{"title":"Comment on \"Severe enterocolitis associated with phosphatidylinositol 3-kinase delta inhibitors: A multicentre cohort study\".","authors":"Hiba Abid, Syed Abdul Nafay Ali","doi":"10.1016/j.dld.2025.08.074","DOIUrl":"https://doi.org/10.1016/j.dld.2025.08.074","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on 'Environmental enteropathy and inflammatory bowel disease are not mutually exclusive'.","authors":"Hao Lin, Lianyi Bao","doi":"10.1016/j.dld.2025.08.068","DOIUrl":"https://doi.org/10.1016/j.dld.2025.08.068","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on \"Liver transplantation in people living with HIV: An Italian nationwide survey focusing on hepatocellular carcinoma and oncologic recurrences\".","authors":"Haad Islam, Muhammad Sudais Hassan, Hafsa Fazal","doi":"10.1016/j.dld.2025.08.067","DOIUrl":"https://doi.org/10.1016/j.dld.2025.08.067","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peter T Dancs, Sandra Swoboda, Fuat H Saner, Tamas Benkö, Jassin Rashidi-Alavijeh, Katharina Willuweit, Jürgen W Treckmann, Daniel Heise, Ulf P Neumann, Dieter P Hoyer
{"title":"Difficult liver transplantation: Definition, risk factors and outcome.","authors":"Peter T Dancs, Sandra Swoboda, Fuat H Saner, Tamas Benkö, Jassin Rashidi-Alavijeh, Katharina Willuweit, Jürgen W Treckmann, Daniel Heise, Ulf P Neumann, Dieter P Hoyer","doi":"10.1016/j.dld.2025.08.070","DOIUrl":"https://doi.org/10.1016/j.dld.2025.08.070","url":null,"abstract":"<p><strong>Background: </strong>Although liver transplantation (LT) is highly complicated, its surgical difficulty was to date not defined. A point-based system, considering cold ischemia, blood transfused, and surgery time, showed promising results in short-term outcomes.</p><p><strong>Aims: </strong>We aimed to validate this model in the Eurotransplant region and to combine donor and recipient data to highlight high-risk candidates.</p><p><strong>Methods: </strong>We analyzed 778 primary LT patients, transplanted between January 2010 and January 2023. After applying the original score, instead of cold ischemia, hepatectomy time was calculated. A LT was considered difficult (Diff-LT), if all values were above the median of the whole population. Mortality was assessed with the Kaplan-Meier method. Predictors of Diff-LT were identified via multivariable analysis. Correlation with survival was tested via Cox regression.</p><p><strong>Results: </strong>Diff-LT was associated with inferior survival in both score systems. MELD score, recipient BMI, and previous abdominal surgery were mostly risk factors of Diff-LT. Whereas, Diff-LT, recipient age, early allograft dysfunction, and portal vein thrombosis (PVT) were identified as predictors of mortality.</p><p><strong>Conclusion: </strong>Diff-LT occurs frequently and results in poorer outcomes. Older and obese recipients with high MELD scores and PVT are at higher risk to undergo a Diff-LT. Identification of these patients, adjusting their risk factors and optimizing donor-recipient matching may improve future results.</p>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Authors' response: Mobile health strategies for gastroesophageal reflux disease management.","authors":"Gang Huang, Yan-Bo Yu","doi":"10.1016/j.dld.2025.08.007","DOIUrl":"https://doi.org/10.1016/j.dld.2025.08.007","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on \"Multiomics insights into functional constipation: Exploring microbiome, metabolome, and lipidome independent of transit time\".","authors":"Ruolin Wang, Chunwei Wu, Ze He","doi":"10.1016/j.dld.2025.08.075","DOIUrl":"https://doi.org/10.1016/j.dld.2025.08.075","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Simone Di Cola, Lucia Lapenna, Silvia Nardelli, Manuela Merli
{"title":"Author's reply: \"Comment on \"Management of ascites in elderly patients with cirrhosis: Results of an Italian survey\".","authors":"Simone Di Cola, Lucia Lapenna, Silvia Nardelli, Manuela Merli","doi":"10.1016/j.dld.2025.08.073","DOIUrl":"https://doi.org/10.1016/j.dld.2025.08.073","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lola-Jade Palmieri, Yaniss Belaroussi, Noémie Huchet, Marianne Fonck, Carine Bellera, Veronique Brouste, Nicolas Milhade, Dominique Bechade, Jeanne Lena, Leila Ayache, Xavier Buy, Simon Pernot, Jean Palussière
{"title":"Corrigendum to 'Impact on survival without chemotherapy of local treatments of lung metastasis of colorectal cancers: Analysis on REPULCO cohort' [Digestive and Liver Disease 56 (2024) 1930-7].","authors":"Lola-Jade Palmieri, Yaniss Belaroussi, Noémie Huchet, Marianne Fonck, Carine Bellera, Veronique Brouste, Nicolas Milhade, Dominique Bechade, Jeanne Lena, Leila Ayache, Xavier Buy, Simon Pernot, Jean Palussière","doi":"10.1016/j.dld.2025.07.031","DOIUrl":"https://doi.org/10.1016/j.dld.2025.07.031","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mingqing Liu, Ying Li, Jiawei Fan, He Zhu, Fengming Ni, Tantan Ma, Erli Cui, Nan Zhang, Hong Xu
{"title":"Comparison of the diagnostic performance of narrow-band imaging endocytoscopy and staining-based endocytoscopy for colorectal lesions.","authors":"Mingqing Liu, Ying Li, Jiawei Fan, He Zhu, Fengming Ni, Tantan Ma, Erli Cui, Nan Zhang, Hong Xu","doi":"10.1016/j.dld.2025.08.012","DOIUrl":"https://doi.org/10.1016/j.dld.2025.08.012","url":null,"abstract":"<p><strong>Background and aims: </strong>Endocytoscopy (EC) enables real-time histopathological evaluation through two modes: narrow-band imaging endocytoscopy (ECNBI) and staining-based endocytoscopy (EC-SB). However, the comparative diagnostic accuracy between ECNBI and EC-SB, and their performance of endoscopists with varying levels of experience remains unclear.</p><p><strong>Methods: </strong>This retrospective study analyzed 565 colorectal lesions from 433 patients. Both expert and non-expert endoscopists evaluated colorectal lesions based on ECNBI and EC-SB images. Sensitivity, specificity, accuracy, positive predictive value (PPV), negative predictive value (NPV), and inter- and intra-observer agreement were compared with histopathological diagnoses.</p><p><strong>Results: </strong>The sensitivity, specificity, and accuracy for diagnosing hyperplastic polyps by experts using EC-SB are 93.0 %, 98.0 %, and 97.0 %, which were significantly higher than the results of ECNBI (86.8 %, 96.1 %, and 94.2 %, respectively; P < 0.05 for all). Similarly, for diagnosing adenomas to intramucosal cancers, EC-SB by experts achieved significantly higher sensitivity, specificity and accuracy (93.0 %, 94.8 % and 93.6 %) compared to ECNBI (90.2 %, 90.1 % and 90.2 %, respectively; P < 0.05 for all). In addition, for diagnosing invasive cancers, EC-SB by experts showed significantly higher specificity (98.7 % vs. 96.1 %, P < 0.05).</p><p><strong>Conclusions: </strong>EC-SB demonstrated higher diagnostic accuracy for colorectal lesions among experts, supporting its utility for precise treatment decisions.</p>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peng Ye, Yizhen Chen, Fang Ye, Weijie Chen, Zhenyuan Zhou, Rong Ye, Hangdong Jia, Ting Zheng, Chunying Zheng
{"title":"Utility of novel composite index in predicting the prognosis of total neoadjuvant therapy for locally advanced rectal cancer: A multicenter real-world cohort study.","authors":"Peng Ye, Yizhen Chen, Fang Ye, Weijie Chen, Zhenyuan Zhou, Rong Ye, Hangdong Jia, Ting Zheng, Chunying Zheng","doi":"10.1016/j.dld.2025.08.011","DOIUrl":"https://doi.org/10.1016/j.dld.2025.08.011","url":null,"abstract":"<p><strong>Objective: </strong>C-reactive protein-albumin-lymphocyte (CALLY) is a novel composite index. Total neoadjuvant therapy (TNT) has become one of the standard treatments for locally advanced rectal cancer (LARC). It remains unclear whether CALLY can predict the prognosis for LARC patients.</p><p><strong>Methods: </strong>Restricted cubic spline (RCS) was employed to assess the relationships of CALLY with perioperative complications, pathologic complete response (pCR), disease-free survival (DFS) and overall survival (OS).</p><p><strong>Results: </strong>This multicenter, real-world study included 995 LARC patients treated with TNT. RCS analysis demonstrated a linear association between CALLY and TNT-related adverse events, postoperative complications, DFS, and OS (all P for nonlinear > 0.05, P overall < 0.05). The high CALLY group (≥13.5) had significantly better DFS and OS than the low CALLY (P < 0.001). The 3- and 5-year DFS of low CALLY patients were 63.0 % and 51.6 %, and the 3- and 5-year OS were 75.6 % and 59.7 %, respectively. In the high CALLY group, the 3- and 5-year DFS were 87.0 % and 77.6 %, and the 3- and 5-year OS were 90.1 % and 81.8 %.</p><p><strong>Conclusion: </strong>Baseline CALLY can serve as an effective prognostic tool for LARC patients undergoing TNT and guide personalized treatment strategies.</p>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}