Designed Monomers and Polymers最新文献

The future of herbicide application: controlled-release formulations for enhanced agricultural sustainability. 除草剂应用的未来：提高农业可持续性的控释制剂。

IF 1.8 4区化学

Designed Monomers and Polymers Pub Date : 2025-05-27 eCollection Date: 2025-01-01 DOI: 10.1080/15685551.2025.2508142

Vijeta Luhach, Jyoti Yadav, Poonam Barala, Parul Sangwan, Shashi Suhag, Vinita Hooda

{"title":"The future of herbicide application: controlled-release formulations for enhanced agricultural sustainability.","authors":"Vijeta Luhach, Jyoti Yadav, Poonam Barala, Parul Sangwan, Shashi Suhag, Vinita Hooda","doi":"10.1080/15685551.2025.2508142","DOIUrl":"10.1080/15685551.2025.2508142","url":null,"abstract":"The agricultural sector faces significant challenges from weed-induced crop losses, driving increased herbicide use and associated environmental and health risks. Controlled-release formulations (CRFs) of herbicides offer a promising solution by employing advanced materials such as synthetic and natural polymers, clay minerals, siliceous materials, and nanoparticles to optimize the release and efficacy of active ingredients (AIs). This review explores the mechanisms of controlled release - desorption, diffusion, osmosis, and matrix dissolution - and examines the role of carrier properties in modulating AI release kinetics. Advances in smart nanocarriers and encapsulation technologies demonstrate improved precision, reduced herbicide usage, and minimal impact on soil microbiomes, fostering sustainable agriculture. Despite these innovations, challenges remain in standardizing processes, enhancing cost-effectiveness, and scaling up field applications. This study emphasizes the critical balance between improving agricultural productivity and minimizing ecological harm, highlighting the potential of CRFs to revolutionize weed management practices while preserving soil health and ecosystem integrity.","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"28 1","pages":"24-43"},"PeriodicalIF":1.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive insight of innovations and recent advancements in nanocarriers for nose-to-brain drug targeting. 鼻-脑药物靶向纳米载体的创新和最新进展的全面见解。

IF 1.8 4区化学

Designed Monomers and Polymers Pub Date : 2025-02-10 eCollection Date: 2025-01-01 DOI: 10.1080/15685551.2025.2464132

Naeem Mubarak, Muhammad Ahsan Waqar, Asad Majeed Khan, Zainab Asif, Aima Subia Alvi, Aqsa Arshad Virk, Sakeena Amir

{"title":"A comprehensive insight of innovations and recent advancements in nanocarriers for nose-to-brain drug targeting.","authors":"Naeem Mubarak, Muhammad Ahsan Waqar, Asad Majeed Khan, Zainab Asif, Aima Subia Alvi, Aqsa Arshad Virk, Sakeena Amir","doi":"10.1080/15685551.2025.2464132","DOIUrl":"10.1080/15685551.2025.2464132","url":null,"abstract":"Central Nervous System (CNS) disorders are the leading cause of illness and affect the everyday lives of people all around the globe and are predicted to increase tremendously in the upcoming decades. Traditional methods of delivering drugs to the CNS face considerable limitations. Nose-to-brain targeting offers a promising alternative that bypasses the blood-brain barrier (BBB), enabling targeted drug administration to the central nervous system (CNS). Nanotechnology has brought forward innovative solutions to the challenges of drug delivery in CNS disorders. Nanocarriers such as liposomes, nanoparticles, nanoemulsions and dendrimers can enhance drug stability, bioavailability, and targeted delivery to the brain. These nanocarriers are designed to overcome physiological barriers and provide controlled and sustained drug release directly to the CNS. Nanocarrier technology has made significant strides in recent years, enabling more effective and targeted delivery of drugs to the brain. With recent advancements, intranasal delivery coupled with nanocarriers seems to be a promising combination that can provide better clinical profiles, pharmacokinetics, and pharmacodynamics for neurodegenerative disorders. This study focuses on exploring the nose-to-brain drug delivery system, emphasizing the use of various nanocarriers designed for this purpose. Additionally, the study encompasses recent advancements in nanocarrier technology tailored specifically to improve the efficiency of drug administration through the nasal route to the brain.","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"28 1","pages":"7-29"},"PeriodicalIF":1.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large-scale synthesis of polydimethylsiloxane as vitreous replacement applications. 大规模合成聚二甲基硅氧烷作为玻璃体替代品的应用。

IF 1.8 4区化学

Designed Monomers and Polymers Pub Date : 2025-01-08 eCollection Date: 2025-01-01 DOI: 10.1080/15685551.2024.2449442

Ajrina Nur Shabrina, Diba Grace Auliya, Risdiana, Lusi Safriani

引用次数: 0

Fabrication and in vitro evaluation of pH/thermo dual responsive hydrogels as controlled ibuprofen sodium in situ depot. 控制布洛芬钠原位库pH/热双响应水凝胶的制备及体外评价。

IF 1.8 4区化学

Designed Monomers and Polymers Pub Date : 2024-12-30 eCollection Date: 2025-01-01 DOI: 10.1080/15685551.2024.2442118

Samiullah Khan, Abdur Rehman, Syed Faisal Badshah, Gamal A Shazly, Amira Metouekel, Fakhreldeen Dabiellil

{"title":"Fabrication and in vitro evaluation of pH/thermo dual responsive hydrogels as controlled ibuprofen sodium in situ depot.","authors":"Samiullah Khan, Abdur Rehman, Syed Faisal Badshah, Gamal A Shazly, Amira Metouekel, Fakhreldeen Dabiellil","doi":"10.1080/15685551.2024.2442118","DOIUrl":"https://doi.org/10.1080/15685551.2024.2442118","url":null,"abstract":"Ibuprofen sodium (IBP) is a commonly used NSAID for multiple pain conditions. However, despite its extensive use, it is associated with multiple GIT adverse effects after oral administration. In the present study, we have fabricated thermoresponsive gel depot using Poly (N-vinylcaprolactam) and sodium alginate as polymers. The designed formulations are intended to be used as IBP depot after being administered subcutaneously. The sol-gel phase transition temperature and gelation time of gel samples were optimized by tube inversion, rheological exploration and optical transmittances. Temperature sweep experiments confirmed that optimized gel samples have sol-gel transition between 32°C and 37°C. Swelling and in vitro drug release displayed that optimized gels have maximum swelling and IBP release at pH 7.4 and at 35°C confirming their pH/thermo sensitivity. The degradation profile of hydrogels displayed controlled degradation for 6 days that with increasing contents. MTT assay showed L929 cells displayed more than 90% cell viability against blank and IBP-loaded PNVCL/NaAlg hydrogels at optimized concentrations. Fourier transform infrared spectroscopy confirmed the polymer blend hydrogels structure formation. Thermogravimetric analysis confirmed the presence of thermoresponsive moieties and thermal stability of polymer blend hydrogel sample. While scanning electron microscopy showed that hydrogel has channels in structure that might facilitate the diffusion of solvent. Results concluded that PNVCL/NaAlg hydrogels can be utilized as IBP sustained depot following subcutaneous application invivo and GIT adverse effects could be avoided associated with its oral administration.","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"28 1","pages":"1-15"},"PeriodicalIF":1.8,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11703540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and properties of bio-based semi-aromatic heat-resistant copolymer polyamide 5T-co-6T. 生物基半芳香族耐热共聚物聚酰胺 5T-co-6T 的合成与性能。

IF 1.8 4区化学

Designed Monomers and Polymers Pub Date : 2024-08-11 eCollection Date: 2024-01-01 DOI: 10.1080/15685551.2024.2390700

Xiangcheng Bian, Liqun Ma, Chen Yang, Fuchun Zhang, Shuo Zhang, Yuan Li, Kai Gao, Bingxiao Liu, Zhongqiang Wang

{"title":"Synthesis and properties of bio-based semi-aromatic heat-resistant copolymer polyamide 5T-co-6T.","authors":"Xiangcheng Bian, Liqun Ma, Chen Yang, Fuchun Zhang, Shuo Zhang, Yuan Li, Kai Gao, Bingxiao Liu, Zhongqiang Wang","doi":"10.1080/15685551.2024.2390700","DOIUrl":"10.1080/15685551.2024.2390700","url":null,"abstract":"Herein, poly(pentanediamine terephthalamide) (PA5T) homopolymer was synthesized via a salt-forming reaction+solid state polycondensation method using bio-based 1,5-pentanediamine and terephthalic acid as the primary raw materials. To address the issue of its narrower processing window, poly(hexamethylene terephthalamide)(PA6T), which also cannot be melt processed due to the processing window is negative, was introduced into its molecular chain to synthesize poly (pentanediamine/hexanediamine terephthaloyl) (PA5T-co-6T) copolymers. The structures were investigated by Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance carbon spectroscopy (13C-NMR). Furthermore, the melting temperature, crystallization temperature, thermal stability, and crystal growth mode of the polymer were tested and analyzed using differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and wide-angle x-ray diffraction (WAXD), respectively. The results demonstrate that the crystal growth mode gradually changes from three-dimensional spherical growth to two-dimensional disk-like or three-dimensional spherical growth with the increase of 6T chain segment content. Simultaneously, the crystallization temperature, melting temperature, and crystallization rate of the polymer all showed a trend of decreasing first and then increasing, which was due to the combined effects of the increase in the content of 6T chain segments on the molecular-chain structure and crystal structure of the polymer. Bio-based PA5T-co-6T has excellent heat resistance and a wider processing window than PA5T and PA6T, which possesses great application prospects in the fields of automotive, electronic appliances, and LED optics.","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"27 1","pages":"87-102"},"PeriodicalIF":1.8,"publicationDate":"2024-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11321112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress in synthesis, modification, characterization and applications of hyperbranched polyphosphate polyesters. 超支化聚磷酸酯的合成、改性、表征和应用进展。

IF 1.8 4区化学

Designed Monomers and Polymers Pub Date : 2024-07-26 eCollection Date: 2024-01-01 DOI: 10.1080/15685551.2024.2376842

Dongyan Hao, Xiaoxiao Guo, Xing Zhu, Chao Wei, Lanchang Gao, Xuechuan Wang

{"title":"Progress in synthesis, modification, characterization and applications of hyperbranched polyphosphate polyesters.","authors":"Dongyan Hao, Xiaoxiao Guo, Xing Zhu, Chao Wei, Lanchang Gao, Xuechuan Wang","doi":"10.1080/15685551.2024.2376842","DOIUrl":"10.1080/15685551.2024.2376842","url":null,"abstract":"Hyperbranched polyphosphate polyesters (HPPs) as a special class of hyperbranched polymers have attracted increased interest and have been intensively studied, because of peculiar structures, excellent biocompatibility, flexibility in physicochemical properties, biodegradability, water soluble, thermal stability, and mechanical properties. HPPs can be divided into phosphates as monomers and phosphates as end groups. In this article, the classification, general synthesis, modifications, and applications of HPP are reviewed. In addition, recent developments in the application of HPP are described, such as modified or functionalized by end capping and hypergrafting to improve the performances in polymer blends, coatings, flame retardant, leather. Furthermore, the modifications and application of HPPs in biomedical materials, such as drug delivery and bone regeneration were discussed. In summary, the hyperbranched polymer enlarges its application range and improves its application performance compared with conventional polymer. In the future, more new HPPs composite materials will be developed through hyperbranched technique. This review of HPPs will provide useful theoretical basis and technical support for the development of new hyperbranched polymer material.","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"27 1","pages":"62-86"},"PeriodicalIF":1.8,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11285245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ionic Organic Network-based C3-symmetric@Triazine core as a selective Hg⁺² sensor. 基于离子有机网络的 C3 对称@三嗪核心作为选择性 Hg+2 传感器。

IF 1.8 4区化学

Designed Monomers and Polymers Pub Date : 2024-06-18 eCollection Date: 2024-01-01 DOI: 10.1080/15685551.2024.2360746

Maha A Alshubramy, M M Alam, Khalid A Alamry, Abdullah M Asiri, Mahmoud A Hussein, Mohammed M Rahman

{"title":"Ionic Organic Network-based C3-symmetric@Triazine core as a selective Hg+2 sensor.","authors":"Maha A Alshubramy, M M Alam, Khalid A Alamry, Abdullah M Asiri, Mahmoud A Hussein, Mohammed M Rahman","doi":"10.1080/15685551.2024.2360746","DOIUrl":"10.1080/15685551.2024.2360746","url":null,"abstract":"The C3-symmetry ionic polymer PPyTri has been designed with multi-walled carbon nanotubes (MWCNTs) or graphene nanoplatelets (GNPs) and studied as an ultrasensitive electrochemical sensor for trace Hg(II) detection. The synthesis approach incorporated attaching three pyridinium cationic components with chloride anions to the triazine core. The precursors, BPy, were synthesized using a condensation process involving 4-pyridine carboxaldehyde and focused nicotinic hydrazide. The polymer PPyTri was further modified with either MWCNTs or GNPs. The resulting ionic polymer PPyTri and its fabricated nanocomposites were characterized using infrared (IR), nuclear magnetic resonance (NMR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and powder X-ray diffraction (XRD). The analysis revealed that both the polymer and its nanocomposites have semi-crystalline structures. The electroactivity of the designed nanocomposites toward Hg + 2 ions revealed that among the nanocomposites and bare copolymer, the glassy carbon electrode (GCE) adapted with the PPyTri GNPs-5% exhibited the greatest current response over a wide range of Hg + 2 concentrations. The nanocomposite-modified electrode presented an excellent sensitivity of 83.33 µAµM - 1 cm - 2, a low detection limit of 0.033 nM, and a linear dynamic range of 0.1 nM to 0.01 mM (R2 = 0.9945).","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"27 1","pages":"35-50"},"PeriodicalIF":1.8,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11188959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of methyl methacrylate concentrations on surface and thermal analysis of composite polymer polymethylmethacrylates with mesogen reactive RM82 甲基丙烯酸甲酯浓度对带有中间反应物 RM82 的复合聚合物聚甲基丙烯酸酯的表面和热分析的影响

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2024-04-04 DOI: 10.1080/15685551.2024.2336657

Afrizal, Yusmaniar, Bryan Valentino, Asep Riswoko, Karin Khairunnisa Gumilar

引用次数: 0

Construction of a corresponding empirical model to bridge thermal properties and synthesis of thermoresponsive poloxamines. 构建相应的经验模型，以桥接热特性和热致性多羟胺的合成。

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2024-02-07 eCollection Date: 2024-01-01 DOI: 10.1080/15685551.2024.2313268

Zichun Yan, D Andrew Brown, Trey Alpi, Jiro Nagatomi, O Thompson Mefford

{"title":"Construction of a corresponding empirical model to bridge thermal properties and synthesis of thermoresponsive poloxamines.","authors":"Zichun Yan, D Andrew Brown, Trey Alpi, Jiro Nagatomi, O Thompson Mefford","doi":"10.1080/15685551.2024.2313268","DOIUrl":"https://doi.org/10.1080/15685551.2024.2313268","url":null,"abstract":"The thermoresponsive properties of poloxamine (tetra-branch PEO-PPO block copolymer) hydrogels are related to several variables. Of particular interest to this study were the molecular weight of the polymer, the molar ratio between PEO and PPO blocks, and the concentration of the aqueous solution. Accurately controlling the thermoresponsive behaviors of the polymer is critical to the application of such materials; therefore, the structure-property relationship of tetra-branch PEO-PPO block copolymer was studied by synthesis via anionic ring-opening polymerization (AROP). The structure-property relationships were studied by measuring the thermoresponsive behavior via differential scanning calorimetry (DSC) and developing an empirical model which statistically fit the collected data. This empirical model was then used for designing poloxamines that have critical micellization temperatures (CMT) between room temperature and physiological temperature. The model was validated with three polymers that targeted a CMT of 308 K (35°C). The empirical model showed great success in guiding the synthesis of poloxamines showing a temperature difference of less than 3 K between the predicted and the observed CMTs. This study showed a great potential of using an empirical model to set synthesis parameters to control the properties of the polymer products.","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"27 1","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10854436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139722022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and performance evaluation of temperature and salt-resistant organic/inorganic composite copolymers 耐温耐盐有机/无机复合共聚物的合成与性能评估

IF 1.6 4区化学

Designed Monomers and Polymers Pub Date : 2023-12-28 DOI: 10.1080/15685551.2023.2296136

Yunbao Zhang, Jiamei Quan, Chengzhou Wang, Wentao Li, Ruofei Du, Hongchao Dong

引用次数: 0