Bowel urgency in ulcerative colitis assessed from patients’ reports: Results of a telemonitoring programme

IF 4 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Digestive and Liver Disease Pub Date : 2025-06-01 DOI:10.1016/j.dld.2025.03.019

Edoardo Carboni , Francesco Maria Stalla , Marco Mendolaro , Brayan Montoya Rodriguez , Enrico Morello , Davide Stradella , Alessandro Lavagna , Guido Pagana , Rodolfo Rocca , Marco Daperno

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引用次数: 0

Abstract

Background

Bowel urgency is common in ulcerative colitis (UC), but which patients are affected, and how, has not been fully studied.

Objective

We explored associations of bowel urgency with the clinical characteristics of unselected outpatients.

Design

The study included adults with UC already enrolled in a telemonitoring programme using the IBD Tool platform. Between January 2021 and May 2024, patients repeatedly completed the Simple Clinical Colitis Activity Index (P-SCCAI) and Monitor at Home IBD – Ulcerative Colitis (MIAH-UC) questionnaires, plus other questionnaires. The submission of contemporary P-SCCAI and MIAH-UC scores was an “event” for analysis. The degree of bowel urgency was determined from responses to three P-SCCAI questions.

Results

Overall, 277 UC patients submitted 2768 events. No urgency was reported in 1813 events (66 %), while mild urgency in 538 (19 %), moderate urgency in 272 (10 %) and severe urgency in 145 (5 %). Variables positively associated with moderate-severe urgency at multivariate analysis (P < 0.0001) were female sex, age at diagnosis, disease duration, extensive UC, higher disease activity (MIAH-UC score), higher disease-related disability (IBD Disk), and any medical treatment. In 1750 events, disease was in clinical remission (MIAH-UC ≤3.5), but moderate-severe urgency was reported in 67 (3.8 %) of them. At multivariate analysis, variables associated with urgency during UC remission were age at diagnosis, disease duration, IBD Disk score, any treatment, and female sex.

Conclusion

Bowel urgency affects UC patients’ lives and is associated with more severe disability, worse quality of life and higher depression scores. Moderate-severe urgency was reported in 1 in 25 events with UC in remission and increased the patients’ disease-related disability.

查看原文本刊更多论文

从患者报告中评估溃疡性结肠炎的肠急症：远程监测项目的结果。

背景：肠道急迫在溃疡性结肠炎（UC）中很常见，但哪些患者受到影响，以及如何受到影响，尚未得到充分研究。目的：探讨未入选门诊患者肠急症与临床特征的关系。设计：该研究纳入了已经使用IBD工具平台注册远程监测计划的UC成人。在2021年1月至2024年5月期间，患者反复完成简单临床结肠炎活动指数（P-SCCAI）和家庭IBD -溃疡性结肠炎监测（MIAH-UC）问卷，以及其他问卷。提交当代P-SCCAI和MIAH-UC评分是一个“事件”进行分析。肠急症程度由对三个P-SCCAI问题的回答来确定。结果：总体而言，277例UC患者发生了2768次事件。1813例（66%）无急迫性，538例（19%）轻度急迫性，272例（10%）中度急迫性，145例（5%）重度急迫性。在多变量分析中，与中重度急症呈正相关的变量（P < 0.0001）是女性、诊断时年龄、病程、广泛的UC、较高的疾病活动性（MIAH-UC评分）、较高的疾病相关残疾（IBD Disk）和任何药物治疗。在1750例事件中，疾病处于临床缓解（MIAH-UC≤3.5），但其中67例（3.8%）报告了中度至重度急症。在多变量分析中，与UC缓解期急迫性相关的变量包括诊断时年龄、病程、IBD Disk评分、任何治疗和女性性别。结论：肠急症影响UC患者的生活，并与更严重的残疾、更差的生活质量和更高的抑郁评分相关。据报道，每25例UC缓解事件中就有1例出现中重度急症，并增加了患者的疾病相关残疾。

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来源期刊

Digestive and Liver Disease 医学-胃肠肝病学

CiteScore

6.10

自引率

2.20%

发文量

632

审稿时长

19 days

期刊介绍： Digestive and Liver Disease is an international journal of Gastroenterology and Hepatology. It is the official journal of Italian Association for the Study of the Liver (AISF); Italian Association for the Study of the Pancreas (AISP); Italian Association for Digestive Endoscopy (SIED); Italian Association for Hospital Gastroenterologists and Digestive Endoscopists (AIGO); Italian Society of Gastroenterology (SIGE); Italian Society of Pediatric Gastroenterology and Hepatology (SIGENP) and Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD). Digestive and Liver Disease publishes papers on basic and clinical research in the field of gastroenterology and hepatology. Contributions consist of: Original Papers Correspondence to the Editor Editorials, Reviews and Special Articles Progress Reports Image of the Month Congress Proceedings Symposia and Mini-symposia.