Digestive and Liver Disease最新文献_第10页

Comment on: Aetiology-specific inflammation patterns in patients and rat models of compensated cirrhosis 评论：代偿性肝硬化患者和大鼠模型的病因特异性炎症模式。

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-06-01 DOI: 10.1016/j.dld.2025.03.003

Ali Khaledi , Amirmahdi Deylami , Hossein Zare

引用次数: 0

A two-transcript classifier model for assessing disease activity in patients with ulcerative colitis: A discovery and validation study 评估溃疡性结肠炎患者疾病活动性的双转录本分类模型：一项发现和验证研究。

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-06-01 DOI: 10.1016/j.dld.2025.02.015

Huipeng Zhang , Nannan Xu , Gang Huang , Guanwei Bi , Jing Zhang , Xiaohan Zhao , Xinrui Guo , Miaolin Lei , Gang Wang , Yanbo Yu

{"title":"A two-transcript classifier model for assessing disease activity in patients with ulcerative colitis: A discovery and validation study","authors":"Huipeng Zhang , Nannan Xu , Gang Huang , Guanwei Bi , Jing Zhang , Xiaohan Zhao , Xinrui Guo , Miaolin Lei , Gang Wang , Yanbo Yu","doi":"10.1016/j.dld.2025.02.015","DOIUrl":"10.1016/j.dld.2025.02.015","url":null,"abstract":"<div><h3>Aims</h3><div>We aimed to develop and validate classifier models to assess disease activity in UC patients by evaluating potential classifier genes expression levels.</div></div><div><h3>Methods</h3><div>The study comprised UC and healthy control participants undergoing colonoscopy. We screened candidate genes (<em>TGF-β1, CEACAM1</em> and <em>CD177</em>) using Differentially Expressed Genes. We compared candidate genes expression levels with the validated UC scores. UC patients were subsequently randomly assigned (1:1) to the discovery or validation groups. A logistic regression model integrating candidate genes expression was developed using discovery group and assessed its predictive effect in validation group.</div></div><div><h3>Results</h3><div>Three candidate genes were differentially associated with UC disease activity. <em>TGF-β1</em> and <em>CD177</em> were used to construct the logistic regression model. The two-transcript classifier model had an area under the receiver operating curve (AUC) of 0.938 (95 % confidence interval [CI]=0.888–0.987) in discriminating between remission and active UC and an AUC of 0.919 (0.862–0.977) in discriminating between remission-mild and moderate-severe activity in UC.</div></div><div><h3>Conclusions</h3><div><em>TGF-β1</em> and <em>CD177</em> transcript levels, measured by RT-PCR, are robust classifiers for assessing disease activity in UC patients, and the measurement of these transcript levels appears to be an effective method of monitoring condition of UC patients and predicting treatment effectiveness over time.</div></div>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages 1180-1189"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author's reply: “Improving screening participation: The need for socioeconomic considerations and psychological interventions in colorectal cancer programs” 作者回复：“提高筛查参与度：结肠直肠癌项目中社会经济因素和心理干预的必要性”。

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-06-01 DOI: 10.1016/j.dld.2025.02.016

João Carlos Silva , Mário Dinis-Ribeiro , Diogo Libânio

引用次数: 0

Accuracy of superb microvascular imaging (SMI) in predicting endoscopic Crohn's disease activity 高超微血管成像（SMI）预测内镜下克罗恩病活动性的准确性。

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-06-01 DOI: 10.1016/j.dld.2025.02.024

Sophie Haberkamp, David Fischmann, Judith Wilde, Sarah Fischer, Marcel Vetter, Laurin Wolf, Francesco Vitali, Daniel Klett, Raja Atreya, Maximilian Waldner, Markus F. Neurath, Deike Strobel , Sebastian Zundler

{"title":"Accuracy of superb microvascular imaging (SMI) in predicting endoscopic Crohn's disease activity","authors":"Sophie Haberkamp, David Fischmann, Judith Wilde, Sarah Fischer, Marcel Vetter, Laurin Wolf, Francesco Vitali, Daniel Klett, Raja Atreya, Maximilian Waldner, Markus F. Neurath, Deike Strobel , Sebastian Zundler","doi":"10.1016/j.dld.2025.02.024","DOIUrl":"10.1016/j.dld.2025.02.024","url":null,"abstract":"<div><h3>Background</h3><div>Treat-to-target therapy in inflammatory bowel disease requires longitudinal assessment of disease activity and intestinal ultrasound (IUS) is a promising non-invasive and cheap technology to provide objective read-outs. Vascularization of the bowel wall is one key parameter on IUS. While this is conventionally done with Color doppler imaging, it is currently unclear whether microvascular flow imaging techniques might improve the diagnostic performance of IUS.</div></div><div><h3>Aims</h3><div>To explore the utility of superb microvascular imaging (SMI) for assessing disease activity in Crohn's disease (CD).</div></div><div><h3>Methods</h3><div>We performed a prospective single-center cross-sectional cohort study including 56 patients with CD. IUS was performed on the terminal ileum or sigmoid colon within 30 days of colonoscopy and the International Bowel Ultrasound (IBUS) group Segmental Activity Score (SAS) as well as SMI signals were determined and correlated to established endoscopic, clinical and biochemical read-outs of disease activity.</div></div><div><h3>Results</h3><div>SMI scores showed superior correlation to endoscopic disease activity than Doppler imaging scores. While this did not further improve the diagnostic performance of the composite IBUS-SAS, SMI scores as a single parameter excellently predicted segmental endoscopic disease activity.</div></div><div><h3>Conclusions</h3><div>SMI is a highly promising tool to improve or simplify the non-invasive assessment of disease activity in CD that should further be investigated in real-world and multi-center trials.</div></div>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages 1273-1279"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distribution of epithelial endoplasmic reticulum stress-related proteins in adult and pediatric Crohn’s disease: Association with inflammation and fibrosis 上皮内质网应激相关蛋白在成人和儿童克罗恩病中的分布：与炎症和纤维化的关系

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-06-01 DOI: 10.1016/j.dld.2025.04.015

E. Bequet , C. Salée , N. Bletard , C. Massot , F. Fonzé , H. Sarter , D. Ley , S. Colinet , P. Delvenne , E. Louis , S. Vieujean , M-A. Meuwis

{"title":"Distribution of epithelial endoplasmic reticulum stress-related proteins in adult and pediatric Crohn’s disease: Association with inflammation and fibrosis","authors":"E. Bequet , C. Salée , N. Bletard , C. Massot , F. Fonzé , H. Sarter , D. Ley , S. Colinet , P. Delvenne , E. Louis , S. Vieujean , M-A. Meuwis","doi":"10.1016/j.dld.2025.04.015","DOIUrl":"10.1016/j.dld.2025.04.015","url":null,"abstract":"<div><h3>Background/Aims</h3><div>Intestinal strictures in Crohn's disease (CD), driven by fibrosis remain challenging to treat. Current treatments focus on inflammation, but are less effective against fibrosis. Endoplasmic Reticulum Stress-Related Proteins, including Protein disulfide isomerases (PDIs), may contribute to fibrosis; their roles in CD remain unclear. This study investigated the distribution of AGR2, BiP, PDIA6, ERP44 in intestinal epithelium and their association with fibrosis and inflammation in pediatric and adult CD.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 224 patients (2009–2023). CD patients with and without strictures, non IBD controls, and ulcerative colitis patients were compared. Immunohistochemistry assessed Endoplasmic Reticulum Stress-Related protein distribution in epithelium. H&E and Masson's trichrome staining evaluated inflammation and fibrosis. Correlations between protein distribution, inflammation and fibrosis were examined.</div></div><div><h3>Results</h3><div>AGR2 and BiP were increased in fibro-inflammatory and fibrotic intestinal epithelial tissues, especially in pediatric-onset CD. ERP44 was associated with fibrosis exclusively in pediatric CD. PDIA6 was upregulated in CD compared to non IBD, without fibrosis association. Distinct protein distribution patterns were observed between pediatric and adult CD, and between ileum and colon.</div></div><div><h3>Conclusions</h3><div>Distinct patterns of AGR2, BiP, PDIA6, and ERP44 in fibrotic and inflammatory intestinal tissues suggest potential roles in CD-associated fibrosis, warranting exploration as biomarkers or therapeutic targets.</div></div>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages 1197-1208"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proton pump inhibitor dosing patterns are less than optimal among new referrals to an outpatient gastroenterology clinic 质子泵抑制剂的剂量模式是小于最佳的新转诊到门诊胃肠病学诊所。

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-06-01 DOI: 10.1016/j.dld.2025.03.031

Alexandra E. Thomson , Kwabena O. Adu-Gyamfi , Carlos Palacio , Christian S. Jackson , Kenneth J. Vega

引用次数: 0

Exosomal CCT3 as a biomarker for diagnosis and immune therapy response in patients diagnosed with hepatocellular carcinoma 外泌体CCT3作为肝细胞癌诊断和免疫治疗反应的生物标志物

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-06-01 DOI: 10.1016/j.dld.2025.03.022

Tiange Liu , Yanyan Cui , Yiben Ouyang , Meilin Wang , Shijing Yue

{"title":"Exosomal CCT3 as a biomarker for diagnosis and immune therapy response in patients diagnosed with hepatocellular carcinoma","authors":"Tiange Liu , Yanyan Cui , Yiben Ouyang , Meilin Wang , Shijing Yue","doi":"10.1016/j.dld.2025.03.022","DOIUrl":"10.1016/j.dld.2025.03.022","url":null,"abstract":"<div><h3>Background</h3><div>Hepatocellular carcinoma (HCC) is the dominant type of liver cancer and is associated with a high mortality rate. However, HCC lacks biomarkers for diagnosis and immune therapy response. Tumor-derived exosomes (TDEs) carcinogen-specific molecules have been used for screening multiple biomarkers. This study aimed to identify new biomarkers for the diagnosis of HCC and response to immune checkpoint blockade (ICB) therapy.</div></div><div><h3>Methods</h3><div>Analysis of differentially expressed genes (DEGs) in HCC and normal tissues was integrated using The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and ExoCarta datasets. The expression of CCT3 was validated in samples from patients with HCC using quantitative polymerase chain reaction (qPCR), Western blotting, and immunohistochemistry (IHC) techniques.</div></div><div><h3>Results</h3><div>Exosomal CCT3 was identified as a potential biomarker with significant impact. The expression of CCT3 in different tumor stages and normal tissues adjacent to the tumors (NATs) was validated using qPCR, western blotting, and IHC. CCT3 expression significantly increased the number of activated natural killer cells in HCC, as confirmed by qPCR and IHC. CCT3 expression significantly increases the expression of immune checkpoints in HCC. HCC-derived exosomes significantly increase the enrichment of CCT3.</div></div><div><h3>Conclusion</h3><div>Exosomal CCT3 is a biomarker for diagnosis and ICB therapy of HCC via MYC pathway activation and immune infiltration.</div></div>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages 1315-1324"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistent antibody positivity and gastrointestinal symptoms predicted progression of potential celiac disease to celiac disease 持续抗体阳性和胃肠道症状预测潜在乳糜泻进展为乳糜泻。

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-06-01 DOI: 10.1016/j.dld.2025.04.004

Sofia Kröger , Laura Kallio , Linnea Aitokari , Marleena Repo , Heini Huhtala , Oona Kähkönen , Veronika Salmio , Katri Kaukinen , Kalle Kurppa , Laura Kivelä

{"title":"Persistent antibody positivity and gastrointestinal symptoms predicted progression of potential celiac disease to celiac disease","authors":"Sofia Kröger , Laura Kallio , Linnea Aitokari , Marleena Repo , Heini Huhtala , Oona Kähkönen , Veronika Salmio , Katri Kaukinen , Kalle Kurppa , Laura Kivelä","doi":"10.1016/j.dld.2025.04.004","DOIUrl":"10.1016/j.dld.2025.04.004","url":null,"abstract":"<div><h3>Background</h3><div>The natural history of potential celiac disease is poorly defined.</div></div><div><h3>Aims</h3><div>To study factors predicting progression of potential celiac disease to overt celiac disease.</div></div><div><h3>Methods</h3><div>Medical data were collected from patients with potential celiac disease defined as positive tissue transglutaminase and/or endomysial autoantibodies without diagnostic duodenal villous atrophy.</div></div><div><h3>Results</h3><div>Of 158 patients with potential celiac disease (61 % women, median age 16 years, range 1-81 years), follow-up data were available for 128. The median follow-up time in patients not receiving a diagnosis was 14.6 years, and the median time until celiac disease diagnosis was 2.1 years. Serology normalized spontaneously in 38 %, while 61 % remained seropositive and 2 % began a gluten-free diet. Seventy-three patients underwent repeat endoscopy and 63 % of them received a celiac disease diagnosis. Those with later celiac disease diagnosis reported symptoms more often (84 % vs. 62 % p = 0.020) and were less frequently screen-detected (23 % vs. 52 %, p = 0.004) at their first endoscopy. During follow-up, they experienced persistent gastrointestinal symptoms more often (54 % vs. 27 %, p = 0.006) and remained seropositive (50 % vs. 16 %, p = 0.018).</div></div><div><h3>Conclusion</h3><div>During long-term follow-up, 63 % of the patients undergoing repeat endoscopy developed celiac disease. Predictive factors included baseline symptoms and persistence of gastrointestinal symptoms and sustained seropositivity.</div></div>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages 1209-1215"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renal cell carcinoma metastasis as an atypical cause of gastrointestinal bleeding 肾细胞癌转移是引起消化道出血的不典型原因。

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-06-01 DOI: 10.1016/j.dld.2025.03.014

Gemma Cerezal-Gómez , David Luján , José Luis Fernández-Cueto , Javier Pérez-Bedmar

引用次数: 0

Erratum regarding updated pagination in previously published articles 关于先前发表的文章中更新的页码的勘误

IF 4 3区医学

Digestive and Liver Disease Pub Date : 2025-06-01 DOI: 10.1016/j.dld.2025.05.018

引用次数: 0