Current rheumatology reviews最新文献

{"title":"The Bidirectional Relationship between Psoriatic Arthritis and Mental Health: A Comprehensive Review.","authors":"Shushank Mahajan, Sanjana Mehta, Soumarshi Das, Unnati Jain, Samrat Chauhan, Sanchit Dhankhar","doi":"10.2174/0115733971402784250807191227","DOIUrl":"https://doi.org/10.2174/0115733971402784250807191227","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriatic arthritis (PsA) is a long-standing inflammatory immune-mediated condition that involves articular and peri-articular tissues and frequently accompanies psoriasis (PsO). It is defined by chronic joint inflammation, pain, and structural damage, resulting in impairment of physical function and quality of life. Increasing evidence points to the close relationship between PsA and mental disorders, especially depression and anxiety.</p><p><strong>Methods: </strong>This review utilized an extensive literature search approach to select studies addressing the correlation between psoriatic arthritis (PsA) and mental comorbidities such as depression, anxiety, and their influence on quality of life and the disease course. Databases like PubMed, Scopus, Web of Science, and Google Scholar were utilized up to 2024 with applicable keywords and Boolean operators.</p><p><strong>Results: </strong>The mutual interaction between PsA and psychological distress is moderated by mechanisms including chronic pain, systemic inflammation, physical disability, and the social stigma of psoriatic lesions. Research suggests that patients with PsA exhibit an increased frequency of anxiety and depression in comparison to the general population, and that mental illness augments the severity of the disease and affects the outcome of treatments adversely. In addition, PsA may also cause systemic inflammation that might lead to neurocognitive dysfunction, adding to the risk for mood disorders.</p><p><strong>Discussion: </strong>Although there is a long-standing, well-documented psychosocial morbidity associated with PsA, mental health comorbidities are frequently underdiagnosed and undertreated. Psychological distress must be treated as an integral part of PsA management to enhance patient-reported outcomes as well as quality of life.</p><p><strong>Conclusion: </strong>This review examines the complex interaction between PsA and mental health, considers the possible underlying mechanisms, and highlights the necessity of an integrated, multidisciplinary treatment strategy for patients.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scurvy in a Patient with Crohn's Disease: A Case Report.","authors":"Kiana Mortezaei, Sofia Audrey B Gonzales, Adam Kreitenberg, Daniel G Arkfeld","doi":"10.2174/0115733971355926250805052920","DOIUrl":"https://doi.org/10.2174/0115733971355926250805052920","url":null,"abstract":"<p><strong>Introduction/background: </strong>Crohn's disease is a chronic autoimmune bowel disease that typically causes inflammation of the lining or wall of the small and large intestines as well as the entire gastrointestinal tract. Patients diagnosed with Crohn's disease can develop oral ulcers, which are also a symptom of vitamin C deficiency, also known as scurvy. Patients with Crohn's disease are prone to experiencing nutritional deficiencies, including vitamin C deficiency due to malabsorption.</p><p><strong>Case presentation: </strong>In this case report, we describe a very interesting presentation of scurvy in the presence of extensive oral Crohn's ulcers. The patient presented to the clinic reporting bleeding gums and painful mouth sores. An extensive workup revealed high inflammatory levels and low vitamin C levels. The patient received vitamin C infusions with improvement in symptoms. However, further workup, including a capsule endoscopy and oral biopsies, revealed Crohn's disease.</p><p><strong>Conclusion: </strong>There have been limited reports regarding the concurrence of both scurvy and Crohn's disease. With oral ulcerations being a characteristic of both conditions, diagnosing Crohn's disease in the setting of Vitamin C deficiency may be challenging.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Complication of Intralesional Corticosteroid Injections: Two Case Reports.","authors":"Omayma Khadiri, Rim Kaoua, Maryem Aboudourib, Said Amal, Ouafa Hocar","doi":"10.2174/0115733971368413250730095105","DOIUrl":"https://doi.org/10.2174/0115733971368413250730095105","url":null,"abstract":"<p><strong>Background: </strong>Intralesional corticosteroid injections are widely used for treating various inflammatory and musculoskeletal conditions. While generally safe, they can cause adverse effects, including hypopigmentation, which may have psychosocial implications for affected patients.</p><p><strong>Case presentation: </strong>We report two cases of hypopigmentation following intralesional triamcinolone acetonide injections. The first case involves a 65-year-old man who developed a well- defined hypopigmented patch on the dorsum of his right hand following treatment for De Quervain's tenosynovitis. The second case describes a 25-year-old patient who presented with linear hypopigmentation along the anterior aspect of his left foot after an intra-articular injection for a synovial cyst. In both cases, hypopigmentation was confirmed using Wood's lamp examination, and spontaneous improvement was noted over time.</p><p><strong>Conclusion: </strong>Clinicians should be aware of this potential side effect when administering corticosteroid injections and inform patients accordingly. While hypopigmentation is typically self-limiting, patient education and reassurance are essential, particularly for individuals with darker skin types.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discoid Lupus Flare with Chondritis Triggered by Eaton Fire Case Report.","authors":"Sofia Audrey B Gonzales, Kiana Mortezaei, Daniel G Arkfeld","doi":"10.2174/0115733971396962250721111020","DOIUrl":"https://doi.org/10.2174/0115733971396962250721111020","url":null,"abstract":"<p><strong>Introduction: </strong>Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disorder with flare-ups often triggered by environmental stressors. While stress is a known trigger for lupus exacerbations, the relationship between environmental stressors, lupus flares, and discoid lupus erythematosus remains underexplored. This case report examines a patient whose symptoms worsened after exposure to the Eaton fire.</p><p><strong>Case presentation: </strong>A 57-year-old female with lupus reported a flare following the Eaton fire, which severely damaged her parents' home. Symptoms began 12 hours after the fire. Examination revealed erythema and deformity in both ears, consistent with chondritis. After starting a prednisone taper, her condition improved within two weeks.</p><p><strong>Conclusion: </strong>Environmental stressors, like natural disasters, can trigger lupus flare-ups and conditions, such as discoid lupus erythematosus (DLE). Stress-induced immune dysregulation exacerbates autoimmune responses, making it challenging to differentiate discoid lupus from other lupus manifestations. This case highlights the need for recognizing environmental triggers in lupus management and further research into the role of stress in lupus flare-ups.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperbaric Oxygen Therapy as a Therapeutic Option for Patients with Fibromyalgia.","authors":"Philippe Pencalet","doi":"10.2174/0115733971370773250625104646","DOIUrl":"https://doi.org/10.2174/0115733971370773250625104646","url":null,"abstract":"<p><strong>Introduction/objective: </strong>This narrative review has briefly outlined the mechanisms of action underlying the therapeutic effects of hyperbaric oxygen (HBO). It was designed to provide researchers and healthcare professionals with a broad overview of the benefits and potential drawbacks of using HBO in FM patients.</p><p><strong>Methods: </strong>For this review, we searched PubMed/Medline, Cochrane Library, Embase, and Google Scholar databases for articles published between 2000 and 2023, using the following search terms: \"hyperbaric oxygen therapy\", \"fibromyalgia\", and \"physical exercise\".</p><p><strong>Results: </strong>In total, more than 90 publications were retrieved, 45 of which were analyzed in depth. The majority of the studies retrieved were of an observational design, whereas there were only a few randomized trials and very few reviews. Based on the compiled literature, there is further support for the hypothesis that reduced oxygen availability may be at the origin of the structural degeneration observed in the muscles of FM patients. In the absence of a universally accepted cure for FM, the therapeutic approach must be multidisciplinary and multimodal. It should be noted that many questions remain unanswered. What is the optimal dose-response range, duration of treatment, and associated economic cost? Larger controlled trials are needed to determine the exact role of HBO as an adjuvant therapy for FM patients.</p><p><strong>Conclusion: </strong>Based on the published literature, repeated exposure to HBO may be a promising therapeutic adjunct for FM patients. However, more clinical research is needed before HBO can be established as a reliable approach for FM patients.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonographic Features of Amyloid Arthropathy in Light Chain Amyloidosis: A Case Report.","authors":"Maroua Slouma, Malek Dhifallah, Imen Gharsallah","doi":"10.2174/0115733971366804250619214510","DOIUrl":"https://doi.org/10.2174/0115733971366804250619214510","url":null,"abstract":"<p><strong>Background: </strong>Amyloid arthropathy is characterized by the deposition of misfolded proteins in the joints and soft tissues. It is often a manifestation of light chain amyloidosis. The ultrasonographic features of amyloid arthropathy are solely reported in the literature.</p><p><strong>Case presentation: </strong>Herein, we present the case of a 70-year-old patient who was diagnosed with light chain amyloidosis. He reported chronic joint pain, bilateral carpal tunnel syndrome, and an inguinal mass. Ultrasound examination revealed tenosynovitis of the flexor digitorum tendons, the extensor carpi ulnaris tendon, and the long head of the biceps tendon, along with synovitis in the wrists, elbows, and shoulders, as well as knee joint effusion. The synovial thickening with heterogeneous echogenic material suggested amyloid deposition.</p><p><strong>Conclusion: </strong>This case underscored key ultrasonographic features of amyloid arthropathy, including synovial thickening with heterogeneous echogenic deposits, tenosynovitis, and subacromialsubdeltoid bursa involvement. Unlike rheumatoid arthritis, amyloidosis lacked erosions and power Doppler signal, highlighting imaging distinctions. The hypoechoic inguinal amyloidoma with calcifications further aligned with amyloid deposition. Although amyloidosis shares certain clinical features with dialysis-related β2-microglobulin amyloidosis (e.g., carpal tunnel syndrome, shoulder deposits), AL amyloidosis may exhibit unique patterns, such as diffuse synovial infiltration without hyperemia. However, ultrasound's non-specificity necessitates histopathological confirmation. While systemic amyloidosis requires pathological confirmation, ultrasonography provides a rapid, cost-effective tool for early diagnostic guidance.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report of an Atypical Presentation of Inclusion Body Myositis Masquerading as Polymyalgia Rheumatica.","authors":"Pallavi Velagapudi, Diego Lugo Baruqui, Ahmed Elghawy, Carlos Pena","doi":"10.2174/0115733971361017250619105000","DOIUrl":"https://doi.org/10.2174/0115733971361017250619105000","url":null,"abstract":"<p><strong>Introduction: </strong>Idiopathic inflammatory myopathies are a group of rheumatologic disorders presenting with progressive muscle weakness and the presence of inflammatory infiltrates in muscle tissue on histopathology. Inclusion body myositis classically has an insidious onset and slow progression and affects the older population, most commonly men. Muscle weakness is usually asymmetric and involves the distal upper extremity muscle groups.</p><p><strong>Case presentation: </strong>This case describes a 59-year-old man presenting with worsening symmetrical upper and lower extremity proximal muscle weakness and disabling muscle pain in his shoulders and hips. Further, weakly positive antinuclear antibodies were also observed. The creatinine phosphokinase was also remarkably elevated, uncharacteristic of both inclusion body myositis and polymyalgia rheumatica. He was initially thought to have polymyalgia rheumatica, but given the time frame and the presence of muscle pain, a muscle biopsy was done, which confirmed the inclusion body myositis.</p><p><strong>Conclusion: </strong>This case underscores the challenges in diagnosing inclusion body myositis due to its slow progression and overlapping features with other conditions, highlighting the importance of recognizing its distinguishing characteristics.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural and Molecular Effects of Dextrose on Cartilage: A Scoping Review.","authors":"Pedro Iván Arias-Vázquez, Kenneth D Reeves, Rosa Giannina Castillo-Avila, Gastón A Topol, Ricardo Quezada-González, Pavel Loeza-Magaña, Elizabeth Carmona-Díaz, Eduardo De la Cruz-Cano, Daniel Cadena-Sandoval","doi":"10.2174/0115733971386046250611073643","DOIUrl":"https://doi.org/10.2174/0115733971386046250611073643","url":null,"abstract":"<p><strong>Background: </strong>Dextrose prolotherapy has been used in the treatment of individuals with osteoarthritis in various locations, reporting favorable therapeutic effects. However, the molecular and/or structural effects of dextrose prolotherapy on cartilage are still unclear. Therefore, this study aimed to analyze the molecular and/or structural effects of dextrose on cartilage and clarify the possible mechanisms of action of dextrose prolotherapy.</p><p><strong>Methods: </strong>A systematic search was conducted using scientific databases, including PubMed, Web of Science, Cochrane Central Register of Controlled Trials, and ScienceDirect, up until November 2024, using the PRISMA-ScR for Scoping Reviews.</p><p><strong>Results: </strong>Twenty-three studies that evaluated the molecular and/or structural effects of dextrose on cartilage were eligible for inclusion. Fifteen studies included in vitro models, three studies involved animal models, and five studies were conducted on humans. Sixteen studies reported favorable effects on cartilage, and seven studies reported unfavorable effects. In all studies performed in vivo (in animals or humans), predominantly favorable effects on cartilage were reported. The favorable effects on cartilage were improved glucose metabolism in chondrocytes, increased deposition of extracellular matrix and the induction of chondrocyte proliferation, increased expression of anabolic growth factors and anti-inflammatory cytokines, as well as decreased activity of some metalloproteinases. Among the unfavorable effects, increased release of proinflammatory and catabolic cytokines was reported.</p><p><strong>Conclusion: </strong>These results suggest that dextrose may have a therapeutic effect on cartilage, though the underlying mechanisms are not fully understood. This study is a starting point for fu-ture experimental studies evaluating the therapeutic effects of dextrose prolotherapy.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatoid Arthritis and Secondary Plant Metabolites: An Analysis.","authors":"Vandana Bhatia, Vir Vikram Sharma, Shagun Thakur, Anjali Chandel, Yavnika Minhas","doi":"10.2174/0115733971336322250605063028","DOIUrl":"https://doi.org/10.2174/0115733971336322250605063028","url":null,"abstract":"<p><p>Chronic rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by persistent joint inflammation, progressive joint destruction, and chronic pain. Although modern therapies like disease-modifying antirheumatic medications (DMARDs) can alleviate symptoms, they may also produce side effects. Because of their anti-inflammatory, antioxidant, and immunomodulatory qualities, plant secondary metabolites such as flavonoids, terpenoids, alkaloids, and phenolic acids have attracted attention as prospective RA treatment agents. This review discusses the pathogenesis of RA and provides an overview of various plant secondary metabolites and their biological activities relevant to RA. It highlights preclinical and clinical studies that have investigated the use of plant metabolites in RA management, demonstrating their potential to reduce inflammation, modulate immune responses, and protect joint structures. The review explores the potential molecular targets and mechanisms of action of plant metabolites in RA, including inflammatory mediators, transcription factors, signalling pathways, oxidative stress, immune cell regulation, cell proliferation and apoptosis, cartilage and bone metabolism, and angiogenesis. Additionally, the challenges and considerations in developing plant-based therapies for RA are discussed, such as efficacy and safety, standardization, bioavailability, regulatory approval, and patient compliance. Finally, future perspectives and research directions are outlined, emphasizing the need for further mechanistic studies, preclinical and clinical investigations, formulation strategies, and interdisciplinary collaborations to fully harness the therapeutic potential of plant secondary metabolites in RA management.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicodemographic Data of Patients with Behçet's Disease: Data from a Tertiary Center in Saudi Arabia.","authors":"Yasser Bawazir, Mohammad Mustafa","doi":"10.2174/0115733971359862250603040950","DOIUrl":"https://doi.org/10.2174/0115733971359862250603040950","url":null,"abstract":"<p><strong>Introduction: </strong>Behçet's disease (BD) is a chronic inflammatory vasculitis involving the arteries and veins. This study was driven by the rarity, chronic multisystemic nature, and heterogeneous spectrum of clinical features and geographical distribution. This study aimed to analyze the demographic and clinical characteristics of patients with BD at the King Abdulaziz University Hospital and identify the association between clinical and laboratory findings and disease severity.</p><p><strong>Methods: </strong>The study was a retrospective core chart review. This study included adult patients who visited the rheumatology clinic of King Abdulaziz University Hospital in Saudi Arabia between 2005 and 2023. The inclusion criteria were age ≥18 years and a diagnosis of Behçet's disease (BD) based on either the International Criteria for Behçet's Disease or the International Study Group classification criteria.</p><p><strong>Results: </strong>In total, 81 patients with BD with almost equal male (51.9%) and female (48.1%) distribution, 75.3% Saudi nationals, mean onset age of 38.48 years, and mean body mass index of 27.57 kg/m2 were identified. The most common clinical manifestations were oral ulcerations (56.8%), genital ulcerations (37%), uveitis (24.7%), arthritis (22.2%), skin lesions (13.6%), and deep vein thrombosis (9.88%). Significant differences in high-density lipoprotein, hemoglobin, Creactive protein, and albumin levels were associated with the age, sex, and nationality of the patients, respectively. Similarly, body mass index was significantly associated with C-reactive protein (p = 0.004), alanine aminotransferase (p = 0.023), aspartate aminotransferase (p = 0.003), and gamma-glutamyl aminotransferase (p = 0.034) levels.</p><p><strong>Conclusion: </strong>This study demonstrated that there are significant associations between demographic factors, laboratory parameters, and BD activity.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}