Effects of Breast Milk or Supplemented Formula Milk on Fecal Metabolomic Profile.

IF 1.3 Q3 PEDIATRICS
Giuseppe De Bernardo, Fabio Centanni, Marta Improta, Valeria Crisci, Maurizio Giordano, Giuseppe Buonocore, Serafina Perrone
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引用次数: 0

Abstract

Breast milk is the best option for the nutritional needs of an infant. In situations where breastfeeding is contraindicated, donor human milk and formula milk are suggested as alternatives. This study highlights findings from two studies that evaluated how different dietary patterns (standard formula, post-biotic fermented formula, and breast milk) affected the intestinal microbiota and metabolome of late preterm and full-term infants. The metabolome of late preterm newborns showed a higher presence of metabolites-such as azelaic acid, N-acetylglucosamine-6- sulfate, and 13(S)-hydroperoxylinolenic acid-in those fed postbiotic-fermented formula, similar to breastfed full-term newborns. The fecal metabolites of breast milk and substitute feeding systems are comparable in these preliminary studies, confirming the effectiveness of formula preparations as breast milk substitutes. Furthermore, newborns fed with postbiotic-supplemented formula or breast milk had several similarities in fecal metabolites. The addition of postbiotics to formula milk appears to be more efficient than standard formula milk and is considered a better alternative to breast milk.

母乳或补充配方奶对粪便代谢组学的影响。
母乳是婴儿营养需求的最佳选择。在禁止母乳喂养的情况下,建议使用供体母乳和配方奶作为替代方案。本研究强调了两项研究的结果,这两项研究评估了不同的饮食模式(标准配方奶粉、生物后发酵配方奶粉和母乳)如何影响晚期早产儿和足月婴儿的肠道微生物群和代谢组。晚期早产新生儿的代谢组显示出较高的代谢物的存在,如壬二酸、n -乙酰氨基葡萄糖-6-硫酸盐和13(S)-氢过氧亚麻酸,在那些喂养生物后发酵配方奶粉的婴儿中,类似于母乳喂养的足月新生儿。在这些初步研究中,母乳和替代喂养系统的粪便代谢物具有可比性,证实了配方制剂作为母乳替代品的有效性。此外,用生物后补充配方奶粉或母乳喂养的新生儿在粪便代谢物方面有几个相似之处。在配方奶中添加后生物制剂似乎比标准配方奶更有效,被认为是母乳的更好替代品。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.30
自引率
0.00%
发文量
66
期刊介绍: Current Pediatric Reviews publishes frontier reviews on all the latest advances in pediatric medicine. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in pediatric medicine.
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