幽门螺杆菌感染与消化系统自身免疫性疾病之间的因果关系:来自孟德尔随机研究的证据

IF 2 4区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY
Shuang Zhang, Pengyue Zhang, Xin Hu
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引用次数: 0

摘要

背景:幽门螺杆菌(h.p ylori)感染与消化自身免疫性疾病之间的关系尚不清楚,先前的观察性研究结果不一致。我们采用孟德尔随机化(Mendelian randomization, MR)分析方法,系统探讨肠道菌群的因果关系和发病机制。方法:本研究包括抗幽门螺杆菌IgG水平和多种消化自身免疫性疾病的全基因组关联研究(GWAS),利用不同的MR方法评估幽门螺杆菌抗体水平与这些疾病之间的因果关系。利用与194种肠道菌群特征相关的MiBioGen基因变异,研究了幽门螺杆菌与溃疡性结肠炎(UC)之间的关系。此外,进行了一系列敏感性分析来验证初始MR分析的结果。结果:我们的研究显示,抗幽门螺杆菌IgG水平与UC发病率之间存在显著相关性(β=-0.001, P=0.011)。未观察到与原发性胆汁性肝硬化(PBC)、原发性硬化性胆管炎(PSC)、乳糜泻和克罗恩病(CD)发生率风险的因果关系。多种肠道菌群与幽门螺杆菌感染和UC相关。特别值得注意的是属的丰度之间的负相关关系。无气膜和幽门螺杆菌抗体水平(β=-0.174, P=0.048)。值得注意的是,属。无气膜与UC风险增加呈正相关(β=0.0014, P=0.0029)。结论:MR分析证实抗幽门螺杆菌IgG与UC有因果关系,但与CD无因果关系。无气膜可能通过抑制幽门螺杆菌感染而增加UC的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Causal relationship between Helicobacter pylori infection and autoimmune diseases of the digestive system: evidence from a Mendelian randomization study.

Background: The association between Helicobacter pylori (H. pylori) infection and digestive autoimmune diseases remains unclear, with inconsistent findings in previous observational studies. We conducted Mendelian randomization (MR) analysis to systematically explore the causal relationship and delve into the pathogenesis based on gut microbiota.

Methods: This study encompassed anti- H. pylori IgG levels and genome-wide association studies (GWAS) for multiple digestive autoimmune diseases, utilizing diverse MR methodologies to assess the causal relationship between H. pylori antibody levels and these diseases. Associations between H. pylori and ulcerative colitis (UC) were examined using genetic variants from MiBioGen associated with 194 gut microbiota traits. Additionally, a series of sensitivity analyses were performed to validate the results of the initial MR analyses.

Results: Our study showed a significant association between anti- H. pylori IgG levels and the incidence risk of UC (β=-0.001, P=0.011). No causal associations were observed with the incidence risk of primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), celiac disease, and Crohn's disease (CD). Multiple gut microbiota were found to be correlated with H. pylori infection and UC. Particularly noteworthy is the negative correlation between the abundance of the genus.Anaerofilum and H. pylori antibody levels (β=-0.174, P=0.048). Notably, genus.Anaerofilum exhibited a positive genetic correlation with an increased risk of UC (β=0.0014, P=0.0029).

Conclusion: MR analysis confirmed a causal association between anti- H. pylori IgG and UC, but not with CD. The genus.Anaerofilum may increase the risk of UC by inhibiting H. pylori infection.

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来源期刊
Digestive Diseases
Digestive Diseases 医学-胃肠肝病学
CiteScore
4.80
自引率
0.00%
发文量
58
审稿时长
2 months
期刊介绍: Each issue of this journal is dedicated to a special topic of current interest, covering both clinical and basic science topics in gastrointestinal function and disorders. The contents of each issue are comprehensive and reflect the state of the art, featuring editorials, reviews, mini reviews and original papers. These individual contributions encompass a variety of disciplines including all fields of gastroenterology. ''Digestive Diseases'' bridges the communication gap between advances made in the academic setting and their application in patient care. The journal is a valuable service for clinicians, specialists and physicians-in-training.
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