Current rheumatology reviews最新文献

{"title":"A Bibliometric Analysis of Systematic Reviews in the Field of Ankylosing Spondylitis from 2007 to 2025.","authors":"Jie Gao, Zhaoqian Wang, Xinlan Lin, Juan Li, Jingjing Li, Tao Pang, Wansheng Chen, Xia Tao, Feng Zhang","doi":"10.2174/0115733971395228251124103324","DOIUrl":"10.2174/0115733971395228251124103324","url":null,"abstract":"<p><strong>Background: </strong>Ankylosing spondylitis (AS) is an inflammatory autoimmune disease and the most common clinical form of spinal arthritis. Over the past decades, tremendous progress has been made in systematic reviews on AS. This study aimed to conduct a bibliometric analysis of AS-related meta-analyses to visualize the hotspots and trends in the field.</p><p><strong>Methods: </strong>A comprehensive search was conducted for publications of AS meta-analysis from 2007 to 2025 using the Web of Science Core Collection database. Bibliometric analysis was performed using the Bibliometrix software package, VOSviewer, and CiteSpace.</p><p><strong>Results: </strong>In total, 1073 articles were identified, and the number of relevant publications showed annual growth. China, the USA, and England were the most productive countries. Annals of the Rheumatic Diseases was the most productive journal (54, 10.65%), Pan Faming was the most productive author (23, 4.54%), and Anhui Medical University (45, 8.88%) was the most productive institution. High-frequency keywords were mainly grouped into five themes: complications, biologics, physical therapy exercises, gut microbiota, and analytical methods.</p><p><strong>Discussion: </strong>This first bibliometric analysis of AS-related EBM research showed a 20-year upward trend in AS meta-analyses, consistent with prior studies. CiteSpace revealed that China (top since 2014) and the USA led in publications (53 countries) but had limited collaboration. Pan Faming (23 articles) was the most active author, and Annals of the Rheumatic Diseases published the most articles. Keyword analysis identified five themes (e.g., AS complications, biologics) and research frontiers: pre-2012 genome-AS links, post-2012 multi-center RCTs, and the recent focus on AS patients' HRQoL. Limitations included database and English-language bias; future meta-analyses should adopt standardized outcomes.</p><p><strong>Conclusion: </strong>In recent years, there has been a remarkable surge in the number of meta-analyses on AS. This significant increase underscores the importance of this research area. Studies in this field have mainly focused on several key aspects: risk factors, network meta-analysis, and quality- of-life studies. These findings are highly valuable for understanding advancements in ASrelated research and can also encourage researchers and clinicians to focus on both effective medical treatments and the well-being of AS patients.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":"e15733971395228"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual Acute Myocarditis Resulting in Severe Active Flare of Ankylosing Spondylitis with Pulmonary and Ocular Involvement: A Case Report.","authors":"Yasmine Ouaddouh, Soumia Boulouiz, Nabila Ismaili, Noha El Ouafi, Zakaria Bazid","doi":"10.2174/0115733971479658260305083011","DOIUrl":"https://doi.org/10.2174/0115733971479658260305083011","url":null,"abstract":"<p><strong>Background: </strong>Acute myocarditis is an inflammatory disorder of the myocardium that can lead to severe cardiac dysfunction, arising from a broad spectrum of infectious and noninfectious etiologies. Ankylosing spondylitis, which primarily affects the axial skeleton, can involve the heart due to its systemic inflammatory nature, occasionally resulting in severe complications such as myocarditis.</p><p><strong>Case presentation: </strong>We report an unusual case of acute myocarditis in a 49-year-old male with ankylosing spondylitis presenting with chest pain and systemic inflammatory symptoms. Diagnostic workup using the 2018 Lake Louise Criteria among cardiac MRI confirmed myocarditis in the absence of coronary artery disease or infectious etiology. The patient also demonstrated extraarticular manifestations with pulmonary and ocular involvement, consistent with an active ankylosing spondylitis flare. Management combined beta blockers, physical activity restriction, and re-introduction of anti-TNF alpha therapy, leading to both clinical and biological improvement.</p><p><strong>Conclusion: </strong>Acute myocarditis represents a rare yet severe cardiac manifestation of ankylosing spondylitis, requiring a high clinical suspicion to prevent heart failure and dilated cardiomyopathy.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":"22 5","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Multi-Omics Methods to Understand Gouty Arthritis.","authors":"Siming Gao, Hui Song","doi":"10.2174/0115733971329652241119060025","DOIUrl":"10.2174/0115733971329652241119060025","url":null,"abstract":"<p><p>Gouty arthritis is a common arthritic disease caused by the deposition of monosodium urate crystals in the joints and the tissues around it. The main pathogenesis of gout is the inflammation caused by the deposition of monosodium urate crystals. Omics studies help us evaluate global changes in gout during recent years, but most studies used only a single omics approach to illustrate the mechanisms of gout. In this review, we review the genomics, transcriptomics, epigenetics, proteomics, and metabolomics of gout, observing that different genes, DNA methylation, miRNAs, LncRNAs, circRNAs, proteins, and metabolites are found between hyperuricemia, acute gout arthritis, and chronic gout arthritis, and some of them are associated with disease activity, prognosis or treatment, which help us broaden our understanding of the pathogenesis and provide important clues for valuable biomarkers. To our knowledge, this is the first study that combines all omics studies from genomics to metabolomics and may serve as a reference for future studies to identify the key underlying pathways in gout.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":"23-29"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Interplay between Osteoarthritis and the Microbiome-joint Axis: A Systemic Perspective on Novel Therapeutic Targets.","authors":"Marco Valentini, Guido Maria Valentini, Ibrahim Akkawi, Sabrina Donati Zeppa, Alessia Bartolacci, Francesco Pegreffi, Hassan Zmerly","doi":"10.2174/0115733971450825260423042902","DOIUrl":"10.2174/0115733971450825260423042902","url":null,"abstract":"<p><p>Osteoarthritis (OA) is a chronic and progressive joint disease involving the articular cartilage, synovium, subchondral bone, and ligaments, ultimately leading to pain, dysfunction, and, in advanced stages, joint destruction. Several factors contribute to the development and progression of OA, including genetic predisposition, biomechanical stress, metabolic imbalance, and chronic low-grade inflammation. Recently, a novel factor has emerged: the gut microbiome. Gut dysbiosis, defined as an alteration in gut microbiota homeostasis, can disrupt immune, metabolic, and inflammatory pathways, promoting systemic inflammation and accelerating degenerative changes in joint tissues. Conversely, restoration of a balanced gut microbiota may play a protective role and represent a promising avenue for innovative therapeutic strategies. The aim of this review is to analyse the relationship between gut dysbiosis and osteoarthritis, and to discuss potential therapeutic approaches targeting the microbiome to prevent disease progression.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13555781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clodronate: The Influence on ATP Purinergic Signaling.","authors":"Sergio Rosini, Stefano Rosini, Gianantonio Saviola, Luigi Molfetta","doi":"10.2174/0115733971358895241216112008","DOIUrl":"10.2174/0115733971358895241216112008","url":null,"abstract":"<p><p>ATP is involved in numerous physiological functions, such as neurotransmission, modulation, and secretion, as well as in cell proliferation, differentiation, and death. While ATP serves an essential intracellular role as a source of energy, it behaves differently in the extracellular environment, where it acts as a signaling molecule capable of activating specific purinergic receptors (P2YRs and P2XRs) that modulate the response to ATP. Extracellular ATP signaling is a dynamic area of research, with particular interest in ATP's effects on inflammatory conditions and pain modulation. Clodronate differs from other bisphosphonates that contain an amino group in their structure (N-BPs), and it is metabolized within osteoclasts into a toxic ATP analog, AppCCl2p, which causes mitochondrial dysfunction and osteoclast apoptosis. This characteristic differentiates Clodronate from N-BPs, as the latters act by interfering with the mevalonate pathway. Clodronate has demonstrated anti-inflammatory and analgesic activity in various bone and musculoskeletal diseases through mechanisms involving macrophages, neutrophils, peripheral nociceptors, and the central nervous system. ATP produced inside cells is accumulated within transport vesicles, where it penetrates via a VNUT channel and is then released extracellularly, playing an active role in acute and chronic inflammatory processes, neurotransmission of pain, and liver disease regulation. Clodronate influences these processes due to its strong inhibitory effect on VNUT-mediated ATP release. The aim of this review is to highlight the therapeutic potential offered by appropriate modulation of cellular ATP release and the inhibitory effects of Clodronate on the channel through which ATP penetrates transport vesicles.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":"17-22"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The TIM-3/Gal-9 Pathway: A Promising Therapeutic Target for Regulation of Immune Checkpoint in Rheumatoid Arthritis.","authors":"Debjeet Sur, Riya Pramanik","doi":"10.2174/0115733971330865250312075719","DOIUrl":"10.2174/0115733971330865250312075719","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) is a chronic autoimmune ailment that is marked by persistent synovial joint inflammation, which causes joint destruction and other systemic consequences. The immune system is equipped with a wide range of effector mechanisms that are capable of inflicting severe harm on pathogens that invade it, as well as inflicting severe harm on the body itself. The immune system must carefully regulate itself to avoid such damage to host tissues and restore equilibrium following an inflammatory response. In the peripheral immune system, the immune cell responses are regulated by a balance of positive and negative signals that are sent to effector cells to adjust them to their environment. The identification of immunological checkpoints has opened up new avenues for studying and perhaps modifying immune responses in the context of RA pathogenesis. T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3), a member of the TIM family, has emerged as a major regulator in immune checkpoint pathways, with several studies on its various functions in immunological homeostasis and autoimmune disorders. This review narrates the critical function of TIM-3 in the control of immunological checkpoints in rheumatoid arthritis also the potential role of TIM-3/GAL-9 signalling as a therapeutic target for the development of a new class of immunotherapeutic agents for the treatment of RA.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":"5-16"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural and Molecular Effects of Dextrose on Cartilage: A Scoping Review.","authors":"Pedro Ivan Arias-Vazquez, Kenneth D Reeves, Rosa Giannina Castillo-Avila, Gaston A Topol, Ricardo Quezada-Gonzalez, Pavel Loeza-Magana, Elizabeth Carmona-Diaz, Eduardo De la Cruz-Cano, Daniel Cadena-Sandoval","doi":"10.2174/0115733971386046250611073643","DOIUrl":"10.2174/0115733971386046250611073643","url":null,"abstract":"<p><strong>Background: </strong>Dextrose prolotherapy has been used in the treatment of individuals with osteoarthritis in various locations, reporting favorable therapeutic effects. However, the molecular and/or structural effects of dextrose prolotherapy on cartilage are still unclear. Therefore, this study aimed to analyze the molecular and/or structural effects of dextrose on cartilage and clarify the possible mechanisms of action of dextrose prolotherapy.</p><p><strong>Methods: </strong>A systematic search was conducted using scientific databases, including PubMed, Web of Science, Cochrane Central Register of Controlled Trials, and ScienceDirect, up until November 2024, using the PRISMA-ScR for Scoping Reviews.</p><p><strong>Results: </strong>Twenty-three studies that evaluated the molecular and/or structural effects of dextrose on cartilage were eligible for inclusion. Fifteen studies included in vitro models, three studies involved animal models, and five studies were conducted on humans. Sixteen studies reported favorable effects on cartilage, and seven studies reported unfavorable effects. In all studies performed in vivo (in animals or humans), predominantly favorable effects on cartilage were reported. The favorable effects on cartilage were improved glucose metabolism in chondrocytes, increased deposition of extracellular matrix and the induction of chondrocyte proliferation, increased expression of anabolic growth factors and anti-inflammatory cytokines, as well as decreased activity of some metalloproteinases. Among the unfavorable effects, increased release of proinflammatory and catabolic cytokines was reported.</p><p><strong>Conclusion: </strong>These results suggest that dextrose may have a therapeutic effect on cartilage, though the underlying mechanisms are not fully understood. This study is a starting point for future experimental studies evaluating the therapeutic effects of dextrose prolotherapy.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":"1-17"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicodemographic Data of Patients with Behçet's Disease: Data from a Tertiary Center in Saudi Arabia.","authors":"Yasser Bawazir, Mohammad Mustafa","doi":"10.2174/0115733971359862250603040950","DOIUrl":"10.2174/0115733971359862250603040950","url":null,"abstract":"<p><strong>Introduction: </strong>Behçet's disease (BD) is a chronic inflammatory vasculitis involving the arteries and veins. This study was driven by the rarity, chronic multisystemic nature, and heterogeneous spectrum of clinical features and geographical distribution. This study aimed to analyze the demographic and clinical characteristics of patients with BD at the King Abdulaziz University Hospital and identify the association between clinical and laboratory findings and disease severity.</p><p><strong>Methods: </strong>The study was a retrospective core chart review. This study included adult patients who visited the rheumatology clinic of King Abdulaziz University Hospital in Saudi Arabia between 2005 and 2023. The inclusion criteria were age ≥18 years and a diagnosis of Behçet's disease (BD) based on either the International Criteria for Behçet's Disease or the International Study Group classification criteria.</p><p><strong>Results: </strong>In total, 81 patients with BD with almost equal male (51.9%) and female (48.1%) distribution, 75.3% Saudi nationals, mean onset age of 38.48 years, and mean body mass index of 27.57 kg/m2 were identified. The most common clinical manifestations were oral ulcerations (56.8%), genital ulcerations (37%), uveitis (24.7%), arthritis (22.2%), skin lesions (13.6%), and deep vein thrombosis (9.88%). Significant differences in high-density lipoprotein, hemoglobin, Creactive protein, and albumin levels were associated with the age, sex, and nationality of the patients, respectively. Similarly, body mass index was significantly associated with C-reactive protein (p = 0.004), alanine aminotransferase (p = 0.023), aspartate aminotransferase (p = 0.003), and gamma-glutamyl aminotransferase (p = 0.034) levels.</p><p><strong>Discussion: </strong>The observed clinical and demographic patterns align with regional and global data, though a slightly older age at onset and high BMI prevalence were noted. Associations between BMI and inflammatory or hepatic markers suggest a possible metabolic influence on disease activity. Laboratory differences across demographic subgroups emphasize the need for individualized disease assessment. These insights can inform tailored care strategies for BD patients in the Saudi context.</p><p><strong>Conclusion: </strong>This study demonstrated that there are significant associations between demographic factors, laboratory parameters, and BD activity.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":"94-103"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13223487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Effect of Hypoxia on Adipose-Derived Mesenchymal Stromal Cells <i>In Vivo</i>: A Systematic Review.","authors":"Benjamin Gompels, Alexandra MacMillan, Simone Castagno, Antonia Vogt, Wasim Khan","doi":"10.2174/0115733971371615250825101351","DOIUrl":"10.2174/0115733971371615250825101351","url":null,"abstract":"<p><strong>Introduction: </strong>Adipose-Derived Mesenchymal Stromal Cells (ADMSCs) are a developing area of cell therapy due to their ease of access and differentiation potential. Within in vitro studies, culturing cells at low oxygen tension (< 21%) can modulate the immune function of MSCs, enhance cell proliferation, and reduce cell senescence. This could impact their clinical utility when implanted in vivo. This systematic review examined the effect of hypoxic culture on ADMSCs in vitro and their behaviour when implanted into an in vivo disease model.</p><p><strong>Methods: </strong>This systematic review was registered on the PROSPERO database with the identification number CRD42023401755. A literature search was performed across four databases: EMBASE, MEDLINE, PubMed, and Cochrane.</p><p><strong>Results: </strong>320 studies were extracted from Embase, 122 from Medline via Ovid, and no studies were selected from the Cochrane database. Before screening the abstracts, 50 records were removed as duplicates. Following the abstract screening, 330 records were excluded from the search. Based on the complete text, 62 papers were included according to the applied criteria, as shown in Table 1. The final number of included articles was five.</p><p><strong>Discussion: </strong>In several selected studies, hypoxic culture (or preconditioning) of ADMSCs has been shown to positively affect motility, promoting cell differentiation and the resolution of ischaemic injury. However, hypoxic culture was not universally successful across the selected in vivo study models. Selected studies indicate that hypoxic preconditioning of ADMSCs improves motility, aiding cell differentiation and the healing of ischaemic injury. While in vivo models suggest enhanced cell function with hypoxic culture, results vary, reflecting differences in culture methods and technical translation issues between in vitro and in vivo models. The limited number of papers reviewed makes it challenging to draw broad conclusions due to the diversity of models and methods.</p><p><strong>Conclusion: </strong>To conclude, a common focus in the studies is VEGF activation, highlighting its potential as a therapeutic target, especially for retinal disorders that affect angiogenesis. Nonetheless, the influence of conditioned MSCs on VEGF-particularly in musculoskeletal research such as cartilage regeneration-has not been thoroughly examined. Future reviews must focus on this gap as the field progresses.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":"1-12"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Vitamin K Intake and Fracture Risk: A Systematic Review and Dose-Response Meta-Analysis on the Interplay with Vitamin D.","authors":"Mohammad Mehdi Lari Haghighat, Babak Haghpanah, Alireza Milajerdi","doi":"10.2174/0115733971393704250828112958","DOIUrl":"10.2174/0115733971393704250828112958","url":null,"abstract":"<p><strong>Background: </strong>Fractures are a significant global health issue, particularly among older adults, and are associated with substantial morbidity and mortality. While several risk factors are well-established, the role of dietary vitamin K in fracture prevention remains unclear, with existing epidemiological studies yielding inconsistent results.</p><p><strong>Objective: </strong>This meta-analysis aimed to comprehensively evaluate the association between dietary vitamin K intake and the risk of fractures, including a dose-response analysis to explore potential non-linear relationships.</p><p><strong>Methods: </strong>A comprehensive search was conducted in the PubMed and EMBASE databases, covering the period from January 1966 to July 2025. The certainty of the evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) framework.</p><p><strong>Results: </strong>A total of six studies encompassing 93,776 participants and 1394 instances of fractures were analyzed. We found a trend towards a decreased risk of overall fractures with increased vitamin K consumption, with a risk ratio of 0.83 (95% CI, 0.68-1.01). Similarly, vitamin K intake showed a trend toward a reduced risk of hip fractures (risk ratio: 0.76, 95% CI: 0.56-1.02; I2 = 43.91%). Furthermore, the risk of overall fractures decreased with dietary vitamin K consumption up to 120 μg/day.</p><p><strong>Conclusions: </strong>Our meta-analysis suggests that dietary vitamin K intake may have a protective effect against fractures. We observed a U-shaped association between fracture risk and vitamin K intake at recommended dietary allowance (RDA) levels. Further studies in diverse populations, examining different forms of vitamin K and their relation to fracture risk at various skeletal sites, are warranted.</p><p><strong>Systematic review registration: </strong>PROSPERO 1016592.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":"1-12"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}