Current rheumatology reviews最新文献

{"title":"The Interplay between Osteoarthritis and the Microbiome-joint Axis: A Systemic Perspective on Novel Therapeutic Targets.","authors":"Marco Valentini, Guido Maria Valentini, Ibrahim Akkawi, Sabrina Donati Zeppa, Alessia Bartolacci, Francesco Pegreffi, Hassan Zmerly","doi":"10.2174/0115733971450825260423042902","DOIUrl":"https://doi.org/10.2174/0115733971450825260423042902","url":null,"abstract":"<p><p>Osteoarthritis (OA) is a chronic and progressive joint disease involving the articular cartilage, synovium, subchondral bone, and ligaments, ultimately leading to pain, dysfunction, and, in advanced stages, joint destruction. Several factors contribute to the development and progression of OA, including genetic predisposition, biomechanical stress, metabolic imbalance, and chronic low-grade inflammation. Recently, a novel factor has emerged: the gut microbiome. Gut dysbiosis, defined as an alteration in gut microbiota homeostasis, can disrupt immune, metabolic, and inflammatory pathways, promoting systemic inflammation and accelerating degenerative changes in joint tissues. Conversely, restoration of a balanced gut microbiota may play a protective role and represent a promising avenue for innovative therapeutic strategies. The aim of this review is to analyse the relationship between gut dysbiosis and osteoarthritis, and to discuss potential therapeutic approaches targeting the microbiome to prevent disease progression.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Progress of Gout Prediction Models Based on Multi-source Data.","authors":"Wenrui Shi, Hongzhu Qu, Xiangdong Fang","doi":"10.2174/0115733971444947260203111252","DOIUrl":"https://doi.org/10.2174/0115733971444947260203111252","url":null,"abstract":"<p><strong>Introduction: </strong>Gout, a highly serious inflammatory disease that is caused by monosodium urate crystals, is becoming an increasingly significant health concern. Artificial Intelligence and multi-omics-based research have made significant gains for the early detection and prevention of gout based on diverse approaches. This review intends to summarize current advances in forecasting gout susceptibility and gout-related symptoms, evaluate the predictive efficacy of different features, and ascertain which clinical and omics characteristics are most effective in these prediction models.</p><p><strong>Methods: </strong>We explored the PubMed database after 2010 using keywords such as \"gout\", \"predictive model\", \"risk prediction\", and \"machine learning\", and confined our search to Englishlanguage articles. The original peer-reviewed research articles that developed gout models were selected. Research that was not original or lacked internal validation was excluded.</p><p><strong>Results: </strong>Clinical features, genomics, microbiomics, radiomics, and metabolomics have been utilized to construct models related to gout and have demonstrated excellent predictive performance. Multisource data prediction models usually exhibit better effectiveness.</p><p><strong>Discussion: </strong>Gout-oriented models performed excellently in predictive performance but present limitations in certain clinical and omics domains. However, if they are to affect actual patient care, they must overcome some external confirmation roadblocks and the fiscal and practical implications they will face ahead of time.</p><p><strong>Conclusion: </strong>This review indicates that clinical and multi-omics models of gout are significant instruments for clinical decision-making. The models constructed in these studies may be crucial for the treatment of gout and its practical benefits.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limited Access to Systemic Lupus Erythematosus: A Systematic Review.","authors":"Pamela Munguía-Realpozo, Claudia Mendoza-Pinto, Ivet Etchegaray-Morales, Edith Ramírez-Lara, Juan Carlos Solis-Poblano, Jorge Ayón-Aguilar, Socorro Méndez-Martínez, Gabriela Medina Valeriano, Máximo Alejandro García Flores","doi":"10.2174/0115733971410947251206094951","DOIUrl":"https://doi.org/10.2174/0115733971410947251206094951","url":null,"abstract":"<p><strong>Introduction: </strong>Inequities in systemic lupus erythematosus (SLE) care affect outcomes (i.e., flares, damage, mortality), interventions (referrals, advanced therapies), and populations (gender, race/ethnicity, and geographic region). This systematic review highlights themes related to access to care for SLE patients and explores potential solutions to address these disparities.</p><p><strong>Methods: </strong>In adherence to PRISMA guidelines, we conducted a systematic review of the literature. We searched for articles published in PubMed, Scopus, Web of Science, Cochrane Library, and EBSCO. Publications related to economic burden, barriers and facilitators to access, and potential solutions were included.</p><p><strong>Results: </strong>A total of 77 articles were identified. Five critical issues concerning access to SLE care were revealed from the literature: (1) economic burden, (2) barriers and facilitators to access, (3) utilization, (4) adherence, and (5) possible solutions to improve healthcare access.</p><p><strong>Discussion: </strong>The usual barriers and facilitators involved several social factors related to health (i.e., transportation, insurance, and limited access to mental health services, among others). Utilization of SLE care is influenced by socioeconomic status (SES), ethnicity, and education level. Factors like low education, low SES, rural residency, and depressive symptom adherence contribute to nonadherence. There were various proposals to improve access to SLE care, including peer support, digital platforms (e.g., telemedicine), and community-based programs (such as PALS and WELL).</p><p><strong>Conclusions: </strong>The SLE care field highlights the inequalities that impact marginalized communities. Emphasizing community-based programs, addressing social determinants of health, acknowledging social exclusion, and adopting digital platforms can help reduce healthcare inequity.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carpal Tunnel Decompression and Occupational Productivity: Assessing Post-Surgical Work Engagement and Absenteeism.","authors":"Noura Belhadj, Olfa Joma, Ines Ghnaya, Ines Rassas, Sirine Abdellatif, Asma Kheder, Taoufik Khalfallah, Aoutef Mahfoudh, Mohamed Younes","doi":"10.2174/0115733971376935251130214051","DOIUrl":"https://doi.org/10.2174/0115733971376935251130214051","url":null,"abstract":"<p><strong>Introduction: </strong>Carpal Tunnel Syndrome (CTS) imposes significant occupational and economic burdens, yet data on postoperative work outcomes in Tunisia remain limited.</p><p><strong>Methods: </strong>This retrospective cross-sectional study (2014-2022) analyzed 118 surgically managed CTS patients from Taher Sfar Mahdia University Hospital using the BCTQ-A (symptom/function severity) and WPAI-GH (work productivity) questionnaires.</p><p><strong>Results: </strong>Key predictors for surgical intervention included bilateral involvement (Adj. OR=22.0, 95%CI:5.5-33.4), thumb opposition loss (p<0.001), and occupational factors like >8h workdays (p=0.04) and >20 years' seniority (p=0.05). Postoperatively, 68.3% required workstation adjustments, while 19.5% underwent job transfers. The cohort demonstrated substantial productivity impairment, with 69.4% overall work productivity loss (WPAI-GH), disproportionately affecting older (>40 years, p=0.02) and less-educated workers (p=0.02). Notably, 84.4% of patients required 30-day medical leave, aligning with global benchmarks (23.4-day average). Multivariate analysis identified nocturnal pain (p<0.001) and difficulty with bottle-opening (p<0.001) as key drivers of productivity decline.</p><p><strong>Discussion: </strong>Operated CTS appears to have a more substantial impact on work quality, likely due to surgical complications and postoperative recovery challenges. This underscores the importance of early conservative management and preventive strategies. These findings underscore the need for early ergonomic interventions, particularly in high-risk sectors like garment manufacturing (81.7% of the cohort) and multidisciplinary prevention strategies combining workplace modifications, health education, and weight management.</p><p><strong>Conclusion: </strong>With CTS costing over $2B annually in the U.S. alone, proactive measures targeting long-tenured manual laborers are urgently needed to mitigate its socioeconomic impact.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Auditory Manifestations of Autoimmune Rheumatologic Diseases: A Review of Current Evidence.","authors":"Zahi Hamdan, Rita Abou Zeid, Pierre Abi Akl, Mira Merashli","doi":"10.2174/0115733971415872260122115355","DOIUrl":"https://doi.org/10.2174/0115733971415872260122115355","url":null,"abstract":"<p><strong>Background: </strong>It is becoming increasingly recognized that rheumatologic diseases and sensorineural hearing loss (SNHL) are linked. These autoimmune disorders can affect the auditory system through both disease-related immune dysregulation and medication-induced ototoxicity. The latest findings on auditory involvement in patients with autoimmune rheumatologic conditions are summarized in this review.</p><p><strong>Methods: </strong>This narrative review was conducted using PubMed, focusing on articles published in English between 2010 and 2024. Clinical, experimental, and epidemiological studies describing hearing outcomes in autoimmune conditions were included. MeSH and keywords related to autoimmune diseases, SNHL, auditory dysfunction, and cochlear implantation were used.</p><p><strong>Results: </strong>Autoimmune-mediated SNHL results from immune complex deposition, vasculitis, antibody- mediated cytotoxicity, and inflammatory injury to cochlear structures. Rheumatoid arthritis, systemic lupus erythematosus, primary Sjögren's syndrome, vasculitis, juvenile idiopathic arthritis, IgG4-related disease, and Behçet's disease all demonstrate variable yet significant auditory involvement. Commonly used medications for these diseases, such as calcineurin inhibitors, methotrexate, cyclophosphamide, and antimalarials, may also cause ototoxicity. Cochlear implantation offers effective rehabilitation for severe or refractory SNHL. However, autoimmune- related cochlear fibrosis or ossification may limit outcomes, highlighting the need for prompt diagnosis.</p><p><strong>Conclusion: </strong>Hearing is affected in patients with rheumatologic disease and those using immunosuppressants as treatment. Routine audiologic monitoring, early identification of auditory symptoms, and personalized therapeutic planning are essential. Further prospective research is needed to clarify the mechanisms and optimize treatment protocols for autoimmune-associated hearing loss.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic Insights and Therapeutic Advances in Natural Bioactive Compounds as Multi-target Agents in Rheumatoid Arthritis.","authors":"K Sunand, Arpan Kumar Tripathi, Akhilesh Patel, Praveen Nasa, Shadab Ali, Shamim Shamim","doi":"10.2174/0115733971409871251206061614","DOIUrl":"https://doi.org/10.2174/0115733971409871251206061614","url":null,"abstract":"<p><strong>Introduction: </strong>Rheumatoid arthritis is a chronic autoimmune disorder characterized by persistent inflammation, synovial hyperplasia, and joint destruction. Despite advances in biologics and disease-modifying antirheumatic drugs, treatment challenges remain due to incomplete responses, adverse effects, and high costs. This has spurred interest in natural bioactive compounds as multi-target therapeutic agents.</p><p><strong>Methods: </strong>A comprehensive review of preclinical and clinical studies was conducted to evaluate the mechanisms of action, therapeutic potential, limitations, and formulation strategies of natural bioactive compounds for rheumatoid arthritis management.</p><p><strong>Results: </strong>natural bioactive compounds derived from plant, marine, and microbial sources, including polyphenols, flavonoids, alkaloids, and terpenoids, exhibit anti-inflammatory, antioxidant, immunomodulatory, and antiproliferative effects. They modulate key rheumatoid arthritis pathways, including NF-κB, JAK/STAT, MAPK, and Nrf2, while restoring immune balance through Th17/Treg regulation. Preclinical studies show efficacy in reducing cytokine storms, oxidative stress, and fibroblast-like synoviocyte proliferation. Clinical trials with curcumin, resveratrol, and boswellic acids demonstrated improvements in disease activity, pain, and inflammatory biomarkers. However, poor bioavailability and variability in extracts remain major limitations.</p><p><strong>Discussion: </strong>Emerging nanotechnology-based delivery systems have enhanced the stability and absorption of natural bioactive compounds. While natural bioactive compounds demonstrate lower toxicity and potential to complement conventional therapies, challenges persist regarding standardization, dosing, and reproducibility. Large-scale, well-designed trials are still needed to validate their clinical utility compared to biologics.</p><p><strong>Conclusion: </strong>Current evidence suggests that natural bioactive compounds hold promise as safe, multi-target adjuncts that may complement existing Rheumatoid arthritis therapies and improve overall disease management, but further rigorous clinical validation is essential.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Sequential Imaging in Psoriatic Arthritis: A Case-Based Review on Identifying Coexisting Microcrystalline Disease.","authors":"Angelo Nigro","doi":"10.2174/0115733971410308260113094637","DOIUrl":"https://doi.org/10.2174/0115733971410308260113094637","url":null,"abstract":"<p><strong>Introduction: </strong>The coexistence of psoriatic arthritis (PsA) and crystal-associated joint disease is an important diagnostic problem in clinical treatment. In patients with established PsA, the presence of new inflammatory responses may indicate disease activity or another pathological state, and thus necessitates differential diagnosis of disease processes and/or a diagnosis of a new disease process.</p><p><strong>Presentation: </strong>We report the case of a 55-year-old man with chronic PsA who presented with acute monoarticular inflammation of the left wrist that was refractory to standard antiinflammatory treatment. The discovery of newly observed calcific deposits in the left wrist, observed during sequential plain radiographic evaluation, raised suspicion of a crystal-associated inflammatory process. This discovery provided insight into the treatment regimen and clinical response.</p><p><strong>Conclusion: </strong>This case illustrates the need to consider crystal-associated inflammation in patients with PsA who present with atypical or treatment-resistant joint pathology. Sequential imaging, especially plain radiography, might facilitate diagnostic clarification and prevent the inappropriate escalation of immunosuppressive therapy.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Multi-Omics of Systemic Lupus Erythematosus.","authors":"Yiyuan Wang, Jing Wang, Zhangwei Lu, Qianqian Zhou, Yangguang Cao, Yujie Du, Xue Jin, Baozhu Li","doi":"10.2174/0115733971421580251203103143","DOIUrl":"https://doi.org/10.2174/0115733971421580251203103143","url":null,"abstract":"<p><p>This comprehensive narrative review examines recent advances in multi-omics research for Systemic Lupus Erythematosus (SLE), emphasizing integrated approaches over singleomics studies. The review critically evaluates technological advancements, methodological innovations, and clinical applications while identifying current limitations and future research directions. We conducted a comprehensive narrative review following SANRA guidelines, searching PubMed, Web of Science, Scopus, and Embase, covering publications from January 2018 to June 2025. The review focuses on studies integrating two or more omics layers in SLE research, with emphasis on computational methods, biomarker validation, and clinical applications. Multiomics integration has revealed critical insights into SLE pathogenesis, including immune cell heterogeneity, gene-environment interactions, and metabolic dysregulation. However, significant challenges remain in data integration methodologies, small sample sizes, and biomarker reproducibility. Current computational approaches include early integration (concatenation), intermediate integration (joint dimensionality reduction), and late integration (ensemble methods). While multi-omics approaches offer unprecedented insights into SLE complexity, standardized integration protocols and robust validation frameworks are urgently needed. Small sample sizes and heterogeneity issues limit reproducibility, particularly affecting biomarker discovery and clinical translation. Multi-omics integration represents a paradigm shift toward precision medicine in SLE, but realizing this potential requires addressing current methodological limitations, standardizing validation processes, and developing robust computational frameworks for reliable clinical applications.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kikuchi-Fujimoto Disease as the Initial Presentation of Dermatomyositis.","authors":"Mohammad Mustafa, Yasser Bawazir","doi":"10.2174/0115733971412019251111163326","DOIUrl":"https://doi.org/10.2174/0115733971412019251111163326","url":null,"abstract":"<p><strong>Background: </strong>Kikuchi-Fujimoto Disease (KD) is a rare necrotizing lymphadenitis that is often self-limiting but occasionally associated with autoimmune conditions. Dermatomyositis is an autoimmune inflammatory myopathy that typically presents with proximal muscle weakness and a characteristic skin rash. In this report, we present a unique case of KD, the first documented association worldwide as the initial manifestation of dermatomyositis, highlighting the rarity and novelty of this case.</p><p><strong>Case presentation: </strong>A 30-year-old Saudi female presented with a persistent fever, cervical lymphadenopathy, and significant weight loss. A lymph node biopsy confirmed the diagnosis of KD. Despite the initial steroid therapy, her symptoms recurred, prompting further investigation, which revealed elevated muscle enzyme levels, myopathic changes on electromyography, and MRI evidence of inflammatory myositis. The clinical presentation, combined with a heliotrope rash, confirmed the diagnosis of dermatomyositis. The patient responded well to pulse steroids, intravenous immunoglobulin, and rituximab, achieving remission and successfully tapering off corticosteroids. She is currently under regular follow-up care at a rheumatology clinic and has been in remission for the past eighteen months.</p><p><strong>Conclusion: </strong>This case highlights the importance of considering underlying autoimmune diseases, such as dermatomyositis, in atypical refractory KD. Early recognition and tailored immunosuppressive therapy are crucial to achieve optimal outcomes.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Bibliometric Analysis of Systematic Reviews in the Field of Ankylosing Spondylitis from 2007 to 2025.","authors":"Jie Gao, Zhaoqian Wang, Xinlan Lin, Juan Li, Jingjing Li, Tao Pang, Wansheng Chen, Xia Tao, Feng Zhang","doi":"10.2174/0115733971395228251124103324","DOIUrl":"https://doi.org/10.2174/0115733971395228251124103324","url":null,"abstract":"<p><strong>Background: </strong>Ankylosing spondylitis (AS) is an inflammatory autoimmune disease and the most common clinical form of spinal arthritis. Over the past decades, tremendous progress has been made in systematic reviews on AS. This study aimed to conduct a bibliometric analysis of AS-related meta-analyses to visualize the hotspots and trends in the field.</p><p><strong>Methods: </strong>A comprehensive search was conducted for publications of AS meta-analyses from 2007 to 2025 using the Web of Science Core Collection database. Bibliometric analysis was performed using the Bibliometrix software package, VOSviewer, and CiteSpace.</p><p><strong>Results: </strong>In total, 507 articles were identified, and the number of relevant publications showed annual growth. China, the USA, and England were the most productive countries. Annals of the Rheumatic Diseases was the most productive journal (54, 10.65%), Pan Faming was the most productive author (23, 4.54%), and Anhui Medical University (45, 8.88%) was the most productive institution. High-frequency keywords were mainly grouped into five themes: complications, biologics, physical therapy exercises, gut microbiota, and analytical methods.</p><p><strong>Discussion: </strong>This first bibliometric analysis of AS-related EBM research showed a 20-year upward trend in AS meta-analyses, consistent with prior studies. CiteSpace revealed that China (top since 2014) and the USA led in publications (53 countries) but had limited collaboration. Pan Faming (23 articles) was the most active author, and Annals of the Rheumatic Diseases published the most articles. Keyword analysis identified five themes (e.g., AS complications, biologics) and research frontiers: pre-2012 genome-AS links, post-2012 multi-center RCTs, and the recent focus on AS patients' HRQoL. Limitations included database and English-language bias; future meta-analyses should adopt standardized outcomes.</p><p><strong>Conclusion: </strong>In recent years, there has been a remarkable surge in the number of meta-analyses on AS. This significant increase underscores the importance of this research area. Studies in this field have mainly focused on several key aspects: risk factors, network meta-analysis, and quality- of-life studies. These findings are highly valuable for understanding advancements in ASrelated research and can also encourage researchers and clinicians to focus on both effective medical treatments and the well-being of AS patients.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}