Digestive Diseases最新文献

{"title":"Causal relationship between Helicobacter pylori infection and autoimmune diseases of the digestive system: evidence from a Mendelian randomization study.","authors":"Shuang Zhang, Pengyue Zhang, Xin Hu","doi":"10.1159/000545597","DOIUrl":"https://doi.org/10.1159/000545597","url":null,"abstract":"<p><strong>Background: </strong>The association between Helicobacter pylori (H. pylori) infection and digestive autoimmune diseases remains unclear, with inconsistent findings in previous observational studies. We conducted Mendelian randomization (MR) analysis to systematically explore the causal relationship and delve into the pathogenesis based on gut microbiota.</p><p><strong>Methods: </strong>This study encompassed anti- H. pylori IgG levels and genome-wide association studies (GWAS) for multiple digestive autoimmune diseases, utilizing diverse MR methodologies to assess the causal relationship between H. pylori antibody levels and these diseases. Associations between H. pylori and ulcerative colitis (UC) were examined using genetic variants from MiBioGen associated with 194 gut microbiota traits. Additionally, a series of sensitivity analyses were performed to validate the results of the initial MR analyses.</p><p><strong>Results: </strong>Our study showed a significant association between anti- H. pylori IgG levels and the incidence risk of UC (β=-0.001, P=0.011). No causal associations were observed with the incidence risk of primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), celiac disease, and Crohn's disease (CD). Multiple gut microbiota were found to be correlated with H. pylori infection and UC. Particularly noteworthy is the negative correlation between the abundance of the genus.Anaerofilum and H. pylori antibody levels (β=-0.174, P=0.048). Notably, genus.Anaerofilum exhibited a positive genetic correlation with an increased risk of UC (β=0.0014, P=0.0029).</p><p><strong>Conclusion: </strong>MR analysis confirmed a causal association between anti- H. pylori IgG and UC, but not with CD. The genus.Anaerofilum may increase the risk of UC by inhibiting H. pylori infection.</p>","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":"1-17"},"PeriodicalIF":2.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LKM immunofluorescence is associated with DILI, especially after metamizole intake.","authors":"Kilian Bock, Bastian Engel, Elmar Jaeckel, Heiner Wedemeyer, Ingmar Mederacke, Young-Seon Mederacke","doi":"10.1159/000545507","DOIUrl":"https://doi.org/10.1159/000545507","url":null,"abstract":"<p><p>Background &amp; Aims: Drug induced liver injury (DILI) is a rare but potentially serious clinical condition. One phenotype of DILI is termed drug-induced autoimmune like hepatitis (DI-ALH) that presents with laboratory and histological features indistinguishable from autoimmune hepatitis. Liver kidney microsomal antibodies (LKM-antibodies) are common in the diagnosis of AIH but were also described to be associated with halothane-induced DILI. Also, the antigens of anti-LKM-1 and anti-LKM-2 belong to the cytochrome P450 enzyme family that is involved in metabolism various drugs. Therefore, we aimed to study the impact of LKM-antibodies in the diagnostic work-up of suspected DILI in a large cohort of patients with liver injury in a tertiary care centre.</p><p><strong>Methods: </strong>We screened a large single centre hospital data base and retrospectively identified 63.300 cases with liver injury as defined: AST or ALT > 3 ULN or AP or TBI > 2 ULN. Of those, 82 cases with LKM immunofluorescence positivity (titre ≥ 1: 160) were identified, of which 64 patients fulfilled the inclusion criteria for this study.</p><p><strong>Results: </strong>Positive LKM immunofluorescence was associated with drug-induced autoimmune-like hepatitis (DI-ALH). Metamizole association was identified in half of the patients (n=33, 52%). Eight patients with metamizole associated DI-ALHs required liver transplantation and one patient died.</p><p><strong>Conclusion: </strong>DI-ALH, especially after metamizole administration, can be a reason for a positivity in LKM immunofluorescence tests. Metamizole DI-ALH has a high liver-related mortality.</p>","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":"1-17"},"PeriodicalIF":2.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gallbladder cancer: A grand challenge for every surgeon.","authors":"Liwei Pang, Hanwen Hu, Zhen Wang","doi":"10.1159/000545510","DOIUrl":"https://doi.org/10.1159/000545510","url":null,"abstract":"","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":"1-5"},"PeriodicalIF":2.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Safety and Efficacy of Diazepam and Midazolam for Moderate Sedation during Gastric Endoscopic Submucosal Dissection.","authors":"Jun Takada, Takuji Iwashita, Kiichi Otani, Naoya Masuda, Hiroki Taniguchi, Yukari Tezuka, Masamichi Arao, Kentaro Kojima, Sachiyo Onishi, Masaya Kubota, Takashi Ibuka, Masahito Shimizu","doi":"10.1159/000545093","DOIUrl":"10.1159/000545093","url":null,"abstract":"<p><strong>Introduction: </strong>The appropriate use of benzodiazepines for sedation during prolonged therapeutic endoscopy has not yet been established. This retrospective observational study compared the safety and efficacy of diazepam (DZP) and midazolam (MDZ) under moderate sedation during gastric endoscopic submucosal dissection (ESD).</p><p><strong>Methods: </strong>We studied 554 patients who underwent gastric ESD under sedation with DZP or MDZ combined with pentazocine. Sedation depth was assessed and recorded using the Richmond Agitation-Sedation Scale (RASS). According to the American Society of Anesthesiologists definition of sedation levels, RASS scores of -4 to -2 points indicated moderate sedation, whereas a score of -5 points indicated deep sedation. Sedation levels, respiratory and circulatory dynamics during the procedure, and the incidence of ESD-related pneumonia were compared.</p><p><strong>Results: </strong>Of these, 273 and 281 patients received DZP and MDZ, respectively. No significant differences were observed in the occurrence of deep sedation (DZP:MDZ = 12.1%:15.4%) or in the proportion of patients who maintained moderate intraoperative sedation (76.2%:80.4%). Respiratory parameters showed no significant differences; however, blood pressure reduction was more common in the MDZ group (4.8%:11.0%, p = 0.007). Multivariate analysis identified MDZ as a significant factor associated with blood pressure reduction. The incidence of ESD-related pneumonia did not differ between the two groups.</p><p><strong>Conclusions: </strong>DZP and MDZ were similarly effective in maintaining adequate sedation levels during gastric ESD. Respiratory depression did not differ between the groups; however, circulatory depression was more pronounced in the MDZ group.</p>","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":"1-9"},"PeriodicalIF":2.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Lens to Scalpel: A Systematic Literature Review of Intestinal Obstruction after Video Capsule Endoscopy.","authors":"Adam Mylonakis, Panagiotis Sakarellos, Paraskevas Gkolfakis, Athanasios Sioulas, Georgios D Lianos, Vasileios Tatsis, George Pappas-Gogos, Ioannis S Papanikolaou, Dimitrios Schizas","doi":"10.1159/000544891","DOIUrl":"10.1159/000544891","url":null,"abstract":"<p><strong>Introduction: </strong>Video capsule endoscopy (VCE) is a valuable noninvasive diagnostic tool for gastrointestinal disorders, but it carries a risk of capsule retention and subsequent bowel obstruction. The aim of the present study was to examine the manifestations, diagnostic approaches, treatment modalities, and outcome of patients with bowel obstruction due to VCE.</p><p><strong>Methods: </strong>A comprehensive search was conducted in PubMed/Medline, Embase, Cochrane, and Scopus databases focusing on intestinal obstruction post-VCE.</p><p><strong>Results: </strong>Out of 399 unique articles, 27 studies were included, involving 30 patients, with an average age of 54 ± 22.3 years and a female-to-male ratio of 1.9:1. Common indications for VCE included Crohn's disease, anemia, abdominal pain with diarrhea, and obscure gastrointestinal bleeding. The obstruction most often occurred in the small intestine, predominantly in the ileum (20 patients, 67%) and the duodenum (5 patients, 17%). Diagnostic methods included CT scans in 19 cases (66%) and X-ray imaging in 8 cases (28%). Treatment varied from conservative management to surgical intervention, and no cases of mortality or morbidity were reported.</p><p><strong>Conclusions: </strong>This study highlights the importance of a multidisciplinary approach of such cases, concentrating on tailored therapeutic strategies to prevent and address complications related to VCE. Further research with larger cohorts is needed for a deeper understanding of risk factors and long-term outcomes.</p>","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":"1-10"},"PeriodicalIF":2.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No increased risk of venous thromboembolism or infectious complications after JAK inhibitor exposure in patients with ulcerative colitis undergoing surgery.","authors":"Ine De Greef, Gabriele Bislenghi, Isabelle Terrasson, João Sabino, Marc Ferrante, André D'Hoore, Bram Verstockt, Séverine Vermeire","doi":"10.1159/000544062","DOIUrl":"https://doi.org/10.1159/000544062","url":null,"abstract":"<p><p>Introduction Total colectomy for ulcerative colitis (UC) is associated with postoperative morbidity, including venous thromboembolic events (VTE). In light of recent concerns on increased major adverse events associated with JAK inhibitor exposure, we aimed to evaluate the postoperative VTE risk as well as other complications in UC patients undergoing colectomy. Methods This single-center retrospective cohort study included all UC patients who underwent (procto)colectomy between 2013 and March 2022, and documented the 180-day postoperative non-infectious and infectious complications. Results One hundred seventy-five UC patients (43.4% women, median age 41.0 years) underwent colectomy. Forty-nine patients (28.0%) were operated in an urgent setting. In the twelve weeks prior to surgery, 53 (30.3%) patients had received anti-TNF agents, 40 (22.9%) anti-adhesion therapy, 16 (9.1%) anti-IL12/23 and 34 (19.4%) JAK inhibitors. Preoperatively, 26 patients (14.9%) received moderate to high doses of systemic corticosteroids. All except two patients received prophylactic LMWH postoperatively. During the 180-day postoperative period, 2 patients developed a thrombosis, all incidental findings on abdominal CT scan. No VTE was seen in the patients who underwent colectomy while on JAK inhibitor. Three out of 34 JAK-inhibitor treated patients (8.8%) developed a postoperative infectious complication, while the overall incidence of infectious complications was 17.1%. Conclusion Our findings suggest that the overall VTE risk in UC patients undergoing colectomy is low with adequate antithrombotic prophylaxis. JAK inhibitor use prior to surgery was not linked to increased short-term thromboembolic or infectious complications. However, the limited sample size warrants further study in larger cohorts.</p>","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":"1-21"},"PeriodicalIF":2.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathological Resection Depth in Cold Snare Polypectomy and Underwater Endoscopic Mucosal Resection for Superficial Nonampullary Duodenal Epithelial Tumors.","authors":"Takayuki Nukui, Takaya Shimura, Shingo Inaguma, Naomi Sugimura, Shigeki Fukusada, Ruriko Nishigaki, Yuki Kojima, Takuya Kanno, Makiko Sasaki, Mamoru Tanaka, Keiji Ozeki, Eiji Kubota, Satoru Takahashi, Hiromi Kataoka","doi":"10.1159/000544939","DOIUrl":"10.1159/000544939","url":null,"abstract":"<p><strong>Introduction: </strong>Cold snare polypectomy (CSP) and underwater endoscopic mucosal resection (UEMR) are used for small superficial nonampullary duodenal epithelial tumors (SNADETs). This study aimed to compare the resection depth of SNADETs removed by CSP versus UEMR.</p><p><strong>Methods: </strong>Data from SNADETs resected with CSP or UEMR between April 2018 and July 2023 at Nagoya City University Hospital were collected retrospectively. An independent pathologist, blinded to clinical information, evaluated the resected specimens and categorized resection depth into four groups: mucosa only (M), incomplete muscularis mucosae with defects (iMM), complete muscularis mucosae without submucosa (cMM), and complete muscularis mucosae with submucosa (SM).</p><p><strong>Results: </strong>Among 109 SNADETs, 78 were resected with CSP and 31 with UEMR. The percentages of M, iMM, cMM, and SM for CSP were 23.1%, 50.0%, 5.1%, and 21.8%, respectively, while for UEMR they were 0%, 6.5%, 6.5%, and 87.1%. The UEMR group had a higher SM resection rate and significantly greater median submucosal depth than the CSP group (783 μm [range, 0-2,220] vs. 0 μm [range, 0-1,226]; p < 0.001). In the multivariate analysis, UEMR was an independent and significant factor for achieving SM resection.</p><p><strong>Conclusion: </strong>UEMR achieved a significantly higher SM resection rate than CSP for all types of SNADETs. Clinically diagnosed duodenal high-grade dysplasia and adenocarcinoma should be treated with UEMR rather than CSP.</p>","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":"1-7"},"PeriodicalIF":2.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Ability of Magnifying Endoscopy Compared to Biopsy Examination for Early Gastric Cancer prior to Endoscopic Submucosal Dissection.","authors":"Takuma Yoshida, Osamu Dohi, Mayuko Seya, Katsuma Yamauchi, Hayato Fukui, Hajime Miyazaki, Takeshi Yasuda, Tsugitaka Ishida, Naoto Iwai, Toshifumi Doi, Ryohei Hirose, Ken Inoue, Naohisa Yoshida, Kazuhiko Uchiyama, Takeshi Ishikawa, Tomohisa Takagi, Hideyuki Konishi, Yukiko Morinaga, Mitsuo Kishimoto, Yoshito Itoh","doi":"10.1159/000544045","DOIUrl":"10.1159/000544045","url":null,"abstract":"<p><strong>Introduction: </strong>Biopsy-specimen examination is the gold standard for the preoperative histological diagnosis of early gastric cancer (EGC). However, few studies have compared the diagnostic accuracies of biopsy and magnifying endoscopy with narrow-band imaging or blue laser imaging (ME-NBI/BLI). Thus, we compared the diagnostic accuracy of biopsy specimens and ME-NBI/BLI to evaluate whether ME-NBI/BLI is a feasible preoperative diagnostic tool for EGC.</p><p><strong>Methods: </strong>This retrospective single-center study enrolled 185 patients who underwent gastric endoscopic submucosal dissection (ESD) between January and December 2018. The sensitivity and positive predictive value (PPV) of the histological diagnosis of ME-NBI/BLI and biopsy were evaluated. Logistic regression analysis was used to assess the risk factors for the misdiagnosis of biopsy specimens and ME-NBI/BLI.</p><p><strong>Results: </strong>In total, 158 patients with EGC were analyzed. Sensitivities of biopsy and ME-NBI/BLI were 1 and 0 for adenomas (p = 0.333), 0.693 and 0.971 for differentiated adenocarcinomas (p < 0.001), and 0.688 and 0.625 for undifferentiated adenocarcinomas (p > 0.999), respectively. PPVs of biopsy and ME-NBI/BLI were 0.077 and 0 for adenomas (p > 0.999), 0.960 and 0.958 for differentiated adenocarcinomas (p > 0.999), and 0.750 and 0.750 for undifferentiated adenocarcinomas (p > 0.999), respectively. The underdiagnosis rate for differentiated adenocarcinomas was significantly higher in biopsy examination than in ME-NBI/BLI (27.9% vs. 0%, respectively, p < 0.001).</p><p><strong>Conclusion: </strong>ME-NBI/BLI had a higher sensitivity than biopsy examination for the preoperative diagnosis of differentiated adenocarcinomas. Therefore, performing ME-NBI/BLI for these lesions may be preferable regardless of their diagnosis as noncancerous lesions from biopsy specimens.</p>","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":"1-10"},"PeriodicalIF":2.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Microbiome Dysbiosis and Inflammatory Bowel Disease Complement Each Other.","authors":"Huan Zhang, Jingrong Xiang, Jie Feng, Mengting Zhang, Qinhua Xi","doi":"10.1159/000544771","DOIUrl":"10.1159/000544771","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract. The worldwide increase in the incidence of IBD imposes a significant economic burden on patients and communities. Recently, numerous studies have shown that disruption of the balance between the host and microbes, known as dysbiosis, is strongly associated with the development of IBD.</p><p><strong>Summary: </strong>Dysbiosis can be influenced by diet, lifestyle rhythms, hygiene conditions, drugs, and the inflammatory state of IBD patients. In the microbiome microenvironment, dysbiosis can be influenced by the microbiome and metabolites. Gut microbiome dysbiosis in IBD patients can play a proinflammatory role by disrupting the intestinal barrier and modulating the immune system, leading to the worsening or recurrence of IBD. In future studies, the mechanisms of dysbiosis in IBD and its influencing factors should be investigated from a more macroscopic perspective to propose new valuable diagnostic and therapeutic approaches.</p><p><strong>Key messages: </strong>Gut microbiome dysbiosis can lead to the development of inflammatory bowel disease, and inflammatory bowel disease can in turn exacerbate gut microbiome dysbiosis, creating a vicious cycle.</p>","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":"1-13"},"PeriodicalIF":2.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HBV Relapse after Discontiniuation of Tenofovir Alafenamide or Entecavir in Non-Cirrhotic Hepatitis B e Antigen-Negative Patients.","authors":"Yi-Jie Huang, Shou-Wu Lee, Chun-Fang Tung, Szu-Chia Liao, Teng-Yu Lee, Yen-Chun Peng, Chung-Hsin Chang, Jun-Sing Wang","doi":"10.1159/000544870","DOIUrl":"10.1159/000544870","url":null,"abstract":"<p><strong>Introduction: </strong>This study investigated the off-therapy relapse in hepatitis B e antigen (HBeAg)-negative non-cirrhotic patients who discontinued tenofovir alafenamide (TAF) or entecavir (ETV).</p><p><strong>Methods: </strong>Non-cirrhotic HBeAg-negative patients who discontinued TAF or ETV were enrolled. The propensity score matching method at a ratio of 1:1 and Cox proportional hazard model were performed to analyze factors associated with virological relapse and clinical relapse.</p><p><strong>Results: </strong>A total of 62 patients were analyzed. The cumulative rates of virological relapse at 12 months after discontinuing TAF and ETV were 80.4% and 60.0%, respectively. The respective rates of clinical relapse at 12 months were 48.7% and 21.1%. Multivariable Cox regression analysis showed that discontinuation of TAF (vs. ETV, HR = 2.279; p = 0.005) and HBsAg levels at EOT (HR = 1.540; p = 0.005) were independently associated with virological relapse. Discontinuation of TAF (vs. ETV, HR = 3.003; p = 0.011) was independently associated with clinical relapse. HBsAg levels at EOT (<3 vs. ≥3 log10 IU/mL) had significant interactions with the treatment regimen (TAF vs. ETV) in terms of the risk of clinical relapse after treatment cessation (p for interaction <0.05).</p><p><strong>Conclusion: </strong>Patients who discontinued TAF had a higher risk of virological relapse and clinical relapse than those who discontinued ETV. HBsAg levels at EOT may be an appropriate predictor to distinguish the different risks of clinical relapse between patients who have discontinued TAF or ETV.</p>","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":"1-9"},"PeriodicalIF":2.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}