Dental Science Updates最新文献

{"title":"Efficacy of Intra-articular Injection of Simvastatin in Treatment of Internal Derangement of Temporomandibular Joint.","authors":"M. Mahmoud, Eman Al Sharawy, Gehan El Desouky, Abdel Badee Abdel Mabood","doi":"10.21608/dsu.2021.52536.1058","DOIUrl":"https://doi.org/10.21608/dsu.2021.52536.1058","url":null,"abstract":"Introduction :ID management is one of challenges in maxillofacial filed. Almost 80% of adult symptomatic patients with TMD have some form of ID (1). Data from related literature has suggested that arthrocentesis may be of some benefit to manage symptoms of TMDs. Such a technique was first introduced for the management of sudden onset of closed lock Aim : This study aimed to evaluate efficacy of simvastatin intra-articular injection in management of internal derangement (ID) of temporomandibular joint ( TMJ). Patients and methods: 15 patients with internal TMJ derangement were included in this study. All patients were subjected to preoperative clinical examination and preoperative magnetic resonance imaging (MRI) for the affected joints. The affected joints treated with arthrocentesis followed by intra-articular injection of 1ml. simvastatin twice a month. Clinical follow up were done at 24 hours postoperatively, one week, one month and six months. Then, after six months MRI was repeated to compare with preoperative images. Results: Patients showed better results in comparison to preoperative parameters at 1 week, 4 and 24 weeks intervals. Patients showed better MRI findings in comparison to preoperative findings where position of the disc was almost returned to its normal anatomical position. Conclusion: Simvastatin intra-articular injection after arthrocentesis was effective technique for management of TMJ internal derangements symptoms.","PeriodicalId":11270,"journal":{"name":"Dental Science Updates","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87258034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Intracanal Cryotherapy on Inflammatory Mediators Expression using Different Irrigation Protocols: A Randomized Clinical Trial","authors":"A. Mourad, N. Abdelsalam, D. Fayyad","doi":"10.21608/dsu.2021.58237.1063","DOIUrl":"https://doi.org/10.21608/dsu.2021.58237.1063","url":null,"abstract":"ABSTRACTAim: To evaluate the effect of intra-canal cryotherapy on interleukin-1βand interleukin-10 expression in teeth with symptomatic apical periodontitis.Methodology: Forty-eight single rooted teeth in patients with symptomatic apical periodontitiswere randomly divided into 4 groups according to the irrigation protocol.Group I (control); 5% sodium hypochlorite at room temperature. Group II; 5% coldsodium hypochlorite (2-5°C). Group III; final rinse with 20 mL of 5% cold sodiumhypochlorite (2-5°C) for 5 minutes. Group IV; final rinse with 20 mL of cold saline (2-5°C) for 5 minutes. Paper point passing 2 mm beyond the apex was used to collect periapicalfluid before, immediately after mechanical instrumentation and after one week tocharacterize the mRNA expression of IL-1β and Il-10 using real-time polymerase chainreaction (PCR). Statistical analysis was performed using one-way ANOVA to comparebetween all groups. Results: Our results revealed statistically significant (at P≤ 0.05)down regulation of IL-1β gene expression levels in all groups after one week with nostatistically significant difference between the four groups and statistically significant(at P≤ 0.05) up regulation of IL-10 gene expression levels in all groups after one week.Conclusion: All the cryotherapy irrigation protocols showed lower levels of expressionof the pro-inflammatory mediators (interleukin-1β) and higher levels of expression ofthe anti-inflammatory mediator (interleukin-10) than the control group after one week.","PeriodicalId":11270,"journal":{"name":"Dental Science Updates","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90778182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Injectable-Platelet Rich Fibrin on marginal adaptation of Bioactive Materials Used as Direct Pulp Capping; An Experimental Animal Study","authors":"N. Mansour, marwa sharraan, Dalia Fayad, Mohammed Abdullah Hashem","doi":"10.21608/dsu.2021.64004.1066","DOIUrl":"https://doi.org/10.21608/dsu.2021.64004.1066","url":null,"abstract":"Introduction: Vital pulp therapy has been known as one of the treatment options to preserve pulp vitality after being exposed by trauma or caries. Aim: This experiment explored the effect of injectable-Platelet Rich Fibrin on marginal adaptation of two pulp capping agents (Mineral Trioxide Aggregate and Bioactive Bone Graft). Materials and methods: A total of 64 teeth were used out of 8 healthy male beagle dogs. The teeth were randomly assigned into four groups, they were exposed and capped with different capping agents. Group A; capped with Mineral Trioxide Aggregate (MTA), Group B; capped with MTA+ i-PRF, Group C; capped with Bioactive Bone Graft (BBG), Group D; capped with BBG+i-PRF. Finally the access cavity was restored with Intermediate Restorative Material (IRM). At each predetermined interval, the dogs were sacrificed (1 month, and 3 months). The samples were then prepared for electron microscopic scanning evaluation. To compare between the gap percentage of four groups at each interval, Kruskal-wallis test; was used. Mann-Whitney U test; was used to pair-wise comparison when Kruskal-wallis test is significant. Bonferroni’s correction was utilized for the pair-wise comparisons. Statistical significance was considered at P < .05. Results: The data revealed that after one and three months the best values were recorded in groups B (MTA+ i-PRF) and D (BBG+ i-PRF), in relation to the lowest gap area between the capping materials and dentin, followed by group C (BBG), with the least value recorded in group A (MTA). Conclusion: the findings from the current study suggested that i-PRF provided a better marginal adaptation of either MTA or BBG to the pulp and dentin, which improved with time from one month to three months.","PeriodicalId":11270,"journal":{"name":"Dental Science Updates","volume":"218 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77243890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL EVALUATION OF THE EFFICACY OF SILVER DIAMINE FLUORIDE IN ARRESTING ACTIVE DENTIN CARIES IN PRIMARY MOLARS","authors":"Mahy Rady, Salah Elbehery, Gihan Eldesouky, Ghada A. Elbaz, Shimaa Mahfouz","doi":"10.21608/dsu.2021.77947.1070","DOIUrl":"https://doi.org/10.21608/dsu.2021.77947.1070","url":null,"abstract":"Introduction: The atrauamatic restorative technique or approach has achieved considerable interest worldwide. Silver Diamine Fluoride (SDF) controls active carious lesions and helps in preventing further progression of the disease. Aim of the study: To evaluate and compare the efficacy of conventional glass ionomer cement (Fuji IX) and silver diamine fluoride in arresting active dentin carious lesions in primary molars through clinical evaluation. Materials and Methods: Sixty primary molars, with active dentin carious lesion (scores 4 or 5) according to ICDAS II in 25 children (4-7 years) were included in the present study. All selected teeth were treated with modified atraumatic restorative technique (ART). The treated teeth were divided into two groups according to the restorative material: Group 1 was restored with Fuji IX while Group II was restored with SDF and Fuji IX. The treated teeth were evaluated clinically for specific parameters and followedup for 3, 6, 9 and 12 months. Results: When compared to Group II regarding all the tested clinical criteria (spontaneous pain, mobility, sensitivity to percussion and sinus or swelling); there was a statistically significant decrease in success rate within both group I (P-value <0.001, effect size = 0.367) and group II (P-value <0.001, effect size = 0.187). According to Kaplan-Meier survival analysis, the mean survival time for Group I was 9.9 months and for Group II was 11.2 months. There was no statistically significant difference between the survival of the two materials within the time frame of the present study (P-value = 0.170). Conclusion: It could be concluded that 38% SDF offers an easy and efficient alternative treatment for early childhood caries in young children in comparison to traditional restorative procedures with better longevity, treatment outcome and prognosis.","PeriodicalId":11270,"journal":{"name":"Dental Science Updates","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74120375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Response of Different Locator Heights in Mandibular Overdenture Wearers .","authors":"Helmy Abdelhafiz, M. Elmahdy, Sayed Elmasry, H. A. Abd El-Hamid","doi":"10.21608/dsu.2021.45428.1050","DOIUrl":"https://doi.org/10.21608/dsu.2021.45428.1050","url":null,"abstract":"Introduction: The locator attachment has been widely and successfully used to support dentures has dual retention and is available in different heights with different retention values; in addition, their repair and replacement are quick and straight forward. Aim: The aim of this study was to compare clinically and radio graphically the biological effect of two different locator heights on peri-implant bone width and probing depth in mandibular implant overdenture wearers. Materials and methods: Conventional complete dentures were constructed for twelve completely edentulous male patients, chosen from Out-clinic of faculty of dentistry Suez Canal University. Two implant were inserted in the lower cusped region then the patients divided randomly into two groups Group A(GA): Six patients received implant retained over denture with 1mm locator height. Group B (GB): Six patients received implant retained over denture with 3mm locator height, the follow up both clinically and radiography were taken at 0, 6, 12 and 18 months starting from the first day of over denture attachment pick up. Peri-implant bone width and probing depth were estimated through the evaluation periods. Results: It was found that the reduction in the peri-implant alveolar buccolingual width and probing depth around the implants were higher in GA than GB at all follow up periods, except for the last follow up period. Conclusion: The locator height has a biological effect on bone width and probing depth as the higher locator height the more preservation of peri-implant bone.","PeriodicalId":11270,"journal":{"name":"Dental Science Updates","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85631882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Different Dentin Posts for the Treatment of Primary Anterior Teeth (An In vitro study)","authors":"Mennatallah El-Shaabany, Ghada El-Baz, shaimaa Mahfouz Omer","doi":"10.21608/dsu.2021.58163.1059","DOIUrl":"https://doi.org/10.21608/dsu.2021.58163.1059","url":null,"abstract":"Introduction: Early childhood Caries is a distressing situation for patients and parents and pediatric dentists. Aim: current research was carried out to evaluate fracture resistance and bond strength for different types of dentin posts compared to fiber posts. Materials and Methods: This Current in-vitro study was conducted on 48 extracted primary incisors. Samples were split randomly into 4 groups of 12 for each group. Group-I (fiber posts 6mm length, 1.4mm diameter), Group-II (dentin posts 6mm length, 1.4 diameter), Group-III (dentin posts 8mm length, 1.4mm diameter), Group-IV (dentin posts 8mm length, 1.6mm diameter). Each group was further subdivided into two subgroups (6 for the Push-Out bond strength test and 6 for the fracture resistance test using Universal Testing Machine). Results: It was observed in the fracture resistance test that, Group III showed the highest fracture resistance means (140.678±11.98) followed by Group IV (131.38±7.03), Group-II (94.23±9.84), and finally Group-I that showed the lowest fracture resistance means (80.465±2.82). Push-Out bond strength test revealed that the highest mean value with Group-IV (8.653±1.49), followed by Group-II (6.08±2.25) and Group III (5.67±2.44) have no statistically significant difference between them, while the lowest mean value was for Group-I. Conclusions: Dentin posts showed increased fracture resistance and bond strength more than fiber posts. The use of dentin post as intra-canal retention in primary anterior teeth possesses the most important advantages over the fiber post. Therefore, biological dentin post is a successful alternative for fiber post. INTRODUCTION Crown damage of primary anterior teeth is a frequent issue in pediatrics dental clinics because of either early childhood caries (ECC) or trauma (1). ECC is a quickly progressing developing type of dental caries that occurs primarily in the cervical third of maxillary incisors till full damage of the crown. It principally affects the primary maxillary incisors shortly following the eruption of teeth and infects other primary teeth quickly causing early tooth loss (2). In primary teeth, gaining intracanal retention through posts is tricky due to that permanent teeth need to find a way for primary counterparts. To ensure well-timed eruption of permanent successors in normal undeflected places, the intracanal post would timely resorb way (3). DOI: 10.21608/dsu.2021.58163.1059 Manuscript ID: DSU-2101-1059","PeriodicalId":11270,"journal":{"name":"Dental Science Updates","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87581436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Intra-articular Injection of Simvastatin versus Hyaluronic Acid in Treatment of Internal Derangement of Temporomandibular Joint","authors":"M. Mahmoud, Eman El Sharrawy, Gehan El Desouky, Abdel Badee Abdel Mabood","doi":"10.21608/dsu.2021.31287.1037","DOIUrl":"https://doi.org/10.21608/dsu.2021.31287.1037","url":null,"abstract":"Introduction: TMJ Internal Derangement is a common form of temporomandibular joint disorder. Almost 80% of adult symptomatic patients with TMD have some form of ID. Temporomandibular joint arthrocentesis consists of lavage of upper joint space of TMJ done with no direct vision, aiming primarily to remove necrotic tissue, blood and pain mediators from the joint. One of these therapeutic substances is hyaluronic acid; which is a polysaccharide of the family of glycosaminoglycans, which can be found in many extracellular tissues, including synovial fluid and cartilage. Simvastatins are group of drugs which have good results in regeneration of degenerated TMJ. Aim: This study aimed to evaluate the intra-articular injection of simvastatin versus sodium hyaluronate following arthrocentesis for management of internal derangement (ID) of the temporomandibular joint(TMJ). Patients and methods: Thirty patients with internal TMJ derangement were included in this study. All patients were subjected to preoperative clinical examination and preoperative magnetic resonance imaging (MRI) for the affected joints. Arthrocentesis was performed firstly for the affected joints in all patients followed by intra-articular injection of 1ml. simvastatin twice a month (in group I) and sodium hyaluronate twice a month ( in group II).Clinical follow up were done at 24 hours post-operatively, one week, one month,and six months. Then, after six months MRI was repeated to compare with preoperative images. Results: Better results were recorded with simvastatin group in comparison to sodium hyaluronate group; at 1 week, 1 month,and six months intervals; which was superior to arthrocentesis followed by sodium hyaluronate intra-articular injection. Patients in group I showed better MRI findings in comparison to group II where the position of the disc was almost returned to its normal anatomical position. Conclusion: Arthrocentesis followed by simvastatin intra-articular injection was superior to the combination of arthrocentesis and sodium hyaluronate intra-articular injection for management of TMJ internal derangements symptoms.","PeriodicalId":11270,"journal":{"name":"Dental Science Updates","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85735328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of systemic administration of silver nanoparticles in treatment of experimental periodontitis in albino rats","authors":"W. Shaker, L. Ghali, Enas M. Hegazy","doi":"10.21608/dsu.2021.60867.1065","DOIUrl":"https://doi.org/10.21608/dsu.2021.60867.1065","url":null,"abstract":"Introduction: Periodontal disease is one of the main dental diseases that affect millions of people around the world. Modern nanotechnology progression and renovations through nanodentistry providing a suitable solution for the treatment of many dental illnesses including periodontal disease. Aim: Histological and ultrastructural evaluation of the effect of silver nanoparticles in treatment of periodontitis in albino rats. Materials and methods: A total of 18 adults male albino rats with body weight ranging from 150 to 180 gm were used and divided into three groups group 1: served as control, group 2: used for induction of experimental periodontitis using wiring around the cervix of mandibular central incisors for two weeks, and group 3: after induction of experimental periodontitis as in group 2 they were subjected to intraperitoneal injection with silver nanoparticles for the treatment of periodontitis three times per week for four weeks. Results: Histological and ultrastructural investigation revealed that periodontal ligament around ligated mandibular incisors showed marked improvement in the degenerated fibers after injection with silver nanoparticles in group 3 compared to group 2 as the fibers regained their association in strong bundles and they regained their attachment to regenerated bone and tooth surface. Conclusions: Marked regeneration of the periodontium of periodontally affected ligated mandibular incisors reflected that silver nanoparticles have a great anti-inflammatory effect","PeriodicalId":11270,"journal":{"name":"Dental Science Updates","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77192940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Remineralizing Effect of Casein Phosphopeptide – Amorphous Calcium Phosphate Fluoride and Silver Diamine Fluoride on Demineralized Enamel Surfaces ( An In Vitro Study)","authors":"Bothaina El Hagry, Ghada El-Baz, A. Abo El Soud","doi":"10.21608/dsu.2021.50737.1057","DOIUrl":"https://doi.org/10.21608/dsu.2021.50737.1057","url":null,"abstract":"Introduction Caries initiation is associated with demineralization of the tooth enamel surface. Calcium and phosphorous are lost from the subsurface enamel, resulting in the formation of a subsurface lesion. Aim: this study aimed to investigate and compare the enamel surface ultramorphology and minerals content by Environmental Scanning Electron Microscope (ESEM) and Energy dispersive x-ray spectroscopy (EDX) and to assess micro-hardness (Vickers test) of demineralized enamel surface treated with CPPACP casein Phosphopeptide-Amorphous Calcium Phosphate Flouride(MI Paste Plus) or SDF ( FAgamine). Materials and methods: This study was conducted on twenty eight human premolars ,were collected from the outpatient clinic of Maxillofacial Department, Faculty of Dentistry, Suez Canal University. The selected premolars distributed into three groups: Group I: consisted of 7 intact sound premolars,(control group) Group II : consisted of 7 demineralized premolars,(demineralized group) while, Group III consisted of 14 premolars ( each one divided into 28 halves mesiodistally) then all 28 specimens of group III were demineralized and half of them were treated by MI Paste plus ( subgroup IIIa) and other were treated by SDF( subgroup IIIb). All Groups I,II&III were placed in artificial saliva for 7days at 37oc. Results: There was a statistically significant difference between calcium and phosphorus values of the three groups; subgroup IIIa showed the highest value followed by subgroup IIIb & group I and finally the least value was related to group II .The highest value of fluoride content related to subgroup IIIb. There was not statistically significant difference between microhardness values of group I and group III while group II revealed the lowest microhardness value. Conclusion: Both CPP-ACPF and SDF show areas of mineralized deposits and improvement of enamel ultrastructure. Also both CPP-ACPF and SDF are efficient remineralizing agent, but CPP-ACPF is more efficient as remineralizing agent than SDF. CPP-ACPF shows better microhardness results than SDF.","PeriodicalId":11270,"journal":{"name":"Dental Science Updates","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86464029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular evaluation of the chemotherapeutic effect of thymoquinone loaded on gold nanoparticles through expression of DNA repair enzymes in induced oral squamous cell carcinoma","authors":"M. Amer, M. Hassan, F. Attia, K. A. El-Nour, Ahmed M. Korraah","doi":"10.21608/dsu.2020.19585.1015","DOIUrl":"https://doi.org/10.21608/dsu.2020.19585.1015","url":null,"abstract":"Different types of DNA damages occur during the induced oral carcinogenesis, which can be eliminated through several DNA repair pathways. XRCC1 and ERCC1 are the main repair enzymes involved in repair of oral squamous cell carcinoma. A combination of thymoquinone with gold nanoparticles as a novel chemotherapeutic modality is the aim of the present work against chemically induced SCC in the classic model of HBP/DMBA carcinogenesis. One hundred male Syrian golden hamsters were divided into: Group A: Ten animals (negative control), group B: Ten animals (positive control) painted with DMBA only 3times / week/ 12weeks. The rest of animals were painted with DMBA (3times / week/ 12weeks) then painted and injected intraperitoneal with TQ only, 0.01mg/kg TQ-GNps, 0.001mg/kg TQ-GNps or GNps only for 6- and 12- weeks, intervals. By end of the experiment, both pouches from all groups were surgically excised, fresh samples from each pouch were processed for RT-PCR technique. The rest of the pouches were fixed and processed for H&E evaluation. Loading of thymoquinone on gold nanoparticles was promising chemotherapeutic combination, through regression of well-differentiated SCC (positive control) to dysplasia and enhanced expression of the studied DNA repair enzymes compared to either thymoquinone or gold nanoparticles groups.","PeriodicalId":11270,"journal":{"name":"Dental Science Updates","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91117073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}