Efficacy of Intra-articular Injection of Simvastatin in Treatment of Internal Derangement of Temporomandibular Joint.

Abstract

Introduction :ID management is one of challenges in maxillofacial filed. Almost 80% of adult symptomatic patients with TMD have some form of ID (1). Data from related literature has suggested that arthrocentesis may be of some benefit to manage symptoms of TMDs. Such a technique was first introduced for the management of sudden onset of closed lock Aim : This study aimed to evaluate efficacy of simvastatin intra-articular injection in management of internal derangement (ID) of temporomandibular joint ( TMJ). Patients and methods: 15 patients with internal TMJ derangement were included in this study. All patients were subjected to preoperative clinical examination and preoperative magnetic resonance imaging (MRI) for the affected joints. The affected joints treated with arthrocentesis followed by intra-articular injection of 1ml. simvastatin twice a month. Clinical follow up were done at 24 hours postoperatively, one week, one month and six months. Then, after six months MRI was repeated to compare with preoperative images. Results: Patients showed better results in comparison to preoperative parameters at 1 week, 4 and 24 weeks intervals. Patients showed better MRI findings in comparison to preoperative findings where position of the disc was almost returned to its normal anatomical position. Conclusion: Simvastatin intra-articular injection after arthrocentesis was effective technique for management of TMJ internal derangements symptoms.