Current Pediatric Reviews最新文献

{"title":"Exploring Internet Health Information Seeking Behavior of Caregivers in a Tertiary Pediatric Outpatient Setting in Eastern India.","authors":"Manoj Kumar, Swati Swati, Rajan Kumar, Bijit Biswas","doi":"10.2174/0115733963380997250823060812","DOIUrl":"https://doi.org/10.2174/0115733963380997250823060812","url":null,"abstract":"<p><strong>Introduction: </strong>To study internet health information-seeking behavior and its determinants among caregivers in a tertiary Pediatric Outpatient Department (OPD) in Eastern India.</p><p><strong>Methods: </strong>A cross-sectional study was conducted between September and December 2022 at the Pediatric Outpatient Department of the All India Institute of Medical Sciences (AIIMS), Deoghar, India. A 13-item validated questionnaire was administered through face-to-face interviews, capturing demographic information and internet health information-seeking behavior. Statistical analyses, including multivariable logistic regression, identified significant determinants.</p><p><strong>Results: </strong>Outpatient visits were primarily for acute diseases (39.3%), followed by chronic disease monitoring (19.5%) and acute follow-ups (19.3%). Approximately 34.4% of caregivers sought health information online. Internet health information-seeking behavior was significantly associated with higher educational attainment and visit reasons. Caregivers with higher secondary education or graduate degrees were 7.5 and 7.6 times more likely, respectively, to seek health information online. Those attending for acute or acute follow-up visits had 2.2- and 3.5-times higher odds, respectively. The multivariable model explained 32.4% variability and had a predictive accuracy of 74.1%.</p><p><strong>Discussion: </strong>The relatively low prevalence of online health information-seeking highlights regional gaps in digital health literacy. Education level and visit type were key predictors, underscoring the need for targeted guidance. Findings are limited by self-reporting and single-center design but offer direction for integrating digital support into pediatric care.</p><p><strong>Conclusion: </strong>One-third of caregivers utilized the internet for children's health information, with higher education and acute visit reasons as key determinants.</p>","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating High-risk Neonatal Intensive Care Unit (NICU) Care: Insights from the Newborn Behavioral Observation (NBO).","authors":"Maria Maddalena Brambilla, Chiara Petrolini, Virginia Beretta, Elena Scarpa, Sabrina Moretti, Paola Palanza, Serafina Perrone","doi":"10.2174/0115733963376442250821002230","DOIUrl":"https://doi.org/10.2174/0115733963376442250821002230","url":null,"abstract":"<p><p>The birth of a baby is a significant milestone for both parents, marking a major life transition into parenthood. In high-risk situations, such as preterm delivery, this event disrupts functional adaptation and greatly impacts parents' ability to recognize and effectively respond to their newborn's physiological and developmental needs. Positive interactions and sensitive responses to an infant's needs enable parents to foster development, supporting regulatory processes and establishing healthy social interaction patterns. The Newborn Behavioral Observation (NBO) Early Intervention is a prevention-focused follow-up program initiated shortly after birth during a developmental window when the infant's brain is highly receptive to environmental influences, maximizing its impact on infant development. Recent applications of the NBO intervention in at-risk contexts have shown promising effects on both infant development and the parent-infant relationship. This educational mini-review aims to summarize the main findings and future prospects of using the NBO to support the transition to parenthood from birth through the first months of life, particularly in high-risk environments such as intensive care units.</p>","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary Insights and Emerging Paradigms in Sedation and Analgesia Management for Ventilated Newborns.","authors":"Federico Costa, Silvia Carloni, Elena Scarpa, Valentina Dell'Orto, Chiara Petrolini, Anna Chiara Titolo, Susanna Maria Roberta Esposito, Eloisa Gitto, Serafina Perrone, Virginia Beretta","doi":"10.2174/0115733963372619250731232838","DOIUrl":"https://doi.org/10.2174/0115733963372619250731232838","url":null,"abstract":"<p><p>Pain management in the first 1000 days of life is crucial for neurodevelopmental outcomes and the quality of life in extremely preterm newborns, who often undergo mechanical ventilation. The use of drugs like midazolam in neonatal care offers advantages such as sedation and muscle relaxation, but can also lead to potential adverse effects. Morphine, a common opioid analgesic, is used in neonatal care for its dual analgesic and sedative properties. Uncertainties regarding short-term pulmonary outcomes and concerns about neurological effects in preterm infants remain. Fentanyl, a synthetic opioid, is a first-line drug for rapid analgesia in various clinical scenarios. Adrenergic agonists and antioxidant substances, dexmedetomidine and melatonin, have shown the potential to be the first analgesic compounds suitable for both clinical trials and clinical use. Dexmedetomidine, an adrenergic agonist, stands out for its opioid-sparing effects and neuroprotective properties. Its efficacy in reducing cumulative morphine administration and supporting mechanical ventilation in certain conditions has been demonstrated. Melatonin has emerged as a neurohormone with potential analgesic properties, and various studies indicate its benefits in reducing pain-related oxidative stress and inflammation. In this educational review, we analyze and discuss pain assessment and management in patients subjected to mechanical ventilation, with a focus on pharmacological management during neonatal intubation, navigating the complexities of balancing effective analgesia and sedation while considering potential risks and outcomes in extremely preterm newborns. The positive effects of new drugs such as melatonin and dexmedetomidine on mechanically ventilated newborns mainly consist of improvements in pain management and amelioration of pulmonary function.</p>","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the Delayed Effects of COVID-19 in Children Hospitalized in Southeastern Iran from 2021 to 2023.","authors":"Shima Groohi-Sardou, Mohammad Mahdi Dehghani, Rasoul Raesi, Kiavash Hushmandi, Salman Daneshi","doi":"10.2174/0115733963373557250725053243","DOIUrl":"https://doi.org/10.2174/0115733963373557250725053243","url":null,"abstract":"<p><strong>Introduction: </strong>Understanding the delayed effects of COVID-19, often called \"long COVID-19,\" is essential for creating effective treatment protocols and support systems for affected children. This study was conducted to determine the delayed effects of COVID-19 in hospitalized children.</p><p><strong>Methods: </strong>This cross-sectional study is descriptive-analytical and was conducted through a census of 137 hospitalized children diagnosed with COVID-19 in Jiroft, Iran, from 2021 to 2023. Data were collected using a checklist from the patients' medical records and through telephone interviews with the children's parents. The data were analyzed using descriptive and inferential statistics at a significance level of p < 0.05.</p><p><strong>Results: </strong>The average age of the children was 7.7 years, with a majority being boys, and a small percentage having underlying medical conditions. Most children were hospitalized for three days. Fatigue was the most common delayed complication, affecting 21.1% of cases, while seizures were the least common at 1.4%. Other notable complications included cough, rhinorrhea, and nausea, with significant relationships observed between age and issues like loss of smell and decreased appetite. Underlying diseases were linked to higher rates of cough and shortness of breath.</p><p><strong>Discussion: </strong>Fatigue was the most common delayed complication of COVID-19 in hospitalized children. Younger children and those with underlying health conditions were particularly vulnerable to these delayed effects.</p><p><strong>Conclusion: </strong>This study underscores the need for personalized follow-up care for pediatric patients recovering from COVID-19. Comprehensive monitoring and support programs are crucial for addressing the specific complications observed in this population, thereby ensuring improved long-term outcomes.</p>","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preface.","authors":"Giuseppe Buonocore","doi":"10.2174/0115733963429271250724114215","DOIUrl":"https://doi.org/10.2174/0115733963429271250724114215","url":null,"abstract":"","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Immunization Perspectives: Exploring Maternal Knowledge, Attitudes, Practice, and Stakeholder Perceptions on Barriers and Challenges in the United Arab Emirates: A Mixed Methods Study.","authors":"Nageena Dileep, Mohamed Anas Patni, Wafa Manaf, Aaesha Yousef Alnuami, Hiba Rabiya, Rasha Aziz Salama Attia, Mohamed El-Tanani, Alaa A Aljabali","doi":"10.2174/0115733963385175250630080411","DOIUrl":"https://doi.org/10.2174/0115733963385175250630080411","url":null,"abstract":"<p><strong>Introduction: </strong>Vaccination is crucial because it protects individuals and communities from infectious diseases, reducing the spread and potential for outbreaks. As mothers are often the primary caregivers of children, they must be well-informed about childhood vaccinations through credible sources. The study investigated the disparities in knowledge, attitudes, and practices regarding immunization among mothers of children aged 0-5 years residing in Ras Al Khaimah. In the qualitative part of the study, the main barriers and challenges to immunization in the UAE were identified, as perceived by different stakeholders.</p><p><strong>Methodology: </strong>This study employed a mixed-method approach to examine childhood vaccination practices and attitudes among Emirati and expatriate mothers in Ras Al Khaimah, UAE, between January and April 2024. Two hundred and seven mothers were interviewed using a structured questionnaire, and 14 stakeholders were interviewed using an in-depth interview guide.</p><p><strong>Results: </strong>Key findings revealed that 95.1% of mothers vaccinated their children, but 18.3% admitted to delays. Expatriate mothers demonstrated higher knowledge of vaccine benefits and fewer concerns about safety compared to Emirati mothers. The themes generated from in-depth interviews- namely, natural immunity, peer influence, and healthcare system challenges-were significant factors influencing vaccination decisions. Cultural norms and systemic issues, such as delays in vaccine administration, also affected vaccination uptake.</p><p><strong>Discussion: </strong>Despite high vaccination rates, there was a persistent lack of awareness and concerns about side effects among both groups. This gap indicates a need for more targeted educational initiatives to address misconceptions and promote vaccine safety. The study's limited interviews, cross-sectional design, and sample may not fully represent all UAE demographic groups.</p><p><strong>Conclusion: </strong>Despite the high vaccination rates, there is a persistent lack of awareness and concerns regarding side effects. This study highlights the importance of culturally tailored communication and increased advocacy by healthcare providers to address concerns about vaccination and prevent misconceptions among the diverse population in the UAE.</p>","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How not to Misdiagnose the Mild Forms of Mucopolysaccharidosis and Juvenile Idiopathic Arthritis.","authors":"Natalia V Buchinskaya, Nato D Vashakmadze, Natalia V Zhurkova, Lubov S Sorokina, Anastasia O Vechkasova, Liudmila K Mikhaylova, Leyla S Namazova-Baranova, Ekaterina Yu Zakharova, Valentina I Larionova, Dmitry O Ivanov, Mikhail M Kostik","doi":"10.2174/0115733963321478250316112649","DOIUrl":"https://doi.org/10.2174/0115733963321478250316112649","url":null,"abstract":"<p><strong>Aims: </strong>The similarity between mucopolysaccharidosis (MPS) patients and juvenile idiopathic arthritis (JIA) leads to ineffective and needless anti-rheumatic treatment and delayed initiation of enzyme-replacement therapy, the early start of which is crucial for diminishing the disease progression and yielding better outcomes Background: The prevalence of joint involvement in the attenuated forms of MPS leads to the JIA misdiagnosis, especially in patients without distinctive facial dysmorphic features.</p><p><strong>Objective: </strong>Our study aimed to compare mild forms of MPS and JIA and create a diagnostic score helping to differentiate both conditions.</p><p><strong>Methods: </strong>41 patients with mild forms of different types of MPS and 255 JIA patients with polyarthritis were included in the retrospective study. The routine clinical and laboratory features were used for the comparison analysis.</p><p><strong>Results: </strong>The main features of the MPS cohort were younger age at the disease onset, lower weight and height lower inflammation, and higher number of affected joints compared to JIA patients and involvement in the organs and system, specific for MPS. The majority of the patients had similar C-reactive protein levels. At least two extra-articular features with polyarticular involvement were the main discriminating factors for both conditions. The sum (>38) of the following criteria:ESR< 12 mm/h (38 points), growth delay (height ≤ -2.0 SD; 20 points), age of joint involvement < 1.0 years (24 points), male sex (15 points), and involvement of both elbows with limited range of motion (29 points) can help in the differentiation If a patient had no extra-articular features, typical for MPS. The specificity and sensitivity of this model are 91.0% and 92.7% respectively.</p><p><strong>Conclusion: </strong>This diagnostic algorithm might increase the suspicion of MPS and should be added to routine testing not miss the mild form of MPS inside JIA. Early diagnosis of mild cases allows for the initiation of treatment in patients with MPS at an earlier stage, which can significantly improve their daily functioning and quality of life.</p>","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Hypotonia and Vestibular Dysfunction in Young Children: A Scoping Review.","authors":"Lena Van den Bossche, Leen Maes, Frederic Acke, Marieke Fontaine, Helene Verhelst, Ann Oostra, Ingeborg Dhooge","doi":"10.2174/0115733963376476250614212203","DOIUrl":"https://doi.org/10.2174/0115733963376476250614212203","url":null,"abstract":"<p><strong>Objective: </strong>To explore the prevalence and characteristics of infantile idiopathic hypotonia in the literature and investigate a potential association with vestibular dysfunction in young children.</p><p><strong>Methods: </strong>A scoping review was conducted following the Joanna Briggs Institute (JBI) guidelines and Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) standards. Literature was searched across MEDLINE, EMBASE, and Web of Science. Google Scholar, GreyNet International, and trial registers were searched for grey literature. Eligible articles were required to report features of children with idiopathic hypotonia or a predefined synonym.</p><p><strong>Results: </strong>Of 4,174 screened articles, 16 met the inclusion criteria. Eleven studies focused on various underlying causes of hypotonia and comprised 1150 hypotonic children, of which 24% remained undiagnosed. The remaining studies delved into the characteristics of idiopathic hypotonic children and described different developmental challenges in these children.</p><p><strong>Discussion: </strong>Clumsiness and poor coordination were commonly reported, and therapy, aiming to enhance muscle strength, coordination, and balance, was often recommended, yet none of the included articles explored vestibular dysfunction. Conclusion Despite diagnostic advancements, the underlying cause of hypotonia remains unidentified in some children. While similarities exist between hypotonic children and children with vestibular dysfunction, none of the reviewed studies explored vestibular dysfunction, warranting further investigation.</p>","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Netherton Syndrome Perspectives.","authors":"Kam Lun Ellis Hon, Yuet Ching Cheung, Zoe Mireille Chan, Yan Tung Law, Hei Tung Lam, Ashleigh Chu, Alexander K C Leung, Nisha Suyien Chandran, Kin Fon Leong","doi":"10.2174/0115733963361849250611072347","DOIUrl":"https://doi.org/10.2174/0115733963361849250611072347","url":null,"abstract":"<p><p>Netherton syndrome (NS), also known as Comèl-Netherton syndrome, is a rare disorder of cornification resulting from pathogenic variants in the Kazal type 5 (SPINK5) gene encoding serine protease inhibitor LEKTI. NS is characterized by the triad of congenital ichthyosiform erythroderma (CIE)/ichthyosis linearis circumflexa (ILC), trichorrhexis invaginata (TI), and atopic diathesis. Due to the severity of pathogenesis and variability in clinical presentations, the management of NS poses significant therapeutic challenges, which often require a multidisciplinary approach. Current treatment modalities predominantly consist of topical interventions and supportive measures. With an improved understanding of NS pathophysiology, emerging literature has suggested novel systemic therapeutic options for NS, which include repurposed biologics like targeted inhibitors and intravenous immunoglobulins, but there remains a paucity of literature regarding their clinical outcomes. Although often cited among dermatologists and allergists, the condition is rare in Hong Kong and Singapore, and most physicians have not managed any case. This review suggests that NS may be underestimated clinically. We aim to raise awareness for clinicians in the specific clinical characteristics and pathophysiology of NS to decide tailor-made treatment plans and improve patient outcomes.</p>","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug Safety Signals for Pediatric Osteopenia and Osteoporosis: Disproportionality Analysis of USFDA Adverse Event Reporting System Analysis.","authors":"Kannan Sridharan","doi":"10.2174/0115733963375307250521100744","DOIUrl":"https://doi.org/10.2174/0115733963375307250521100744","url":null,"abstract":"","PeriodicalId":11175,"journal":{"name":"Current Pediatric Reviews","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}