Digestive and Liver Disease最新文献

{"title":"Erratum regarding updated pagination in previously published articles","authors":"","doi":"10.1016/j.dld.2025.05.017","DOIUrl":"10.1016/j.dld.2025.05.017","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages 1362-1363"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full Title Page /Editorial Board","authors":"","doi":"10.1016/S1590-8658(25)00763-7","DOIUrl":"10.1016/S1590-8658(25)00763-7","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages i-ii"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic fat density and post-ERCP pancreatitis: A complex relationship or a novel predictor?","authors":"Amir Farah , Amir Mari","doi":"10.1016/j.dld.2025.02.019","DOIUrl":"10.1016/j.dld.2025.02.019","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages 1352-1353"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “A comprehensive RCT in screening, surveillance, and diagnostic AI-assisted colonoscopies (ACCENDO-Colo study)” [Digestive and Liver Disease 57 (2025) 762-9]","authors":"Cristiano Spada , Daniele Salvi , Clarissa Ferrari , Cesare Hassan , Federico Barbaro , Nicoletta Belluardo , Leonardo Minelli Grazioli , Sebastian Manuel Milluzzo , Nicola Olivari , Luigi Giovanni Papparella , Silvia Pecere , Eugenia Vittoria Pesatori , Lucio Petruzziello , Stefania Piccirelli , Alessandro Quadarella , Paola Cesaro , Guido Costamagna","doi":"10.1016/j.dld.2025.02.029","DOIUrl":"10.1016/j.dld.2025.02.029","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Page 1361"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of adipose body composition using an artificial intelligence-based CT Protocol and its association with severe acute pancreatitis in hospitalized patients","authors":"Pedro Cortés ,&nbsp;Tyler A. Mistretta ,&nbsp;Brittany Jackson ,&nbsp;Caroline G. Olson ,&nbsp;Ahmed M. Al Qady ,&nbsp;Fernando F. Stancampiano ,&nbsp;Panagiotis Korfiatis ,&nbsp;Jason R. Klug ,&nbsp;Dana M. Harris ,&nbsp;J. Dan Echols ,&nbsp;Rickey E. Carter ,&nbsp;Baoan Ji ,&nbsp;Heather D. Hardway ,&nbsp;Michael B. Wallace ,&nbsp;Vivek Kumbhari ,&nbsp;Yan Bi","doi":"10.1016/j.dld.2025.02.010","DOIUrl":"10.1016/j.dld.2025.02.010","url":null,"abstract":"<div><h3>Background/Objectives</h3><div>The clinical utility of body composition in predicting the severity of acute pancreatitis (AP) remains unclear. We aimed to measure body composition using artificial intelligence (AI) to predict severe AP in hospitalized patients.</div></div><div><h3>Methods</h3><div>We performed a retrospective study of patients hospitalized with AP at three tertiary care centers in 2018. Patients with computer tomography (CT) imaging of the abdomen at admission were included. A fully automated and validated abdominal segmentation algorithm was used for body composition analysis. The primary outcome was severe AP, defined as having persistent single- or multi-organ failure as per the revised Atlanta classification.</div></div><div><h3>Results</h3><div>352 patients were included. Severe AP occurred in 35 patients (9.9%). In multivariable analysis, adjusting for male sex and first episode of AP, intermuscular adipose tissue (IMAT) was associated with severe AP, OR = 1.06 per 5 cm², p = 0.0207. Subcutaneous adipose tissue (SAT) area approached significance, OR = 1.05, p = 0.17. Neither visceral adipose tissue (VAT) nor skeletal muscle (SM) was associated with severe AP. In obese patients, a higher SM was associated with severe AP in unadjusted analysis (86.7 vs 75.1 and 70.3 cm² in moderate and mild, respectively p = 0.009).</div></div><div><h3>Conclusion</h3><div>In this multi-site retrospective study using AI to measure body composition, we found elevated IMAT to be associated with severe AP. Although SAT was non-significant for severe AP, it approached statistical significance. Neither VAT nor SM were significant. Further research in larger prospective studies may be beneficial.</div></div>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages 1218-1225"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of immune checkpoint inhibitor-related pancreatic injury with pancreatitis in patients with advanced malignancies","authors":"Takaya Suzuki ,&nbsp;Kazuyuki Mizuno ,&nbsp;Takafumi Yamamoto ,&nbsp;Takanori Ito ,&nbsp;Takuya Ishikawa ,&nbsp;Takashi Honda ,&nbsp;Shusuke Akamatsu ,&nbsp;Makoto Ishii ,&nbsp;Yuichi Ando ,&nbsp;Hiroki Kawashima","doi":"10.1016/j.dld.2025.02.027","DOIUrl":"10.1016/j.dld.2025.02.027","url":null,"abstract":"<div><h3>Background/Purpose</h3><div>Immune checkpoint inhibitor (ICIs) therapy can cause immune checkpoint inhibitor-related pancreatic injury (ICI-PI). This study aimed to elucidate the clinical characteristics of ICI-PI and explore treatment approaches.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed data from patients with malignancies treated with ICIs at Nagoya University Hospital between September 2014 and June 2023. ICI-PI and pancreatitis were identified and classified using the Common terminology Criteria for Adverse Events (CTCAE) ver.5.0, and the patients with ICI-PI with/without pancreatitis were analyzed.</div></div><div><h3>Results</h3><div>This study included data from 930 patients treated with ICIs. Of these, eight (0.85 %) and 10 (1.08 %) patients were diagnosed with ICI-PI without and with pancreatitis, respectively. Five of the 10 patients received standard pancreatitis treatment, while three received additional glucocorticoid therapy. One patient experienced recurrent pancreatitis and developed a pancreatic pseudocyst, which improved after high-dose glucocorticoid treatment. ICI rechallenge was pursued in five patients. Two patients received ICIs without an interval.</div></div><div><h3>Conclusions</h3><div>ICI-PI with pancreatitis is rare but has become more prevalent with the increasing use of ICIs. Future prospective multicenter studies are needed to confirm these findings and develop standardized diagnostic and treatment protocols.</div></div>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages 1230-1237"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bowel urgency in ulcerative colitis assessed from patients’ reports: Results of a telemonitoring programme","authors":"Edoardo Carboni ,&nbsp;Francesco Maria Stalla ,&nbsp;Marco Mendolaro ,&nbsp;Brayan Montoya Rodriguez ,&nbsp;Enrico Morello ,&nbsp;Davide Stradella ,&nbsp;Alessandro Lavagna ,&nbsp;Guido Pagana ,&nbsp;Rodolfo Rocca ,&nbsp;Marco Daperno","doi":"10.1016/j.dld.2025.03.019","DOIUrl":"10.1016/j.dld.2025.03.019","url":null,"abstract":"<div><h3>Background</h3><div>Bowel urgency is common in ulcerative colitis (UC), but which patients are affected, and how, has not been fully studied.</div></div><div><h3>Objective</h3><div>We explored associations of bowel urgency with the clinical characteristics of unselected outpatients.</div></div><div><h3>Design</h3><div>The study included adults with UC already enrolled in a telemonitoring programme using the IBD Tool platform. Between January 2021 and May 2024, patients repeatedly completed the Simple Clinical Colitis Activity Index (P-SCCAI) and Monitor at Home IBD – Ulcerative Colitis (MIAH-UC) questionnaires, plus other questionnaires. The submission of contemporary P-SCCAI and MIAH-UC scores was an “event” for analysis. The degree of bowel urgency was determined from responses to three P-SCCAI questions.</div></div><div><h3>Results</h3><div>Overall, 277 UC patients submitted 2768 events. No urgency was reported in 1813 events (66 %), while mild urgency in 538 (19 %), moderate urgency in 272 (10 %) and severe urgency in 145 (5 %). Variables positively associated with moderate-severe urgency at multivariate analysis (<em>P</em> &lt; 0.0001) were female sex, age at diagnosis, disease duration, extensive UC, higher disease activity (MIAH-UC score), higher disease-related disability (IBD Disk), and any medical treatment. In 1750 events, disease was in clinical remission (MIAH-UC ≤3.5), but moderate-severe urgency was reported in 67 (3.8 %) of them. At multivariate analysis, variables associated with urgency during UC remission were age at diagnosis, disease duration, IBD Disk score, any treatment, and female sex.</div></div><div><h3>Conclusion</h3><div>Bowel urgency affects UC patients’ lives and is associated with more severe disability, worse quality of life and higher depression scores. Moderate-severe urgency was reported in 1 in 25 events with UC in remission and increased the patients’ disease-related disability.</div></div>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages 1190-1196"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving screening participation: The need for socioeconomic considerations and psychological interventions in colorectal cancer programs","authors":"Chaopeng Zheng ,&nbsp;Chengfei Du ,&nbsp;Jianyu Lv","doi":"10.1016/j.dld.2025.02.005","DOIUrl":"10.1016/j.dld.2025.02.005","url":null,"abstract":"<div><div>This correspondence discusses Silva et al.'s study on colorectal cancer (CRC) screening adherence and preferences, highlighting its contributions to understanding screening education, method choices, and barriers. While acknowledging the study’s insights, we identify critical limitations, including insufficient consideration of socioeconomic disparities in screening access and participation. Lower socioeconomic groups often face barriers such as financial constraints, time limitations, and healthcare mistrust, which may skew adherence outcomes. Additionally, the study overlooks post-screening psychological impacts (e.g., anxiety from false positives) on long-term compliance. We propose integrating socioeconomic analyses, psychological interventions, and technological innovations (e.g., AI-driven tools for personalized reminders and counseling) to enhance screening equity and adherence. Future research should prioritize these dimensions to optimize CRC screening strategies globally.</div></div>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages 1331-1332"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonmedical switch of anti-TNF-α biosimilars has no major clinical, pharmacokinetic and psychological impact on patients with IBD - the SAFER Study","authors":"Giuseppe Privitera ,&nbsp;Lucia Monastero ,&nbsp;Elena Melita ,&nbsp;Elisa Schiavoni ,&nbsp;Daniele Napolitano ,&nbsp;Antonella Barini ,&nbsp;Angela Barini ,&nbsp;Barbara Tolusso ,&nbsp;Lucrezia Laterza ,&nbsp;Antonio Gasbarrini ,&nbsp;Franco Scaldaferri ,&nbsp;Daniela Pugliese ,&nbsp;Alessandro Armuzzi ,&nbsp;SAFER Study Group","doi":"10.1016/j.dld.2025.01.206","DOIUrl":"10.1016/j.dld.2025.01.206","url":null,"abstract":"<div><h3>Background</h3><div>Data on nonmedical switching from one anti-Tumor Necrosis Factor (TNF)-α biosimilar to another in inflammatory bowel disease (IBD) are relatively sparse. We aimed to study the effects of nonmedical switch from infliximab biosimilar CT-P13 to SB2 and from adalimumab biosimilar ABP 501 to SB5.</div></div><div><h3>Methods</h3><div>In this observational study, consecutive IBD patients receiving nonmedical switch were prospectively followed-up for 12 months. The primary outcome was treatment persistence; other outcomes included: secondary effectiveness outcomes, safety, immunogenicity, inflammatory makers levels and psychometric assessments.</div></div><div><h3>Results</h3><div>A total of 119 and 76 patients were enrolled in the SB2 and SB5 cohorts. Persistence on treatment at 12 months was 84.0 % in the SB2 cohort and 78.9 % in the SB5 cohort. No clinically meaningful changes in other secondary effectiveness outcomes were recorded. Rates of 0.38 and 0.63 adverse events of interest per 100 patient-years were observed in the SB2 and SB5 cohorts. The pharmacokinetics and immunogenicity of either drug were unaffected by nonmedical switch; similarly, levels of inflammatory cytokines remained largely unchanged. No changes in psychometric assessments were recorded.</div></div><div><h3>Conclusion</h3><div>Nonmedical switch of infliximab and adalimumab biosimilars does not significantly affect treatment effectiveness, safety and pharmacokinetics, nor does it have major psychological implications for patients.</div></div>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages 1171-1179"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic dysfunction-associated steatotic liver disease as a predictor of cognitive performance","authors":"Shicheng Zhao,&nbsp;Qinghua Zhang","doi":"10.1016/j.dld.2025.03.001","DOIUrl":"10.1016/j.dld.2025.03.001","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages 1355-1356"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}