Digestive and Liver Disease最新文献

{"title":"Comment on \"The impact of bacterial infection on the risk of portal vein thrombosis development in patients with cirrhosis: A post-hoc analysis\".","authors":"Sidra Amjad, Manal Sharif, Hafsa Rehman, Zahid Ullah","doi":"10.1016/j.dld.2025.07.007","DOIUrl":"https://doi.org/10.1016/j.dld.2025.07.007","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The need for life-long holistic follow-up after pancreaticoduodenectomy.","authors":"Mary E Phillips, Graham Pinn, Nariman D Karanjia, Rajesh Kumar, Adam E Frampton, Kathryn H Hart","doi":"10.1016/j.dld.2025.07.017","DOIUrl":"https://doi.org/10.1016/j.dld.2025.07.017","url":null,"abstract":"<p><strong>Background: </strong>Pancreaticoduodenectomy (PD) results in surgical, metabolic and nutritional consequences with unknown frequency.</p><p><strong>Methods: </strong>This observational single centre study attempted to quantify the incidence of the long-term consequences after PD in patients offered routine surveillance with a specialist dietitian and nurse specialist.</p><p><strong>Results: </strong>One hundred and thirty-four patients participated (52 % male, mean age 64.7 years [SD 10.2]. The mean time from surgery was 4.48 years [SD 3.7]. Malnutrition occurred in <10 %. Consequences were experienced by 82 % of patients (mean number 2.02, [SD 1.52]), 28 % were related to the surgical anastomosis. Eight patients (6 %) had late revisional surgery. Metabolic and gastrointestinal consequences were common, and >50 % had diabetes after 2 years. Pancreatin doses increased with time, with mean mealtime doses of 54,449 units of lipase [SD 19,452] increasing to 100,450 units [SD 33,351] by 10 years (p < 0.001). The onset of complications was associated with time from surgery (p < 0.001) but not histology or use of chemotherapy.</p><p><strong>Conclusions: </strong>Our study is the first to provide data on the long-term consequences of PD (>10 years). Long-term screening for malnutrition, diabetes, micronutrient deficiency, steatotic liver disease, ongoing abdominal symptoms, and osteoporosis should be routine after PD, and cost benefit analysis undertaken to support the allocation of appropriate funding.</p>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CCT3 as a promising diagnostic and prognostic biomarker in HCC.","authors":"Valbert Oliveira Costa Filho, Mariana Macambira Noronha, Carlos Alberto Barbosa Neto, Pedro Robson Costa Passos, Silvia Helena Barem Rabenhorst, Felipe Pantoja Mesquita","doi":"10.1016/j.dld.2025.07.015","DOIUrl":"https://doi.org/10.1016/j.dld.2025.07.015","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of action and clinical effectiveness of herbal treatments for disorders of gut-brain interaction","authors":"Md Moniruzzaman ,&nbsp;Ayesha Shah ,&nbsp;Mark Morrison ,&nbsp;Natasha Koloski ,&nbsp;Kok Ann Gwee ,&nbsp;Minhu Chen ,&nbsp;YongSung Kim ,&nbsp;Kana Ayaki ,&nbsp;Thomas Efferth ,&nbsp;Gerald Holtmann","doi":"10.1016/j.dld.2025.07.010","DOIUrl":"10.1016/j.dld.2025.07.010","url":null,"abstract":"<div><div>Disorders of gut-brain interaction (DGBI), such as functional dyspepsia (FD) and irritable bowel syndrome (IBS), affect about one-third of the global population. Many patients turn to traditional and herbal medicines for relief, given the lack of effective therapies. This review assesses the clinical and preclinical evidence for herbal treatments used for patients with DGBI. Placebo-controlled trials show that specific herbal preparations, including peppermint oil, ginger, and commercial formulations like STW-5, ZZKZ and Rikkunshito significantly improve gastrointestinal symptoms. Their effectiveness likely arises from various mechanisms, such as alterations in gastrointestinal motility, desensitization of visceral sensory function, and suppression of low-grade mucosal or systemic inflammation. Recent studies of the effects of herbal extracts on the gastrointestinal microbiome also implicate microbial involvement in their effectiveness. Most herbal preparations contain multiple bioactive compounds to address various disease mechanisms, and there remains a significant gap in dose-response studies for optimizing therapeutic outcomes.</div></div>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 9","pages":"Pages 1717-1729"},"PeriodicalIF":3.8,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transanal irrigation in patients affected by low anterior resection syndrome (LARS): Long-term results from an Italian national study.","authors":"Jacopo Martellucci, Ezio Falletto, Simona Ascanelli, Laura Chimisso, Piera Rossitti, Elena Zucchi, Andrea Lauretta, Mariagrazia Mirafiori, Andrea Bondurri, Gloria Zaffaroni, Ilaria Clementi, Silvia Cornaglia, Paolo Tonello, Francesca Di Candido, Davide Zattoni, Valter Ripetti, Paolo Luffarelli, Lucia d'Alba, Giovanni Cestaro, Corrado Bottini, Christian Lambiase, Massimo Bellini","doi":"10.1016/j.dld.2025.07.002","DOIUrl":"https://doi.org/10.1016/j.dld.2025.07.002","url":null,"abstract":"<p><strong>Background: </strong>Low Anterior Resection Syndrome (LARS) is a debilitating condition post-surgery, requiring long-term management.</p><p><strong>Aim: </strong>To evaluate the benefits of long-term transanal irrigation (TAI) treatment (up to 24 months) for LARS patients.</p><p><strong>Methods: </strong>A multicenter study across 13 centers included 159 patients to assess satisfaction with TAI for bowel control and quality of life (QoL). Secondary objectives included evaluating symptom improvement, dropout rates, and TAI characteristics (frequency, water volume, duration). Validated questionnaires were administered at baseline (T0) and after 1 (T1), 6 (T6), 12 (T12), and 24 (T24) months. Statistical analyses included signed rank sum tests for score differences, F-tests for symptom frequency, mixed-effects models for LARS category changes.</p><p><strong>Results: </strong>TAI significantly improved satisfaction and QoL (p < 0.001). At T0, 84.8 % of patients had major LARS, decreasing to 16.5 % at T24. Mean LARS score improved by 19.8 ± 12.3 points from baseline to T24, showing a sustained and significant long-term improvement (p < 0.001). Symptom frequency decreased from 4.3 events per patient at T0 to 0.5 at T24 (p < 0.001). Dropouts occurred in 5 (11.4 %) cases by T6, 9 (6.8 %) by T12, and 12 (8.9 %) by T24.</p><p><strong>Conclusion: </strong>This study confirmed for the first time that long-term TAI treatment benefits LARS patients by improving symptoms, satisfaction, and QoL, with effects sustained over 24 months.</p>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full Title Page /Editorial Board","authors":"","doi":"10.1016/S1590-8658(25)00913-2","DOIUrl":"10.1016/S1590-8658(25)00913-2","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 8","pages":"Pages i-ii"},"PeriodicalIF":4.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ``ABC'' of genetics in cholestatic liver diseases.","authors":"Giovanni Vitale, Laura Turco, Francesco Azzaroli, Fabio Piscaglia","doi":"10.1016/j.dld.2025.06.027","DOIUrl":"https://doi.org/10.1016/j.dld.2025.06.027","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiomics insights into functional constipation: Exploring microbiome, metabolome, and lipidome independent of transit time.","authors":"Ji Eun Ryu, Seung Yong Shin, Ji-Seon Ahn, Jung Min Moon, Hyun Jin Joo, Jeongkuk Seo, Jung Seop Kim, Ye-Been Lee, Yoonho Jeong, Jae-Yeon Cho, SoHee Park, Seung Ki Kwok, Hea-Jong Chung, Chang Hwan Choi, Hyung-Kyoon Choi","doi":"10.1016/j.dld.2025.07.011","DOIUrl":"https://doi.org/10.1016/j.dld.2025.07.011","url":null,"abstract":"<p><strong>Background/aims: </strong>Functional constipation (FC) is a prevalent form of functional gastrointestinal disorder with an elusive etiology. Despite numerous investigations into the role of the gut microbiome in FC, no study has yet integrated microbiome, metabolome, and lipidome profiling to characterize FC.</p><p><strong>Methods: </strong>In this study, fecal samples were collected from patients with FC both before and after laxative administration to minimize the impact of intestinal transit time and to identify the characteristics unique to patients with FC. These samples underwent comprehensive microbiome, metabolome, and lipidome analyses to discern the unique properties of FC.</p><p><strong>Results: </strong>Beneficial microbiota such as Anerobutyricum hallii, Blautia luti, Blautia wexlerae, Collinsella aerofaciens, and Fusicatenibacter saccharivorans were predominantly found in healthy controls (HC), while harmful microbiota, Blautia faecis, was prevalent in patients with FC. Metabolome profiling showed that chenodeoxycholic acid, glucose, glycine, malic acid, phenylalanine, ribose, serine, and uracil decreased in patients with FC, suggesting a decreased energy metabolism and a reduced nutrient utilization for energy production compared to HCs. In terms of lipidome profiling, no significant differences in lipid levels were observed between pre- and post-laxative FC samples.</p><p><strong>Conclusions: </strong>Our findings offer novel insights into FC-specific alterations in the gut microbiota and metabolome and potentially lead to the development of targeted therapeutic approaches for FC.</p>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critique of Pancreatic Cyst Biomarker Study.","authors":"Limao Xu, Yan Chen, Jianmei Zeng","doi":"10.1016/j.dld.2025.07.008","DOIUrl":"https://doi.org/10.1016/j.dld.2025.07.008","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality improvement for vibration controlled transient elastography using a novel analysis algorithm.","authors":"Jeffrey Schwartz, Shalini Tripathi, Omar T Sims, William Carey, Dian-Jung Chiang","doi":"10.1016/j.dld.2025.05.029","DOIUrl":"https://doi.org/10.1016/j.dld.2025.05.029","url":null,"abstract":"<p><strong>Background: </strong>The correlation of liver stiffness (LS) score with histopathology is limited by diagnostic equipoise and variability by fibrosis etiology. This study devised a novel probabilistic reporting algorithm for VCTE output, stratified by etiology of liver disease, and obtained feedback from providers about this new framework.</p><p><strong>Methods: </strong>We devised a novel probability algorithm by re-analyzing and converting optimal sensitivity and specificity cut-offs from the Refining the Baveno VI Elastography Criteria Study (i.e., <7 kPa, 10 to 15 kPa, and >15 kPa) into probabilities of F0-F4. We subsequently conducted an email-based, 9-item survey to hepatology providers at the Cleveland Clinic, assessing patient and provider experience. Responses to each question ranged from 1 to 5 (strongly disagree to strongly agree); each question was aggregated to create 3 categories of response: favorable, neutral, and not favorable.</p><p><strong>Results: </strong>The statistical conversion yielded probabilities of LS on VCTE for patients with cACLD stratified by MASLD, Hepatitis B, Hepatitis C, and Alcoholic Liver Disease and was implemented in VCTE output in March 2023 at the Cleveland Clinic. Survey of provider experience showed it overall more favorable than the conventional algorithm with respect to facilitating understanding of fibrosis, communicating with referring physicians and surveying patients. The new algorithm was most beneficial for patient experience when biopsy and VCTE results are divergent.</p><p><strong>Conclusion: </strong>Our novel probabilistic algorithm acknowledging the intrinsic limitations of correlating LSM with histologic fibrosis stage, particularly at intermediate values. Overall, providers found this reporting output improved their experience in caring for patients and helpful for the patient experience when biopsy and VCTE results are discordant. Refinements to this reporting output are needed to enhance patients' understanding of test results.</p>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}