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Biological Drugs for the Treatment of Uncontrolled Severe Asthma in Children. 治疗儿童不受控制的严重哮喘的生物药物。
IF 2
Current Pediatric Reviews Pub Date : 2024-01-01 DOI: 10.2174/1573396320666230912103115
Cristiana Indolfi, Angela Klain, Chiara Lucia Bencivenga, Elisabetta D'Addio, Giulio Dinardo, Alberto Decimo, Michele Miraglia Del Giudice
{"title":"Biological Drugs for the Treatment of Uncontrolled Severe Asthma in Children.","authors":"Cristiana Indolfi, Angela Klain, Chiara Lucia Bencivenga, Elisabetta D'Addio, Giulio Dinardo, Alberto Decimo, Michele Miraglia Del Giudice","doi":"10.2174/1573396320666230912103115","DOIUrl":"10.2174/1573396320666230912103115","url":null,"abstract":"<p><p>The introduction of biological drugs for the treatment of severe allergic asthma in children, almost twenty years ago, had a substantial impact on both the pathology's clinical course and the quality of life of the patients who receive treatment. Over the years, several molecules have been developed that inhibit molecular targets involved in the pathogenesis of the asthmatic disease. Biological drugs demonstrate a significant improvement in several key clinical parameters in patients with severe asthma. In this review, we provide a concise summary of the evidence on biological therapy for children and adolescents with severe asthma.</p>","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10215336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hereditary Rickets: A Quick Guide for the Pediatrician. 遗传性佝偻病：儿科医生快速指南》。
IF 1.3
Current Pediatric Reviews Pub Date : 2024-01-01 DOI: 10.2174/1573396319666221205123402
Abdulmajeed AlSubaihin, Jennifer Harrington
{"title":"Hereditary Rickets: A Quick Guide for the Pediatrician.","authors":"Abdulmajeed AlSubaihin, Jennifer Harrington","doi":"10.2174/1573396319666221205123402","DOIUrl":"10.2174/1573396319666221205123402","url":null,"abstract":"<p><p>With the increased discovery of genes implicated in vitamin D metabolism and the regulation of calcium and phosphate homeostasis, a growing number of genetic forms of rickets are now recognized. These are categorized into calciopenic and phosphopenic rickets. Calciopenic forms of hereditary rickets are caused by genetic mutations that alter the enzymatic activity in the vitamin D activation pathway or impair the vitamin D receptor action. Hereditary forms of phosphopenic rickets, on the other hand, are caused by genetic mutations that lead to increased expression of FGF23 hormone or that impair the absorptive capacity of phosphate at the proximal renal tubule. Due to the clinical overlap between acquired and genetic forms of rickets, identifying children with hereditary rickets can be challenging. A clear understanding of the molecular basis of hereditary forms of rickets and their associated biochemical patterns allow the health care provider to assign the correct diagnosis, avoid non-effective interventions and shorten the duration of the diagnostic journey in these children. In this mini-review, known forms of hereditary rickets listed on the Online Mendelian Inheritance in Man database are discussed. Further, a clinical approach to identify and diagnose children with hereditary forms of rickets is suggested.</p>","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35211653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reactive Arthritis in Children: Case Report, Narrative Review and Proposed Therapy. 儿童反应性关节炎：病例报告、叙事回顾和建议疗法。
IF 1.3
Current Pediatric Reviews Pub Date : 2024-01-01 DOI: 10.2174/1573396320666230913103007
Milad Alshaya, Nouf Almutairi, Abdulrahman Alrasheed, Ihtifal Albanaqi, Ronald M Laxer, Abdullah Alhammad
{"title":"Reactive Arthritis in Children: Case Report, Narrative Review and Proposed Therapy.","authors":"Milad Alshaya, Nouf Almutairi, Abdulrahman Alrasheed, Ihtifal Albanaqi, Ronald M Laxer, Abdullah Alhammad","doi":"10.2174/1573396320666230913103007","DOIUrl":"10.2174/1573396320666230913103007","url":null,"abstract":"<p><p>Reactive arthritis is an acute inflammatory aseptic arthritis that is preceded by an infectious process in genetically predisposed individuals. It has been associated with gastrointestinal or genitourinary infection. Reactive arthritis is rare in children. In this review, we present two index cases that need biologic treatment followed by a thorough review of reactive arthritis in children and adolescents with proposed treatment algorithm.</p>","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10215342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review of the Effects of the COVID-19 Pandemic on Children and Adolescents' Mental Health. 回顾 COVID-19 大流行对儿童和青少年心理健康的影响。
IF 1.3
Current Pediatric Reviews Pub Date : 2024-01-01 DOI: 10.2174/1573396319666230213104546
Damilola Deborah Omoleye, Oluwayemisi Olubukola Abidakun, Rachael Oluwadamilola Akinje, Oluwaseun Hannah Ademuyiwa, Beatrice Mofoluwaso Fasogbon
{"title":"A Review of the Effects of the COVID-19 Pandemic on Children and Adolescents' Mental Health.","authors":"Damilola Deborah Omoleye, Oluwayemisi Olubukola Abidakun, Rachael Oluwadamilola Akinje, Oluwaseun Hannah Ademuyiwa, Beatrice Mofoluwaso Fasogbon","doi":"10.2174/1573396319666230213104546","DOIUrl":"10.2174/1573396319666230213104546","url":null,"abstract":"<p><p>Disaster poses a huge threat to physical health as much as mental health, and COVID-19 is not any different. Understanding that physical and social factors can all contribute to mental health disruptions explains the rising concern of the global community about the impacts of COVID-19 on mental health, especially among the vulnerable, including children and adolescents. It is imperative to explore the diverse impacts of COVID-19 on the paediatric age group, especially to better address its effect and adequately strategize for its resulting conditions. This narrative review, therefore, explores literature reports on the effect of the pandemic on the mental health of children and adolescents. As observed in the literature, COVID-19 did not only threaten the physical health of children and adolescents but also their mental health, especially in terms of anxiety, depression, sleep alteration, etc. In this paper, we have discussed interventions, such as adequate sleep, healthy lifestyles, and nutritious foods, to improve paediatric mental health even after the pandemic.</p>","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10705555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are we Compressing and Ventilating Effectively during Cardiopulmonary Resuscitation? 在心肺复苏过程中，我们是否进行了有效的按压和通气？
IF 1.3
Current Pediatric Reviews Pub Date : 2024-01-01 DOI: 10.2174/1573396320666230607115318
Kam Lun Hon, Siu-To Cheung, Yok Weng Tan, Karen Ka Yan Leung, Alice Ho, Hin Bill Chan, Suyun Qian
{"title":"Are we Compressing and Ventilating Effectively during Cardiopulmonary Resuscitation?","authors":"Kam Lun Hon, Siu-To Cheung, Yok Weng Tan, Karen Ka Yan Leung, Alice Ho, Hin Bill Chan, Suyun Qian","doi":"10.2174/1573396320666230607115318","DOIUrl":"10.2174/1573396320666230607115318","url":null,"abstract":"","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9964556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric COVID-19 Acute Encephalopathy and Mortality. 小儿 COVID-19 急性脑病和死亡率。
IF 1.3
Current Pediatric Reviews Pub Date : 2024-01-01 DOI: 10.2174/1573396318666220617161606
Kam Lun Hon, Yok Weng Tan, Karen K Y Leung, Wing Lum Cheung, Wun Fung Hui, Fung Shan Chung, Alcy R Torres
{"title":"Pediatric COVID-19 Acute Encephalopathy and Mortality.","authors":"Kam Lun Hon, Yok Weng Tan, Karen K Y Leung, Wing Lum Cheung, Wun Fung Hui, Fung Shan Chung, Alcy R Torres","doi":"10.2174/1573396318666220617161606","DOIUrl":"10.2174/1573396318666220617161606","url":null,"abstract":"","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39999402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perinatal Exposure to Trace Elements: The Dubious Culprit of Autistic Spectrum Disorder in Children. 围产期接触微量元素：儿童自闭症谱系障碍的罪魁祸首。
IF 1.3
Current Pediatric Reviews Pub Date : 2024-01-01 DOI: 10.2174/0115733963251295231031102941
Kriti Mohan, Balram Ji Omar, Swathi Chacham, Ajay Bharti
{"title":"Perinatal Exposure to Trace Elements: The Dubious Culprit of Autistic Spectrum Disorder in Children.","authors":"Kriti Mohan, Balram Ji Omar, Swathi Chacham, Ajay Bharti","doi":"10.2174/0115733963251295231031102941","DOIUrl":"10.2174/0115733963251295231031102941","url":null,"abstract":"<p><p>There is evidence that few trace elements in the environment work as hazardous materials in terms of their exposure in the perinatal period, causing autistic spectrum disorder (ASD) in children, and avoiding these exposures in the environment can reduce the number of new cases. This perspective study provides preliminary evidence to consider a few trace elements as culprits for ASD. More studies with larger cohorts are needed, but meanwhile, as per available evidence, exposure to these hazardous materials must be warranted during pregnancy and early stages of life.</p>","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71479299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rectal Bleeding in Infants: Diagnostic Work-up and Management. 婴儿直肠出血：诊断和处理。
IF 2
Current Pediatric Reviews Pub Date : 2024-01-01 DOI: 10.2174/1573396319666230210111048
Paolo Quitadamo, Sara Isoldi, Saverio Mallardo, Letizia Zenzeri, Silvia Ceccanti, Ilaria Battagliere, Margherita Del Bene, Giovanni Di Nardo
{"title":"Rectal Bleeding in Infants: Diagnostic Work-up and Management.","authors":"Paolo Quitadamo, Sara Isoldi, Saverio Mallardo, Letizia Zenzeri, Silvia Ceccanti, Ilaria Battagliere, Margherita Del Bene, Giovanni Di Nardo","doi":"10.2174/1573396319666230210111048","DOIUrl":"10.2174/1573396319666230210111048","url":null,"abstract":"<p><p>Lower gastrointestinal bleeding is an alarming symptom in pediatrics, especially in infancy. However, it is commonly secondary to benign and self-limiting conditions, such as anal fissures, infections, and allergies; more rarely it is caused by more serious disorders, such as necrotizing enterocolitis, very early onset inflammatory bowel diseases, and vascular malformations. The present review aims at summarizing the different clinical conditions presenting with rectal bleeding in infancy and provides an evidence-based diagnostic work-up for the clinical management of patients with this occurrence.</p>","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10747784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric Immunology and Allergy: Clinical Aspects. 儿科免疫学与过敏：临床方面。
IF 2
Current Pediatric Reviews Pub Date : 2024-01-01 DOI: 10.2174/157339632003231116214000
Roberto Bernardini
{"title":"Pediatric Immunology and Allergy: Clinical Aspects.","authors":"Roberto Bernardini","doi":"10.2174/157339632003231116214000","DOIUrl":"10.2174/157339632003231116214000","url":null,"abstract":"","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139570080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emergency Management of Food-induced Anaphylaxis and Severe Reactions in Young Infants. 紧急处理幼婴因食物引起的过敏性休克和严重反应。
IF 1.3
Current Pediatric Reviews Pub Date : 2024-01-01 DOI: 10.2174/1573396319666221027115126
Kam Lun Hon, Yok Weng Tan, Karen Ka Yan Leung, Genevieve P G Fung, Philip Hei Li
{"title":"Emergency Management of Food-induced Anaphylaxis and Severe Reactions in Young Infants.","authors":"Kam Lun Hon, Yok Weng Tan, Karen Ka Yan Leung, Genevieve P G Fung, Philip Hei Li","doi":"10.2174/1573396319666221027115126","DOIUrl":"10.2174/1573396319666221027115126","url":null,"abstract":"","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40652321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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