, excision of endometrioid infiltrates located in the area of the postoperative scar was performed, followed by histological verification. \u0000CONCLUSION: Taking into account the relative rarity of AWE, the difficulty of its early identification, the need for differential diagnosis using additional examination methods, greater awareness of this disease is required among doctors of related specialties. Diagnostic alertness is especially relevant for patients with a history of surgical delivery if they have a formation in the area of a postoperative scar and a cyclic pain symptom in its projection.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"11 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140732608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Galanin Neuropeptide in Pathogenesis of Postural Disorders in Parkinson’s Disease","authors":"N. V. Selyanina, Yulia Karakulova, O. V. Khegay","doi":"10.17816/pavlovj340859","DOIUrl":"https://doi.org/10.17816/pavlovj340859","url":null,"abstract":"INTRODUCTION: Postural disorders in Parkinson’s disease (PD) are symptoms with poorly understood pathogenesis, and the early objective diagnosis is difficult. In the literature, the influence of galanin neuromodulator on many structures of peripheral and central nervous system has been described, which indicates the probable involvement of the nervous system in the formation of motor disorders in PD. \u0000AIM: To study the content of galanin neuromodulator in blood serum of patients with PD and to determine its effect on clinical manifestations of postural disorders. \u0000MATERIALS AND METHODS: Seventy-three patients with PD diagnosis were examined, the control group included 22 healthy volunteers. The complaints, history and neurological status were evaluated. In the main group, ‘classic’ complaints and clinical manifestations were identified. The Hoehn and Yahr unified rating scale for PD was used. The content of galanin in blood serum was determined using the enzyme-linked immunoassay. \u0000RESULTS: The stage of the disease on average was 2 [2; 3], severity of motor deficit on the unified PD assessment scale was 46 [36; 56] points. In 8 patients, severe postural disorders were identified, moderate disorders — in 21, mild disorders — in 28 patients, very mild — in 8 patients. The level of galanin in the main group was 6.0 [4.2; 10.3] pg/ml, which is considerably lower than in the control group (16.9 [9.8; 18.1] pg/ml; р = 0.001). The correlation analysis revealed the relationship between the level of galanin and severity of postural disorders (R = -0.73; p = 0.001). With the content of galanin above 26 pg/ml, no postural disorders were present in the patients, the content 8 pg/ml — 26 pg/ml was associated with the minimal and mild disorders, 5 pg/ml – 8 pg/ml — with moderate disorders, and the content below 5 pg/ml — with severe disorders. \u0000CONCLUSION: Reduction of serum galanin level is associated with the degree of severity of postural disorders in Parkinson’s disease.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"2 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140733070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Polymorphisms of NOD2/CARD15, CRP and FTO Genes with Cardiovascular Risk Factors, Damages to Target Organs and Cardiovascular Diseases in Patients with Ulcerative Colitis and Crohn’s Disease","authors":"D. Y. Boyakov, Vadim S. Petrov, Aleksandr A. Nikiforov, A. G. Yakubovskaya, O. Kodyakova, Veronika A. Ostyakova","doi":"10.17816/pavlovj280037","DOIUrl":"https://doi.org/10.17816/pavlovj280037","url":null,"abstract":"INTRODUCTION: The role of genetic factors in the development of cardiovascular diseases (CVD) in patients with inflammatory bowel diseases (IBD) is practically unknown. \u0000AIM: To study the frequency of carriage of allelic polymorphous variants of NOD2/CARD15 (3020insC rs5743293, Gly908Arg rs2066845), CRP (+1444CT rs1130864), FTO (A23525T rs9939609) genes and to perform a comprehensive assessment of damage to the target organs, diastolic myocardial dysfunction of the left ventricle and CVD in patients with ulcerative colitis and Crohn’s disease living in the Ryazan District. \u0000MATERIALS AND METHODS: The study involved 62 patients (41 (66%) women, 40.5 [33.5; 52.25] years old) with IBD (51 patients with ulcerative colitis, 11 patients with Crohn’s disease) in whom 3020insC and Gly908Arg polymorphisms in CARD15 (NOD2) gene, C1444T in CRP gene and А23525Т in FTO gene were determined using allele-specific polymerase chain reaction. After that, the frequency of carriage of their allelic variants and association with CVRFs, damage to the target organs (through evaluation of the arterial stiffness, pulse pressure, hypertrophy of the left ventricular myocardium, ankle-brachial index) and CVDs was evaluated. \u0000RESULTS: According to the aims of the study, the frequency of carriage of allelic polymorphic variants of genes was determined: 3020insC in gene CARD15 (NOD2) rs5743293 85.5% — homozygote for allele 1, 14,5% — heterozygote; Gly908Arg in gene CARD15 (NOD2) rs2066845 93.5% — homozygote for allele 1, 6.5% — heterozygote; C1444T in gene CRP rs1130864 50% — homozygote for allele 1, 41.9% — heterozygote, 8.1% — homozygote for allele 2; А23525Т in gene FTO rs9939609 38.7% — homozygote for allele 1, 38.7% — heterozygote, 22.6% — homozygote for allele 2. The prevalence of arterial hypertension was 31%, of obesity by body mass index — 18%, by waist circumference — 29%, and of dyslipidemia — 53%. Statistically significant associations were found between: 1) hypercholesterolemia and Gly908Arg polymorphism in gene CARD15 (NOD2) rs2066845 (÷2 = 6.005; p = 0.014), 2) family history of early CVD and 3020insC polymorphism in gene CARD15 (NOD2) rs2066845 (÷2 = 4.561; p = 0.033), 3) arterial hypertension and 3020insC polymorphism in genеCARD15 (NOD2) rs5743293 (÷2 = 4.65; p = 0.031). \u0000CONCLUSION: The prevalence of arterial hypertension, obesity and dyslipidemia in patients with IBD is considerably lower in the given study than in the individuals of comparable age in the epidemiological MERIDIAN-RO study conducted in the Ryazan region. Statistically significant associations were found between the studied polymorphisms and hypercholesterolemia, family history of early cardiovascular diseases and arterial hypertension.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140732976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Hypoxia-Inducible Factor 1α in Adaptation to Hypoxia in the Pathogenesis of Novel Coronavirus Disease 2019","authors":"R. Y. Kalinin, I. Suchkov, Sergey N. Raitsev, V. Zvyagina, Eduard S. Bel'skikh","doi":"10.17816/pavlovj165536","DOIUrl":"https://doi.org/10.17816/pavlovj165536","url":null,"abstract":"INTRODUCTION: A novel coronavirus (severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2)) emerged in December 2019 and rapidly spread over the world having provoked a pandemic of respiratory disease. This highly pathogenic virus can attack the lung tissue and derange gas exchange leading to acute respiratory distress syndrome and systemic hypoxia. Hypoxic conditions trigger activation of adaptation mechanisms including hypoxia-inducible factor-1á (HIF-1á) which is involved in the regulation of the key processes, e. g, proliferation and metabolism of cells and angiogenesis. Besides, the level of HIF-1á expression is associated with the intensity of the immune response of an organism including that of the innate immunity mediating inflammatory reaction. Therefore, understanding the peculiarities of the mechanisms underlying the pathogenesis of this disease is of great importance for effective therapy of coronavirus disease 2019 (COVID-19). \u0000AIM: Analysis of the current data on HIF-1á and its effect on the pathogenesis and progression of COVID-19. \u0000The analysis of the relevant domestic and international literature sources was performed in the following sections: HIF-1á as a key factor of adaptation to hypoxia, targets for HIF-1á in the aspect of the pathogenesis of COVID-19, disorders in HIF-1á-mediated adaptation to hypoxia as an element of the pathogenesis of hyperactivation of the immune cells. \u0000CONCLUSION: HIF-1á prevents penetration of SARS-CoV-2 virus into a cell and primarily acts as the main regulator of the proinflammatory activity at the inflammation site surrounded by hypoxia. In the conditions of the deranged metabolic flexibility, a high level of HIF-1á evokes an excessive inflammatory response of the immune cells. A high HIF-1á level in cells of the inflammation focus is associated with enhanced production of the factors of angiogenesis mediating vascular permeability and capillary leakage process. This is accompanied by tissue damage and organ failure. At the same time, HIF-1á can mediate the anti-inflammatory effect through activation of adenosine receptor-dependent pathway, which is considered as a probable protection of cells and organs against damage by hyperactive immune cells.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"2 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140733259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}