Digestive and Liver Disease最新文献

Procoagulant imbalance is associated with hepatic and vascular complications in patients with MASLD and diabetes. Key role of factor VIII. 促凝剂失衡与MASLD和糖尿病患者的肝脏和血管并发症有关。因子VIII的关键作用。

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-06-19 DOI: 10.1016/j.dld.2025.05.011

Rosa Lombardi, Roberta Forlano, Gabriele Maffi, Annalisa Cespiati, Felice Cinque, Daniela Bignamini, Paola Dongiovanni, Paolo Francione, Giordano Sigon, Jian Huang, Pinelopi Manousou, Flora Peyvandi, Armando Tripodi, Anna Ludovica Fracanzani

{"title":"Procoagulant imbalance is associated with hepatic and vascular complications in patients with MASLD and diabetes. Key role of factor VIII.","authors":"Rosa Lombardi, Roberta Forlano, Gabriele Maffi, Annalisa Cespiati, Felice Cinque, Daniela Bignamini, Paola Dongiovanni, Paolo Francione, Giordano Sigon, Jian Huang, Pinelopi Manousou, Flora Peyvandi, Armando Tripodi, Anna Ludovica Fracanzani","doi":"10.1016/j.dld.2025.05.011","DOIUrl":"https://doi.org/10.1016/j.dld.2025.05.011","url":null,"abstract":"Background: Metabolic-dysfunction associated steatotic liver disease (MASLD) promotes fibrosis and vascular complications, especially if associated with type 2 diabetes.Aim: To evaluate the association between procoagulant imbalance, hepatic and vascular damage.Methods: 185 diabetic MASLD patients (62±11ys, 59% males) underwent assessment of of FibroScan® (LSM≥8 kPa), macro- and micro-vascular complications. In 96 patient PNPLA3 genotyping, coagulation factors (i.e., factor (F)VIII, protein C (PC), antithrombin and thrombin generation assay were also assessed.Results: The endogenous-thrombin-potential [ETP (with/without thrombomodulin), called ETP-TM ratio)] and the FVIII/PC ratio increased from tertile 1 to 3 (from 0.65±0.15 to 0.92±0.41, p<0.001), as well as FVIII/PC (from 1.23±0.41 to 1.57±0.77, p=0.003) and were independently associated with increasing LSM values (b-coefficient, 6.11; CI95% 3.59-8.64; b-coefficient, 4.80; CI95% 2.28-7.32). Antithrombin and PC correlated to LSM≥ 8kpa (OR 0.92, CI95% 0.88-0.97; OR 0.97, CI95% 0.94-0.99). When added to the model, PNPLA3 modified some of these associations, but remained independently associated with peak-thrombin ratio (b-coefficient 0.063; CI95% 0.001-0.126) and antithrombin (b-coefficient -6.14; CI95% -11.82 -0.46). FVIII and fibrinogen were independently associated with micro-vascular complications.Conclusion: MASLD diabetic patients display a procoagulant profile, which is independently associated with the severity of hepatic fibrosis and micro-vascular complications. PNPLA3 determine a possible procoagulant profile associated with fibrosis, but further studies are warranted to elucidate this mechanism.","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the clinical spectrum of Porto-Sinusoidal Vascular Disorder (PSVD) with chronic HBV infection: insights from a retrospective Chinese cohort. 揭示慢性HBV感染的门窦血管病变（PSVD）的临床谱：来自中国回顾性队列的见解

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-06-19 DOI: 10.1016/j.dld.2025.05.028

Jinyu Wang, Tiantian Hu, Xiangyu Chi, Hao Wang, Yuqi Liu, Wentao Xie, Jiajia Han, Qian Qiu, Kangkang Yu, Chong Huang, Jubo Zhang, Qingchun Fu, Qi Miao, Zunguo Du, Haoxiang Zhu, Jiming Zhang

{"title":"Unveiling the clinical spectrum of Porto-Sinusoidal Vascular Disorder (PSVD) with chronic HBV infection: insights from a retrospective Chinese cohort.","authors":"Jinyu Wang, Tiantian Hu, Xiangyu Chi, Hao Wang, Yuqi Liu, Wentao Xie, Jiajia Han, Qian Qiu, Kangkang Yu, Chong Huang, Jubo Zhang, Qingchun Fu, Qi Miao, Zunguo Du, Haoxiang Zhu, Jiming Zhang","doi":"10.1016/j.dld.2025.05.028","DOIUrl":"https://doi.org/10.1016/j.dld.2025.05.028","url":null,"abstract":"Background: Porto-Sinusoidal Vascular Disorder (PSVD) is a non-cirrhotic vascular liver disease associated with or without signs of portal hypertension (PH). Chronic hepatitis B virus (HBV) infection frequently coexists with PSVD, but its clinical impact remains unclear. This study investigates the clinical and histopathological features of PSVD with and without chronic HBV infection.Methods: Liver biopsy records of 2007 patients from Huashan Hospital, Shanghai, China (2017-2024), were reviewed, identifying 73 cases of PSVD, of which 31 had concurrent chronic HBV infection. Clinical, histological, and imaging data were analyzed from diagnosis to follow-up. A matched analysis by age and gender compared PSVD patients with and without HBV infection.Results: HBV prevalence among PSVD patients (43.1%) was significantly higher than in the general population (6.1%, < 0.0001). HBV-positive patients had lower nodular regenerative hyperplasia (p = 0.008) and higher nonzonal sinusoidal dilation (p = 0.068). The HBV-negative group had higher BMI and more severe PH manifestations, including varices and portosystemic collaterals (p < 0.0001). Liver enzyme levels differed significantly between groups (p < 0.05).Conclusion: HBV-infected PSVD patients exhibit milder PH and distinct histopathological features. Routine PSVD screening is recommended in long-term HBV management.","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibrinogen and coagulation factor VIII levels as indicators of disease severity in Hyperlipidemic Acute Pancreatitis: A comparison with biliary etiology. 纤维蛋白原和凝血因子VIII水平作为高脂血症急性胰腺炎疾病严重程度的指标：与胆道病因的比较

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-06-17 DOI: 10.1016/j.dld.2025.03.008

Yanqi Wang, Ning Yang, Zhen Liu, Xinjuan Liu, Guangyong Sun, Dong Zhang, Yanwei Hu, Gaowei Fan, Lixin Yang, Jianyu Hao, Donglei Zhang, Guang Li

{"title":"Fibrinogen and coagulation factor VIII levels as indicators of disease severity in Hyperlipidemic Acute Pancreatitis: A comparison with biliary etiology.","authors":"Yanqi Wang, Ning Yang, Zhen Liu, Xinjuan Liu, Guangyong Sun, Dong Zhang, Yanwei Hu, Gaowei Fan, Lixin Yang, Jianyu Hao, Donglei Zhang, Guang Li","doi":"10.1016/j.dld.2025.03.008","DOIUrl":"https://doi.org/10.1016/j.dld.2025.03.008","url":null,"abstract":"Background and aims: Research on the variance of coagulation factors in acute pancreatitis (AP) with different etiologies remains limited. This study aims to explore the coagulation profiles in patients with biliary AP (BAP) and hyperlipidemic AP (HLAP), focusing on their role in predicting disease severity.Methods: A single-center retrospective cohort study was conducted on patients diagnosed with BAP or HLAP at Beijing Chaoyang Hospital from January 2020 to December 2021.Results: A total of 112 patients were enrolled, including 43 with BAP and 69 with HLAP. Among these, 82 had mild acute pancreatitis (MAP) and 30 had moderately severe acute pancreatitis (MSAP). HLAP patients had significantly higher levels of fibrinogen, protein C, coagulation factors II and X compared to BAP patients. Receiver Operating Characteristic (ROC) analysis identified fibrinogen, with an area under the curve (AUC) of 0.721, and coagulation factor VIII(FVIII), with an AUC of 0.700, as significant predictors of disease severity in HLAP. Correlation analysis showed significant associations between fibrinogen and FVIII with Ranson and computed tomography severity index (CTSI) scores, as well as positive correlations with cholesterol and triglyceride levels in these patients.Conclusion: Compared with BAP, HLAP patients exhibit significant coagulation disorders from the mild stages. Fibrinogen and FVIII may be useful biomarkers for assessing HLAP severity.","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feasibility of ESD after transanal microsurgery. 经肛门显微手术后ESD的可行性。

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-06-17 DOI: 10.1016/j.dld.2025.05.025

Mariam Fatima, Shanzay Jan

引用次数: 0

The current success of precision oncology relies on precision diagnostics: how quality and quantity of endoscopic biopsies impact cancer patient outcome. 目前精确肿瘤学的成功依赖于精确诊断：内窥镜活检的质量和数量如何影响癌症患者的预后。

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-06-17 DOI: 10.1016/j.dld.2025.05.026

Matteo Fassan, Federica Grillo, Paola Parente, Luca Mastracci, Alessandro Vanoli, Edoardo V Savarino, Cristiano Spada, Fabio Farinati, Cesare Hassan, Renato Cannizzaro

引用次数: 0

Pemphigus Vulgaris: A rare cause of esophageal bleeding and stricture. 寻常型天疱疮：一种罕见的食管出血和狭窄的原因。

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-06-17 DOI: 10.1016/j.dld.2025.06.001

Chun-Yan Zhang, Ya-Qi Gao, Yun Cui, Dan-Feng Sun

引用次数: 0

IBD impact on quality of life and perception of disease activity in Italian patients and physicians: An IBD-PODCAST study sub analysis. IBD对意大利患者和医生生活质量和疾病活动感知的影响：一项IBD- podcast研究亚分析

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-06-13 DOI: 10.1016/j.dld.2025.05.006

Edoardo Vincenzo Savarino, Flavio Andrea Caprioli, Davide Giuseppe Ribaldone, Sara Onali, Angela Variola, Giovanni Monteleone, Anna Viola, Simone Saibeni, Fabiana Castiglione, Sabrina Monaco, Ambrogio Orlando, Mariabeatrice Principi, Maria Emanuela Di Stefano, Maria Guerra, Linda Ceccarelli, Giammarco Mocci, Davide Boy, Maria Chiara Cartei, Lorenzo Gemignani, Giuliana Gualberti, Francesca Marando, Ferdinando D'Amico

{"title":"IBD impact on quality of life and perception of disease activity in Italian patients and physicians: An IBD-PODCAST study sub analysis.","authors":"Edoardo Vincenzo Savarino, Flavio Andrea Caprioli, Davide Giuseppe Ribaldone, Sara Onali, Angela Variola, Giovanni Monteleone, Anna Viola, Simone Saibeni, Fabiana Castiglione, Sabrina Monaco, Ambrogio Orlando, Mariabeatrice Principi, Maria Emanuela Di Stefano, Maria Guerra, Linda Ceccarelli, Giammarco Mocci, Davide Boy, Maria Chiara Cartei, Lorenzo Gemignani, Giuliana Gualberti, Francesca Marando, Ferdinando D'Amico","doi":"10.1016/j.dld.2025.05.006","DOIUrl":"https://doi.org/10.1016/j.dld.2025.05.006","url":null,"abstract":"Background: IBD-PODCAST was a global real-world study to assess suboptimal disease control (SDC) in patients with Crohn's disease (CD) and ulcerative colitis (UC) using STRIDE-II criteria.Aim: To evaluate quality of life (QoL), disease characteristics and control in patients with SDC, comparing perspectives of patients and healthcare providers (HCPs) in the Italian subpopulation.Methods: IBD-PODCAST-Italy enrolled adult outpatients from 17 centers. The study used a combination of retrospective chart reviews and cross-sectional assessments to gather data on treatment, patient-reported outcomes (QoL, fatigue, work productivity) and clinical activity. Patient and HCP perceptions of disease control based on STRIDE-II criteria, which included clinical, laboratory and endoscopic findings were also assessed.Results: SDC was identified in 53.4 % (95 % CI: 44-62.8 %) of CD and 49.0 % (95 % CI: 39.1-59.0 %) of UC patients. Those with SDC had lower short IBD questionnaire scores (45.9 ± 12.0) compared to optimal disease control (ODC) patients (57.4 ± 9.9). Extraintestinal manifestations and bowel urgency were more frequent in SDC patients. Physician-perceived SDC (14.5 %) was higher than patient-perceived SDC (8.8 %) and agreement between patient and HCP assessments was low.Conclusions: Patients with SDC experienced impaired QoL. The discrepancy between patient and physician perceptions of disease control, alongside objective measures, highlights the need for further research to optimize care and improve outcomes.","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Association of smoking with progression from low-risk to high-risk intraductal papillary mucinous neoplasms and pancreatic cancer". 对“吸烟与导管内乳头状粘液瘤和胰腺癌从低危向高危发展的关系”的评论。

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-06-13 DOI: 10.1016/j.dld.2025.05.012

Aimen Ilyas, Anashara Butt

引用次数: 0

Risk factors for angiodysplasias of the upper and lower gastrointestinal tract. 上、下胃肠道血管发育不良的危险因素。

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-06-13 DOI: 10.1016/j.dld.2025.02.028

Qing Li, Jian Chen, Ximin Jiang

引用次数: 0

Unveiling the role of HIV in HCC recurrence after liver transplantation: An Italian perspective. 揭示HIV在肝移植后HCC复发中的作用：意大利的观点。