Digestive and Liver Disease最新文献

Gastrointestinal hormone receptor agonists: Time for gastroenterologists to lead, not to hesitate. 胃肠激素受体激动剂：是时候让胃肠病学家带头了，不要犹豫。

IF 3.8 3区医学

Digestive and Liver Disease Pub Date : 2025-10-21 DOI: 10.1016/j.dld.2025.08.093

Antonio Gasbarrini, Giovanni Gasbarrini

引用次数: 0

Research gaps in eosinophilic esophagitis: unanswered questions and future directions. 嗜酸性粒细胞性食管炎的研究空白：未解决的问题和未来方向。

IF 3.8 3区医学

Digestive and Liver Disease Pub Date : 2025-10-21 DOI: 10.1016/j.dld.2025.10.010

Luisa Bertin, Andrea Pasta, Matteo Ghisa, Francesco Calabrese, Pierfrancesco Visaggi, Nicola de Bortoli, Vincenzo Savarino, Elisa Marabotto, Edoardo Vincenzo Savarino

{"title":"Research gaps in eosinophilic esophagitis: unanswered questions and future directions.","authors":"Luisa Bertin, Andrea Pasta, Matteo Ghisa, Francesco Calabrese, Pierfrancesco Visaggi, Nicola de Bortoli, Vincenzo Savarino, Elisa Marabotto, Edoardo Vincenzo Savarino","doi":"10.1016/j.dld.2025.10.010","DOIUrl":"https://doi.org/10.1016/j.dld.2025.10.010","url":null,"abstract":"Eosinophilic esophagitis (EoE) has emerged as a leading cause of dysphagia worldwide, yet significant knowledge gaps persist across fundamental aspects of disease management. This comprehensive narrative review examines critical research opportunities spanning five interconnected domains that collectively hamper optimal patient care. Despite advances in understanding type 2 inflammation, EoE pathogenesis remains incompletely characterized, particularly regarding gene-environment interactions, epithelial barrier dysfunction mechanisms, and tissue remodeling pathways. The diagnosis currently relies on endoscopy with biopsies with an arbitrary eosinophil threshold of 15 eosinophils/high-power field, while molecular endotypes and non-invasive biomarkers lack validation. Treatment strategies remain largely empirical without strong evidence-based therapeutic hierarchies, comparative effectiveness data, or reliable response predictors. The lack of head-to-head comparison trials of different interventions limits evidence-based treatment selection, while combination therapy approaches remain mostly underexplored. Challenges in defining optimal treatment targets persist, as recent eosinophil-depleting biologics achieved histologic responses without symptomatic improvement, highlighting the limitations of eosinophil-centric disease models. Disease trajectory prediction and long-term outcome monitoring lack systematic approaches, while primary prevention strategies remain undefined despite escalating global incidence. Addressing these research gaps through coordinated multidisciplinary efforts has the potential to transform EoE management from empirical to personalized, evidence-based approaches, ultimately improving patient outcomes and potentially enabling disease prevention.","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145344224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical features and outcomes of perianal disease in pediatric onset Crohn's disease. 小儿发病克罗恩病肛周疾病的临床特点和预后。

IF 3.8 3区医学

Digestive and Liver Disease Pub Date : 2025-10-21 DOI: 10.1016/j.dld.2025.09.003

Lin Wang, Yuhuan Wang, Ping Li, Shengnan Wang, Cuifang Zheng, Ying Huang

{"title":"Clinical features and outcomes of perianal disease in pediatric onset Crohn's disease.","authors":"Lin Wang, Yuhuan Wang, Ping Li, Shengnan Wang, Cuifang Zheng, Ying Huang","doi":"10.1016/j.dld.2025.09.003","DOIUrl":"https://doi.org/10.1016/j.dld.2025.09.003","url":null,"abstract":"Background: Limited data have explored perianal involvement in pediatric Crohn's disease (CD). We aimed to investigate the characteristics and clinical outcomes of pediatric onset CD with perianal disease.Methods: The medical records of diagnosed CD with perianal disease were reviewed retrospectively. The clinical characteristics, genetic testing, treatments and surgical outcomes among very early onset (VEO group) and later onset (LO group) were investigated. The occurrence of perianal fistulizing CD (pfCD) and intestinal resection were analyzed.Results: Of the 155 included patients, 52.3 % and 47.7 % were enrolled in VEO and LO group, respectively. At diagnosis, VEO patients had more colonic and rectal involvement and higher disease activity score (P < 0.001). A monogenic disease was found in 94.9 % (74/78) of patients in VEO group and in 28.6 % (2/7) of patients in LO group. Infliximab treatment was more common among LO group (P < 0.001). VEO group had a higher rate of intestinal resection (P < 0.001). During follow-up, an additional 13 VEO patients and 8 LO patients developed pfCD. Moreover, B2 behavior and recto-vaginal fistulae were found to be predictive factors for intestinal resection.Conclusion: VEOCD with perianal involvement is associated with higher monogenic mutation, more severe disease phenotypes, less utilization of biologics and higher rate of intestinal resection than LOCD.","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145344242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Esophageal motility disorders among elderly patients: An international multicenter study" [Digestive and Liver Disease 57 (2025) 1615-1621]. “老年患者食管运动障碍：一项国际多中心研究”的勘误表[消化与肝脏疾病]57(2025)1615-1621。

IF 3.8 3区医学

Digestive and Liver Disease Pub Date : 2025-10-17 DOI: 10.1016/j.dld.2025.09.029

Pierfrancesco Visaggi, Daniel L Cohen, Elisa Marabotto, Andrea Pasta, Francesco Calabrese, Nicola de Bortoli, Amir Farah, Alessia Gargani, Jawad Hindy, Basem Hijazi, Wisam Abboud, Mentore Ribolsi, Luisa Bertin, Edoardo V Savarino, Amir Mari

引用次数: 0

Editorial: Advancing gastroenterology practice through collaborative guidelines: Evidence-based recommendations on DGBIs, GERD and IBD. 社论：通过协作指南推进胃肠病学实践：关于dgbi、GERD和IBD的循证建议。

IF 3.8 3区医学

Digestive and Liver Disease Pub Date : 2025-10-17 DOI: 10.1016/j.dld.2025.10.002

Luisa Bertin, Edoardo Vincenzo Savarino

引用次数: 0

Author's Reply: Comment on ``A switch to infliximab may be more effective than ustekinumab following adalimumab pharmacodynamic failure in paediatric patients with Crohn's disease''. 作者回复：关于“在阿达木单抗药效学失败后改用英夫利昔单抗可能比乌斯特金单抗更有效”的评论。

IF 3.8 3区医学

Digestive and Liver Disease Pub Date : 2025-10-17 DOI: 10.1016/j.dld.2025.09.028

Galit Driban, Amit Assa

引用次数: 0

A rare case of metastatic papillary thyroid carcinoma to the esophagus treated by endoscopic submucosal dissection. 内镜下粘膜下剥离术治疗甲状腺乳头状癌转移至食道一例。

IF 3.8 3区医学

Digestive and Liver Disease Pub Date : 2025-10-15 DOI: 10.1016/j.dld.2025.09.005

Jianhuang Su, Yijun Chen, Chuntao Liu, Can Sun

引用次数: 0

It takes two to tango: Preserving liver function competes with response to systemic therapy in patients with HCC and decompensated cirrhosis. 一个巴掌拍不响：在HCC和失代偿肝硬化患者中，维持肝功能与对全身治疗的反应是相互竞争的。

IF 3.8 3区医学

Digestive and Liver Disease Pub Date : 2025-10-15 DOI: 10.1016/j.dld.2025.10.006

Andrea Pasta, Edoardo G Giannini

引用次数: 0

Cecal Trichuris trichiura infection discovered by colonoscopy. 结肠镜检查发现盲肠三毛杆菌感染。

IF 3.8 3区医学

Digestive and Liver Disease Pub Date : 2025-10-13 DOI: 10.1016/j.dld.2025.10.001

Lai-En Shen, Zhi-Ying Zhu, Wei Xie

引用次数: 0

Comment on "A switch to infliximab may be more effective than ustekinumab following adalimumab pharmacodynamic failure in paediatric patients with Crohn's disease". 评论“在阿达木单抗药效学失败后，改用英夫利昔单抗可能比乌斯特金单抗更有效”。

IF 3.8 3区医学

Digestive and Liver Disease Pub Date : 2025-10-11 DOI: 10.1016/j.dld.2025.09.015

Weijian Liang, Jinyan Guo, Weifeng Yao

引用次数: 0