Effect of systemic administration of silver nanoparticles in treatment of experimental periodontitis in albino rats

Introduction: Periodontal disease is one of the main dental diseases that affect millions of people around the world. Modern nanotechnology progression and renovations through nanodentistry providing a suitable solution for the treatment of many dental illnesses including periodontal disease. Aim: Histological and ultrastructural evaluation of the effect of silver nanoparticles in treatment of periodontitis in albino rats. Materials and methods: A total of 18 adults male albino rats with body weight ranging from 150 to 180 gm were used and divided into three groups group 1: served as control, group 2: used for induction of experimental periodontitis using wiring around the cervix of mandibular central incisors for two weeks, and group 3: after induction of experimental periodontitis as in group 2 they were subjected to intraperitoneal injection with silver nanoparticles for the treatment of periodontitis three times per week for four weeks. Results: Histological and ultrastructural investigation revealed that periodontal ligament around ligated mandibular incisors showed marked improvement in the degenerated fibers after injection with silver nanoparticles in group 3 compared to group 2 as the fibers regained their association in strong bundles and they regained their attachment to regenerated bone and tooth surface. Conclusions: Marked regeneration of the periodontium of periodontally affected ligated mandibular incisors reflected that silver nanoparticles have a great anti-inflammatory effect