Designed Monomers and Polymers最新文献

{"title":"Biologically active sulfur-containing polyamides as promising anticancer materials.","authors":"Gadeer R Ashour,&nbsp;Sara A Alqarni,&nbsp;Youssef O Al-Ghamdi,&nbsp;W Abd El-Fattah,&nbsp;Abeer M Alosaimi,&nbsp;Mahmoud A Hussein","doi":"10.1080/15685551.2023.2205734","DOIUrl":"https://doi.org/10.1080/15685551.2023.2205734","url":null,"abstract":"<p><p>Thiazol-based molecules have practically infinite biological implementation. Today, there are many medical applications for compounds containing the thiazole moiety owing to their presence in most clinically applied anticancer drugs, such as dasatinib, dabrafenib, ixabepilone, patellamide A and epothilone. In this study, the polycondensation, of a new group of thiazole-containing polyamides with the formulas PA_1-4 was carried out by the interaction of 2-aminothiazole diphenyl sulfide and variable diacid chlorides in dimethyl formamide in the presence of potassium carbonate anhydrous as a catalyst. Fourier transform-infrared spectroscopy (FTIR) was initially used to figure out the PA_1-4 structures, which were further characterized using solubility, gel permeation chromatography (GPC), X-ray diffraction analyses (XRD) and scanning electron microscopy (SEM). The solubility results revealed that the presence of heteroaromatic thiazole ring units and sulfur content in the polyamides main chain, made the solubility easier as it increases the chain packing distance. From the values of average molecular weight, it was clear that all synthesized polyamides have almost the same chain length which ranged from 37,561.80 to 39,827.66. Moreover, the thermogravimetric analysis (TGA) confirm that PA_1-4 were thermally stable even at high temperatures especially the polyamides which were synthesized from aromatic diacid chlorides. Furthermore, the newly synthesized polyamides were investigated for their antimicrobial properties against different species of Gram-positive and Gram-negative bacteria and also against different fungi. The results revealed that compound PA₂ showed the highest antibacterial activity. Also, their inhibitory activity against breast carcinoma cells (MCF-7 cell line) and colon carcinoma cells (HCT cell line) was evaluated. It was clear that there was an enhancement in the anticancer activity for the synthesized polyamides owing to the presence of the thiazole moiety as well as sulfur linkage. According to the results of the 50% inhibitory concentration (IC50), the synthesized polymers were found to be more active against the MCF-7 cell line than the HCT cell line.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"26 1","pages":"150-162"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5a/c1/TDMP_26_2205734.PMC10171123.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10563583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and structural characterization of β -cyclodextrin butenate.","authors":"Yong-Fu Li,&nbsp;Zhu-Xi Tian,&nbsp;Bin Shi,&nbsp;Yang-Bo He,&nbsp;Ming-Xiu Long","doi":"10.1080/15685551.2023.2205741","DOIUrl":"https://doi.org/10.1080/15685551.2023.2205741","url":null,"abstract":"<p><p>β-cyclodextrin butenate was synthesized by using N, N'-Carbonyldiimidazole (CDI) activating reagent and 4-Dimethylaminopyridine (DMAP) as catalyst. The best preparation condition of β-CD butenate was described as below: reaction temperature was 25°C, concentration of 2-butenoic acid was 450 mmol/L, concentration of DMAP was 12.5 mmol/L and reaction time was 20 minutes and at this condition the yield of β-CD butenate was 0.83 mmol/g. According to the results of FT-IR spectrum, NMR spectroscopy and HPLC-QTof-mass spectrum of β-CD butenate, there were four types β-CD butenate synthesized, which were β-CD-2-butenoic acid monoester, β-CD-2-butenoic acid diester, β-CD-2-butenoic acid triester and β-CD-2-butenoic acid tetraester, respectively.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"26 1","pages":"132-139"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/14/bb/TDMP_26_2205741.PMC10142337.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9399552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and synthesis of novel poly (aryl ether ketones) containing trifluoromethyl and trifluoromethoxy groups.","authors":"Xiaolong Liu,&nbsp;Yunlong Sun,&nbsp;Yue Chen,&nbsp;Zhongfu Zhao,&nbsp;Zhipeng Wang,&nbsp;Guangyuan Zhou","doi":"10.1080/15685551.2023.2205733","DOIUrl":"https://doi.org/10.1080/15685551.2023.2205733","url":null,"abstract":"<p><p>The high-frequency and high-speed communication in the 5 G era puts forward requirements for the dielectric properties of polymers. Introducing fluorine into poly(ary ether ketone) can improve its dielectric properties. In this work, by introducing the fluorine group strategy, we successfully designed and synthesized three novel trifluoromethyl (-CF₃) or trifluoromethoxy (-OCF₃)-containing bisphenol monomers and their F-substitution PEK-based polymers (PEK-Ins). All these PEK-Ins exhibited good thermal, mechanical and dielectric properties. The T d5% of the three polymers is all higher than 520℃. The free volume fraction of novel polymers increased from 3.75% to 5.72%. Among the three polymers, exhibited the lowest dielectric constant of the films is 2.839, and the dielectric loss is 0.0048, ascribing to the increasing free volume. The Young's modulus of the polymer film is as high as 2.9 GPa and the tensile strength is as high as 84 MPa. PEK-Ins reduced the dielectric constant by introducing a low fluorine content. This study provides a new way to design PEK to synthesize low dielectric constant polymers.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"26 1","pages":"140-149"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/92/42/TDMP_26_2205733.PMC10150610.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9411940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mini-review on the novel synthesis and potential applications of carbazole and its derivatives.","authors":"Zhichao Xu,&nbsp;Di Wu,&nbsp;Cong Fang,&nbsp;Yuanzhe Li","doi":"10.1080/15685551.2023.2194174","DOIUrl":"https://doi.org/10.1080/15685551.2023.2194174","url":null,"abstract":"<p><p>Microporous organic polymers (MOPs) are a new type of porous materials, which have advantages of synthetic diversity, chemical and physical stability, microporous size controllability, etc. MOPs indicate broad applications in various fields such as heterogeneous catalysis, gas adsorption, separation, and storage. In recent years, MOPs have attracted an enormous attention in greenhouse gas capture due to their great potential in physisorptive gas storage. Carbazole and its derivatives have been studied extensively as Metal-Organic Polyhedra (MOPs) building blocks due to their unique structural features and versatile functionalization possibilities. This paper systematically reviews the synthesis, characterization and application of carbazole-based polymers, and relationship of structures and properties of these polymers. The application of the polymers in carbon dioxide (CO₂) capture field is analysed taking advantage of their adjustable microporous structure and electron rich properties. This review also provides novel insights regarding functional polymer materials that have high ability of greenhouse gas capture and absorbing selectivity will be obtained by reasonable molecular design and efficient synthesis.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"26 1","pages":"90-105"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9241823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temperature sensitive nanogels for real-time imaging during transcatheter arterial embolization.","authors":"Hongfu Zhou,&nbsp;Wenjing Xie,&nbsp;Anran Guo,&nbsp;Bin Chen,&nbsp;Sanming Hu,&nbsp;Min Zheng,&nbsp;Houqiang Yu,&nbsp;Hongan Tian,&nbsp;Ling Li","doi":"10.1080/15685551.2022.2164445","DOIUrl":"https://doi.org/10.1080/15685551.2022.2164445","url":null,"abstract":"<p><p>Several vascular embolization materials are commonly used in clinical practice, however, having application defects of varying degrees, such as poor intraoperative imaging and easy recanalization of embolized blood vessels, they are challenging for application during Transcatheter arterial embolization (TAE). Thus, an intraoperative visible vascular embolization material with good embolization effect and biocompatibility can improve transcatheter arterial embolization clinical efficacy to some extent. Our study aimed to synthesize a novel vascular embolization material that can achieve complete embolization of arterial trunks and peripheral vessels, namely poly (N-isopropyl acrylamide)-<i>co</i>-acrylic acid nanogel (NIPAM-<i>co</i>-AA). Iohexol 200 mg/mL was co-assembled with 7 wt% NIPAM-<i>co</i>-AA nanogel to create an intelligent thermosensitive radiopaque nanogel (INCA), which achieves a good intraoperative imaging effect and is convenient for transcatheter arterial bolus injection due to its good fluidity and temperature-sensitive sol-gel phase transition. The normal rabbit kidney embolism model further confirmed that INCA could effectively use Digital subtraction angiography (DSA) to achieve intraoperative imaging, and real-time monitoring of the embolization process could avoid mis-embolization and leakage. Meanwhile, in a 42-day study, INCA demonstrated an excellent embolization effect on the right renal artery of New Zealand white rabbits, with no vascular recanalization and ischemic necrosis and calcification remaining. As a result, this radiopaque thermosensitive nanogel has the potential to be an intelligent thermosensitive medical vascular embolization material, providing dual benefits in TAE intraoperative imaging and long-term postoperative embolization while effectively addressing the shortcomings and challenges of commonly used clinical vascular embolization agents.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"26 1","pages":"31-44"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10635618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of inorganic salt on the morphology and nucleation of polyaniline nanofibers synthesized via self-assembly.","authors":"Ruijuan Wang,&nbsp;Yiqi Jing","doi":"10.1080/15685551.2023.2166727","DOIUrl":"https://doi.org/10.1080/15685551.2023.2166727","url":null,"abstract":"<p><p>Polyaniline (PANI), due to the various and controllable shapes, the environmental stability, the excellent physical and chemical property, has gained significant attention. PANI with abundant morphologies were successfully prepared through adjusting and controlling the state of the initial micelle-like in the micelle-like system composed by aniline and organic acids with relatively weak intermolecular interaction. Although the influence of the inorganic salts on their morphology, including the surface and the diameter, was investigated, the influence of salt on the nucleation of PANI was still unclear. Therefore, PANI nanofibers were fabricated through the addition of inorganic salt such as NaCl, MgSO₄ and AlCl₃ into the micelle-like composed of aniline and D-camphor-10-sulfonic acid. The influence of types and concentration of inorganic salts, doped acids and temperature on PANI was studied by Transmission Electron Microscope (TEM), UV-vis and Fourier Transform Infrared Spectroscopy (FTIR) spectroscopy. In addition, in situ UV-vis and ¹H Nuclear Magnetic Resonance technology (NMR) were applied to observe the process of aniline polymerization, and it was indicated the polymerization rate of aniline changed after the addition of inorganic salt NaCl into the initial solution.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"26 1","pages":"45-53"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9132344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A spotlight on application of microwave-assisted modifications of plant derived polymers in designing novel drug delivery systems.","authors":"Girish Meravanige Basavarajappa,&nbsp;K M Priyanka,&nbsp;Prakash Goudanavar,&nbsp;Lakshmi G Narasimha,&nbsp;N Raghavendra Naveen,&nbsp;Buduru Gowthami,&nbsp;Santosh Fattepur,&nbsp;Predeepkumar Narayanappa Shiroorkar,&nbsp;Sreeharsha Nagaraja,&nbsp;Mallikarjun Telsang,&nbsp;Veeriah Chowdary Jasthi,&nbsp;Pavan Kumar Pavagada Sreenivasalu","doi":"10.1080/15685551.2023.2194176","DOIUrl":"https://doi.org/10.1080/15685551.2023.2194176","url":null,"abstract":"<p><p>Polymers are a fundamental part of numerous industries and can be conjugated with many other materials and components to have a vast array of products. Biomaterials have been extensively studied for their application in pharmaceutical formulation development, tissue engineering, and biomedical areas. However, the native form of many polymers has limitations concerning microbial contamination, susceptibility, solubility, and stability. Chemical or physical modifications can overcome these limitations by tailoring the properties of polymers to meet several requirements. The polymer modifications are interdisciplinary, cutting across conventional materials, physics, biology, chemistry, medicine, and engineering limitations. Microwave irradiation has become a well-established technique for a few decades to drive and promote chemical modification reactions. This technique allows ease of temperature and power control to perform the synthesis protocols efficiently. Additionally, microwave irradiation contributes to green and sustainable chemistry. In this contribution, microwave-assisted polymer modifications were described with a special focus on their application in developing several novel dosage forms.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"26 1","pages":"106-116"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6a/1a/TDMP_26_2194176.PMC10064828.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9241826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and physicochemical studies on polymeric nanocomposites containing copper oxide nanoparticles.","authors":"Soad Alsheheri,&nbsp;Zahra Alamshany,&nbsp;Magdy Y Abdelaal","doi":"10.1080/15685551.2023.2190222","DOIUrl":"https://doi.org/10.1080/15685551.2023.2190222","url":null,"abstract":"<p><p>The current work aims to modify carboxymethyl cellulose (CMC) and polyvinylpyrrolidone (PVP) with copper oxide nanoparticles (CuO NPs) to obtain new nanocomposites of CMC, PVP, and CuO NPs (CMC/PVP/CuO NPs) with distinguished properties. The interaction between the components of the nanocomposites was suggested and supported by using Gaussian 09W 07 Software and the average particle size was manually determined from TEM images using ImageJ software developed at the National Institutes of Health (NIH). The preparation methods were optimized, and the obtained nanocomposites were characterized with suitable techniques to explore their characteristics and to help expect or predict the suitable fields of applications.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"26 1","pages":"68-76"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10026763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9534663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile fabrication of polystyrene particles/graphene composites for improved dielectric and thermal properties.","authors":"Wei Deng,&nbsp;Guoan Li,&nbsp;Wanyu Li,&nbsp;Meng Yang,&nbsp;Weiwei Cui","doi":"10.1080/15685551.2022.2162282","DOIUrl":"https://doi.org/10.1080/15685551.2022.2162282","url":null,"abstract":"<p><p>In this paper, polystyrene (PS)-based reduced graphene oxide (rGO) composites were prepared by mixing PS latex particles with graphene oxide (GO) and the following in-situ reduction. The structure and morphology of PS/rGO composites were characterized, and the effects of rGO content on the dielectric properties as well as thermal stability of PS/rGO composites were investigated. Results showed that rGO sheets armoured on the surface of PS particles and exhibited well dispersion in the PS matrix after hot compression. The introduction of rGO improved the dielectric properties of the composites remarkably. When rGO content was 0.12 vol%, the dielectric permittivity and breakdown strength of PS/rGO arrived at 6.3 at10² Hz and 107 kV/mm, with 50% and 35.4% enhancement compared to the pristine PS. Furthermore, PS/rGO presented better thermal stability than the pristine PS, but the overlapping of rGO sheets in PS matrix induced the instability of dielectric loss with frequency.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"26 1","pages":"23-30"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10481965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and characterization of novel thermoresponsive suspensions via physical adsorption of poly[di(ethylene glycol) methyl methacrylate] onto polystyrene microparticles.","authors":"Azad Sadraddin","doi":"10.1080/15685551.2023.2211356","DOIUrl":"https://doi.org/10.1080/15685551.2023.2211356","url":null,"abstract":"<p><p>Thermoreversible colloidal suspensions/gels have attracted recent research attention in the field of biomedical applications. In this study, a novel thermoresponsive particle suspension with thermoreversible gelation properties has been prepared for biomedical application. First, polystyrene (PS) microspheres were synthesized by dispersion polymerization and poly diethyleneglycolmethylmethacrylate (PDEGMA) polymer were synthesized via free radical polymerisation. Then, the new developed thermoresponsive suspensions were prepared via physical adsorption of a thermoresponsive polymer, poly[di (ethylene glycol) methyl methacrylate] (PDEGMA), onto the surface of polystyrene microspheres. PDEGMA acts as a steric stabilizer and induces thermoreversible gelation via chain extending and collapsing below and above its lower critical solution temperature (LCST), respectively. Scanning electron microscopy (SEM), ¹H NMR spectroscopy, Gel permeation chromatography (GPC), UV-vis spectroscopy, Rheometric measurement were conducted to characterize the prepared particles, polymers and suspensions. SEM images show that monodisperse microspheres with the sizes range 1.5-3.5 μm were prepared. UV-vis measurements demonstrate thermoresponsive properties of PDEGMA. ¹H NMR and GPC analysis confirms structural properties of prepared PDEGMA. Tube inversion tests demonstrated that the aqueous suspensions of the particles and polymer exhibited thermoreversible fluid-to-gel transitions. Rheological characterization revealed that the viscoelastic properties of the prepared suspension/gels can be fine tuned. This enables applications of the prepared gels as scaffolds for three-dimensional (3D) cell cultures.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"26 1","pages":"163-170"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10192345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}