基因组印记：洞察不同的表观遗传调控机制。

IF 1.7 4区生物学 Q4 CELL BIOLOGY

Cytogenetic and Genome Research Pub Date : 2025-07-22 DOI:10.1159/000547555

Gaurav Kumar Pandey, Rajiva Raman

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引用次数: 0

摘要

基因组印记是一种众所周知的现象，其中某些基因以父母性别特异性的方式表达，导致单等位基因表达。多年来，在印迹基因簇中观察到的机制多样性为探索表观遗传学的复杂性提供了一个有价值的模型系统，可以扩展到其他细胞和疾病模型。这篇综述探讨了这些不同的机制在整个早期胚胎发育过程中，并提供了关键参与者之间的相互作用的见解，如DNA甲基化，组蛋白修饰和非编码rna，以及它们对基因表达的调控影响。

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Genomic Imprinting: Insights into diverse epigenetic regulatory mechanisms.

Genomic imprinting is a well-known phenomenon in which certain genes are expressed in a sex-of-the-parent-specific manner resulting in mono-allelic expression. Over the years the diversity of mechanisms observed in imprinted gene clusters has provided a valuable model system for exploring the complexities of epigenetics, which can be extended to other cellular and disease models. This review examines these different mechanisms throughout early embryonic development and offers insights into the interactions among key players such as DNA methylation, histone modifications, and non-coding RNAs, as well as their regulatory impact on gene expression.

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来源期刊

Cytogenetic and Genome Research 生物-细胞生物学

CiteScore

3.10

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： During the last decades, ''Cytogenetic and Genome Research'' has been the leading forum for original reports and reviews in human and animal cytogenetics, including molecular, clinical and comparative cytogenetics. In recent years, most of its papers have centered on genome research, including gene cloning and sequencing, gene mapping, gene regulation and expression, cancer genetics, comparative genetics, gene linkage and related areas. The journal also publishes key papers on chromosome aberrations in somatic, meiotic and malignant cells. Its scope has expanded to include studies on invertebrate and plant cytogenetics and genomics. Also featured are the vast majority of the reports of the International Workshops on Human Chromosome Mapping, the reports of international human and animal chromosome nomenclature committees, and proceedings of the American and European cytogenetic conferences and other events. In addition to regular issues, the journal has been publishing since 2002 a series of topical issues on a broad variety of themes from cytogenetic and genome research.