Cytogenetic and Genome Research最新文献

Complex congenital cardiac defect associated with the combination of 5p deletion and 4q duplication in a newborn: A case report. 新生儿5p缺失和4q重复合并相关的复杂先天性心脏缺陷1例报告

IF 1.7 4区生物学

Cytogenetic and Genome Research Pub Date : 2025-01-21 DOI: 10.1159/000543591

Ülkü Nur Kırman, Ferid Aliyev, Merve Soğukpınar, Pelin Özlem Şimşek Kiper, Hayrettin Hakan Aykan, Hasan Tolga Çelik

引用次数: 0

The Association between Short Telomere Length and Cardiovascular Disease. 短端粒长度与心血管疾病之间的关系。

IF 1.7 4区生物学

Cytogenetic and Genome Research Pub Date : 2024-12-11 DOI: 10.1159/000542795

Persefoni Fragkiadaki, Miruna-Maria Apetroaei, Elisavet Kouvidi, Elena Vakonaki, Elissavet Renieri, Irene Fragkiadoulaki, Marios Spanakis, Stella Baliou, Athanasios Alegakis, Aristidis Tsatsakis

{"title":"The Association between Short Telomere Length and Cardiovascular Disease.","authors":"Persefoni Fragkiadaki, Miruna-Maria Apetroaei, Elisavet Kouvidi, Elena Vakonaki, Elissavet Renieri, Irene Fragkiadoulaki, Marios Spanakis, Stella Baliou, Athanasios Alegakis, Aristidis Tsatsakis","doi":"10.1159/000542795","DOIUrl":"10.1159/000542795","url":null,"abstract":"Introduction: Telomeres, repetitive DNA sequences at chromosome ends, shorten with cell division, countered by telomerase. Short telomeres are linked to cardiovascular disease (CVD), alongside its risk factors like aging, hypertension, diabetes, obesity, inactivity, and smoking. Many studies have claimed the implication of telomere length (TL) in cardiac diseases. This study examined TL's impact on heart conditions using quantitative fluorescence in situ hybridization (Q-FISH) technology.Methods: Thirteen CVD patients (nine men and four women) aged 30-70 years and aged-matched healthy participants from the BIOTEL population TL database, were included in the study. Each chromosome's TL from peripheral blood cells was measured using metaphase Q-FISH. An independent sample t test was used to compare participants' mean or median TL with various medical factors and habits.Results: The mean TL of whole and short telomeres in cardiac disease patients was lower compared to aged-matched healthy controls; however, there was no statistical significance due to the limited patient sample. The mean TL of short telomeres in cardiac disease patients showed a remarkable decline with advanced age. Accordingly, the mean TL of whole and short telomeres in patients with cardiac diseases showed a similar reduced trend.Conclusion: In our study, shorter TL was observed in cardiac disease patients compared to those of healthy controls by using metaphase Q-FISH. However, more cases need to be studied to elucidate the use of TL as a potential biomarker for the diagnosis of patients with CVD.","PeriodicalId":11206,"journal":{"name":"Cytogenetic and Genome Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytogenomic Characterization of Murine Osteosarcoma Cell Line SEWA. 小鼠骨肉瘤细胞系SEWA的细胞基因组学特征。

IF 1.7 4区生物学

Cytogenetic and Genome Research Pub Date : 2024-12-11 DOI: 10.1159/000543063

Thomas Liehr, Martina Rincic

引用次数: 0

A Detailed Karyological Investigation of three Endemic Cobitis Linnaeus, 1758 Species (Teleostei, Cobitidae) in Anatolia, Türkiye. 中国安那托利亚地区3个Cobitis L. 1758特有种（Teleostei, Cobitidae）的详细核学调查。

IF 1.7 4区生物学

Cytogenetic and Genome Research Pub Date : 2024-12-02 DOI: 10.1159/000542804

Sevgi Unal Karakus, Muhammet Gaffaroğlu, Muradiye Karasu Ayata, Martin Knytl

{"title":"A Detailed Karyological Investigation of three Endemic Cobitis Linnaeus, 1758 Species (Teleostei, Cobitidae) in Anatolia, Türkiye.","authors":"Sevgi Unal Karakus, Muhammet Gaffaroğlu, Muradiye Karasu Ayata, Martin Knytl","doi":"10.1159/000542804","DOIUrl":"10.1159/000542804","url":null,"abstract":"Introduction: Comparative cytogenetics is a vital approach for diagnosing chromosome abnormalities and identifying species-specific patterns. In this study, chromosomal analysis of three Anatolian endemic Cobitis species was performed: Cobitis bilseli, C. fahireae, and C. turcica.Methods: Conventional cytogenetic techniques such as Giemsa staining, C-banding, and Ag-NOR staining were applied, followed by measurements of chromosome arm lengths including analysis of the measured data.Results: The diploid chromosome number, 2n = 50, was determined for all three species. The karyotype formulas were as follows: four pairs of metacentric, 5 pairs of submetacentric, and 16 pairs of subtelo-telocentric chromosomes in C. bilseli; 11 pairs of metacentric, 7 pairs of submetacentric, and 7 pairs of subtelo-telocentric chromosomes in C. fahireae; and 4 pairs of metacentric, 4 pairs of submetacentric, and 17 pairs of subtelo-telocentric chromosomes in C. turcica. Dark C-bands were observed on the pericentromeres of nearly all chromosomes in C. bilseli and C. turcica, whereas light C-bands appeared on the pericentromeres of some chromosomes in C. fahireae. Silver-stained metaphases revealed signals on the short arm of a submetacentric chromosome pair in C. fahireae (each homologous chromosome carries one signal), while in C. bilseli and C. turcica, Ag-NOR signals were detected on the long arm of a single metacentric chromosome (only one homologous chromosome carries the signal, and the signal-carrying chromosome is the largest chromosome in the karyotype).Conclusion: This study provides new cytogenetic data consistent with the phylogenetic distances between the studied species, indicating that pericentric inversions and/or translocations govern the formation of Cobitis karyotypes.","PeriodicalId":11206,"journal":{"name":"Cytogenetic and Genome Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Key Genes and Drug Recommendations in Diffuse Large B-Cell Lymphoma Based on Analysis of Glutathione-Related Genes. 根据谷胱甘肽相关基因分析确定弥漫大 B 细胞淋巴瘤的关键基因和用药建议。

IF 1.7 4区生物学

Cytogenetic and Genome Research Pub Date : 2024-11-22 DOI: 10.1159/000542722

Yu Ren, Aijun He

{"title":"Identification of Key Genes and Drug Recommendations in Diffuse Large B-Cell Lymphoma Based on Analysis of Glutathione-Related Genes.","authors":"Yu Ren, Aijun He","doi":"10.1159/000542722","DOIUrl":"10.1159/000542722","url":null,"abstract":"Background: Various malignancies can be efficiently combated by focusing on glutathione. It is unclear how glutathione-related genes link to diffuse large B-cell lymphoma (DLBCL).Methods: Clinical information was gathered from DLBCL patients, and differences in glutathione-related differentially expressed genes (DEGs) between DLBCL and healthy groups were found. Enrichment analysis was run on the DEGs associated with glutathione. We discovered hub genes in glutathione, confirmed hub genes' capacity for diagnosis and function prediction, and estimated drug sensitivity. Immune microenvironmental variations between healthy and DLBCL people were assessed, and hub genes for transcription factor (TF) targeting and miRNAs were found.Results: The glutathione-related DEGs were linked to biological processes such as response to oxidative stress and response to xenobiotic stimulus, according to enrichment analysis. Out of DEGs associated with glutathione, six hub genes were chosen. In the DLBCL population, there was a notable upregulation of the six hub genes. All the genes' AUC values in the diagnostic ability category were more than 0.7, showing strong hub gene diagnostic capacity. The DLBCL population had a high level of T-cell infiltration, according to immune infiltration analysis techniques. Similar activities, such as the cell cycle G2/M phase transition and the negative control of organelle formation, are demonstrated by gene function prediction for hub. According to drug sensitivity prediction, there was a favorable link between KPNA2 with pracinostat, BRCA1 with B-7100, and LEE-011. The gene KPNA2 was shown to be concurrently targeted by many miRNAs and TFs, according to the miRNA-gene-TF interaction network.Conclusion: The relationship between DLBCL and glutathione-related genes was uncovered by our research, and six glutathione genes were linked to DLBCL. These genes might be used as diagnostic biomarkers or targets for treatment for DLBCL patients.","PeriodicalId":11206,"journal":{"name":"Cytogenetic and Genome Research","volume":" ","pages":"1-18"},"PeriodicalIF":1.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Chromosome Test Results of 24,175 Miscarried Fetuses in Japan from 2000 to 2021. 对 2000 年至 2021 年日本 24,175 名流产胎儿的染色体检测结果进行分析。

IF 1.7 4区生物学

Cytogenetic and Genome Research Pub Date : 2024-11-15 DOI: 10.1159/000542086

Haruyoshi Takaki, Rie Kitagawa, Takako Takano

{"title":"Analysis of Chromosome Test Results of 24,175 Miscarried Fetuses in Japan from 2000 to 2021.","authors":"Haruyoshi Takaki, Rie Kitagawa, Takako Takano","doi":"10.1159/000542086","DOIUrl":"10.1159/000542086","url":null,"abstract":"Background: Fetal chromosome abnormalities, the most common cause of spontaneous abortion, were investigated pre-1980s. In recent years, chromosome testing has been outsourced to testing companies in Japan, and there have been few epidemiological studies of chromosome testing of miscarried fetuses on a nationwide scale.Methods: We analyzed the chromosome test data of SRL Inc., one of the largest clinical laboratories that has collected tissue specimens of products of conception derived from miscarried fetuses from hospitals throughout Japan from 2000 to 2021.Results: We collected and analyzed 24,175 cases, among which 8,726 (36.1%) with normal chromosomes, 1,298 (5.4%) with sex chromosome aberrations, 9,735 (40.3%) with autosomal trisomy, 73 (0.3%) with autosomal monosomy, 840 (3.5%) with polyploidy, 512 (2.1%) with chromosomal structural abnormality, and 2,991 (12.4%) with mosaic, respectively. The frequency of autosomal trisomy increased at the older maternal ages. By chromosome number, trisomies 22, 16, 21, and 15 were associated with advanced maternal age, but trisomies 13, 14, and 18 were not associated with advanced maternal age. The presence or absence of this maternal age effect was correlated with the chromosome segregation being due to maternal meiosis I or meiosis II. For the sex ratios of the fetuses, we focused on trisomies 22, 21, 18, 16, 15, 14, and 13 and found that only trisomy 16 was significantly more frequently seen in female fetuses.Conclusion: The findings of this study provide insights into the basic understanding of miscarriage and will be useful in counseling and medical education.","PeriodicalId":11206,"journal":{"name":"Cytogenetic and Genome Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delineating the W Sex Chromosome in the Clam Shrimp, Eulimnadia texana. 划定蛤虾（Eulimnadia texana）的 W 性染色体。

IF 1.7 4区生物学

Cytogenetic and Genome Research Pub Date : 2024-10-28 DOI: 10.1159/000542284

Chathumadavi Ediriweera, Stephen C Weeks

{"title":"Delineating the W Sex Chromosome in the Clam Shrimp, Eulimnadia texana.","authors":"Chathumadavi Ediriweera, Stephen C Weeks","doi":"10.1159/000542284","DOIUrl":"10.1159/000542284","url":null,"abstract":"Introduction: Sex chromosomes have evolved independently across various lineages, often showing convergent degradation of the sex-limited chromosome. While extensively studied in model organisms with ancient sex chromosomal systems, the evolution of early-stage sex chromosomes remains poorly understood. Eulimnadia texana, a freshwater crustacean with a unique androdioecious breeding system (ZZ, ZW, and viable WW genotypes), provides a rare opportunity to study early sex chromosome evolution. This study examines E. texana's W chromosome for evidence of a small localized non-recombining region, characterized by a transposable element (TE) \"hotspot,\" low gene density, and low GC content.Methods: Sex-linked markers were mapped onto the W chromosome (scaffold 1). TEs in the WW genome were identified using RepeatModeler and RepeatMasker. Statistical analyses compared TE distribution between the genome and scaffold 1, which was then divided into 20 equal-sized \"bins\" for finer-scale statistical analyses. Gene density and GC content were analyzed across these bins.Results: While no significant TE accumulation was found across the entire W chromosome compared to the remaining genome, a specific region (6.6-8.8 Mb, fourth bin) showed significantly higher TE accumulation. This region also exhibited low gene density and low GC content, indicative of reduced recombination.Conclusion: Our findings suggest that E. texana's W chromosome contains a smaller region of crossover suppression, supporting the hypothesis that it is a proto-sex chromosome in early evolutionary development. This study provides valuable insights into early sex chromosome evolution and establishes E. texana as an ideal model for further investigation of evolutionary processes driving proto-sex chromosome differentiation.","PeriodicalId":11206,"journal":{"name":"Cytogenetic and Genome Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Leukocyte Telomere Length and the Risk of Disease Severity and Metabolic Comorbidities in Arab Patients with Psoriasis. 阿拉伯银屑病患者的白细胞端粒长度与疾病严重程度和代谢合并症风险的关系。

IF 1.7 4区生物学

Cytogenetic and Genome Research Pub Date : 2024-10-28 DOI: 10.1159/000542323

Materah Salem Alwehaidah, Moiz Bakhiet

{"title":"Association of Leukocyte Telomere Length and the Risk of Disease Severity and Metabolic Comorbidities in Arab Patients with Psoriasis.","authors":"Materah Salem Alwehaidah, Moiz Bakhiet","doi":"10.1159/000542323","DOIUrl":"10.1159/000542323","url":null,"abstract":"Introduction: Several studies have related shortened leukocyte telomere length (LTL) with age-related diseases and worse prognosis. Telomere length attrition has recently been associated with inflammatory diseases, including psoriasis (Ps). However, no study has demonstrated an association between LTL and the risk of disease severity and metabolic comorbidities in Arab patients with Ps.Methods: 68 patients with Ps and 42 normal controls were included. LTL and oxidative damage were determined by quantitative (q) PCR. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression. Statistical differences between the groups were determined using χ2 and t tests.Results: Patients with Ps had significantly shorter LTL (p = 0.032) and higher oxidative damage (p = 0.015) than those without Ps. Patients with moderate-to-severe index (p = 0.03) and metabolic comorbidity showed significantly shorter LTL (p = 0.003) compared to patients with mild index and without metabolic comorbidity, respectively. Patients with short LTL (≤0.9) were correlated with higher risk of moderate-to-severe conditions (OR = 6.98, 95% CI = 2.3-20.8, p = 0.001) and metabolic comorbidities (OR = 2.89, 95% CI = 1.02-8.2, p = 0.04).Conclusion: LTL shortening may be a consequence of increased oxidative damage and is related to the risk of severe Ps and metabolic comorbidities. Therefore, LTL may be a good candidate biomarker for predicting the risk of poor prognosis in patients with Ps.","PeriodicalId":11206,"journal":{"name":"Cytogenetic and Genome Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Karyotypes and Chromosomal Mapping of Some Repetitive DNAs in Two Stingless Bee Species (Apidae: Meliponini), with the Description of a B Chromosome in Plebeia Genus. 两种无刺蜜蜂（Apidae: Meliponini）的核型和一些重复 DNA 的染色体图谱，并描述了 Plebeia 属的 B 染色体。

IF 1.7 4区生物学

Cytogenetic and Genome Research Pub Date : 2024-10-28 DOI: 10.1159/000542295

Bárbara L F Andrade, Ana Luiza G Lopes, Gisele A Teixeira, Mara G Tavares

{"title":"Karyotypes and Chromosomal Mapping of Some Repetitive DNAs in Two Stingless Bee Species (Apidae: Meliponini), with the Description of a B Chromosome in Plebeia Genus.","authors":"Bárbara L F Andrade, Ana Luiza G Lopes, Gisele A Teixeira, Mara G Tavares","doi":"10.1159/000542295","DOIUrl":"10.1159/000542295","url":null,"abstract":"Introduction: Cytogenetic studies on stingless bees have significantly contributed to our understanding of karyotypic evolution and the composition of euchromatin and heterochromatin regions, including repetitive sequences.Methods: In this study, we performed classical cytogenetics, chromosomal banding, and mapping of some repetitive sequences in two stingless bee species, Frieseomelitta trichocerata and Plebeia poecilochroa.Results: The species exhibit the typical diploid chromosome number of each genera, 2n = 30 for Frieseomelitta and 2n = 34 for Plebeia. Additionally, some individuals of P. poecilochroa presented a small heterochromatic B chromosome, showing a numeric variation of n = 17-18 in males and 2n = 34-35 in females. In both species, heterochromatin is primarily distributed in the short arm and centromeric regions. Centromeric regions were found to be AT-rich in both species, while subterminal/terminal regions of the short arms of one and six chromosomes presented GC-rich sites in P. poecilochroa and F. trichocerata, respectively. The rDNA clusters were mapped on two chromosomes in F. trichocerata, and in only one chromosome pair in P. poecilochroa. Microsatellites (GA)n, (GAG)n, and (CAA)n were predominantly mapped in euchromatic regions, while the telomeric motif (TTAGG)n mapped to the ends of most chromosomes, including the B chromosome of P. poecilochroa. The other repetitive probes used, including the rDNA clusters, do not label the B chromosome of P. poecilochroa.Conclusions: Our cytogenetic data highlight both similarities and differences when compared to other congeneric species, expanding the chromosomal data for both genera.","PeriodicalId":11206,"journal":{"name":"Cytogenetic and Genome Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescence in situ Hybridization Analysis of Oligonucleotide 5S Ribosomal DNA, 45S Ribosomal DNA, and (TTTAGGG)3 Locations in Gloriosa superba L. 5S rDNA、45S rDNA 和 (TTTAGGG)3 寡核苷酸位置的荧光原位杂交分析。

IF 1.7 4区生物学

Cytogenetic and Genome Research Pub Date : 2024-10-12 DOI: 10.1159/000541706

Hongyou Zhao, Duo Wang, Haitao Li, Shuang Li, Yanfang Wang, Anshun Xu, Chunyong Yang, Ge Li, Yanqian Wang, Lixia Zhang

{"title":"Fluorescence in situ Hybridization Analysis of Oligonucleotide 5S Ribosomal DNA, 45S Ribosomal DNA, and (TTTAGGG)3 Locations in Gloriosa superba L.","authors":"Hongyou Zhao, Duo Wang, Haitao Li, Shuang Li, Yanfang Wang, Anshun Xu, Chunyong Yang, Ge Li, Yanqian Wang, Lixia Zhang","doi":"10.1159/000541706","DOIUrl":"10.1159/000541706","url":null,"abstract":"Introduction: Gloriosa superba L. is a horticulturally and medicinally important plant native to Africa. However, the few cytogenetic studies of the species are mainly focused on chromosome counting and chromosome morphology-based karyotyping. Fluorescence in situ hybridization (FISH) is a powerful tool for the detection of DNA repetitive elements in a specific region of a chromosome.Methods: Here, detailed karyotypes of G. superba were constructed by FISH using 5S and 45S rDNAs, and telomeric repeat (TTTAGGG)3 oligonucleotides.Results and conclusion: Twenty-two chromosomes were observed. Two 5S rDNA hybridization signals were detected in the proximal regions of the short arms of one pair of chromosomes, which were adjacent to the (TTTAGGG)3 terminal signals. Four 45S rDNA signals were detected near the centromere region of the short arm of the four chromosomes, but one of these was very weak and almost undetectable compared to the others. Telomeric repeat hybridization signals were distributed at the terminal region of each chromosome. The chromosomes displayed were intact, and the chromosome counts were accurate. Chromosome length ranged from 3.46 to 9.31 μm. These results will facilitate the cytogenetic mapping of other major repeats, thus contributing to an improved understanding of the G. superba genome structure and evolutionary history.","PeriodicalId":11206,"journal":{"name":"Cytogenetic and Genome Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0