Current Pediatric Reviews最新文献_第6页

Diagnostic and New Therapeutic Approaches to Two Challenging Pediatric Metabolic Bone Disorders: Hypophosphatasia and X-linked Hypophosphatemic Rickets. 两种具有挑战性的儿童代谢性骨病的诊断和新治疗方法：低磷血症和X连锁低磷血症性里克茨。

IF 1.3

Current Pediatric Reviews Pub Date : 2024-01-01 DOI: 10.2174/0115733963206838231031102750

Fahad Aljuraibah, Ibrahim Alalwan, Abdelhadi Habeb

{"title":"Diagnostic and New Therapeutic Approaches to Two Challenging Pediatric Metabolic Bone Disorders: Hypophosphatasia and X-linked Hypophosphatemic Rickets.","authors":"Fahad Aljuraibah, Ibrahim Alalwan, Abdelhadi Habeb","doi":"10.2174/0115733963206838231031102750","DOIUrl":"10.2174/0115733963206838231031102750","url":null,"abstract":"The diagnosis and management of metabolic bone disease among children can be challenging. This difficulty could be due to many factors, including limited awareness of these rare conditions, the complex pathophysiology of calcium and phosphate homeostasis, the overlapping phenotype with more common disorders (such as rickets), and the lack of specific treatments for these rare disorders. As a result, affected individuals could experience delayed diagnosis or misdiagnosis, leading to improper management. In this review, we describe the challenges facing diagnostic and therapeutic approaches to two metabolic bone disorders (MBD) among children: hypophosphatasia (HPP) and X-linked hypophosphatemia (XLH). We focus on explaining the pathophysiological processes that conceptually underpin novel therapeutic approaches, as well as these conditions' clinical or radiological similarity to nutritional rickets. Particularly in areas with limited sun exposure and among patients not supplementing vitamin D, nutritional rickets are still more common than HPP and XLH, and pediatricians and primary physicians frequently encounter this disorder in their practices. More recently, our understanding of these disorders has significantly improved, leading to the development of novel therapies. Asfotas alfa, a recombinant, human- tissue, nonspecific alkaline phosphatase, improved the survival of patients with HPP. Burosumab, a human monoclonal anti-FGF23 antibody, was recently approved as a specific therapy for XLH. We also highlight the current evidence on these two specific therapies' safety and effectiveness, though long-term data are still needed. Both HPP and XLH are multisystemic disorders that should be managed by multidisciplinary teams. Finally, recognizing these conditions in early stages will enable affected children and young adults to benefit from newly introduced, specific therapies.","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":" ","pages":"395-404"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71479297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of the Effects of the COVID-19 Pandemic on Children and Adolescents' Mental Health. 回顾 COVID-19 大流行对儿童和青少年心理健康的影响。

IF 1.3

Current Pediatric Reviews Pub Date : 2024-01-01 DOI: 10.2174/1573396319666230213104546

Damilola Deborah Omoleye, Oluwayemisi Olubukola Abidakun, Rachael Oluwadamilola Akinje, Oluwaseun Hannah Ademuyiwa, Beatrice Mofoluwaso Fasogbon

{"title":"A Review of the Effects of the COVID-19 Pandemic on Children and Adolescents' Mental Health.","authors":"Damilola Deborah Omoleye, Oluwayemisi Olubukola Abidakun, Rachael Oluwadamilola Akinje, Oluwaseun Hannah Ademuyiwa, Beatrice Mofoluwaso Fasogbon","doi":"10.2174/1573396319666230213104546","DOIUrl":"10.2174/1573396319666230213104546","url":null,"abstract":"Disaster poses a huge threat to physical health as much as mental health, and COVID-19 is not any different. Understanding that physical and social factors can all contribute to mental health disruptions explains the rising concern of the global community about the impacts of COVID-19 on mental health, especially among the vulnerable, including children and adolescents. It is imperative to explore the diverse impacts of COVID-19 on the paediatric age group, especially to better address its effect and adequately strategize for its resulting conditions. This narrative review, therefore, explores literature reports on the effect of the pandemic on the mental health of children and adolescents. As observed in the literature, COVID-19 did not only threaten the physical health of children and adolescents but also their mental health, especially in terms of anxiety, depression, sleep alteration, etc. In this paper, we have discussed interventions, such as adequate sleep, healthy lifestyles, and nutritious foods, to improve paediatric mental health even after the pandemic.","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":" ","pages":"129-136"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10705555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological Drugs for the Treatment of Uncontrolled Severe Asthma in Children. 治疗儿童不受控制的严重哮喘的生物药物。

IF 2

Current Pediatric Reviews Pub Date : 2024-01-01 DOI: 10.2174/1573396320666230912103115

Cristiana Indolfi, Angela Klain, Chiara Lucia Bencivenga, Elisabetta D'Addio, Giulio Dinardo, Alberto Decimo, Michele Miraglia Del Giudice

引用次数: 0

Are we Compressing and Ventilating Effectively during Cardiopulmonary Resuscitation? 在心肺复苏过程中，我们是否进行了有效的按压和通气？

IF 1.3

Current Pediatric Reviews Pub Date : 2024-01-01 DOI: 10.2174/1573396320666230607115318

Kam Lun Hon, Siu-To Cheung, Yok Weng Tan, Karen Ka Yan Leung, Alice Ho, Hin Bill Chan, Suyun Qian

引用次数: 0

Perinatal Exposure to Trace Elements: The Dubious Culprit of Autistic Spectrum Disorder in Children. 围产期接触微量元素：儿童自闭症谱系障碍的罪魁祸首。

IF 1.3

Current Pediatric Reviews Pub Date : 2024-01-01 DOI: 10.2174/0115733963251295231031102941

Kriti Mohan, Balram Ji Omar, Swathi Chacham, Ajay Bharti

引用次数: 0

Reactive Arthritis in Children: Case Report, Narrative Review and Proposed Therapy. 儿童反应性关节炎：病例报告、叙事回顾和建议疗法。

IF 1.3

Current Pediatric Reviews Pub Date : 2024-01-01 DOI: 10.2174/1573396320666230913103007

Milad Alshaya, Nouf Almutairi, Abdulrahman Alrasheed, Ihtifal Albanaqi, Ronald M Laxer, Abdullah Alhammad

引用次数: 0

Rectal Bleeding in Infants: Diagnostic Work-up and Management. 婴儿直肠出血：诊断和处理。

IF 2

Current Pediatric Reviews Pub Date : 2024-01-01 DOI: 10.2174/1573396319666230210111048

Paolo Quitadamo, Sara Isoldi, Saverio Mallardo, Letizia Zenzeri, Silvia Ceccanti, Ilaria Battagliere, Margherita Del Bene, Giovanni Di Nardo

引用次数: 0

A Brief Survey of Post-COVID-19 Vaccination Mucocutaneous and Dermatological Reactions in Children and Adolescents: Answer to Many Highly Questioned Concerns. 关于儿童和青少年接种 COVID-19 疫苗后粘膜和皮肤反应的简要调查：回答许多备受质疑的问题。

IF 1.3

Current Pediatric Reviews Pub Date : 2024-01-01 DOI: 10.2174/1573396319666230228112039

Yekta Ghane, Sara Sadeghi, Azadeh Goodarzi

引用次数: 0

Pediatric Immunology and Allergy: Clinical Aspects. 儿科免疫学与过敏：临床方面。

IF 2

Current Pediatric Reviews Pub Date : 2024-01-01 DOI: 10.2174/157339632003231116214000

Roberto Bernardini

引用次数: 0

A Case Series of Appendicitis and Pseudo-appendicitis in a Paediatric Intensive Care Unit. 儿科重症监护病房阑尾炎和假性阑尾炎病例系列。

IF 1.3

Current Pediatric Reviews Pub Date : 2024-01-01 DOI: 10.2174/1573396320666230811092837

Kam L Hon, Alexander K C Leung, Yan T K Lee, Stephanie Tsang, Karen K Y Leung, Wun F A Hui, Wing L Cheung, Wai Y M Leung

{"title":"A Case Series of Appendicitis and Pseudo-appendicitis in a Paediatric Intensive Care Unit.","authors":"Kam L Hon, Alexander K C Leung, Yan T K Lee, Stephanie Tsang, Karen K Y Leung, Wun F A Hui, Wing L Cheung, Wai Y M Leung","doi":"10.2174/1573396320666230811092837","DOIUrl":"10.2174/1573396320666230811092837","url":null,"abstract":"Introduction: Appendicitis is a common childhood condition that can be diagnostically challenging. Severe cases may necessitate support in the critical or intensive care unit. These \"critical appendicitis diagnoses\" have rarely been described.Case description: We retrospectively reviewed the Paediatric Intensive Care Unit (PICU) database of the Hong Kong Children's Hospital and identified cases of suspected and confirmed appendicitis. Clinical features, radiologic findings and final diagnosis of each case were summarized and reported in this case series. We review six anonymized cases of appendicitis managed in a PICU to illustrate the different age spectrum and clinical manifestations of the condition. Rupture of the inflamed appendix, peritonitis and pancreatitis were some of the complications encountered. Crohn's disease was found in one case as an underlying diagnosis. Also, one girl clinically diagnosed with appendicitis was found to be a case of ruptured hepatoblastoma with no appendicitis (i.e., pseudoappendicitis).Conclusion: Prompt diagnosis, surgical removal of the inflamed appendix, and use of appropriate antimicrobials when indicated are essential in reducing mortality and morbidity associated with severe appendicitis. Significant premorbid conditions such as acute myeloid leukemia, Mitochondrial Encephalopathy Lactic Acidosis Syndrome (MELAS), inflammatory bowel disease and complications may be present in patients needing intensive care as is illustrated in the present cases. Pseudoappendicitis is an important differential diagnosis. Imaging is crucial and useful in establishing and confirming the diagnosis of appendicitis and pseudo-appendicitis in these PICU cases.","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":" ","pages":"75-79"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10078123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0