Digestive and Liver Disease最新文献

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IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-04-25 DOI: 10.1016/S1590-8658(25)00717-0

引用次数: 0

Neurogastroenterology: The Cinderella among the ecological niches of gastroenterology?

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-04-07 DOI: 10.1016/j.dld.2025.03.011

Gabrio Bassotti, Christian Lambiase, Francesca Galeazzi, Massimo Bellini

{"title":"Neurogastroenterology: The Cinderella among the ecological niches of gastroenterology?","authors":"Gabrio Bassotti, Christian Lambiase, Francesca Galeazzi, Massimo Bellini","doi":"10.1016/j.dld.2025.03.011","DOIUrl":"https://doi.org/10.1016/j.dld.2025.03.011","url":null,"abstract":"Neurogastroenterology (NGE) refers to a specific sub-specialty of gastroenterology that investigates the pathophysiology, diagnostics and therapeutic approaches to the \"disorders of gut-brain interaction\" (DGBIs), frequently encountered in clinical practice and often associated with poor quality of life and high healthcare costs. Two recent national surveys, focused on common DGBIs, highlighted two main issues. Despite the high incidence of DGBIs there is a lack of awareness and appropriate training to effectively treat these conditions and a lack of specific referral centers in each region. Indeed, specific training and a multidisciplinary approach are required to properly manage these patients, but these are not always available. As a result, NGE lacks attractiveness for many young gastroenterologists. We believe that NGE has great potential to emerge among the various sub-branches of gastroenterology. However, its growth is limited by lack of specific training, knowledge, accessibility, diagnostic capabilities, multidisciplinary integration, and financial investments in research. To bridge this gap, it would be helpful to overcome these limits through an increase in specific training concerning DGBIs among students, residents, physicians and general practitioners. This, coupled with improved access to advanced diagnostic tests, innovative therapies, and a better multidisciplinary approach, could help expand the knowledge in this still niche area and achieve better treatment outcomes for patients.","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Effectiveness and safety of intravenous lidocaine in the analgesic management of acute pancreatitis: A retrospective study.

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-04-05 DOI: 10.1016/j.dld.2025.03.025

Louise Ghilardi, Paul Tarpin, Ottilie Trocheris-Fumery, Franck Brazier, Sami Hakim, Mathurin Fumery, Clara Yzet

{"title":"Effectiveness and safety of intravenous lidocaine in the analgesic management of acute pancreatitis: A retrospective study.","authors":"Louise Ghilardi, Paul Tarpin, Ottilie Trocheris-Fumery, Franck Brazier, Sami Hakim, Mathurin Fumery, Clara Yzet","doi":"10.1016/j.dld.2025.03.025","DOIUrl":"https://doi.org/10.1016/j.dld.2025.03.025","url":null,"abstract":"Introduction: Intravenous (IV) lidocaine has both analgesic and anti-inflammatory effects. Its use has never been evaluated for analgesia for patients with acute pancreatitis (AP). We aimed to evaluate the effectiveness and safety of IV lidocaine in the management of AP resistant to weak opioids.Materials and methods: We conducted a retrospective, monocentric study between January 2015 and December 2021 that included consecutive patients with (i) AP and (ii) pain resistant to non-opioid and weak-opioid analgesia (tramadol) (iii) treated with IV lidocaine. The effectiveness of the treatment was defined as a decrease in the numerical pain scale (NPS) of at least one point from the initiation of lidocaine and the absence of a need for opioid analgesia (morphine or oxycodone).Results: In total, 154 patients were included. The patients were predominantly male (69 %), with a median age of 48.5 years [37.0; 58.0]. The main etiology of AP was alcoholic (36 %), and necrotizing AP was observed for 69 % of patients. Lidocaine was continuously administered at a dose of 2 g/24 h. Lidocaine treatment was effective for 88.3 % of patients (136/154). The median score on the NPS before the administration of lidocaine was 8.0 [7.0; 9.0] and significantly decreased to 5.8 [4.5; 7.0] by day 1 (p < 0.001). No factors were associated with lidocaine failure. Two (1.3 %) patients experienced lidocaine-related adverse events, including skin rash and dysgeusia, and no severe adverse events were observed.Conclusion: IV lidocaine administration appears to be effective and safe for patients with AP with pain resistant to weak-opioid analgesia. Further prospective studies are needed to confirm these results.","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptation of the European Crohn's Colitis Organisation quality of care standards to Italy: The Italian Group for the study of inflammatory bowel disease consensus.

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-04-05 DOI: 10.1016/j.dld.2025.03.010

Gionata Fiorino, Flavio Andrea Caprioli, Sara Onali, Fabio Salvatore Macaluso, Cristina Bezzio, Franco Armelao, Alessandro Armuzzi, Monia Baldoni, Giorgia Bodini, Fabiana Castiglione, Marco Daperno, Stefano Festa, Federica Furfaro, Paolo Gionchetti, Salvatore Leone, Gaetano Luglio, Monica Milla, Giammarco Mocci, Daniele Napolitano, Ambrogio Orlando, Enrica Previtali, Daniela Pugliese, Sara Renna, Antonio Rispo, Simone Saibeni, Gianluca Sampietro, Edoardo Savarino, Franco Scaldaferri, Rocco Spagnuolo, Angela Variola, Anna Viola, Angelo Viscido, Giovanna Vitale, Debora Zaetta, Fabiana Zingone, Agostino Colli, Massimo Claudio Fantini

{"title":"Adaptation of the European Crohn's Colitis Organisation quality of care standards to Italy: The Italian Group for the study of inflammatory bowel disease consensus.","authors":"Gionata Fiorino, Flavio Andrea Caprioli, Sara Onali, Fabio Salvatore Macaluso, Cristina Bezzio, Franco Armelao, Alessandro Armuzzi, Monia Baldoni, Giorgia Bodini, Fabiana Castiglione, Marco Daperno, Stefano Festa, Federica Furfaro, Paolo Gionchetti, Salvatore Leone, Gaetano Luglio, Monica Milla, Giammarco Mocci, Daniele Napolitano, Ambrogio Orlando, Enrica Previtali, Daniela Pugliese, Sara Renna, Antonio Rispo, Simone Saibeni, Gianluca Sampietro, Edoardo Savarino, Franco Scaldaferri, Rocco Spagnuolo, Angela Variola, Anna Viola, Angelo Viscido, Giovanna Vitale, Debora Zaetta, Fabiana Zingone, Agostino Colli, Massimo Claudio Fantini","doi":"10.1016/j.dld.2025.03.010","DOIUrl":"https://doi.org/10.1016/j.dld.2025.03.010","url":null,"abstract":"Introduction: Inflammatory bowel disease (IBD) poses significant clinical challenges due to its chronic, disabling nature. Despite established guidelines, care standards remain inconsistent globally. In 2020, the European Crohn's Colitis Organisation (ECCO) developed quality-of-care standards. The Italian Group for the Study of IBD (IG-IBD) aimed to adapt those recommendations to Italy.Methods: A 42-member interdisciplinary panel used a Delphi consensus to evaluate and modify ECCO statements and levels of importance, incorporating patient representatives and regional experts. Those statements were revised, some missing statements were added, and a two-round voting session was held among participants. Agreement ≥80 % was needed to approve a statement.Results: From 101 ECCO statements, 112 tailored criteria were developed. In comparison to the ECCO statements, 80 were confirmed with the same level of importance, 9 were confirmed with different levels of importance, 9 points were merged in a broader statement, 3 points were dropped out during the two voting rounds, and 12 were added as new points.Conclusion: The adapted standards provide a framework for standardizing IBD care in Italy. This model might help other countries in aligning with ECCO standards.","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Author's Reply: "From Data to practice: The necessity of optimizing ustekinumab treatment strategies".

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-04-05 DOI: 10.1016/j.dld.2025.03.020

Zhaopeng Huang, Lang Lin, Kang Chao, Jian Tang

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Comments on "Establishing a nomogram for predicting necrotizing enterocolitis in premature infants: A retrospective multicenter cohort study".

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-04-05 DOI: 10.1016/j.dld.2025.03.016

Muhammad Hamza Butt, Zain Ul Abideen, Muhammad Adeel Ashraf, Muhammad Jan

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Optimization of ustekinumab dosing in Crohn's disease: Addressing variability in treatment strategies and dosing evaluation.

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-04-02 DOI: 10.1016/j.dld.2025.03.005

Shuyuan Wang, Lingkang Wu

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Author's Reply: "Comment on: Aetiology-specific inflammation patterns in patients and rat models of compensated cirrhosis".

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-04-02 DOI: 10.1016/j.dld.2025.03.018

Benedikt Silvester Hofer, Thomas Reiberger

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BOC.01.1 THE PODIUM STUDY: A THREE-ARM COMPARISON OF TARGET THERAPIES AFTER ANTI-TNFα IN ULCERATIVE COLITIS – AN INTERIM ANALYSIS

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-04-01 DOI: 10.1016/S1590-8658(25)00334-2

G. Privitera, C. Bezzio, E. Savarino, D. Pugliese, D. Noviello, I. Rodriguez–Lago, M. Barreiro De Acosta, S. Onali, M. Fantini, K. Karmiris, H. Yanai, A. Gutierrez–Casbas, L. Pastorelli, M. Chaparro, Y. Zabana, U. Kopylov, A. Armuzzi

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OC.04.9 OPTIMIZING CA19.9 ROLE IN BD-IPMN SURVEILLANCE: ENHANCED VALUE OF NEW THRESHOLDS

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-04-01 DOI: 10.1016/S1590-8658(25)00417-7

S. Kayali, E. Marabotto, S. Dibitetto, A. Busatto, S. Chierici, S. Caprioli, A.P. Luzzi, S. Fantasia, F. Gaiani, E. Savarino, L. Laghi, C.G. De Angelis, E.G. Giannini

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