Digestive and Liver Disease最新文献

{"title":"Author's Reply: ``Comment on \"The crackers challenge\": A reassuring low-dose gluten challenge in adults on gluten-free diet without proper diagnosis of coeliac disease.","authors":"Antonio Rispo, Carolina Ciacci","doi":"10.1016/j.dld.2025.02.018","DOIUrl":"https://doi.org/10.1016/j.dld.2025.02.018","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing the landscape of coeliac crisis in adult and paediatric populations: A systematic review and meta-analysis.","authors":"Arkadeep Dhali, Rick Maity, Hareesha Rishab Bharadwaj, Syed Hasham Ali, Muhammad Hamza Shah, David Surendran Sanders","doi":"10.1016/j.dld.2025.02.011","DOIUrl":"https://doi.org/10.1016/j.dld.2025.02.011","url":null,"abstract":"<p><strong>Background: </strong>Coeliac crisis (CC) is a rare, potentially life-threatening manifestation of coeliac disease (CD).</p><p><strong>Aims: </strong>To comprehensively explore the clinical aspects, management strategies, and outcomes related to CC in both adult and paediatric populations.</p><p><strong>Methods: </strong>We conducted a comprehensive literature search to identify studies eligible for inclusion up to 28 December 2024. The study protocol was registered in PROSPERO (CRD42024510682).</p><p><strong>Results: </strong>A total of 46 included articles and 195 patients were analyzed. The median age of presentation was 18 years (range: 8 months to 83 years), predominantly affecting the paediatric population. An overwhelming majority (180 patients, 92.8 %) had CC as their first presentation, whereas the others were previously diagnosed CD cases with poor adherence to gluten-free diet (GFD). Clinically, patients presented with diarrhoea (88.2 %), abdominal pain (72.8 %), vomiting (56.4 %), confusion and lethargy (11.3 %). Electrolyte derangements in the form of hypokalemia (89.7 %) and hyponatremia (64.1 %), along with metabolic acidosis (79.5 %) and hypoalbuminemia (76.9 %), reflected the severity of malabsorption. Treatment with GFD caused clinical improvement in 186 (95.4 %) patients and mostly favourable long-term outcomes.</p><p><strong>Conclusion: </strong>CC is a poorly understood, life-threatening complication of CD. Given its similarity with infectious conditions, clinicians require a high index of suspicion for recognizing CC to diagnose early and provide proper management.</p>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential candidate characteristics associated with increasing ALD and MASH among liver transplant listings in the US.","authors":"Ashwani K Singal, Winston Dunn, Robert Wong, Anand Kulkarni, Yong-Fang Kuo","doi":"10.1016/j.dld.2025.01.191","DOIUrl":"https://doi.org/10.1016/j.dld.2025.01.191","url":null,"abstract":"<p><strong>Background and aim: </strong>Alcohol-associated liver disease (ALD) and metabolic associated steatohepatitis (MASH) are leading indications for liver transplant (LT). Data are limited on their trends and association with candidate characteristics.</p><p><strong>Methods and results: </strong>UNOS database (2002-22) examined on proportion of ALD or of NASH etiology among LT listings comparing 2002-11 vs. 2012-22. Of 169,385 listings, 41,558 (24.5 %) and 21,789 (12.9 %) listed for ALD and MASH respectively. Proportion of ALD increased 2 folds between 2002-11 and 2012-22. Stratified multivariable logistic regression models showed age <35 yrs., females, blacks and Asians, non-diabetics, education below high school, Medicaid insurance, and MELD > 35 with highest increase in ALD. Candidates listed with ALD vs. others had lower 90-d waitlist mortality, SHR 0.85 [0.83-0.87]. Although, AH as listing diagnosis only contributed to 3.2 % of ALD candidates, this subtype of ALD was associated with increasing ALD trends among candidates <35 yrs. of age, with college or higher education, and MELD ≥35. The proportion of MASH increased 3 folds between 2002-11 and 2012-22. Stratified models showed age 35-64 yrs., males, blacks and Asians, diabetics, college or above education, Medicare insurance, and MELD < 25 with highest increase in MASH. Candidates listed with MASH vs. others had similar 90-d waitlist mortality, SHR 0.99 [0.97-1.03].</p><p><strong>Conclusions: </strong>MASH and ALD in LT listing increased, with differential increase based on candidate characteristics. These findings are relevant in organ allocation and designing public policies to control MASH and ALD.</p>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor agreement between biopsies and endoscopic submucosal dissection specimens of Esophageal and Gastric Epithelial Lesions in a western setting.","authors":"Elisa Cantú-Germano, Glòria Fernández-Esparrach, Alberto Herreros De Tejada, José Carlos Marín-Gabriel, Hugo Uchima, Felipe Ramos-Zabala, Eduardo Albéniz, José Santiago, Oscar Nogales, Enrique Rodríguez De Santiago, Joan B Gornals, Beatriz Peñas, Joaquín Rodríguez-Sánchez, Pedro Rosón, Unai Goikoetxea, Pablo Miranda, Sofía Parejo, Diego De Frutos, Liseth Rivero-Sánchez, Andrés Del Pozo, Álvaro Terán, Daniel Pérez, Pedro de María, José Díaz-Tasende, Oswaldo Ortiz","doi":"10.1016/j.dld.2025.02.025","DOIUrl":"https://doi.org/10.1016/j.dld.2025.02.025","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic forceps biopsy is the primary method for obtaining mucosal tissues, but can lead to false negatives.</p><p><strong>Aims: </strong>To assess the agreement between endoscopic biopsies and submucosal dissection specimens in esophageal and gastric epithelial lesions and to identify factors associated.</p><p><strong>Methods: </strong>Cross-sectional study using data from the Spanish national multicenter endoscopic submucosal dissection register. Patients, lesions and technical characteristics were prospectively collected. Prognostic factors for discrepancies were analyzed.</p><p><strong>Results: </strong>604 endoscopic submucosal dissection with previous biopsies were performed between January 2016 and December 2023 across 32 centers. 48.7% presented disagreement between biopsies and endoscopic submucosal dissection; specifically, 40.4% were underestimated by endoscopic biopsy. Carcinoma was detected in 270 endoscopic submucosal dissection specimens, with 54.8% not suspected on the initial biopsy. The carcinomas already diagnosed with the biopsy presented more submucosal and lymphovascular invasion. Notably, a larger lesion (≥ 22 mm) was a significant predictor for histological upstaging.</p><p><strong>Conclusions: </strong>The high rate of disagreement between endoscopic forceps biopsy and endoscopic submucosal dissection highlights biopsies limitations in accurately diagnosing esophageal and gastric epithelial lesions. In this setting, endoscopic submucosal dissection should be used not only as a treatment option, but also as a valuable diagnostic tool.</p>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic dysfunction-associated steatotic liver disease as a predictor of cognitive performance.","authors":"Shicheng Zhao, Qinghua Zhang","doi":"10.1016/j.dld.2025.03.001","DOIUrl":"https://doi.org/10.1016/j.dld.2025.03.001","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of recurrent pancreatitis was diagnosed as intraductal papillary mucinous neoplasm of the pancreas through MRCP and EUS.","authors":"Yu-Ling Xiong, Chao Peng, Yuan-Lin Zhang, Yue Tian","doi":"10.1016/j.dld.2025.02.013","DOIUrl":"https://doi.org/10.1016/j.dld.2025.02.013","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's reply: \"Nutritional evaluations and post-treatment strategies in Achalasia\".","authors":"Marcella Pesce, Sara Rurgo, Giovanni Aprea, Giuseppe Esposito, Eleonora Efficie, Giovanni Sarnelli","doi":"10.1016/j.dld.2025.02.017","DOIUrl":"https://doi.org/10.1016/j.dld.2025.02.017","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Intrahepatic cholangiocarcinoma with FGFR alterations: A series of Chinese cases with an emphasis on their clinicopathologic and genetic features\".","authors":"Preeti Advani, Santosh Kumar","doi":"10.1016/j.dld.2025.02.023","DOIUrl":"https://doi.org/10.1016/j.dld.2025.02.023","url":null,"abstract":"<p><p><Dummy abstract>.</p>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ustekinumab and Vedolizumab: A step forward in managing complex perianal fistulas in Crohn's disease.","authors":"Rai Muhammad Umar Khan, Muhammad Umar Ahsan, Abdul Rehman, Muhammad Hamza Amir","doi":"10.1016/j.dld.2025.02.026","DOIUrl":"https://doi.org/10.1016/j.dld.2025.02.026","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of gallbladder cancer in 2022 and predictions to 2042.","authors":"Hanfeng Guo, Decai Zhang, Zhaoqi Li, Shaojun Liu, Rui Wang","doi":"10.1016/j.dld.2025.02.007","DOIUrl":"https://doi.org/10.1016/j.dld.2025.02.007","url":null,"abstract":"<p><strong>Background & aims: </strong>This study aims to provide updated estimate on the global burden of Gallbladder cancer (GBC) in 2022 and to predict the trends through the year 2042.</p><p><strong>Methods: </strong>Data were extracted from GLOBOCAN 2022 database. Incidence and mortality rates were calculated by sex, country, world region and Human Development Index (HDI). Trends up to the year 2042 were predicted based on global demographic projections by HDI.</p><p><strong>Results: </strong>Worldwide, there were 122,469 new GBC cases and 89,045 deaths identified in 2022. While the highest absolute number was observed in South Central Asia and Eastern Asia, particularly India and China, countries in South America, particularly Bolivia, showed the highest age-standardised rate. Medium HDI countries showed more than double the incidence and mortality rates compared to low HDI countries. Over half of GBC cases and deaths occurred in individuals aged 50-74 years. Predictions indicate a 65.3 % increase in new cases and a 67.6 % increase in deaths by 2042, with High HDI countries and Low HDI countries experiencing the largest absolute and percentage increases, respectively.</p><p><strong>Conclusions: </strong>The global burden of GBC is substantial, especially concentrated in South Central Asia, Eastern Asia and South America. With significant increase of burden over the next 20 years, there is an urgent need for effective cancer control strategies in regions exhibiting great GBC burden.</p>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}