Cytokine & Growth Factor Reviews最新文献_第9页

Extracellular vesicles as mediators of cell-cell communication in ovarian cancer and beyond – A lipids focus 细胞外小泡作为细胞间通讯的介质在卵巢癌症及其后-脂质焦点。

IF 13 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2023-10-01 DOI: 10.1016/j.cytogfr.2023.06.004

Shikha Rani , Andrew Lai , Soumya Nair , Shayna Sharma , Aase Handberg , Flavio Carrion , Andreas Möller , Carlos Salomon

引用次数: 4

Extracellular vesicles: Emerging mediators of cell communication in gastrointestinal cancers exhibiting metabolic abnormalities 细胞外小泡：表现出代谢异常的胃肠道癌症中新出现的细胞通讯介质。

IF 13 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2023-10-01 DOI: 10.1016/j.cytogfr.2023.08.001

Ghazaleh Pourali , Nima Zafari , Hamid Fiuji , Jyotsna Batra , Elham Nazari , Majid Khazaei , Seyed Mahdi Hassanian , Mahrou Vahabi , MohammadAli Kiani , Majid Ghayour-Mobarhan , Godefridus J. Peters , Gordon A. Ferns , Alfred King-yin Lam , Elisa Giovannetti , Amir Avan

{"title":"Extracellular vesicles: Emerging mediators of cell communication in gastrointestinal cancers exhibiting metabolic abnormalities","authors":"Ghazaleh Pourali , Nima Zafari , Hamid Fiuji , Jyotsna Batra , Elham Nazari , Majid Khazaei , Seyed Mahdi Hassanian , Mahrou Vahabi , MohammadAli Kiani , Majid Ghayour-Mobarhan , Godefridus J. Peters , Gordon A. Ferns , Alfred King-yin Lam , Elisa Giovannetti , Amir Avan","doi":"10.1016/j.cytogfr.2023.08.001","DOIUrl":"10.1016/j.cytogfr.2023.08.001","url":null,"abstract":"<div><p>There is a complex interaction between pro-tumoural and anti-tumoural networks in the tumour microenvironment (TME). Throughout tumourigenesis, communication between malignant cells and various cells of the TME contributes to metabolic reprogramming. Tumour Dysregulation of metabolic pathways offer an evolutional advantage in the TME and enhance the tumour progression, invasiveness, and metastasis. Therefore, understanding these interactions within the TME is crucial for the development of innovative cancer treatments. Extracellular vesicles (EVs) serve as carriers of various materials that include microRNAs, proteins, and lipids that play a vital role in the communication between tumour cells and non-tumour cells. EVs are actively involved in the metabolic reprogramming process. This review summarized recent findings regarding the involvement of EVs in the metabolic reprogramming of various cells in the TME of gastrointestinal cancers. Additionally, we highlight identified microRNAs involved in the reprogramming process in this group of cancers and explained the abnormal tumour metabolism targeted by exosomal cargos as well as the novel potential therapeutic approaches.</p></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"73 ","pages":"Pages 101-113"},"PeriodicalIF":13.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10036308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles as a novel mediator of interkingdom communication 细胞外小泡作为一种新的王国间通讯媒介。

IF 13 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2023-10-01 DOI: 10.1016/j.cytogfr.2023.08.005

Jumin Huang , Xuanrun Wang , Ziming Wang , Liyan Deng , Yuwei Wang , Yuping Tang , Lianxiang Luo , Elaine Lai-Han Leung

{"title":"Extracellular vesicles as a novel mediator of interkingdom communication","authors":"Jumin Huang , Xuanrun Wang , Ziming Wang , Liyan Deng , Yuwei Wang , Yuping Tang , Lianxiang Luo , Elaine Lai-Han Leung","doi":"10.1016/j.cytogfr.2023.08.005","DOIUrl":"10.1016/j.cytogfr.2023.08.005","url":null,"abstract":"<div><p><span><span>Extracellular vesicles (EVs) are nanosized lipid bilayer-delimited particles secreted from almost all types of cells including bacteria, mammals and plants, and are presumed to be mediators of intercellular communication. Bacterial extracellular vesicles (BEVs) are nanoparticles with diverse diameters, ranging from 20 to 400 nm. BEVs are composed of soluble microbial metabolites, including </span>nucleic acid, proteins, lipoglycans, and short-chain fatty acids (SCFAs). In addition, EVs may contain </span>quorum sensing<span><span><span><span> peptides that are endowed with the ability to protect bacteria against bacteriophages, form and maintain bacterial communities, and modulate the host immune system. BEVs are potentially promising therapeutic modalities for use in vaccine development, </span>cancer immunotherapy regimens, and drug delivery cargos. Plant-derived EVs (PEVs), such as EVs derived from herbal medicines, can be absorbed by the </span>gut microbiota and influence the composition and </span>homeostasis of gut microbiota. This review highlights the roles of BEVs and PEVs in bacterial and plant physiology and discusses crosstalk among gut bacteria, host metabolism and herbal medicine. In summary, EVs represent crucial communication messengers in the gut microbiota, with potential therapeutic value in the delivery of herbal medicines.</span></p></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"73 ","pages":"Pages 173-184"},"PeriodicalIF":13.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10439160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Role of lipid signalling in extracellular vesicles-mediated cell-to-cell communication 脂质信号传导在细胞外小泡介导的细胞间通讯中的作用。

IF 13 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2023-10-01 DOI: 10.1016/j.cytogfr.2023.08.006

Jordan Fyfe , Ilaria Casari , Marcello Manfredi , Marco Falasca

{"title":"Role of lipid signalling in extracellular vesicles-mediated cell-to-cell communication","authors":"Jordan Fyfe , Ilaria Casari , Marcello Manfredi , Marco Falasca","doi":"10.1016/j.cytogfr.2023.08.006","DOIUrl":"10.1016/j.cytogfr.2023.08.006","url":null,"abstract":"<div><p>Lipid signalling plays a crucial role in extracellular vesicle (EV)-mediated cell-to-cell communication. Extracellular vesicles are small membrane-bound structures released by various cell types into the extracellular environment. They include exosomes, microvesicles, and apoptotic bodies. These vesicles contain a variety of bioactive molecules, including proteins, nucleic acids (such as miRNAs and mRNAs), and lipids. Lipids are important components of EVs and are involved in various aspects of their biogenesis, cargo sorting, and functional effects on target cells. In this review, we will discuss how lipid signalling is involved in EV-mediated cell-to-cell communication. In summary, lipid signalling is intricately involved in extracellular vesicle-mediated cell-to-cell communication. The lipid composition of EVs influences their biogenesis, cargo sorting, interactions with target cells, and functional effects on recipient cells. Understanding the role of lipids in EV-mediated communication is essential for deciphering the mechanisms underlying intercellular signalling and developing potential therapeutic strategies based on EVs.</p></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"73 ","pages":"Pages 20-26"},"PeriodicalIF":13.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10112539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Lipid metabolism in regulation of B cell development and autoimmunity 脂质代谢在调节B细胞发育和自身免疫中的作用。

IF 13 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2023-10-01 DOI: 10.1016/j.cytogfr.2023.06.008

Xing Ji , Liang Wu , Tony Marion , Yubin Luo

引用次数: 0

The role of Extracellular Vesicles in glycolytic and lipid metabolic reprogramming of cancer cells: Consequences for drug resistance 细胞外囊泡在癌症细胞糖酵解和脂质代谢重编程中的作用：耐药性的后果。

IF 13 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2023-10-01 DOI: 10.1016/j.cytogfr.2023.05.001

Bárbara Polónia , Cristina P.R. Xavier , Joanna Kopecka , Chiara Riganti , M. Helena Vasconcelos

{"title":"The role of Extracellular Vesicles in glycolytic and lipid metabolic reprogramming of cancer cells: Consequences for drug resistance","authors":"Bárbara Polónia , Cristina P.R. Xavier , Joanna Kopecka , Chiara Riganti , M. Helena Vasconcelos","doi":"10.1016/j.cytogfr.2023.05.001","DOIUrl":"10.1016/j.cytogfr.2023.05.001","url":null,"abstract":"<div><p>In order to adapt to a higher proliferative rate and an increased demand for energy sources, cancer cells rewire their metabolic pathways, a process currently recognized as a hallmark of cancer. Even though the metabolism of glucose is perhaps the most discussed metabolic shift in cancer, lipid metabolic alterations have been recently recognized as relevant players in the growth and proliferation of cancer cells. Importantly, some of these metabolic alterations are reported to induce a drug resistant phenotype in cancer cells. The acquisition of drug resistance traits severely hinders cancer treatment, being currently considered one of the major challenges of the oncological field. Evidence suggests that Extracellular Vesicles (EVs), which play a crucial role in intercellular communication, may act as facilitators of tumour progression, survival and drug resistance by modulating several aspects involved in the metabolism of cancer cells. This review aims to gather and discuss relevant data regarding metabolic reprograming in cancer, particularly involving the glycolytic and lipid alterations, focusing on its influence on drug resistance and highlighting the relevance of EVs as intercellular mediators of this process.</p></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"73 ","pages":"Pages 150-162"},"PeriodicalIF":13.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9516764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Role of exosomes in transferring chemoresistance through modulation of cancer glycolytic cell metabolism 外泌体在通过调节癌症糖酵解细胞代谢转移化疗耐药性中的作用。

IF 13 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2023-10-01 DOI: 10.1016/j.cytogfr.2023.07.004

Mahrou Vahabi , Annalisa Comandatore , Marika A. Franczak , Ryszard T. Smolenski , Godefridus J. Peters , Luca Morelli , Elisa Giovannetti

{"title":"Role of exosomes in transferring chemoresistance through modulation of cancer glycolytic cell metabolism","authors":"Mahrou Vahabi , Annalisa Comandatore , Marika A. Franczak , Ryszard T. Smolenski , Godefridus J. Peters , Luca Morelli , Elisa Giovannetti","doi":"10.1016/j.cytogfr.2023.07.004","DOIUrl":"10.1016/j.cytogfr.2023.07.004","url":null,"abstract":"<div><p>Chemoresistance constitute a major obstacle in cancer treatment, leading to limited options and decreased patient survival. Recent studies have revealed a novel mechanism of chemoresistance acquisition: the transfer of information via exosomes, small vesicles secreted by various cells. Exosomes play a crucial role in intercellular communication by carrying proteins, nucleic acids, and metabolites, influencing cancer cell behavior and response to treatment. One crucial mechanism of resistance is cancer metabolic reprogramming, which involves alterations in the cellular metabolic pathways to support the survival and proliferation of drug-resistant cancer cells. This metabolic reprogramming often includes increased glycolysis, providing cancer cells with the necessary energy and building blocks to evade the effects of chemotherapy. Notably, exosomes have been found to transport glycolytic enzymes, as identified in proteomic profiling, leading to the reprogramming of metabolic pathways, facilitating altered glucose metabolism and increased lactate production. As a result, they profoundly impact the tumor microenvironment, promoting tumor progression, survival, immune evasion, and drug resistance.Understanding the complexities of such exosome-mediated cell-to-cell communication might open new therapeutic avenues and facilitate biomarker development in managing cancers characterized by aggressive glycolytic features. Moreover, given the intricate nature of metabolic abnormalities combining future exosome-based-targeted therapies with existing treatments like chemotherapy, immunotherapy, and targeted therapies holds promise for achieving synergistic effects to overcome resistance and improve cancer treatment outcomes.</p></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"73 ","pages":"Pages 163-172"},"PeriodicalIF":13.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9936890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomes as a modulator of immune resistance in human cancers 外泌体作为人类癌症免疫抵抗的调节剂。

IF 13 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2023-10-01 DOI: 10.1016/j.cytogfr.2023.07.007

Lanzhou Li , Chunyue Wang , Qiucheng Li , Yue Guan , Xin Zhang , Fange Kong , Zixin Feng , Yuanjun Lu , Di Wang , Ning Wang

{"title":"Exosomes as a modulator of immune resistance in human cancers","authors":"Lanzhou Li , Chunyue Wang , Qiucheng Li , Yue Guan , Xin Zhang , Fange Kong , Zixin Feng , Yuanjun Lu , Di Wang , Ning Wang","doi":"10.1016/j.cytogfr.2023.07.007","DOIUrl":"10.1016/j.cytogfr.2023.07.007","url":null,"abstract":"<div><p><span><span><span><span>In the tumor microenvironment<span> (TME), exosomes secreted by cells form interactive networks between the tumor cells and </span></span>immune cells, thereby regulating immune signaling cascades in the TME. As key messengers of cell-to-cell communication in the TME, exosomes not only take charge of </span>tumor cell antigen presentation to the immune cells, but also regulate the activities of immune cells, inhibit immune function, and, especially, promote immune resistance, all of which affects the therapeutic outcomes of tumors. Exosomes, which are small-sized vesicles, possess some remarkable advantages, including strong biological activity, a lack of </span>immunogenicity and toxicity, and a strong targeting ability. Based on these characteristics, research on exosomes as biomarkers or carriers of tumor therapeutic </span>drugs<span><span> has become a research hotspot in related fields. This review describes the role of exosomes in cell communications in the TME, summarizes the effectiveness of exosome-based immunotherapy in overcoming immune resistance in cancer treatment, and systematically summarizes and discusses the characteristics of exosomes from different cell sources. Furthermore, the prospects and challenges of exosome-related </span>therapies are discussed.</span></p></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"73 ","pages":"Pages 135-149"},"PeriodicalIF":13.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9938012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liquid biopsy analysis of lipometabolic exosomes in pancreatic cancer 癌症脂肪代谢外泌体的液体活检分析。

IF 13 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2023-10-01 DOI: 10.1016/j.cytogfr.2023.07.006

Wei Guo , Peiyao Ying , Ruiyang Ma , Zuoqian Jing , Gang Ma , Jin Long , Guichen Li , Zhe Liu

{"title":"Liquid biopsy analysis of lipometabolic exosomes in pancreatic cancer","authors":"Wei Guo , Peiyao Ying , Ruiyang Ma , Zuoqian Jing , Gang Ma , Jin Long , Guichen Li , Zhe Liu","doi":"10.1016/j.cytogfr.2023.07.006","DOIUrl":"10.1016/j.cytogfr.2023.07.006","url":null,"abstract":"<div><p><span>Pancreatic cancer<span> is characterized by its high malignancy, insidious onset and poor prognosis. Most patients with pancreatic cancer are usually diagnosed at advanced stage or with the </span></span>distant metastasis<span><span> due to the lack of an effective early screening method. Liquid biopsy<span> technology is promising in studying the occurrence, progression, and early metastasis<span> of pancreatic cancer. In particular, exosomes are pivotal biomarkers in </span></span></span>lipid metabolism<span> and liquid biopsy of blood exosomes is valuable for the evaluation of pancreatic cancer. Lipid metabolism is crucial for the formation and activity of exosomes in the extracellular environment. Exosomes and lipids<span> have a complex relationship of mutual influence. Furthermore, spatial metabolomics<span> can quantify the levels and spatial locations of individual metabolites in cancer tissue, cancer stroma, and para-cancerous tissue in pancreatic cancer. However, the relationship among exosomes, lipid metabolism, and pancreatic cancer is also worth considering. This study mainly updates the research progress of metabolomics in pancreatic cancer, their relationship with exosomes, an important part of liquid biopsy, and their lipometabolic roles in pancreatic cancer. We also discuss the mechanisms by which possible metabolites, especially lipid metabolites through exosome transport and other processes, contribute to the recurrence and metastasis of pancreatic cancer.</span></span></span></span></p></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"73 ","pages":"Pages 69-77"},"PeriodicalIF":13.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10243570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles in cancer: Shaping the intricate network of metabolic reprogramming and immune interactions in the tumor microenvironment 癌症的细胞外囊泡：在肿瘤微环境中形成代谢重编程和免疫相互作用的复杂网络。

IF 13 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2023-10-01 DOI: 10.1016/j.cytogfr.2023.09.001

Elisa Giovannetti, Tian Li

引用次数: 0