Current rheumatology reviews最新文献

{"title":"Integrative Lifestyle Strategies for Osteoarthritis Management in Post- Menopausal Women: Insights on Exercise and Diet.","authors":"Sourav Ghosh, Srabona Dutta, Ayan Chatterjee, Monosiz Rahaman, Biswajit Basu, Bhupendra Prajapati","doi":"10.2174/0115733971385075251120014221","DOIUrl":"10.2174/0115733971385075251120014221","url":null,"abstract":"<p><strong>Introduction: </strong>Osteoarthritis (OA) disproportionately affects postmenopausal women due to estrogen deficiency, which accelerates cartilage degradation, synovial inflammation, and bone remodeling. Existing pharmacological treatments, such as NSAIDs and COX-2 inhibitors, primarily provide symptomatic relief and carry gastrointestinal risks. This review aims to clarify the pathophysiological mechanisms underlying OA progression and highlight non-pharmacological interventions, specifically diet and physical exercise, as viable strategies for management in postmenopausal women.</p><p><strong>Methods: </strong>A systematic literature review was conducted using PubMed, Scopus, and Web of Science databases. Keywords related to osteoarthritis, inflammation, exercise, diet, and postmenopausal women were used. Articles providing mechanistic or clinical insights into OA management were included, with a focus on exercise and nutritional approaches.</p><p><strong>Results: </strong>Aerobic and resistance training improve joint function, reduce pain, and modulate inflammatory mediators. Moderate-intensity exercise is particularly effective for advanced OA, while high-intensity regimens benefit early-stage disease. Dietary interventions, including omega- 3 fatty acids, calcium, and vitamin D, help mitigate inflammation and disease progression. However, awareness remains low: 87% of women were unaware of menopause-OA links, and 90% lacked knowledge about the inflammatory effects of dairy.</p><p><strong>Discussion: </strong>The findings emphasise the need for personalised lifestyle-based interventions. While exercise and diet show clear therapeutic potential, gaps remain in public awareness, implementation strategies, and integration with hormonal therapies.</p><p><strong>Conclusion: </strong>An integrative approach combining targeted exercise, dietary modification, and hormonal balance offers a promising, low-risk strategy to manage OA in postmenopausal women.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":"e15733971385075"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146028970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Periorbital Erythema and Swelling as an Initial Presentation of Systemic Lupus Erythematosus: A Rare Case.","authors":"Jitendra Singh, Anju Dinkar, Nilesh Kumar, Kailash Kumar, Isha Atam","doi":"10.2174/0115733971381153250418075039","DOIUrl":"10.2174/0115733971381153250418075039","url":null,"abstract":"<p><strong>Introduction: </strong>Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem involvement due to autoantibody production and immune complex deposition. While classical cutaneous manifestations, such as malar rash, are common, atypical presentations, like periorbital erythema and swelling, are rare and pose diagnostic challenges. Early recognition is crucial to prevent disease progression and complications.</p><p><strong>Case presentation: </strong>A 16-year-old girl presented with a three-month history of intermittent bilateral periorbital swelling. Clinical examination revealed pallor and localized alopecia with no significant systemic abnormalities. Laboratory investigations showed pancytopenia with normal renal, hepatic, and thyroid functions and unremarkable urinalysis, chest X-ray, and ECG. Autoimmune markers were positive, with a strongly positive ANA titer of 1:1000 and significantly elevated anti- dsDNA antibodies of 380 IU/mL (reference range: 0-200 IU/mL). According to the 2019 EULAR/ ACR classification criteria, a diagnosis of SLE was established. The patient was treated with pulse intravenous methylprednisolone (1g daily for three days), followed by oral prednisolone (1 mg/kg/day), in a tapering regimen and hydroxychloroquine at standard doses. She showed marked improvement, with resolution of periorbital swelling, recovery of pancytopenia, and hair regrowth. At two-month follow-up, she remained asymptomatic and continued hydroxychloroquine for maintenance therapy.</p><p><strong>Conclusion: </strong>This case underscores the importance of considering SLE in patients with atypical presentations, like periorbital erythema and pancytopenia. Early diagnosis based on clinical and serological findings, followed by appropriate therapy, can achieve remission and prevent complications. The case highlights the need for heightened clinical suspicion and multidisciplinary management in young patients.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":"118-122"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Sequential Imaging in Psoriatic Arthritis: A Case-Based Review on Identifying Coexisting Microcrystalline Disease.","authors":"Angelo Nigro","doi":"10.2174/0115733971410308260113094637","DOIUrl":"10.2174/0115733971410308260113094637","url":null,"abstract":"<p><strong>Introduction: </strong>The coexistence of psoriatic arthritis (PsA) and crystal-associated joint disease is an important diagnostic problem in clinical treatment. In patients with established PsA, the presence of new inflammatory responses may indicate disease activity or another pathological state, and thus necessitates differential diagnosis of disease processes and/or a diagnosis of a new disease process.</p><p><strong>Presentation: </strong>We report the case of a 55-year-old man with chronic PsA who presented with acute monoarticular inflammation of the left wrist that was refractory to standard antiinflammatory treatment. The discovery of newly observed calcific deposits in the left wrist, observed during sequential plain radiographic evaluation, raised suspicion of a crystal-associated inflammatory process. This discovery provided insight into the treatment regimen and clinical response.</p><p><strong>Conclusion: </strong>This case illustrates the need to consider crystal-associated inflammation in patients with PsA who present with atypical or treatment-resistant joint pathology. Sequential imaging, especially plain radiography, might facilitate diagnostic clarification and prevent the inappropriate escalation of immunosuppressive therapy.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Management of Systemic Sclerosis: Review of Literature.","authors":"Weronika Ewa Nowak, Natalia Klepacz, Zuzanna Cudzilo, Karina Grzesik, Hubert Sawczuk, Katarzyna Pilarczyk, Hanna Adamska, Aleksandra Rabeda, Marta Kaus, Marta Malicka","doi":"10.2174/0115733971399582251106114832","DOIUrl":"10.2174/0115733971399582251106114832","url":null,"abstract":"<p><p>Systemic sclerosis is a rare, progressive, multisystem autoimmune disease that can affect the skin, digestive system, internal organs, joints, and hands. Pharmacological treatment remains the standard of care; however, it does not always adequately address all the distressing symptoms experienced by patients. This study aimed to review and summarise the available surgical options for systemic sclerosis. A comprehensive literature review was conducted using a broad search strategy to encompass the wide-ranging aspects of the disease. Systemic sclerosis is associated with a broad spectrum of clinical manifestations. Surgical interventions have been attempted for many of these, with the goals of improving patients' quality of life, reducing pain, and lowering disability. The most common procedures performed in patients with systemic sclerosis include anti-reflux operations and other gastrointestinal surgeries, various hand surgeries, organ transplantation, and selected orthopaedic or plastic procedures. Available evidence suggests that, although systemic sclerosis presents additional challenges in surgical management, it is not an absolute contraindication when surgery is indicated. Surgical management remains a valuable option in systemic sclerosis, particularly when conservative treatments are insufficient. Organ-specific procedures can improve quality of life and, in selected cases, be life-saving. By comprehensively reviewing the available surgical literature, this study may assist clinicians in considering operative approaches where appropriate. Further research is needed to standardise reporting and define clear surgical indications in patients with systemic sclerosis.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":"e15733971399582"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kikuchi-Fujimoto Disease as the Initial Presentation of Dermatomyositis.","authors":"Mohammad Mustafa, Yasser Bawazir","doi":"10.2174/0115733971412019251111163326","DOIUrl":"10.2174/0115733971412019251111163326","url":null,"abstract":"<p><strong>Background: </strong>Kikuchi-Fujimoto Disease (KD) is a rare necrotizing lymphadenitis that is often self-limiting but occasionally associated with autoimmune conditions. Dermatomyositis is an autoimmune inflammatory myopathy that typically presents with proximal muscle weakness and a characteristic skin rash. In this report, we present a unique case of KD, the first documented association worldwide as the initial manifestation of dermatomyositis, highlighting the rarity and novelty of this case.</p><p><strong>Case presentation: </strong>A 30-year-old Saudi female presented with a persistent fever, cervical lymphadenopathy, and significant weight loss. A lymph node biopsy confirmed the diagnosis of KD. Despite the initial steroid therapy, her symptoms recurred, prompting further investigation, which revealed elevated muscle enzyme levels, myopathic changes on electromyography, and MRI evidence of inflammatory myositis. The clinical presentation, combined with a heliotrope rash, confirmed the diagnosis of dermatomyositis. The patient responded well to pulse steroids, intravenous immunoglobulin, and rituximab, achieving remission and successfully tapering off corticosteroids. She is currently under regular follow-up care at a rheumatology clinic and has been in remission for the past eighteen months.</p><p><strong>Conclusion: </strong>This case highlights the importance of considering underlying autoimmune diseases, such as dermatomyositis, in atypical refractory KD. Early recognition and tailored immunosuppressive therapy are crucial to achieve optimal outcomes.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":"e15733971412019-7"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limited Access to Systemic Lupus Erythematosus: A Systematic Review.","authors":"Pamela Munguia-Realpozo, Claudia Mendoza-Pinto, Ivet Etchegaray-Morales, Edith Ramirez-Lara, Juan Carlos Solis-Poblano, Jorge Ayon-Aguilar, Socorro Mendez-Martinez, Gabriela Medina-Valeriano, Maximo Alejandro Garcia-Flores","doi":"10.2174/0115733971410947251206094951","DOIUrl":"10.2174/0115733971410947251206094951","url":null,"abstract":"<p><strong>Introduction: </strong>Inequities in systemic lupus erythematosus (SLE) care affect outcomes (i.e., flares, damage, mortality), interventions (referrals, advanced therapies), and populations (gender, race/ethnicity, and geographic region). This systematic review highlights themes related to access to care for SLE patients and explores potential solutions to address these disparities.</p><p><strong>Methods: </strong>In adherence to PRISMA guidelines, we conducted a systematic review of the literature. We searched for articles published in PubMed, Scopus, Web of Science, Cochrane Library, and EBSCO. Publications related to economic burden, barriers and facilitators to access, and potential solutions were included.</p><p><strong>Results: </strong>A total of 77 articles were identified. Five critical issues concerning access to SLE care were revealed from the literature: (1) economic burden, (2) barriers and facilitators to access, (3) utilization, (4) adherence, and (5) possible solutions to improve healthcare access.</p><p><strong>Discussion: </strong>The usual barriers and facilitators involved several social factors related to health (i.e., transportation, insurance, and limited access to mental health services, among others). Utilization of SLE care is influenced by socioeconomic status (SES), ethnicity, and education level. Factors like low education, low SES, rural residency, and depressive symptom adherence contribute to nonadherence. There were various proposals to improve access to SLE care, including peer support, digital platforms (e.g., telemedicine), and community-based programs (such as PALS and WELL).</p><p><strong>Conclusions: </strong>The SLE care field highlights the inequalities that impact marginalized communities. Emphasizing community-based programs, addressing social determinants of health, acknowledging social exclusion, and adopting digital platforms can help reduce healthcare inequity.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":"1-11"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Frequency of Musculoskeletal Disorders and Nerve Entrapment Syndromes Around the Shoulder in a Cohort of Egyptian Patients.","authors":"Dalia Salah Saif, Suzan Omar, Aya Hanafy Ibrahiem, Mohamed Abdelaziz Fayed, Yousra Hiham Abdel Fattah","doi":"10.2174/0115733971338169250327074446","DOIUrl":"10.2174/0115733971338169250327074446","url":null,"abstract":"<p><strong>Background: </strong>Shoulder pain is a common musculoskeletal (MSK) disorder. However, proper diagnosis of shoulder dysfunction and causes of pain remains challenging.</p><p><strong>Objective: </strong>The objective of this study is to identify the frequency of musculoskeletal and neurological disorders among a cohort of Egyptian patients with chronic shoulder pain.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on 120 patients with chronic shoulder pain. Clinical, imaging, and electrophysiology studies were conducted on each participant to assess the frequency of musculoskeletal and neurological causes of shoulder pain.</p><p><strong>Results: </strong>The commonest causes of shoulder pain in the present study were musculoskeletal disorders, representing 94.2% of the whole cases, of which rotator cuff pathology was the commonest in 78.3%. Neurological disorders were found in 45.8%, of which suprascapular neuropathy was the commonest in 31.7%. At the same time, combined musculoskeletal and neurological disorders were found in 59.2% of cases. The frequency of musculoskeletal disorders was significantly associated with the duration of shoulder pain, as well as patients' occupation, specifically manual working. While the frequency of neurological disorders was significantly associated with shoulder pain duration, old age, sex, and patient's occupation (mainly manual working).</p><p><strong>Conclusion: </strong>Musculoskeletal disorders are the most common causes of chronic shoulder pain, especially rotator cuff disorders. While suprascapular neuropathy is the most common neurological cause of chronic shoulder pain. The combination of musculoskeletal and neurological disorders together is also an important cause of shoulder pain in many cases, which may not be obvious and must be detected early to provide early and appropriate therapeutic intervention. Manual work is a risk factor for developing MSK and neuropathic shoulder disease.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":"84-93"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasal Chondrocytes Intensively Invade and Repair Pathologically Altered Cartilage Through Intrinsic Genomic Mechanisms: A Narrative Review.","authors":"Victoria A Shestakova, Ekaterina I Smirnova, Longfeng Rao, Ilya V Kolobaev, Dmitry A Atiakshin, Michael A Ignatyuk, Mikhail E Krasheninnikov, Bagavdin G Ahmedov, Sergey A Ivanov, Ilya D Klabukov, Peter V Shegay, Andrey D Kaprin, Denis S Baranovskii","doi":"10.2174/0115733971359145250329194434","DOIUrl":"10.2174/0115733971359145250329194434","url":null,"abstract":"<p><p>Articular cartilage, a crucial component of joint structure, ensures smooth articulation and efficient load distribution within the joint. However, its integrity is compromised in various pathological conditions, such as osteoarthritis, leading to significant alterations in its structure and function. This process was significantly correlated with Extracellular Matrix (ECM) degradation, loss of collagen type II, and increased expression of matrix metalloproteinases (MMPs), particularly MMP-13. The ability of chondrocytes to invade into the ECM in pathologically altered tissue leads to cartilage repair and regeneration, and becomes the basis of chondrocyte cell therapy. Furthermore, the altered mechanical properties of the ECM in diseased cartilage, alongside the upregulation of chemotactic factors, contribute to the enhanced migratory behavior of chondrocytes. Interestingly, chondrocytes invading the ECM displayed signs of phenotypic changes, such as increased proliferation and expression of markers associated with chondrocytes' intrinsic genetic properties. The invasion of chondrocytes into the ECM is a response to cartilage damage, possibly driven by an attempt to repair the degraded ECM, and varies in chondrocytes from different sources, i.e., articular cartilage or nasal septum. Nasal chondrocytes highlight the increase of ACAN, SOX9, N-cadherin, COL2A expression and decrease of IL1B, CXCL8, and MMPs gene family expression, which could relate to their unique phenotype properties. However, this response may paradoxically contribute to the progression of cartilage pathology by disrupting the tissue architecture and promoting further degeneration. Our review highlights the endogenous genetic properties of nasal chondrocytes to invade and repair damaged cartilage, offering promising avenues for cartilage repair and regeneration.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":"60-73"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13223486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Progress of Gout Prediction Models Based on Multi-source Data.","authors":"Wenrui Shi, Hongzhu Qu, Xiangdong Fang","doi":"10.2174/0115733971444947260203111252","DOIUrl":"10.2174/0115733971444947260203111252","url":null,"abstract":"<p><strong>Introduction: </strong>Gout, a highly serious inflammatory disease that is caused by monosodium urate crystals, is becoming an increasingly significant health concern. Artificial Intelligence and multi-omics-based research have made significant gains for the early detection and prevention of gout based on diverse approaches. This review intends to summarize current advances in forecasting gout susceptibility and gout-related symptoms, evaluate the predictive efficacy of different features, and ascertain which clinical and omics characteristics are most effective in these prediction models.</p><p><strong>Methods: </strong>We explored the PubMed database after 2010 using keywords such as \"gout\", \"predictive model\", \"risk prediction\", and \"machine learning\", and confined our search to Englishlanguage articles. The original peer-reviewed research articles that developed gout models were selected. Research that was not original or lacked internal validation was excluded.</p><p><strong>Results: </strong>Clinical features, genomics, microbiomics, radiomics, and metabolomics have been utilized to construct models related to gout and have demonstrated excellent predictive performance. Multisource data prediction models usually exhibit better effectiveness.</p><p><strong>Discussion: </strong>Gout-oriented models performed excellently in predictive performance but present limitations in certain clinical and omics domains. However, if they are to affect actual patient care, they must overcome some external confirmation roadblocks and the fiscal and practical implications they will face ahead of time.</p><p><strong>Conclusion: </strong>This review indicates that clinical and multi-omics models of gout are significant instruments for clinical decision-making. The models constructed in these studies may be crucial for the treatment of gout and its practical benefits.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":"1-10"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13555784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Determining the Switch of the First Biological Treatment in Spondyloarthritis: Data from the RBSMR Registry.","authors":"Oumaima Idrissi Ouali, Imane El Mezouar, Nessrine Akasbi, Salma Mikou, Moncef Maiouak, Ihsane Hmamouchi, Redouane Abouqal, Ahmed Bezza, Fadoua Allali, Rachid Bahiri, Imane El Bouchti, Imad Ghozlani, Hasna Hassikou, Linda Ichchou, Saadia Janani, Radouane Niamane, Abdellah El Maghraoui, Taoufik Harzy","doi":"10.2174/0115733971396081251103030150","DOIUrl":"10.2174/0115733971396081251103030150","url":null,"abstract":"<p><strong>Introduction: </strong>Despite the substantial progress made in the therapeutic management of spondylarthritis (SpA) after the advent of biotherapy, some patients still undergo, for various reasons, therapeutic switches to an alternative biological agent. This study aimed to identify the factors leading to the switch from the initial biological treatment in patients with SpA, with a view toward tailoring the prescription to the patient's profile.</p><p><strong>Methods: </strong>Adult patients (aged >18 years) with spondylarthritis treated with biotherapy were enrolled in a cohort derived from a national historical-prospective multicenter registry between June 2017 and January 2019. The selection was based on the ASAS criteria, and patients were assessed every six months with a planned three-year follow-up. Baseline demographics and disease characteristics at the time of biologic therapy initiation were collected. Factors determining the switch to first bDMARDs were identified through univariate and multivariate logistic regression, reporting odds ratios (OR) with 95% confidence intervals (CI).</p><p><strong>Results and discussions: </strong>A total of 194 SpA patients were included. By the end of follow-up, 46 patients (23.71%) had switched to a second biologic agent (TNFα inhibitor or secukinumab). This switch was significantly associated with: advanced age (p = 0.030), higher Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) (p = 0.024), and the absence of specific comorbidities, including heart disease and stroke (p = 0.011 for both).</p><p><strong>Conclusion: </strong>The new bio-medications have considerably improved the prognosis of patients suffering from chronic inflammatory rheumatism, necessitating regular monitoring to detect events that could lead to a treatment switch. In our study, we identified factors associated with therapeutic switching, particularly advanced age, a history of corticosteroid therapy, and specific comorbidities. These findings highlight potential risk factors; however, further studies with larger cohorts and immunogenicity data are required before firm clinical recommendations can be made.</p>","PeriodicalId":11188,"journal":{"name":"Current rheumatology reviews","volume":" ","pages":"e15733971396081"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}