Post-translational modifications of the Werner syndrome protein WRN.

IF 1.3 4区生物学 Q4 CELL BIOLOGY

Cytogenetic and Genome Research Pub Date : 2025-07-02 DOI:10.1159/000547163

Amrita Machwe, David K Orren

引用次数: 0

Abstract

Background: Werner syndrome has been an excellent model for the study of human aging, and how chromosomal instability is related to phenotypes of normal aging including cancer. George Martin devoted his life to the study of Werner syndrome and human aging, and this review is dedicated to his memory.

Summary: In this review, we highlight the post-translational modifications of WRN, the protein whose function is lacking in individuals with Werner syndrome. WRN is subject to phosphorylation, acetylation, ubiquitination and SUMOylation.

Key messages: These modifications of WRN control its localization and function in the response to replication fork stress and repair of double-strand breaks that are a consequence of this stress.

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Werner综合征蛋白WRN的翻译后修饰。

背景：Werner综合征是研究人类衰老以及染色体不稳定性如何与包括癌症在内的正常衰老表型相关的一个很好的模型。乔治·马丁一生致力于研究维尔纳综合症和人类衰老，这篇评论是献给他的记忆。摘要：在这篇综述中，我们强调了WRN的翻译后修饰，该蛋白在Werner综合征患者中缺乏功能。WRN可发生磷酸化、乙酰化、泛素化和SUMOylation。关键信息：WRN的这些修饰控制其定位和功能，以响应复制叉应力和修复双链断裂，这是该应力的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytogenetic and Genome Research 生物-细胞生物学

CiteScore

3.10

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： During the last decades, ''Cytogenetic and Genome Research'' has been the leading forum for original reports and reviews in human and animal cytogenetics, including molecular, clinical and comparative cytogenetics. In recent years, most of its papers have centered on genome research, including gene cloning and sequencing, gene mapping, gene regulation and expression, cancer genetics, comparative genetics, gene linkage and related areas. The journal also publishes key papers on chromosome aberrations in somatic, meiotic and malignant cells. Its scope has expanded to include studies on invertebrate and plant cytogenetics and genomics. Also featured are the vast majority of the reports of the International Workshops on Human Chromosome Mapping, the reports of international human and animal chromosome nomenclature committees, and proceedings of the American and European cytogenetic conferences and other events. In addition to regular issues, the journal has been publishing since 2002 a series of topical issues on a broad variety of themes from cytogenetic and genome research.