Cytokine & Growth Factor Reviews最新文献

{"title":"Proteomics analysis of circulating small extracellular vesicles: Focus on the contribution of EVs to tumor metabolism","authors":"Federica Anastasi ,&nbsp;Asia Botto ,&nbsp;Benoit Immordino ,&nbsp;Elisa Giovannetti ,&nbsp;Liam A. McDonnell","doi":"10.1016/j.cytogfr.2023.08.003","DOIUrl":"10.1016/j.cytogfr.2023.08.003","url":null,"abstract":"<div><p>The term <em>small extracellular vesicle</em><span><span><span> (sEV) is a comprehensive term that includes any type of cell-derived, membrane-delimited particle that has a diameter &lt; 200 nm, and which includes exosomes and smaller </span>microvesicles<span><span>. sEVs transfer bioactive molecules between cells and are crucial for cellular homeostasis and particularly during tumor development, where sEVs provide important contributions to the formation of the premetastic niche and to their altered metabolism. sEVs are thus legitimate targets for intervention and have also gained increasing interest as an easily accessible source of biomarkers because they can be rapidly isolated from serum/plasma and their molecular cargo provides information on their cell-of origin. To target sEVs that are specific for a given cell/disease it is essential to identify EV </span>surface proteins<span> that are characteristic of that cell/disease. Mass-spectrometry based proteomics is widely used for the identification and quantification of sEV proteins. The methods used for isolating the sEVs, preparing the sEV sample for proteomics analysis, and mass spectrometry analysis, can have a strong influence on the results and requires careful consideration. This review provides an overview of the approaches used for sEV proteomics and discusses the inherent compromises regarding EV purity versus depth of coverage. Additionally, it discusses the practical applications of the methods to unravel the involvement of sEVs in regulating the metabolism of </span></span></span>pancreatic ductal adenocarcinoma<span><span> (PDAC). The metabolic reprogramming in PDAC includes enhanced glycolysis, elevated glutamine metabolism, alterations in lipid metabolism, mitochondrial dysfunction and </span>hypoxia<span><span>, all of which are crucial in promoting tumor cell growth. A thorough understanding of these metabolic adaptations is imperative for the development of targeted therapies to exploit </span>PDAC's vulnerabilities.</span></span></span></p></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"73 ","pages":"Pages 3-19"},"PeriodicalIF":13.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10128582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosome-mediated metabolic reprogramming: Implications in esophageal carcinoma progression and tumor microenvironment remodeling","authors":"Yong Xi ,&nbsp;Yaxing Shen ,&nbsp;Lijie Chen ,&nbsp;Lijie Tan ,&nbsp;Weiyu Shen ,&nbsp;Xing Niu","doi":"10.1016/j.cytogfr.2023.08.010","DOIUrl":"10.1016/j.cytogfr.2023.08.010","url":null,"abstract":"<div><p><span>Esophageal carcinoma<span><span> is among the most fatal malignancies<span><span> with increasing incidence globally. Tumor onset and progression can be driven by metabolic reprogramming, especially during esophageal carcinoma development. Exosomes, a subset of extracellular vesicles, display an average size of ∼100 nanometers, containing multifarious components (nucleic acids, proteins, </span>lipids<span>, etc.). An increasing number of studies have shown that exosomes are capable of transferring molecules with biological functions into recipient cells, which play crucial roles in esophageal carcinoma progression and tumor microenvironment<span> that is a highly heterogeneous ecosystem through rewriting the metabolic processes in tumor cells and environmental stromal cells. The review introduces the reprogramming of glucose, lipid, </span></span></span></span>amino acid<span>, mitochondrial metabolism in esophageal carcinoma, and summarize current </span></span></span>pharmaceutical<span><span> agents targeting such aberrant metabolism rewiring. We also comprehensively overview the biogenesis and release of exosomes, and recent advances of exosomal cargoes and functions in esophageal carcinoma and their promising clinical application. Moreover, we discuss how exosomes trigger tumor growth, metastasis<span>, drug resistance, and immunosuppression as well as tumor microenvironment remodeling through focusing on their capacity to transfer materials between cells or between cells and tissues and modulate metabolic reprogramming, thus providing a theoretical reference for the design potential pharmaceutical agents targeting these mechanisms. Altogether, our review attempts to fully understand the significance of exosome-based metabolic rewriting in esophageal carcinoma progression and remodeling of the tumor microenvironment, bringing novel insights into the prevention and </span></span>treatment of esophageal carcinoma in the future.</span></p></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"73 ","pages":"Pages 78-92"},"PeriodicalIF":13.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10579878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomal noncoding RNA-mediated spatiotemporal regulation of lipid metabolism: Implications in immune evasion and chronic inflammation","authors":"Mangala Hegde ,&nbsp;Aviral Kumar ,&nbsp;Sosmitha Girisa ,&nbsp;Mohammed S. Alqahtani ,&nbsp;Mohamed Abbas ,&nbsp;Akul Goel ,&nbsp;Kam Man Hui ,&nbsp;Gautam Sethi ,&nbsp;Ajaikumar B. Kunnumakkara","doi":"10.1016/j.cytogfr.2023.06.001","DOIUrl":"10.1016/j.cytogfr.2023.06.001","url":null,"abstract":"<div><p><span><span>The hallmark of chronic inflammatory diseases is immune evasion. Successful immune evasion involves numerous mechanisms to suppress both adaptive and </span>innate immune responses<span><span><span>. Either direct contact between cells or paracrine signaling triggers these responses. Exosomes are critical drivers of these interactions and exhibit both immunogenic and immune evasion properties during the development and progression of various chronic inflammatory diseases. Exosomes carry diverse molecular cargo, including </span>lipids, proteins, and </span>RNAs<span><span> that are crucial for immunomodulation. Moreover, recent studies have revealed that exosomes and their cargo-loaded molecules are extensively involved in lipid remodeling and metabolism during </span>immune surveillance and disease. Many studies have also shown the involvement of lipids in controlling </span></span></span>immune cell<span><span> activities and their crucial upstream functions in regulating inflammasome activation, suggesting that any perturbation in </span>lipid metabolism results in abnormal immune responses. Strikingly, the expanded immunometabolic reprogramming capacities of exosomes and their contents provided insights into the novel mechanisms behind the prophylaxis of inflammatory diseases. By summarizing the tremendous therapeutic potential of exosomes, this review emphasizes the role of exosome-derived noncoding RNAs in regulating immune responses through the modulation of lipid metabolism and their promising therapeutic applications.</span></p></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"73 ","pages":"Pages 114-134"},"PeriodicalIF":13.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10119602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes: Another intercellular lipometabolic communication mediators in digestive system neoplasms?","authors":"Shaodong Li ,&nbsp;Ruizhi Dong ,&nbsp;Zhenhua Kang ,&nbsp;Hucheng Li ,&nbsp;Xueliang Wu ,&nbsp;Tian Li","doi":"10.1016/j.cytogfr.2023.06.005","DOIUrl":"10.1016/j.cytogfr.2023.06.005","url":null,"abstract":"<div><p><span><span><span>Neoplasms are one of the most concerned public health problems worldwide. </span>Digestive system neoplasms<span>, with a high morbidity and mortality, is one of the most common malignant tumors in human being. It is found that exosomes act as an intercellular communication media to carry the metabolic and </span></span>genetic information of parental cells to target cells. Likely, exosomes participate in </span>lipid metabolism<span> and regulates multiple processes in digestive system neoplasms, including the information transmission among cancer cells<span><span><span>, the formation of neoplastic microenvironment, and the neoplastic biological behaviors like </span>metastasis, invasion, and the chemotherapy resistance. In this review, we firstly introduce the main mechanisms whereas exosomes act as intercellular lipometabolic communication mediator in digestive system neoplasms. Thereafter we introduce the relationship between exosomes lipid metabolism and various type of digestive system neoplasms, including gastric cancer, hepatocellular carcinoma, </span>pancreatic cancer<span>, and colorectal cancer. Eventually, we summarized and prospected the development and implication of exosomes in digestive system neoplasms. The further research of exosomes as intercellular lipid metabolism mediator will contribute to accurate and efficient diagnosis and treatment of digestive system neoplasms.</span></span></span></p></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"73 ","pages":"Pages 93-100"},"PeriodicalIF":13.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9936893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes-regulated lipid metabolism in tumorigenesis and cancer progression","authors":"Leiguang Ye ,&nbsp;Yingpu Li ,&nbsp;Sifan Zhang ,&nbsp;Jinsong Wang ,&nbsp;Bo Lei","doi":"10.1016/j.cytogfr.2023.05.002","DOIUrl":"10.1016/j.cytogfr.2023.05.002","url":null,"abstract":"<div><p><span>Increasing evidence highlights the role of lipid metabolism<span><span> in tumorigenesis and tumor progression. Targeting the processes of lipid metabolism, including </span>lipogenesis, lipid uptake, </span></span>fatty acid oxidation<span><span><span><span>, and lipolysis, is an optimal strategy for anti-cancer therapy. Beyond cell-cell membrane surface interaction, </span>exosomes are pivotal factors that transduce intercellular signals in the </span>tumor microenvironment<span> (TME). Most research focuses on the role of lipid metabolism in regulating exosome biogenesis and extracellular matrix (ECM) remodeling. The mechanisms of exosome and ECM-mediated reprogramming of lipid metabolism are currently unclear. We summarize several mechanisms associated with the regulation of lipid metabolism in cancer, including transport of exosomal carriers and </span></span>membrane receptors<span>, activation of the PI3K<span> pathway, ECM ligand-receptor interactions, and mechanical stimulation. This review aims to highlight the significance of these intercellular factors in TME and to deepen the understanding of the functions of exosomes and ECM in the regulation of lipid metabolism.</span></span></span></p></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"73 ","pages":"Pages 27-39"},"PeriodicalIF":13.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9648938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in the treatment of IBD: Targets, mechanisms and related therapies","authors":"Juan Liu ,&nbsp;Bin Di ,&nbsp;Li-li Xu","doi":"10.1016/j.cytogfr.2023.07.001","DOIUrl":"10.1016/j.cytogfr.2023.07.001","url":null,"abstract":"<div><p><span><span>Inflammatory bowel disease<span> (IBD), as a representative inflammatory disease, currently has multiple effective </span></span>treatment<span> options available and new therapeutic strategies are being actively explored to further increase the treatment options for patients with IBD. Furthermore, biologic agents and small molecule </span></span>drugs<span><span><span> developed for ulcerative colitis (UC) and </span>Crohn's disease (CD) have evolved toward fewer side effects and more accurate targeting. Novel inhibitors that target cytokines (such as IL-12/23 inhibitors, PDE4 inhibitors), </span>integrins<span><span> (such as integrin inhibitors), cytokine signaling pathways (such as </span>JAK inhibitors<span><span>, SMAD7 blocker) and cell signaling receptors (such as S1P receptor modulator) have become the preferred treatment choice for many IBD patients. Conventional therapies such as 5-aminosalicylic acid, corticosteroids, </span>immunomodulators and anti-tumor necrosis factor agents continue to demonstrate therapeutic efficacy, particularly in combination with drug therapy. This review integrates research from chemical, biological and adjuvant therapies to evaluate current and future IBD therapies, highlighting the mechanism of action of each therapy and emphasizing the potential of development prospects.</span></span></span></p></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"71 ","pages":"Pages 1-12"},"PeriodicalIF":13.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10343200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acinar cells and the development of pancreatic fibrosis","authors":"Jianhong An ,&nbsp;Tingting Jiang ,&nbsp;Ling Qi ,&nbsp;Keping Xie","doi":"10.1016/j.cytogfr.2023.05.003","DOIUrl":"10.1016/j.cytogfr.2023.05.003","url":null,"abstract":"<div><p><span><span><span><span><span>Pancreatic fibrosis<span> is caused by excessive deposition of extracellular matrixes of collagen and </span></span>fibronectin in the pancreatic tissue as a result of repeated injury often seen </span>in patients<span><span> with chronic pancreatic diseases. The most common causative conditions include </span>inborn errors of metabolism<span>, chemical toxicity<span> and autoimmune disorders. Its pathophysiology is highly complex, including </span></span></span></span>acinar cell injury, acinar stress response, duct dysfunction, pancreatic </span>stellate cell<span> activation, and persistent inflammatory response. However, the specific mechanism remains to be fully clarified. Although the current therapeutic strategies targeting pancreatic stellate cells show good efficacy in cell culture and animal models<span><span>, they are not satisfactory in the clinic. Without effective intervention, pancreatic fibrosis can promote the transformation from pancreatitis to </span>pancreatic cancer<span>, one of the most lethal malignancies. In the normal pancreas, the acinar component accounts for 82% of the exocrine tissue. Abnormal acinar cells may activate pancreatic stellate cells directly as cellular source of fibrosis or indirectly via releasing various substances and initiate pancreatic fibrosis. A comprehensive understanding of the role of acinar cells in pancreatic fibrosis is critical for designing effective intervention strategies. In this review, we focus on the role of and mechanisms underlying pancreatic acinar injury in pancreatic fibrosis and their potential </span></span></span></span>clinical significance.</p></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"71 ","pages":"Pages 40-53"},"PeriodicalIF":13.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9961021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TGF-β mediated drug resistance in solid cancer","authors":"Marta Turati ,&nbsp;Alexandra Mousset ,&nbsp;Nervana Issa ,&nbsp;Andrei Turtoi ,&nbsp;Roberto Ronca","doi":"10.1016/j.cytogfr.2023.04.001","DOIUrl":"10.1016/j.cytogfr.2023.04.001","url":null,"abstract":"<div><p><span>Transforming growth factor β<span> (TGF-β) is an important signaling molecule which is expressed in three different isoforms in mammals (</span></span><em>i.e.</em><span><span><span> TGF-β1, -β2, and -β3). The interaction between TGF-β and its receptor triggers several pathways, which are classified into SMAD-dependent (canonical) and SMAD-independent (non-canonical) signaling, whose activation/transduction is finely regulated by several mechanisms. TGF-β is involved in many physiological and pathological processes, assuming a dualistic role in cancer progression depending on tumor stage. Indeed, TGF-β inhibits cell proliferation in early-stage tumor cells, while it promotes cancer progression and invasion in advanced tumors, where high levels of TGF-β have been reported in both tumor and </span>stromal cells. In particular, TGF-β signaling has been found to be strongly activated in cancers after </span>treatment with chemotherapeutic agents and radiotherapy, resulting in the onset of drug resistance conditions. In this review we provide an up-to-date description of several mechanisms involved in TGF-β-mediated drug resistance, and we report different strategies that are currently under development in order to target TGF-β pathway and increase tumor sensitivity to therapy.</span></p></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"71 ","pages":"Pages 54-65"},"PeriodicalIF":13.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9967058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain-derived neurotrophic factor: Its role in energy balance and cancer cachexia","authors":"Barış Çerçi ,&nbsp;Ayşenur Gök ,&nbsp;Aytekin Akyol","doi":"10.1016/j.cytogfr.2023.07.003","DOIUrl":"10.1016/j.cytogfr.2023.07.003","url":null,"abstract":"<div><p><span><span><span><span>Brain-derived neurotrophic factor (BDNF) plays an important role in the development of the central and peripheral nervous system during embryogenesis. In the mature </span>central nervous system, BDNF is required for the maintenance and enhancement of </span>synaptic transmissions and the survival of neurons. Particularly, it is involved in the modulation of neurocircuits that control energy balance through food intake, energy expenditure, and locomotion. Regulation of BDNF in the central nervous system is complex and </span>environmental factors<span> affect its expression in murine models which may reflect to phenotype dramatically. Furthermore, BDNF and its high-affinity receptor tropomyosin receptor kinase B (TrkB), as well as pan-neurotrophin receptor (p75</span></span>^NTR<span><span><span>) is expressed in peripheral tissues in adulthood and their signaling is associated with regulation of energy balance. BDNF/TrkB signaling is exploited by cancer cells as well and BDNF expression is increased in tumors. Intriguingly, previously demonstrated roles of BDNF in regulation of food intake, </span>adipose tissue and muscle overlap with derangements observed in </span>cancer cachexia. However, data about the involvement of BDNF in cachectic cancer patients and murine models are scarce and inconclusive. In the future, knock-in and/or knock-out experiments with murine cancer models could be helpful to explore potential new roles for BDNF in the development of cancer cachexia.</span></p></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"71 ","pages":"Pages 105-116"},"PeriodicalIF":13.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10324845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth differentiation factor 11: A new hope for the treatment of cardiovascular diseases","authors":"Yingchun Shao ,&nbsp;Yanhong Wang ,&nbsp;Jiazhen Xu ,&nbsp;Yang Yuan ,&nbsp;Dongming Xing","doi":"10.1016/j.cytogfr.2023.06.007","DOIUrl":"10.1016/j.cytogfr.2023.06.007","url":null,"abstract":"<div><p>Growth differentiation factor 11<span> (GDF11) is a member of the transforming growth factor-β superfamily that has garnered significant attention due to its anti-cardiac aging properties. Many studies have revealed that GDF11 plays an indispensable role in the onset of cardiovascular diseases (CVDs). Consequently, it has emerged as a potential target and novel therapeutic agent for CVD treatment. However, currently, no literature reviews comprehensively summarize the research on GDF11 in the context of CVDs. Therefore, herein, we comprehensively described GDF11’s structure, function, and signaling in various tissues. Furthermore, we focused on the latest findings concerning its involvement in CVD development and its potential for clinical translation as a CVD treatment. We aim to provide a theoretical basis for the prospects and future research directions of the GDF11 application regarding CVDs.</span></p></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"71 ","pages":"Pages 82-93"},"PeriodicalIF":13.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9973543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}