Cytokine & Growth Factor Reviews最新文献_第2页

Impact of chronic stress on intestinal mucosal immunity in colorectal cancer progression. 慢性压力对结直肠癌进展过程中肠粘膜免疫的影响

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2024-12-01 Epub Date: 2024-10-22 DOI: 10.1016/j.cytogfr.2024.10.007

Shengya Yang, Ying Li, Yingru Zhang, Yan Wang

引用次数: 0

JAK inhibitors in immune regulation and treatment of vitiligo. JAK 抑制剂在免疫调节和白癜风治疗中的作用。

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2024-12-01 Epub Date: 2024-11-10 DOI: 10.1016/j.cytogfr.2024.11.002

Kewei Liu, Linyi Zhou, Meihui Shi, Tianxin Cong, Xiaoyi Yang, Xiangnan Zhou, Ming Cheng, Cong Ma, Shulan Yao, Peiyao Ying, Zhenzhen Mu, Yan Wu

{"title":"JAK inhibitors in immune regulation and treatment of vitiligo.","authors":"Kewei Liu, Linyi Zhou, Meihui Shi, Tianxin Cong, Xiaoyi Yang, Xiangnan Zhou, Ming Cheng, Cong Ma, Shulan Yao, Peiyao Ying, Zhenzhen Mu, Yan Wu","doi":"10.1016/j.cytogfr.2024.11.002","DOIUrl":"10.1016/j.cytogfr.2024.11.002","url":null,"abstract":"Vitiligo, a disorder marked by hypopigmentation, significantly impacts patients' quality of life and mental health. This condition results from the reduction or dysfunction of melanocytes, which are crucial for skin and hair pigmentation. Current treatments include glucocorticoids, immunosuppressants, phototherapy, vitamin D3 analogues, and surgical interventions. Recent research has revealed that hyperactivation of Janus kinase (JAK) and its downstream signaling pathways intensifies cytotoxic T cell activity and weakens melanocytes' defense against environmental stressors. Additionally, the aberrant expression of pro-inflammatory cytokines such as Interferon-gamma (IFN-γ) and Tumor Necrosis Factor-alpha (TNF-α) plays a critical role in the pathogenesis of vitiligo by disrupting melanocyte function and promoting immune-mediated destruction. Clinical trials and basic research have demonstrated the efficacy of JAK inhibitors in modulating these cytokine pathways and promoting melanocyte repigmentation. This review provides a comprehensive analysis of JAK inhibitors, exploring their mechanisms and latest applications in regulating cytokine and skin immune responses, aiming to optimize their use in vitiligo therapy.","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":" ","pages":"87-96"},"PeriodicalIF":9.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central role of Galectin-3 at the cross-roads of cardiac inflammation and fibrosis: Implications for heart failure and transplantation. Galectin-3 在心脏炎症和纤维化交叉点上的核心作用：对心力衰竭和移植的影响。

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2024-12-01 Epub Date: 2024-10-20 DOI: 10.1016/j.cytogfr.2024.10.002

Ignacio M Seropian, Mohammad El-Diasty, Adham H El-Sherbini, Germán E González, Gabriel A Rabinovich

{"title":"Central role of Galectin-3 at the cross-roads of cardiac inflammation and fibrosis: Implications for heart failure and transplantation.","authors":"Ignacio M Seropian, Mohammad El-Diasty, Adham H El-Sherbini, Germán E González, Gabriel A Rabinovich","doi":"10.1016/j.cytogfr.2024.10.002","DOIUrl":"10.1016/j.cytogfr.2024.10.002","url":null,"abstract":"Cardiac inflammation and fibrosis are central pathogenic mechanisms leading to heart failure. Transplantation is still the treatment of choice for many patients undergoing end-stage heart failure who remain symptomatic despite optimal medical therapy. In spite of considerable progress, the molecular mechanisms linking inflammation, fibrosis and heart failure remain poorly understood. Galectin-3 (GAL3), a chimera-type member of the galectin family, has emerged as a critical mediator implicated in cardiac inflammatory, vascular and fibrotic processes through modulation of different cellular compartments including monocytes and macrophages, fibroblasts, endothelial cells and vascular smooth muscle cells via glycan-dependent or independent mechanisms. GAL3-driven circuits may hierarchically amplify cytokine production and function, immune cell activation and fibrosis cascades, influencing a wide range of cardiovascular disorders. Thus, GAL3 emerges as a potential therapeutic target to counteract aberrant inflammation and fibrosis during heart failure and a potential biomarker of heart failure and clinical outcome of heart transplantation.","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":" ","pages":"47-58"},"PeriodicalIF":9.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the intricacies of neutrophil extracellular traps in inflammatory bowel disease: Pathways, biomarkers, and promising therapies. 揭开炎症性肠病中中性粒细胞胞外捕获物的神秘面纱：途径、生物标志物和有前景的疗法。

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2024-12-01 Epub Date: 2024-10-18 DOI: 10.1016/j.cytogfr.2024.10.003

Yilin Wu, Jun Shen

{"title":"Unraveling the intricacies of neutrophil extracellular traps in inflammatory bowel disease: Pathways, biomarkers, and promising therapies.","authors":"Yilin Wu, Jun Shen","doi":"10.1016/j.cytogfr.2024.10.003","DOIUrl":"10.1016/j.cytogfr.2024.10.003","url":null,"abstract":"The development of inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, involves various factors and is characterized by persistent inflammation of the mucosal lining. However, the role of neutrophils in this process remains controversial. Neutrophil extracellular traps (NETs), which consist of chromatin, antimicrobial proteins, and oxidative enzymes, are released by neutrophils to trap pathogens. They are also involved in various immune-mediated and vascular diseases. NETs act as a vital defense mechanisms at the gut-mucosal interface and are frequently exposed to bacterial, viral, and fungal threats. However, they can also contribute to inflammation and worsen imbalances in the gut bacteria. Recent studies have suggested that NETs have a significant impact on IBD development. Previous studies have shown increased levels of NETs in tissue and blood samples from patients with IBD, as well as in experimental colitis mouse models. Therefore, this review discusses how NETs are formed and their role in the pathophysiology of IBD. It discusses how NETs may lead to tissue damage and contribute to IBD-associated complications. Moreover, non-invasive biomarkers are needed to replace invasive procedures such as endoscopy to better evaluate the disease status. Given the crucial role of NETs in IBD progression, this review focuses on potential NET biomarkers that can help predict the evolution of IBD. Furthermore, this review identifies potential therapeutic targets for regulating NET production, which could expand the range of available treatment options for IBD.","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":" ","pages":"156-167"},"PeriodicalIF":9.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NLRP1 inflammasome in neurodegenerative disorders: From pathology to therapies. 神经退行性疾病中的 NLRP1 炎症小体：从病理学到疗法

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2024-12-01 Epub Date: 2024-10-16 DOI: 10.1016/j.cytogfr.2024.10.004

Meng-Jie Zhang, Long Yang, Zhuo-Yao Li, Long-Yun Zhou, Yong-Jun Wang, Hong-Shen Wang, Xue-Jun Cui, Min Yao

{"title":"NLRP1 inflammasome in neurodegenerative disorders: From pathology to therapies.","authors":"Meng-Jie Zhang, Long Yang, Zhuo-Yao Li, Long-Yun Zhou, Yong-Jun Wang, Hong-Shen Wang, Xue-Jun Cui, Min Yao","doi":"10.1016/j.cytogfr.2024.10.004","DOIUrl":"10.1016/j.cytogfr.2024.10.004","url":null,"abstract":"Neuroinflammation is a critical component in neurodegenerative disorders. The inflammasome, facilitates the cleavage of caspase-1, leading to the maturation and subsequent secretion of inflammatory factors interleukin (IL)-1β and IL-18. Consequently, pyroptosis mediated by gasdermin D, exacerbates neuroinflammation. Among the inflammasomes, NLRP1/3 are predominant in the central nervous system (CNS), Although NLRP1 was the earliest discovered inflammasome, the specific involvement of NLRP1 in neurodegenerative diseases remains to be fully elucidated. Recently, the discovery of an endogenous inhibitor of NLRP1, dipeptidyl peptidase 9, suggests the feasibility of producing of small-molecule drugs targeting NLRP1. This review describes the latest findings on the role of the NLRP1 inflammasome in the pathology of neurodegenerative disorders, including Alzheimer's disease, and summarises the regulatory mechanisms of NLRP1 inflammasome activation in the CNS. Furthermore, we highlight the recent progress in developing small-molecule and biological inhibitors that modulate the NLRP1 infammasome for the treatment of neurodegenerative disorders, some of which are advancing to preclinical testing. SIGNIFICANCE STATEMENT: The objective of this review is to synthesise the research on the structure, activation, and regulatory mechanisms of the NLRP1 inflammasome, along with its potential impact on both acute and chronic neurodegenerative conditions. The discovery of endogenous inhibitors, such as dipeptidyl peptidase 9 and thioredoxin, and their interaction with NLRP1 suggest the possibility of developing NLRP1-targeted small-molecule drugs for the treatment of neurodegenerative disorders. This review also discusses the use of both direct and indirect NLRP1 inhibitors as prospective therapeutic strategies for these conditions.","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":" ","pages":"138-155"},"PeriodicalIF":9.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytokine modulation and immunoregulation of uterine NK cells in pregnancy disorders. 妊娠障碍中子宫 NK 细胞的细胞因子调节和免疫调节。

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2024-11-23 DOI: 10.1016/j.cytogfr.2024.11.007

Jun Zhou, Ping Yan, Wenxue Ma, Jing Li

{"title":"Cytokine modulation and immunoregulation of uterine NK cells in pregnancy disorders.","authors":"Jun Zhou, Ping Yan, Wenxue Ma, Jing Li","doi":"10.1016/j.cytogfr.2024.11.007","DOIUrl":"https://doi.org/10.1016/j.cytogfr.2024.11.007","url":null,"abstract":"Uterine natural killer (uNK) cells play a pivotal role in promoting placental development and supporting maternal-fetal immune tolerance, primarily through cytokine regulation and growth factor production. While the importance of uNK cells in pregnancy is well-established, the mechanisms of their interactions with trophoblasts and contributions to various pregnancy complications remain incompletely understood. This review highlights recent advancements in understanding uNK cell functions, with a focus on cytokine production, growth factor secretion, and receptor-ligand interactions, particularly involving killer immunoglobulin-like receptors (KIR) and human leukocyte antigen-C (HLA-C). We explore how uNK cell dysfunction contributes to pregnancy complications, including preeclampsia, recurrent pregnancy loss, and placenta accreta spectrum (PAS) disorders, emphasizing their roles in immune tolerance and placental health. By detailing the distinct cytokine signaling pathways and functional subtypes of uNK cells, this review provides insights into their regulatory mechanisms essential for pregnancy maintenance. Additionally, we discuss emerging therapeutic strategies targeting uNK-trophoblast interactions and propose future research directions, including the development of non-invasive biomarkers and personalized interventions. This comprehensive review addresses critical knowledge gaps, aiming to advance research in reproductive immunology and guide therapeutic innovations in maternal health.","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IL-33 in cancer immunotherapy: Pleiotropic functions and biological strategies.

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2024-11-22 DOI: 10.1016/j.cytogfr.2024.11.005

Keying Che, Jinyu Li, Zheng Chen, Qiang Li, Qiang Wen, Chuanxi Wang, Zhe Yang

引用次数: 0

The activin-follistatin system: Key regulator of kidney development, regeneration, inflammation, and fibrosis. 激活素-软骨素系统：肾脏发育、再生、炎症和纤维化的关键调节因子

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2024-11-19 DOI: 10.1016/j.cytogfr.2024.11.004

Izumi Nagayama, Yoshinori Takei, Shunsuke Takahashi, Mari Okada, Akito Maeshima

引用次数: 0

The Yin and Yang of TLR4 in COVID-19. TLR4 在 COVID-19 中的阴与阳。

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2024-10-09 DOI: 10.1016/j.cytogfr.2024.10.001

Suprabhat Mukherjee, Jagadeesh Bayry

{"title":"The Yin and Yang of TLR4 in COVID-19.","authors":"Suprabhat Mukherjee, Jagadeesh Bayry","doi":"10.1016/j.cytogfr.2024.10.001","DOIUrl":"https://doi.org/10.1016/j.cytogfr.2024.10.001","url":null,"abstract":"Various pattern recognition receptors (PRRs), including toll-like receptors (TLRs), play a crucial role in recognizing invading pathogens as well as damage-associated molecular patterns (DAMPs) released in response to infection. The resulting signaling cascades initiate appropriate immune responses to eliminate these pathogens. Current evidence suggests that SARS-CoV-2-driven activation of TLR4, whether through direct recognition of the spike glycoprotein (alone or in combination with endotoxin) or by sensing various TLR4-activating DAMPs or alarmins released during viral infection, acts as a critical mediator of antiviral immunity. However, TLR4 exerts a dual role in COVID-19, demonstrating both beneficial and deleterious effects. Dysregulated TLR4 signaling is implicated in the proinflammatory consequences linked to the immunopathogenesis of COVID-19. Additionally, TLR4 polymorphisms contribute to severity of the disease. Given its significant immunoregulatory impact on COVID-19 immunopathology and host immunity, TLR4 has emerged as a key target for developing inhibitors and immunotherapeutic strategies to mitigate the adverse effects associated with SARS-CoV-2 and related infections. Furthermore, TLR4 agonists are also being explored as adjuvants to enhance immune responses to SARS-CoV-2 vaccines.","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ubiquitination in pyroptosis pathway: A potential therapeutic target for sepsis. 热蛋白沉积途径中的泛素化：败血症的潜在治疗靶点

IF 13 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2024-09-06 DOI: 10.1016/j.cytogfr.2024.09.001

Yan Liao,Wangzheqi Zhang,Miao Zhou,Chenglong Zhu,Zui Zou

引用次数: 0