Synthesis and characterization of novel thermoresponsive suspensions via physical adsorption of poly[di(ethylene glycol) methyl methacrylate] onto polystyrene microparticles.
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引用次数: 0
Abstract
Thermoreversible colloidal suspensions/gels have attracted recent research attention in the field of biomedical applications. In this study, a novel thermoresponsive particle suspension with thermoreversible gelation properties has been prepared for biomedical application. First, polystyrene (PS) microspheres were synthesized by dispersion polymerization and poly diethyleneglycolmethylmethacrylate (PDEGMA) polymer were synthesized via free radical polymerisation. Then, the new developed thermoresponsive suspensions were prepared via physical adsorption of a thermoresponsive polymer, poly[di (ethylene glycol) methyl methacrylate] (PDEGMA), onto the surface of polystyrene microspheres. PDEGMA acts as a steric stabilizer and induces thermoreversible gelation via chain extending and collapsing below and above its lower critical solution temperature (LCST), respectively. Scanning electron microscopy (SEM), 1H NMR spectroscopy, Gel permeation chromatography (GPC), UV-vis spectroscopy, Rheometric measurement were conducted to characterize the prepared particles, polymers and suspensions. SEM images show that monodisperse microspheres with the sizes range 1.5-3.5 μm were prepared. UV-vis measurements demonstrate thermoresponsive properties of PDEGMA. 1H NMR and GPC analysis confirms structural properties of prepared PDEGMA. Tube inversion tests demonstrated that the aqueous suspensions of the particles and polymer exhibited thermoreversible fluid-to-gel transitions. Rheological characterization revealed that the viscoelastic properties of the prepared suspension/gels can be fine tuned. This enables applications of the prepared gels as scaffolds for three-dimensional (3D) cell cultures.
期刊介绍：
Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work.
The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications.
DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to:
-macromolecular science, initiators, macroinitiators for macromolecular design
-kinetics, mechanism and modelling aspects of polymerization
-new methods of synthesis of known monomers
-new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization)
-functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers
-new polymeric materials with biomedical applications
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